Enriching Peptide Libraries for Binding Affinity and Specificity Through Computationally Directed Library Design.

scientific article

Enriching Peptide Libraries for Binding Affinity and Specificity Through Computationally Directed Library Design. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/978-1-4939-6798-8_13
P932PMC publication ID5553629
P698PubMed publication ID28236241

P50authorAmy KeatingQ28914832
P2093author name stringT Scott Chen
Daniel Richman
Glenna Wink Foight
P2860cites workGenome-wide prediction and validation of peptides that bind human prosurvival Bcl-2 proteinsQ21145296
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Computational Design of Proteins Targeting the Conserved Stem Region of Influenza HemagglutininQ27667831
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Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanesQ28259812
High-throughput analysis of peptide-binding modulesQ28267042
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Structure-based prediction of the Saccharomyces cerevisiae SH3-ligand interactionsQ30157316
Designing specific protein-protein interactions using computation, experimental library screening, or integrated methodsQ30416858
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Quantum dots as a visual aid for screening bead-bound combinatorial librariesQ33194959
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Optimizing the affinity and specificity of proteins with molecular displayQ33252425
Computationally designed libraries of fluorescent proteins evaluated by preservation and diversity of functionQ33267087
Optimal protein library design using recombination or point mutations based on sequence-based scoring functionsQ33293659
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High-resolution mapping of protein sequence-function relationshipsQ33658465
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Experimental library screening demonstrates the successful application of computational protein design to large structural ensemblesQ33736505
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Peptide ligands for pro-survival protein Bfl-1 from computationally guided library screeningQ34567408
Enzyme engineering by targeted librariesQ34592014
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Computational design of selective peptides to discriminate between similar PDZ domains in an oncogenic pathwayQ35468530
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Locating Herpesvirus Bcl-2 Homologs in the Specificity Landscape of Anti-Apoptotic Bcl-2 Proteins.Q35640928
Massively Parallel Functional Analysis of BRCA1 RING Domain VariantsQ35821029
Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains.Q35917117
A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein functionQ36342633
Predictive Bcl-2 family binding models rooted in experiment or structureQ36692693
Peptide docking and structure-based characterization of peptide binding: from knowledge to know-how.Q38153851
Hydrophile scanning as a complement to alanine scanning for exploring and manipulating protein-protein recognition: application to the Bim BH3 domainQ39639296
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Modeling backbone flexibility to achieve sequence diversity: the design of novel alpha-helical ligands for Bcl-xL.Q41365386
In silico and in vitro elucidation of BH3 binding specificity toward Bcl-2Q41958792
P407language of work or nameEnglishQ1860
P304page(s)213-232
P577publication date2017-01-01
P1433published inMethods in Molecular BiologyQ15752859
P1476titleEnriching Peptide Libraries for Binding Affinity and Specificity Through Computationally Directed Library Design
P478volume1561

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cites work (P2860)
Q33779035Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1
Q90003530Multi-input chemical control of protein dimerization for programming graded cellular responses

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