| scholarly article | Q13442814 |
| P356 | DOI | 10.1111/J.1600-079X.2012.00973.X |
| P698 | PubMed publication ID | 22335196 |
| P2093 | author name string | Yun Zhang | |
| Wenlin Huang | |||
| Wangbing Chen | |||
| Wuguo Deng | |||
| Xiangsheng Xiao | |||
| Dingbo Shi | |||
| Jingshu Wang | |||
| Tiebang Kang | |||
| Fangyun Xie | |||
| Lingyi Fu | |||
| Liqun Liu | |||
| P2860 | cites work | An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9 | Q22009407 |
| Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B | Q27860731 | ||
| Melatonin attenuates lipopolysaccharide-induced acute lung inflammation in sleep-deprived mice | Q46450256 | ||
| Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. | Q53425055 | ||
| Apaf-1 is a transcriptional target for E2F and p53 | Q57274134 | ||
| Structure of the apoptotic protease-activating factor 1 bound to ADP | Q28245105 | ||
| Role of cyclooxygenase-2 in colorectal cancer | Q28248317 | ||
| Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization | Q28275527 | ||
| Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance | Q28303717 | ||
| Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes | Q28354545 | ||
| Molecular mechanisms of caspase regulation during apoptosis | Q29617861 | ||
| Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis | Q33229065 | ||
| Quercetin suppresses cyclooxygenase-2 expression and angiogenesis through inactivation of P300 signaling | Q33999059 | ||
| mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. | Q34098956 | ||
| Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer | Q34168873 | ||
| Present and future evolution of advanced breast cancer therapy | Q34274925 | ||
| Angiogenesis - still a worthwhile target for breast cancer therapy? | Q34423550 | ||
| Inhibition of breast cancer cell invasion by melatonin is mediated through regulation of the p38 mitogen-activated protein kinase signaling pathway | Q34613650 | ||
| Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives. | Q34994700 | ||
| Role of cyclooxygenase-2 in breast cancer | Q35020362 | ||
| Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night | Q35181910 | ||
| Cyclooxygenase-2 inhibition in colorectal cancer: boom or bust? | Q36052281 | ||
| Melatonin as a cytoskeletal modulator: implications for cell physiology and disease | Q36325041 | ||
| Therapeutic actions of melatonin in cancer: possible mechanisms | Q37278725 | ||
| HER2 as a target for breast cancer therapy. | Q37705396 | ||
| Targeting IGF-I, IGFBPs and IGF-I receptor system in cancer: the current and future in breast cancer therapy | Q37830086 | ||
| Melatonin as a natural ally against oxidative stress: a physicochemical examination. | Q37900675 | ||
| Melatonin and associated signaling pathways that control normal breast epithelium and breast cancer | Q37902966 | ||
| Clinical trials in triple negative breast cancer | Q37903579 | ||
| Melatonin sensitizes Caki renal cancer cells to kahweol-induced apoptosis through CHOP-mediated up-regulation of PUMA. | Q39606466 | ||
| Melatonin reduces pancreatic tumor cell viability by altering mitochondrial physiology | Q39625808 | ||
| Interleukin-1β induces ceruloplasmin and ferroportin-1 gene expression via MAP kinases and C/EBPβ, AP-1, and NF-κB activation | Q39665126 | ||
| In vitro and in vivo antitumor activity of melatonin receptor agonists | Q39683381 | ||
| Melatonin down-regulates hTERT expression induced by either natural estrogens (17beta-estradiol) or metalloestrogens (cadmium) in MCF-7 human breast cancer cells | Q39982517 | ||
| Melatonin modulates the expression of VEGF and HIF-1 alpha induced by CoCl2 in cultured cancer cells | Q40010652 | ||
| Role of COX-2, thromboxane A2 synthase, and prostaglandin I2 synthase in papillary thyroid carcinoma growth | Q40505648 | ||
| Role of p300 and PCAF in regulating cyclooxygenase-2 promoter activation by inflammatory mediators | Q40614798 | ||
| Melatonin as a free radical scavenger: implications for aging and age-related diseases | Q40660399 | ||
| Apaf-1 overexpression partially overcomes apoptotic resistance in a cisplatin-selected HeLa cell line | Q40779227 | ||
| Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding | Q41905999 | ||
| Quantitative analysis of binding of transcription factor complex to biotinylated DNA probe by a streptavidin–agarose pulldown assay | Q42452924 | ||
| Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-alpha-induced cyclooxygenase-2 promoter activation | Q42528542 | ||
| Melatonin and celecoxib improve the outcomes in hamsters with experimental pancreatic cancer | Q42971837 | ||
| Histone acetylation by p300 is involved in CREB-mediated transcription on chromatin | Q43832505 | ||
| Involvement of the mt1 melatonin receptor in human breast cancer | Q43913260 | ||
| P433 | issue | 1 | |
| P921 | main subject | breast cancer | Q128581 |
| melatonin | Q180912 | ||
| apoptotic process | Q14599311 | ||
| P304 | page(s) | 77-90 | |
| P577 | publication date | 2012-02-16 | |
| P1433 | published in | Journal of Pineal Research | Q15056565 |
| P1476 | title | Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells | |
| P478 | volume | 53 |
| Q26997809 | 5-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis |
| Q46255367 | A novel function for CUGBP2 in controlling the pro-inflammatory stimulus in H9c2 cells: subcellular trafficking of messenger molecules. |
| Q42366619 | Antiproliferative and pro-apoptotic activity of melatonin analogues on melanoma and breast cancer cells |
| Q28085136 | Artificial light at night: melatonin as a mediator between the environment and epigenome |
| Q48158214 | Citalopram attenuates tau hyperphosphorylation and spatial memory deficit induced by social isolation rearing in middle-aged rats |
| Q46238476 | Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation |
| Q38645158 | Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway |
| Q92083437 | Deciphering the Molecular Basis of Melatonin Protective Effects on Breast Cells Treated with Doxorubicin: TWIST1 a Transcription Factor Involved in EMT and Metastasis, a Novel Target of Melatonin |
| Q41573138 | Effects of Melatonin on Early Pregnancy in Mouse: Involving the Regulation of StAR, Cyp11a1, and Ihh Expression |
| Q34685634 | Effects of melatonin on the proliferation and apoptosis of sheep granulosa cells under thermal stress |
| Q28543963 | Effusanin E suppresses nasopharyngeal carcinoma cell growth by inhibiting NF-κB and COX-2 signaling |
| Q33837257 | Exosomes from Melatonin Treated Hepatocellularcarcinoma Cells Alter the Immunosupression Status through STAT3 Pathway in Macrophages |
| Q39208543 | Expression of melatonin receptor MT1 in cells of human invasive ductal breast carcinoma |
| Q36632043 | High expression levels of COX-2 and P300 are associated with unfavorable survival in laryngeal squamous cell carcinoma |
| Q38972593 | Immunomodulatory effect of melatonin in SK-LU-1 human lung adenocarcinoma cells co-cultured with peripheral blood mononuclear cells |
| Q49230527 | Is melatonin of value in cancer treatment? Experience with a case of feline mammary carcinoma |
| Q28539006 | Lasiodin inhibits proliferation of human nasopharyngeal carcinoma cells by simultaneous modulation of the Apaf-1/caspase, AKT/MAPK and COX-2/NF-κB signaling pathways |
| Q34438693 | Melatonin Attenuates Her-2, p38 MAPK, p-AKT, and mTOR Levels in Ovarian Carcinoma of Ethanol-Preferring Rats |
| Q92749740 | Melatonin Regulates Breast Cancer Progression by the lnc010561/miR-30/FKBP3 Axis |
| Q54660309 | Melatonin and Cancer Hallmarks. |
| Q64053319 | Melatonin and non-small cell lung cancer: new insights into signaling pathways |
| Q26825609 | Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology |
| Q38219604 | Melatonin and ubiquitin: what's the connection? |
| Q99565353 | Melatonin and urological cancers: a new therapeutic approach |
| Q55051489 | Melatonin as a Therapy for Traumatic Brain Injury: A Review of Published Evidence. |
| Q26751220 | Melatonin as a potential anticarcinogen for non-small-cell lung cancer |
| Q35125118 | Melatonin combined with endoplasmic reticulum stress induces cell death via the PI3K/Akt/mTOR pathway in B16F10 melanoma cells |
| Q37465949 | Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway |
| Q33889427 | Melatonin for the prevention and treatment of cancer |
| Q38902157 | Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation |
| Q39145326 | Melatonin induces apoptosis through a caspase-dependent but reactive oxygen species-independent mechanism in human leukemia Molt-3 cells |
| Q30368127 | Melatonin induces apoptosis through biomolecular changes, in SK-LU-1 human lung adenocarcinoma cells. |
| Q36772001 | Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells |
| Q91731419 | Melatonin is a potential drug for the prevention of bone loss during space flight |
| Q33844198 | Melatonin modulation of crosstalk among malignant epithelial, endothelial and adipose cells in breast cancer (Review). |
| Q45922732 | Melatonin overcomes apoptosis resistance in human hepatocellular carcinoma by targeting survivin and XIAP. |
| Q38920808 | Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells |
| Q51405325 | Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model. |
| Q38318403 | Melatonin potentiates the antiproliferative and pro-apoptotic effects of ursolic acid in colon cancer cells by modulating multiple signaling pathways |
| Q39092878 | Melatonin promotes circadian rhythm-induced proliferation through Clock/histone deacetylase 3/c-Myc interaction in mouse adipose tissue |
| Q38717313 | Melatonin promotes sorafenib-induced apoptosis through synergistic activation of JNK/c-jun pathway in human hepatocellular carcinoma |
| Q34358832 | Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways |
| Q33667195 | Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway |
| Q38730168 | Melatonin synergizes the chemotherapeutic effect of 5-fluorouracil in colon cancer by suppressing PI3K/AKT and NF-κB/iNOS signaling pathways |
| Q39028476 | Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells |
| Q30489143 | Melatonin, an inhibitory agent in breast cancer. |
| Q38906542 | Melatonin-mediated Bim up-regulation and cyclooxygenase-2 (COX-2) down-regulation enhances tunicamycin-induced apoptosis in MDA-MB-231 cells |
| Q58587207 | Melatonin: An Anti-Tumor Agent in Hormone-Dependent Cancers |
| Q91668966 | Melatonin: an anti-tumor agent for osteosarcoma |
| Q37007219 | Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases. |
| Q38137168 | Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review |
| Q34405806 | Nicotine promotes proliferation of human nasopharyngeal carcinoma cells by regulating α7AChR, ERK, HIF-1α and VEGF/PEDF signaling |
| Q34429082 | PRAS40 is an integral regulatory component of erythropoietin mTOR signaling and cytoprotection |
| Q38803216 | Potential pleiotropic beneficial effects of adjuvant melatonergic treatment in posttraumatic stress disorder |
| Q58554204 | Promising Antineoplastic Actions of Melatonin |
| Q41036251 | The ABC7 regimen: a new approach to metastatic breast cancer using seven common drugs to inhibit epithelial-to-mesenchymal transition and augment capecitabine efficacy |
| Q39080754 | Transcriptional and post-translational regulation of Bim controls apoptosis in melatonin-treated human renal cancer Caki cells |
| Q28533451 | Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells |
| Q33597963 | What is known about melatonin, chemotherapy and altered gene expression in breast cancer |
| Q36465550 | Wnt1 inducible signaling pathway protein 1 (WISP1) targets PRAS40 to govern β-amyloid apoptotic injury of microglia |
| Q46039292 | XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers. |
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