The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways

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The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways is …
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scholarly articleQ13442814

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P819ADS bibcode1993PNAS...90.4441B
P356DOI10.1073/PNAS.90.10.4441
P932PMC publication ID46527
P698PubMed publication ID8389450
P5875ResearchGate publication ID14810757

P2093author name stringS K Nordeen
N L Weigel
C A Beck
D P Edwards
M L Moyer
P2860cites workLigand and DNA-dependent phosphorylation of human progesterone receptor in vitroQ24318363
Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptorQ33923267
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The Molecular Biology of RU486. Is There a Role for Antiprogestins in the Treatment of Breast Cancer?*Q36266619
Hormone-induced progesterone receptor phosphorylation consists of sequential DNA-independent and DNA-dependent stages: analysis with zinc finger mutants and the progesterone antagonist ZK98299.Q36935311
Coupling of dual signaling pathways: epidermal growth factor action involves the estrogen receptorQ37021857
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Endocrine pharmacology of antiestrogens as antitumor agentsQ38038012
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Differential DNA-binding abilites of estrogen receptor occupied with two classes of antiestrogens: studies using human estrogen receptor overexpressed in mammalian cellsQ40509133
Two types of antiprogestins identified by their differential action in transcriptionally active extracts from T47D cellsQ40532210
Progesterone enhances target gene transcription by receptor free of heat shock proteins hsp90, hsp56, and hsp70.Q40641073
Modulation of glucocorticoid receptor function by protein kinase A.Q41605052
Effects of hormone and cellular modulators of protein phosphorylation on transcriptional activity, DNA binding, and phosphorylation of human progesterone receptorsQ41633387
Effects of okadaic acid, a protein phosphatase inhibitor, on glucocorticoid receptor-mediated enhancementQ41651305
Dopaminergic and Ligand-Independent Activation of Steroid Hormone ReceptorsQ41653040
Dopamine activation of an orphan of the steroid receptor superfamilyQ41679723
Regulation of Vasopressin Messenger RNA Levels in the Small Cell Lung Carcinoma Cell Line GLC-8: Interactions between Glucocorticoids and Second MessengersQ41682281
Regulation of progesterone receptor-mediated transcription by phosphorylationQ41710148
Proenkephalin Gene Expression in C6 Rat Glioma Cells: Potentiation of Cyclic Adenosine 3′,5′- Monophosphate-Dependent Transcription by GlucocorticoidsQ42463495
A quantitative comparison of dual control of a hormone response element by progestins and glucocorticoids in the same cell lineQ42814888
Progesterone metabolism in T47Dco human breast cancer cells--II. Intracellular metabolic path of progesterone and synthetic progestinsQ43630135
Cyclic AMP-dependent protein kinase modulation of the glucocorticoid-induced cytolytic response in murine T-lymphoma cellsQ46111540
Phosphotryptic peptide analysis of human progesterone receptor. New phosphorylated sites formed in nuclei after hormone treatmentQ46526574
Effects of the steroid antagonist RU486 on dimerization of the human progesterone receptorQ52442325
Acquired tamoxifen resistance: correlation with reduced breast tumor levels of tamoxifen and isomerization of trans-4-hydroxytamoxifen.Q54286500
Receptors bound to antiprogestin form abortive complexes with hormone responsive elementsQ59081172
Progesterone receptor regulation in uterine cells: stimulation by estrogen, cyclic adenosine 3',5'-monophosphate, and insulin-like growth factor I and suppression by antiestrogens and protein kinase inhibitorsQ67684561
Estrogen receptor phosphorylation. Hormonal dependence and consequence on specific DNA bindingQ68091393
A rapid, sensitive, and inexpensive assay for chloramphenicol acetyltransferaseQ68760342
Human progesterone receptor complexed with the antagonist RU 486 binds to hormone response elements in a structurally altered formQ69419589
Progesterone induction of metallothionein-IIA gene expressionQ69837448
Dimerization of the chicken progesterone receptor in vitro can occur in the absence of hormone and DNAQ70256794
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectmifepristoneQ411240
P1104number of pages5
P304page(s)4441-4445
P577publication date1993-05-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleThe progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways
P478volume90