Ursolic acid, a natural pentacyclic triterpenoid, inhibits intracellular trafficking of proteins and induces accumulation of intercellular adhesion molecule-1 linked to high-mannose-type glycans in the endoplasmic reticulum

scientific article published on 22 February 2014

Ursolic acid, a natural pentacyclic triterpenoid, inhibits intracellular trafficking of proteins and induces accumulation of intercellular adhesion molecule-1 linked to high-mannose-type glycans in the endoplasmic reticulum is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.FOB.2014.02.009
P932PMC publication ID3958921
P698PubMed publication ID24649404
P5875ResearchGate publication ID260314620

P2093author name stringTakao Kataoka
Satoshi Mitsuda
Tomonobu Yokomichi
Junpei Yokoigawa
P2860cites workIs NF-kappaB a good target for cancer therapy? Hopes and pitfallsQ24570128
Brefeldin A: insights into the control of membrane traffic and organelle structureQ24643698
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Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1Q28156175
Enhancement of chemotherapeutic agent-induced apoptosis by inhibition of NF-kappaB using ursolic acidQ43243801
Ursolic acid inhibits IL-1beta or TNF-alpha-induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC-zeta and downregulating the MMP-9 expressionQ43812484
Contribution of N-linked glycans to the conformation and function of intercellular adhesion molecules (ICAMs).Q45151651
Three new triterpenes from Nerium oleander and biological activity of the isolated compoundsQ45281983
Two new chiratane-type triterpenoids from Swertia kouitchensis.Q46090113
Structural basis for dimerization of ICAM-1 on the cell surfaceQ47729587
Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1)Q57962449
Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)Q68202545
Synergistic activation of intercellular adhesion molecule 1 (ICAM-1) by TNF-alpha and IFN-gamma is mediated by p65/p50 and p65/c-Rel and interferon-responsive factor Stat1 alpha (p91) that can be activated by both IFN-gamma and IFN-alphaQ72798753
Taraxasterane- and ursane-type triterpenes from Nerium oleander and their biological activitiesQ80170192
Quantitation of ursolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry and its pharmacokinetic studyQ82946804
α-Glucosidase inhibitory triterpenoids from the stem barks of Uncaria laevigataQ87097500
Retention of unassembled components of integral membrane proteins by calnexinQ28258174
Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cellsQ28533451
Shared principles in NF-kappaB signalingQ29547234
NF-kappaB: linking inflammation and immunity to cancer development and progressionQ29614597
LC-MS determination and pharmacokinetic studies of ursolic acid in rat plasma after administration of the traditional chinese medicinal preparation Lu-Ying extractQ33433492
Active ingredients in Chinese medicines promoting blood circulation as Na+/K+ -ATPase inhibitorsQ33565693
Brefeldin A: the advantage of being uncompetitiveQ33603162
Regulation of intercellular adhesion molecule-1 (CD54) gene expressionQ33805930
Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathwaysQ34199851
Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.).Q34533089
New regulators of NF-kappaB in inflammationQ34858737
Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1.Q35927303
Active participation of endothelial cells in inflammationQ35998467
ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18)Q36224191
A phase I pharmacokinetic study of ursolic acid nanoliposomes in healthy volunteers and patients with advanced solid tumorsQ36520764
Chemical technologies for probing glycansQ36588596
Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathwayQ36637883
Inhibitors of NF-kappaB signaling: 785 and countingQ36637918
Glycosidase inhibitors: inhibitors of N‐linked oligosaccharide processingQ36791925
Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabineQ36916312
Identification of a high-mannose ICAM-1 glycoform: effects of ICAM-1 hypoglycosylation on monocyte adhesion and outside in signalingQ37051315
Ursolic acid: an anti- and pro-inflammatory triterpenoidQ37059823
Ubiquitylation in innate and adaptive immunity.Q37424798
Chemical biology of inflammatory cytokine signalingQ37615916
Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+ -ATPaseQ37729233
NF-κB, inflammation, and metabolic disease.Q37825008
Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies.Q38090246
Inhibition of cell proliferation, invasion and migration by ursolic acid in human lung cancer cell linesQ39548885
Mycotrienin II, a translation inhibitor that prevents ICAM-1 expression induced by pro-inflammatory cytokinesQ39568589
Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell linesQ39764144
Odoroside A and ouabain inhibit Na+/K+-ATPase and prevent NF-kappaB-inducible protein expression by blocking Na+-dependent amino acid transportQ39832403
Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathwayQ39832426
Ursolic Acid Inhibits Na+/K+-ATPase Activity and Prevents TNF-α-Induced Gene Expression by Blocking Amino Acid Transport and Cellular Protein SynthesisQ39868145
Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cellsQ39981116
Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers.Q40402637
Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cellsQ40518741
Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-α-induced E-selectin expression by cultured umbilical vein endothelial cellsQ43004951
P4510describes a project that usesImageQuantQ112270642
P921main subjectendoplasmic reticulumQ79927
P304page(s)229-239
P577publication date2014-02-22
P1433published inFEBS Open BioQ27724062
P1476titleUrsolic acid, a natural pentacyclic triterpenoid, inhibits intracellular trafficking of proteins and induces accumulation of intercellular adhesion molecule-1 linked to high-mannose-type glycans in the endoplasmic reticulum
P478volume4

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cites work (P2860)
Q38718438HIV-1 Vpu Downmodulates ICAM-1 Expression, Resulting in Decreased Killing of Infected CD4+ T Cells by NK Cells
Q48174470Quinacrine Inhibits ICAM-1 Transcription by Blocking DNA Binding of the NF-κB Subunit p65 and Sensitizes Human Lung Adenocarcinoma A549 Cells to TNF-α and the Fas Ligand

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