Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance

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Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.200405053
P932PMC publication ID2172574
P698PubMed publication ID15557120
P5875ResearchGate publication ID8170442

P50authorJoseph TcherkezianQ107490486
P2093author name stringNathalie Lamarche-Vane
Mayya Meriane
Sarah McFarlane
Christine A Webber
Evelyne Bloch-Gallego
Ibtissem Triki
Eric I Danek
P2860cites workSignaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidanceQ35099606
Rac proteins and the control of axon developmentQ35172832
Signalling mechanisms mediating neuronal responses to guidance cuesQ35610287
Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cellsQ38292096
The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1.Q39454809
Sustained activation of N-WASP through phosphorylation is essential for neurite extensionQ40690235
Tyrosine phosphorylation and axon guidance: of mice and fliesQ41353232
Chimeric axon guidance receptors: the cytoplasmic domains of slit and netrin receptors specify attraction versus repulsionQ41678046
A unique role for Fyn in CNS myelination.Q43540465
Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.Q43726475
UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domainsQ44218952
Guidance of developing axons by netrin-1 and its receptors.Q46882126
Tyrosine phosphorylation in early embryonic growth conesQ48245946
Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebratesQ22010646
Deleted in Colorectal Cancer (DCC) encodes a netrin receptorQ24313278
Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant miceQ24338349
Multiple signaling mechanisms of the UNC-6/netrin receptors UNC-5 and UNC-40/DCC in vivoQ24548195
SU6656, a selective src family kinase inhibitor, used to probe growth factor signalingQ24551043
Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose platesQ27860715
SH2 domains recognize specific phosphopeptide sequencesQ27860748
Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axonsQ28176698
Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complexQ28203651
The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidanceQ28587510
An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1Q29614256
Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous systemQ29616040
Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activationQ29617586
The molecular biology of axon guidanceQ29617857
Genistein, a specific inhibitor of tyrosine-specific protein kinasesQ29618097
The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanismQ30165268
c-src gene product in developing rat brain is enriched in nerve growth cone membranesQ33631204
Conservation and divergence of axon guidance mechanisms.Q33745357
A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsionQ33867499
Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activationQ34126386
Chemotropic guidance of developing axons in the mammalian central nervous systemQ34169868
Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesisQ34183568
The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.Q34332258
Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cordQ34332262
UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cuesQ34401959
Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC.Q34451947
Axon guidance: receptor complexes and signaling mechanismsQ34671376
Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticityQ34762533
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)687-698
P577publication date2004-11-01
P1433published inJournal of Cell BiologyQ1524550
P1476titlePhosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance
P478volume167