brawn for brains: the role of MEF2 proteins in the developing nervous system

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brawn for brains: the role of MEF2 proteins in the developing nervous system is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0070-2153(05)69009-6
P698PubMed publication ID16243602

P2093author name stringAzad Bonni
Aryaman K Shalizi
P2860cites workRegulation of the MEF2 family of transcription factors by p38Q22008562
Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factorsQ22010041
mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activityQ22253463
Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localizationQ22254367
Regulation of histone deacetylase 4 by binding of 14-3-3 proteinsQ24290142
Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylasesQ24290235
Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiationQ24290523
Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5Q24290618
Differential localization of HDAC4 orchestrates muscle differentiationQ24291565
ERK5 is targeted to myocyte enhancer factor 2A (MEF2A) through a MAPK docking motifQ24292700
Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factorsQ24294604
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulatorQ24294798
Class II histone deacetylases: versatile regulatorsQ24300376
Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiationQ24307379
Phosphorylation motifs regulating the stability and function of myocyte enhancer factor 2AQ72999432
Calcineurin Co-regulates contractile and metabolic components of slow muscle phenotypeQ73703912
A dominant-negative form of transcription factor MEF2 inhibits myogenesisQ73960028
RNA interference reveals a requirement for myocyte enhancer factor 2A in activity-dependent neuronal survivalQ74796123
Regulation of mitochondrial biogenesis in skeletal muscle by CaMKQ77932716
Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23Q24318522
Components of a new human protein kinase signal transduction pathwayQ24319086
hMEF2C gene encodes skeletal muscle- and brain-specific transcription factorsQ24322986
Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factorsQ24519076
Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cellsQ24522573
BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2CQ24532869
Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosisQ24534050
MEF-2 function is modified by a novel co-repressor, MITRQ24534397
HDAC4 deacetylase associates with and represses the MEF2 transcription factorQ24534407
Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defectsQ24534817
p300/cAMP-response-element-binding-protein ('CREB')-binding protein (CBP) modulates co-operation between myocyte enhancer factor 2A (MEF2A) and thyroid hormone receptor-retinoid X receptorQ24535129
Histone deacetylases (HDACs): characterization of the classical HDAC familyQ24535587
Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1Q24548255
Identification of a signal-responsive nuclear export sequence in class II histone deacetylasesQ24550848
Histone deacetylase 4 possesses intrinsic nuclear import and export signalsQ24550857
HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressorQ24554388
14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiationQ24555638
D-MEF2: a MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesisQ24562839
MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortexQ24563497
Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosisQ24599847
DNA binding by MADS-box transcription factors: a molecular mechanism for differential DNA bendingQ24646362
Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2CQ24647260
Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2CQ24649105
Neurotrophins: roles in neuronal development and functionQ24656166
Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylasesQ24682791
Neurotrophin signal transduction in the nervous systemQ27876223
Big mitogen-activated kinase regulates multiple members of the MEF2 protein familyQ28137985
Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factorQ28140525
Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2Q28143007
Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4Q28145073
Neuronal activity-dependent cell survival mediated by transcription factor MEF2Q28146016
Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2Q28146018
Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survivalQ28191655
MEF2: a calcium-dependent regulator of cell division, differentiation and deathQ28215798
Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteinsQ28263821
The Sir2 family of protein deacetylasesQ28266179
Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1Q28283417
Roles of histone acetyltransferases and deacetylases in gene regulationQ28286019
MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cellsQ28289460
Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteinsQ28294155
Neurotrophin-3 is required for proper cerebellar developmentQ28505292
MEF2B is a potent transactivator expressed in early myogenic lineagesQ28505977
MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardiumQ28506129
Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factorQ28510070
Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiationQ28510551
The expression of MEF2 genes is implicated in CNS neuronal differentiationQ28511872
The transcriptional corepressor MITR is a signal-responsive inhibitor of myogenesisQ28513025
Cdk5-Mediated Inhibition of the Protective Effects of Transcription Factor MEF2 in Neurotoxicity-Induced ApoptosisQ28571515
Calcineurin enhances MEF2 DNA binding activity in calcium-dependent survival of cerebellar granule neuronsQ28583015
Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insultsQ28583500
Mouse Mef2b gene: unique member of MEF2 gene familyQ28584926
Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2CQ28589290
Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7Q28594917
p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factorQ28646220
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibresQ29555845
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signalsQ29620470
Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons.Q31840769
Direct interaction of Ca2+/calmodulin inhibits histone deacetylase 5 repressor core binding to myocyte enhancer factor 2.Q33186316
Calcineurin. Structure, function, and inhibitionQ33547330
ERK5 is a novel type of mitogen-activated protein kinase containing a transcriptional activation domainQ33605384
A network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: a role for c-Jun NH2-terminal kinase, p38s, and extracellular signal-regulated kinase 5.Q33652314
Signaling from G protein-coupled receptors to ERK5/Big MAPK 1 involves Galpha q and Galpha 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras AND Rho-independent pathwayQ33899529
Calcium regulation of neuronal gene expressionQ33944216
Signaling chromatin to make muscleQ35021248
The sounds of silence--histone deacetylation meets histone methylationQ35118113
Review of the in vivo functions of the p160 steroid receptor coactivator familyQ35153867
An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscleQ35163135
Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiationQ35163278
ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neuronsQ35168574
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber typeQ35207780
D-mef2: a Drosophila mesoderm-specific MADS box-containing gene with a biphasic expression profile during embryogenesisQ35644544
Calcineurin: a central controller of signalling in eukaryotesQ35732880
Role of extracellular signal regulated kinase 5 in neuronal survival.Q35778139
Mitochondrial mechanisms of neural cell apoptosisQ35876358
A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicingQ36647589
Phosphorylation and alternative pre-mRNA splicing converge to regulate myocyte enhancer factor 2C activityQ37493082
The calcineurin-NFAT pathway and muscle fiber-type gene expressionQ38308118
A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation.Q38335789
The nerve growth factor 35 years laterQ39667849
Post-translational control of the MEF2A transcriptional regulatory proteinQ39728215
Activation of the MEF2 transcription factor in skeletal muscles from myotonic miceQ39737926
Calcium regulation of gene expression in neurons: the mode of entry mattersQ40425906
Calcium signaling in neurons: molecular mechanisms and cellular consequencesQ40506441
TGF-beta-activated Smad3 represses MEF2-dependent transcription in myogenic differentiationQ40573337
Calcium and excitotoxic neuronal injury.Q40586805
The molecular mechanisms of neuronal apoptosisQ40588445
Adhesion-related kinase repression of gonadotropin-releasing hormone gene expression requires Rac activation of the extracellular signal-regulated kinase pathwayQ40715854
Excitotoxicity, free radicals, and cell membrane changesQ40753471
The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2.Q40768023
A dynamic role for HDAC7 in MEF2-mediated muscle differentiation.Q40816173
Signal transduction by the neurotrophin receptorsQ41382912
Conservation of Brachyury, Mef2, and Snail in the myogenic lineage of jellyfish: a connection to the mesoderm of bilateriaQ42674022
Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibersQ43736479
Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5.Q44365117
A myocyte enhancer factor 2D (MEF2D) kinase activated during neuronal apoptosis is a novel target inhibited by lithiumQ44465691
Insulin-like growth factor-I suppresses degradation of the pro-survival transcription factor myocyte enhancer factor 2D (MEF2D) during neuronal apoptosisQ44718177
Time-dependent changes in the expression of the MEF2 transcription factor family during topographic map reorganization in mammalian visual cortexQ44980283
Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression.Q45265401
The MADS-Box factor CeMEF2 is not essential for Caenorhabditis elegans myogenesis and developmentQ47069122
Functional characterization of an amino-terminal region of HDAC4 that possesses MEF2 binding and transcriptional repressive activityQ47957936
SUMO promotes HDAC-mediated transcriptional repressionQ48017954
Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern.Q48226926
Abnormal cerebellar development and foliation in BDNF-/- mice reveals a role for neurotrophins in CNS patterningQ48644054
Subcellular localization of the steroid receptor coactivators (SRCs) and MEF2 in muscle and rhabdomyosarcoma cells.Q52136057
Myocyte enhancer factor 2C upregulates MASH-1 expression and induces neurogenesis in P19 cells.Q52168870
Muscle development: electrical control of gene expression.Q52181707
Calcineurin: From structure to functionQ61995636
Classification and phylogeny of the MADS-box multigene family suggest defined roles of MADS-box gene subfamilies in the morphological evolution of eukaryotesQ71695780
Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturationQ71978735
Myocyte-specific enhancer binding factor 2C expression in human brain developmentQ72119328
Calcineurin controls nerve activity-dependent specification of slow skeletal muscle fibers but not muscle growthQ33949126
A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression.Q33965285
Ca(2+)/CREB/CBP-dependent gene regulation: a shared mechanism critical in long-term synaptic plasticity and neuronal survivalQ33967665
Apoptosis in the nervous systemQ34068965
Neuronal apoptosis after CNS injury: the roles of glutamate and calcium.Q34076418
The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking.Q34084949
Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons.Q34087738
Control of muscle development by dueling HATs and HDACsQ34088887
Neurotrophins use the Erk5 pathway to mediate a retrograde survival response.Q34090264
Calcium, calcineurin, and the control of transcriptionQ34092392
Mechanisms of Ca(2+)-dependent transcriptionQ34278048
Regulation and functions of myogenic regulatory factors in lower vertebratesQ34317952
Neurotrophin signalling pathways regulating neuronal apoptosisQ34350914
Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity.Q34384721
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammationQ34419537
Location, location, location: a spatial view of neurotrophin signal transductionQ34536363
Coactivators in transcription initiation: here are your orders.Q34563250
MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber typeQ34669135
Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha ) and mitochondrial function by MEF2 and HDAC5Q34761571
MEF2 proteins, including MEF2A, are expressed in both muscle and non-muscle cellsQ34778070
P304page(s)239-266
P577publication date2005-01-01
P1433published inCurrent Topics in Developmental BiologyQ15745419
P1476titlebrawn for brains: the role of MEF2 proteins in the developing nervous system
P478volume69

Reverse relations

cites work (P2860)
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