Saracatinib (AZD0530) is a potent modulator of ABCB1-mediated multidrug resistance in vitro and in vivo

scientific article

Saracatinib (AZD0530) is a potent modulator of ABCB1-mediated multidrug resistance in vitro and in vivo is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/IJC.27649
P932PMC publication ID3459133
P698PubMed publication ID22623106
P5875ResearchGate publication ID225059067

P50authorSatyakam SinghQ42858875
P2093author name stringXiao-Dong Su
Fang Wang
Zhe-Sheng Chen
Suresh V Ambudkar
Tanaji T Talele
Hai-Ying Wu
Ke-Jun Liu
Xing-Gui Chen
Li-Wu Fu
Jie-Hua He
Hong-May Sim
Jing-Dun Xie
Kamlesh Sodani
Yong-Ju Liang
P2860cites workGefitinib reverses chemotherapy resistance in gefitinib-insensitive multidrug resistant cancer cells expressing ATP-binding cassette family proteinQ40390330
Reversal of P-gp mediated multidrug resistance in-vitro and in-vivo by FG020318.Q40530013
Valproic acid inhibits proliferation and induces apoptosis in acute myeloid leukemia cells expressing P-gp and MRP1.Q40561425
Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530Q41130127
Reduced drug accumulation and multidrug resistance in human breast cancer cells without associated P-glycoprotein or MRP overexpressionQ42814970
Phase I safety, pharmacokinetics, and inhibition of SRC activity study of saracatinib in patients with solid tumorsQ42921884
Combined pharmacophore modeling, docking, and 3D QSAR studies of ABCB1 and ABCC1 transporter inhibitorsQ43273710
Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoproteinQ44543802
Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistanceQ44687014
Screening novel, potent multidrug-resistant modulators from imidazole derivativesQ45011364
Computational models for identifying potential P-glycoprotein substrates and inhibitorsQ48547412
Quantitative structure-activity relationship of multidrug resistance reversal agentsQ73626792
Effect of BIBF 1120 on reversal of ABCB1-mediated multidrug resistanceQ83360720
LAPTM4B: a novel cancer-associated gene motivates multidrug resistance through efflux and activating PI3K/AKT signalingQ24296238
Src family kinases in tumor progression and metastasisQ24311656
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell lineQ24338329
Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transportersQ24617999
Structure of P-glycoprotein reveals a molecular basis for poly-specific drug bindingQ24657908
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
The human ATP-binding cassette (ABC) transporter superfamilyQ28204495
The role of ABC transporters in drug resistance, metabolism and toxicityQ28283237
Vandetanib (Zactima, ZD6474) antagonizes ABCC1- and ABCG2-mediated multidrug resistance by inhibition of their transport functionQ28475378
Cellular functions regulated by Src family kinasesQ29616038
Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)Q33194199
Characterization of a side population of cancer cells from human gastrointestinal systemQ33225639
Inhibition of PI3K/Akt partially leads to the inhibition of PrP(C)-induced drug resistance in gastric cancer cellsQ33399904
Structural, mechanistic and clinical aspects of MRP1.Q33784449
Src in cancer: deregulation and consequences for cell behaviourQ33959239
P-glycoprotein: from genomics to mechanism.Q34272173
Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).Q34743441
Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance.Q34803651
Identifying and characterizing binding sites and assessing druggabilityQ34980548
Activation of the PI3K/Akt pathway and chemotherapeutic resistanceQ35046899
Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoproteinQ35076190
A phase II trial of the Src-kinase inhibitor AZD0530 in patients with advanced castration-resistant prostate cancer: a California Cancer Consortium studyQ35576853
Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense systemQ36610461
Phase II study of saracatinib (AZD0530) for patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC).Q36995781
Mutational analysis of ABC proteinsQ37104958
Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2Q37119716
Structural and functional properties of human multidrug resistance protein 1 (MRP1/ABCC1).Q37818370
Pharmacology of drugs that alter multidrug resistance in cancerQ37969138
Up-regulation of breast cancer resistance protein plays a role in HER2-mediated chemoresistance through PI3K/Akt and nuclear factor-kappa B signaling pathways in MCF7 breast cancer cellsQ38333889
Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cellsQ38337454
ERK activation by thymosin-beta-4 (TB4) overexpression induces paclitaxel-resistanceQ38510908
Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2.Q39881351
Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxolQ40036920
Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistanceQ40050525
Reversal of MDR1/P-glycoprotein-mediated multidrug resistance by vector-based RNA interference in vitro and in vivoQ40345597
P4510describes a project that usesImageQuantQ112270642
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectsaracatinibQ21098957
multiple drug resistanceQ643839
P304page(s)224-235
P577publication date2012-06-13
P1433published inInternational Journal of CancerQ332492
P1476titleSaracatinib (AZD0530) is a potent modulator of ABCB1-mediated multidrug resistance in vitro and in vivo
P478volume132

Reverse relations

cites work (P2860)
Q28541630A new 2α,5α,10β,14β-tetraacetoxy-4(20),11-taxadiene (SIA) derivative overcomes paclitaxel resistance by inhibiting MAPK signaling and increasing paclitaxel accumulation in breast cancer cells
Q36413392Afatinib reverses multidrug resistance in ovarian cancer via dually inhibiting ATP binding cassette subfamily B member 1.
Q41471408Bufalin reverses ABCB1-mediated drug resistance in colorectal cancer
Q33654580Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid
Q58572040Effect of five novel 5-substituted tetrandrine derivatives on P-glycoprotein-mediated inhibition and transport in Caco-2 cells
Q36335981Hedyotis diffusa Willd overcomes 5-fluorouracil resistance in human colorectal cancer HCT-8/5-FU cells by downregulating the expression of P-glycoprotein and ATP-binding casette subfamily G member 2.
Q38810143Nobiletin enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cancer cells
Q39152151PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells
Q36182381Prognostic Value and Implication for Chemotherapy Treatment of ABCB1 in Epithelial Ovarian Cancer: A Meta-Analysis
Q49347037Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy
Q30679405Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer
Q47214772The synergistic role of ATP-dependent drug efflux pump and focal adhesion signaling pathways in vinorelbine resistance in lung cancer.
Q49888021Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells.
Q36702964Zuo Jin Wan, a Traditional Chinese Herbal Formula, Reverses P-gp-Mediated MDR In Vitro and In Vivo

Search more.