Effect of BIBF 1120 on reversal of ABCB1-mediated multidrug resistance

scientific article published on 28 January 2011

Effect of BIBF 1120 on reversal of ABCB1-mediated multidrug resistance is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S13402-010-0003-7
P698PubMed publication ID21290212

P2093author name stringFang Wang
Li-wu Fu
Wei-qiang Chen
Yong-ju Liang
Yan-jun Mi
Xiao-dong Su
Li-sheng Zheng
Qing-feng Xiang
P2860cites workABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversalQ21246014
A multidrug resistance transporter from human MCF-7 breast cancer cellsQ22008574
Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistanceQ24645668
BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacyQ27650860
The human ATP-binding cassette (ABC) transporter superfamilyQ28204495
Multidrug resistance in cancer: role of ATP-dependent transportersQ28208049
Vandetanib (Zactima, ZD6474) antagonizes ABCC1- and ABCG2-mediated multidrug resistance by inhibition of their transport functionQ28475378
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumorsQ29615445
Targeting multidrug resistance in cancerQ29616803
Tumour stem cells and drug resistanceQ29617742
Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)Q33194199
Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity.Q33194953
Characterization of a side population of cancer cells from human gastrointestinal systemQ33225639
Biochemical, cellular, and pharmacological aspects of the multidrug transporterQ33636699
Structural, mechanistic and clinical aspects of MRP1.Q33784449
Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugsQ34060806
Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and pemetrexed in pretreated non-small cell lung cancer patientsQ34114767
The Role of ABC Transporters in Clinical PracticeQ34268081
VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance proteinQ34304819
A phase I open-label dose-escalation study of oral BIBF 1120 combined with standard paclitaxel and carboplatin in patients with advanced gynecological malignanciesQ35011280
Activation of the PI3K/Akt pathway and chemotherapeutic resistanceQ35046899
Multidrug resistance: retrospect and prospects in anti-cancer drug treatment.Q36536479
Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: current status and future directions.Q36552808
Therapeutic options to target angiogenesis in human malignanciesQ36634261
Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2Q37119716
Photodynamic therapy inhibits P-glycoprotein mediated multidrug resistance via JNK activation in human hepatocellular carcinoma using the photosensitizer pheophorbide a.Q37318005
Intedanib, a triple kinase inhibitor of VEGFR, FGFR and PDGFR for the treatment of cancer and idiopathic pulmonary fibrosisQ37739938
BIBF 1120 for the treatment of non-small cell lung cancerQ37750755
Pharmacology of drugs that alter multidrug resistance in cancerQ37969138
Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cellsQ38337454
ERK activation by thymosin-beta-4 (TB4) overexpression induces paclitaxel-resistanceQ38510908
Cediranib (recentin, AZD2171) reverses ABCB1- and ABCC1-mediated multidrug resistance by inhibition of their transport functionQ39877772
Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2.Q39881351
Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxolQ40036920
Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistanceQ40050525
Reversal of MDR1/P-glycoprotein-mediated multidrug resistance by vector-based RNA interference in vitro and in vivoQ40345597
Gefitinib, an EGFR tyrosine kinase inhibitor, directly inhibits the function of P-glycoprotein in multidrug resistant cancer cells.Q40410062
Reversal of P-gp mediated multidrug resistance in-vitro and in-vivo by FG020318.Q40530013
Inhibition of P-glycoprotein activity and reversal of cancer multidrug resistance by Momordica charantia extractQ40536780
Valproic acid inhibits proliferation and induces apoptosis in acute myeloid leukemia cells expressing P-gp and MRP1.Q40561425
P-glycoprotein--a mediator of multidrug resistance in tumour cellsQ41078108
Pharmacological considerations in the modulation of multidrug resistanceQ41078223
HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.Q44450066
Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistanceQ44687014
Screening novel, potent multidrug-resistant modulators from imidazole derivativesQ45011364
The anti-angiogenesis agent, AG-013736, has minimal activity in elderly patients with poor prognosis acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).Q46839213
Effects of modulators of multidrug resistance on the expression of the MDR1 gene in human KB cells in cultureQ59358946
Bevacizumab reduces VEGF expression in patients with relapsed and refractory acute myeloid leukemia without clinical antileukemic activityQ79849693
Overcoming multidrug resistance in cancer: clinical studies of p-glycoprotein inhibitorsQ84966132
P433issue1
P921main subjectmultiple drug resistanceQ643839
P304page(s)33-44
P577publication date2011-01-28
P1433published inCellular OncologyQ2160503
P1476titleEffect of BIBF 1120 on reversal of ABCB1-mediated multidrug resistance
P478volume34