Two types of antiprogestins identified by their differential action in transcriptionally active extracts from T47D cells

scientific article published on March 1991

Two types of antiprogestins identified by their differential action in transcriptionally active extracts from T47D cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/NAR/19.6.1227
P932PMC publication ID333847
P698PubMed publication ID2030942
P5875ResearchGate publication ID21124953

P2093author name stringHenderson D
Ryffel GU
Cato AC
Klein-Hitpass L
P2860cites workTwo distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and BQ24556548
The steroid and thyroid hormone receptor superfamilyQ27861095
The effects of an antiprogesterone steroid in women: interruption of the menstrual cycle and of early pregnancyQ28274326
Mechanisms of nuclear localization of the progesterone receptor: evidence for interaction between monomersQ28276809
Gene regulation by steroid hormonesQ29618291
Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerizationQ33777797
The hormone regulatory element of mouse mammary tumour virus mediates progesterone inductionQ33880358
Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptorQ33923267
The hormone response element of the mouse mammary tumour virus DNA mediates the progestin and androgen induction of transcription in the proviral long terminal repeat region.Q33928807
Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptorQ34544071
Liver cell specific gene transcription in vitro: the promoter elements HP1 and TATA box are necessary and sufficient to generate a liver-specific promoterQ35864691
Antiprogestins, a new form of endocrine therapy for human breast cancerQ36024326
Repression of the alpha-fetoprotein gene promoter by progesterone and chimeric receptors in the presence of hormones and antihormonesQ36726228
Specific binding of estrogen receptor to the estrogen response elementQ36752836
Factors involved in specific transcription by human RNA polymerase II: analysis by a rapid and quantitative in vitro assayQ37522721
Regulation of gene expression by nuclear hormone receptorsQ38326537
Progesterone receptor stimulates transcription of mouse mammary tumour virus in a cell-free systemQ38341540
The progesterone receptor stimulates cell-free transcription by enhancing the formation of a stable preinitiation complexQ38342253
Steroid hormone-dependent interaction of human progesterone receptor with its target enhancer elementQ38345947
Identification of a functional intermediate in receptor activation in progesterone-dependent cell-free transcriptionQ41731206
In situ photolinked nuclear progesterone receptors of human breast cancer cells: subunit molecular weights after transformation and translocationQ44011636
Antitumor activity of the antiprogestins ZK 98.299 and RU 38.486 in hormone dependent rat and mouse mammary tumors: mechanistic studiesQ45152380
Reduced levels of hsp90 compromise steroid receptor action in vivoQ45391521
Differential gene activation by glucocorticoids and progestins through the hormone regulatory element of mouse mammary tumor virusQ45841615
Glucocorticoid and progesterone receptors bind to the same sites in two hormonally regulated promotersQ48381314
The antiprogestin RU38 486: receptor-mediated progestin versus antiprogestin actions screened in estrogen-insensitive T47Dco human breast cancer cells.Q53845998
Carcinogenesis: A superfamily of potentially oncogenic hormone receptorsQ59077092
Receptors bound to antiprogestin form abortive complexes with hormone responsive elementsQ59081172
Steroid hormone receptors compete for factors that mediate their enhancer functionQ61818663
The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimerQ67927526
Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formationQ67927534
A high-efficiency HeLa cell nuclear transcription extractQ68287469
Interaction of the antioestrogen ICI 164,384 with the oestrogen receptorQ68419252
Studies on the mechanisms of action of progesterone antagonistsQ68930079
A rapid method of epitope mapping. Application to the study of immunogenic domains and to the characterization of various forms of rabbit progesterone receptorQ69039233
Antitumor activity of the progesterone antagonists ZK 98.299 and RU 38.486 in the hormone-dependent MXT mammary tumor model of the mouse and the DMBA- and the MNU-induced mammary tumor models of the ratQ69194540
Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at target enhancer elementsQ69369913
The antitumor mechanism of progesterone antagonists is a receptor mediated antiproliferative effect by induction of terminal cell deathQ69449192
Immunologic analysis of human breast cancer progesterone receptors. 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodiesQ69464715
Viral enhancer activity in teratocarcinoma cellsQ70133049
A secreted glycoprotein induced by estrogen in human breast cancer cell linesQ71235918
New steroids with antiprogestational and antiglucocorticoid activitiesQ72602909
P433issue6
P304page(s)1227-1234
P577publication date1991-03-01
P1433published inNucleic Acids ResearchQ135122
P1476titleTwo types of antiprogestins identified by their differential action in transcriptionally active extracts from T47D cells
P478volume19

Reverse relations

cites work (P2860)
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Q38340041Antiprogestins mediate differential effects on glucocorticoid receptor remodeling of chromatin structure
Q35909300Antiprogestins prevent progesterone receptor binding to hormone responsive elements in vivo
Q73830146Characterization of ligand binding, DNA binding and phosphorylation of progesterone receptor by two novel progesterone receptor antagonist ligands
Q28202581Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486
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Q28366589Demonstration of mixed properties of RU486 in progesterone receptor (PR)-transfected MDA-MB-231 cells: a model for studying the functions of progesterone analogues
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Q95721243Hormone-induced nucleosome positioning in the MMTV promoter is reversible
Q36935311Hormone-induced progesterone receptor phosphorylation consists of sequential DNA-independent and DNA-dependent stages: analysis with zinc finger mutants and the progesterone antagonist ZK98299.
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Q41296506Identification of a Transactivation Function in the Progesterone Receptor That Interacts with the TAFII110 Subunit of the TFIID Complex
Q36298269In vivo evidence against the existence of antiprogestins disrupting receptor binding to DNA
Q42543741Interference between progesterone and dioxin signal transduction pathways. Different mechanisms are involved in repression by the progesterone receptor A and B isoforms
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Q38993290Molecular screening of Chinese medicinal plants for progestogenic and anti-progestogenic activity
Q36379145Nuclear progesterone receptor is mainly heat shock protein 90-free in vivo
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Q35189958p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation
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