Infectious HIV-1 assembles in late endosomes in primary macrophages

scientific article

Infectious HIV-1 assembles in late endosomes in primary macrophages is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1083/JCB.200304008
P932PMC publication ID2172706
P698PubMed publication ID12885763
P5875ResearchGate publication ID10640063

P50authorMark MarshQ37383678
P2093author name stringBeatrice Kramer
Annegret Pelchen-Matthews
P2860cites workIsolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)Q22242256
Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 buddingQ24291784
The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]Q24530181
B lymphocytes secrete antigen-presenting vesiclesQ24678522
Human macrophages accumulate HIV-1 particles in MHC II compartmentsQ28201737
Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHCQ28292719
Exosomes: composition, biogenesis and functionQ29547721
Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomesQ31048369
In vivo attenuation of simian immunodeficiency virus by disruption of a tyrosine-dependent sorting signal in the envelope glycoprotein cytoplasmic tailQ33834814
Differential incorporation of CD45, CD80 (B7-1), CD86 (B7-2), and major histocompatibility complex class I and II molecules into human immunodeficiency virus type 1 virions and microvesicles: implications for viral pathogenesis and immune regulationQ33842620
The membrane-proximal intracytoplasmic tyrosine residue of HIV-1 envelope glycoprotein is critical for basolateral targeting of viral budding in MDCK cellsQ33886113
Plasma membrane rafts play a critical role in HIV-1 assembly and releaseQ33950207
Regulated secretion of conventional lysosomesQ33960468
Isolation of Lymphocytopathic Retroviruses from San Francisco Patients with AIDSQ34250436
Secretory lysosomesQ34522863
The biogenesis and functions of exosomesQ34609715
Potential roles of cellular proteins in HIV-1.Q34985857
Macrophage activation and HIV infection: can the Trojan horse turn into a fortress?Q35014653
Mechanisms of enveloped RNA virus buddingQ35032061
The influence of cytokines, chemokines and their receptors on HIV-1 replication in monocytes and macrophages.Q35040074
Human immunodeficiency virus type 1 envelope protein endocytosis mediated by a highly conserved intrinsic internalization signal in the cytoplasmic domain of gp41 is suppressed in the presence of the Pr55gag precursor proteinQ35869312
The presence of host-derived HLA-DR1 on human immunodeficiency virus type 1 increases viral infectivityQ35877952
An internalization signal in the simian immunodeficiency virus transmembrane protein cytoplasmic domain modulates expression of envelope glycoproteins on the cell surfaceQ36236526
Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytesQ36354762
Macrophages as susceptible targets for HIV infection, persistent viral reservoirs in tissue, and key immunoregulatory cells that control levels of virus replication and extent of diseaseQ37974635
Characterization of monoclonal antibodies against the human immunodeficiency virus (HIV) gag products and their use in monitoring HIV isolate variationQ38891588
Potential role for CD63 in CCR5-mediated human immunodeficiency virus type 1 infection of macrophagesQ39732524
Cytoplasmic assembly and accumulation of human immunodeficiency virus types 1 and 2 in recombinant human colony-stimulating factor-1-treated human monocytes: an ultrastructural studyQ40130110
A lipid associated with the antiphospholipid syndrome regulates endosome structure and functionQ41056430
Transmission of human immunodeficiency virus from monocytes to epitheliaQ41702389
Immunocytochemical characterization of the endocytic and phagolysosomal compartments in peritoneal macrophagesQ42545057
Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59.Q44368034
The simian immunodeficiency virus envelope glycoprotein contains multiple signals that regulate its cell surface expression and endocytosisQ45738527
The acquisition of host-derived major histocompatibility complex class II glycoproteins by human immunodeficiency virus type 1 accelerates the process of virus entry and infection in human T-lymphoid cells.Q45761409
Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteinsQ45830218
Recruitment of HIV and its receptors to dendritic cell-T cell junctionsQ47563778
Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytesQ47761769
Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane.Q50335826
T-cell engagement of dendritic cells rapidly rearranges MHC class II transport.Q54026692
The HIV-TSG101 interface: recent advances in a budding fieldQ73029426
The acquisition of host-encoded proteins by nascent HIV-1Q77111813
DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infectionQ77589727
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectHIVQ15787
macrophageQ184204
P304page(s)443-455
P577publication date2003-07-28
P1433published inJournal of Cell BiologyQ1524550
P1476titleInfectious HIV-1 assembles in late endosomes in primary macrophages
P478volume162

Reverse relations

cites work (P2860)
Q3338184125 years of HIV-1 research - progress and perspectives
Q40889648A Phase 1b/2a study of the safety, pharmacokinetics and antiviral activity of BIT225 in patients with HIV-1 infection
Q24681865A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein
Q37229056A critical role for CD63 in HIV replication and infection of macrophages and cell lines
Q34460625A large extension to HIV-1 Gag, like Pol, has negative impacts on virion assembly
Q34434813A mutation in the human immunodeficiency virus type 1 Gag protein destabilizes the interaction of the envelope protein subunits gp120 and gp41.
Q34699365A post-entry role for CD63 in early HIV-1 replication
Q36320477A primate virus generates transformed human cells by fusion
Q21245053A role for CD81 on the late steps of HIV-1 replication in a chronically infected T cell line
Q42727113A seek-and-hide game between Cd1-restricted T cells and herpesviruses
Q28115418A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex
Q40542002APOBEC3G is incorporated into virus-like particles by a direct interaction with HIV-1 Gag nucleocapsid protein
Q24336178ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles
Q34186317Absence of DICER in monocytes and its regulation by HIV-1.
Q35192642After Hrs with HIV
Q34635209Alix serves as an adaptor that allows human parainfluenza virus type 1 to interact with the host cell ESCRT system
Q33987373Amino acid residues in the cytoplasmic domain of the Mason-Pfizer monkey virus glycoprotein critical for its incorporation into virions
Q36667906An endothelial cell-specific requirement for the UL133-UL138 locus of human cytomegalovirus for efficient virus maturation
Q43236292Annexin 2: a novel human immunodeficiency virus type 1 Gag binding protein involved in replication in monocyte-derived macrophages
Q33422993Anx2 interacts with HIV-1 Gag at phosphatidylinositol (4,5) bisphosphate-containing lipid rafts and increases viral production in 293T cells
Q27491003Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review
Q42140364Architecture and regulation of the HIV-1 assembly and holding compartment in macrophages
Q45402964Assembly and budding of a hepatitis B virus is mediated by a novel type of intracellular vesicles
Q37280434Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages
Q30245414Barriers to HIV Cure
Q37205286Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages
Q35952753Biosynthesis and alternate targeting of the lysosomal cysteine protease cathepsin L.
Q79961023Both clathrin-positive and -negative coats are involved in endosomal sorting of the EGF receptor
Q40202125Budding of Marburgvirus is associated with filopodia
Q35965263Budding of alphaviruses
Q24799613Budding viral hijackers co-opt the endocytic machinery to make a getaway
Q30557430CD36-specific antibodies block release of HIV-1 from infected primary macrophages and its transmission to T cells.
Q35946467CD4-independent use of the CCR5 receptor by sequential primary SIVsm isolates
Q34353412CD4-specific transgenic expression of human cyclin T1 markedly increases human immunodeficiency virus type 1 (HIV-1) production by CD4+ T lymphocytes and myeloid cells in mice transgenic for a provirus encoding a monocyte-tropic HIV-1 isolate
Q36594161CD63 is not required for production of infectious human immunodeficiency virus type 1 in human macrophages
Q28594550Ca2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes
Q36597945Cell biology of membrane trafficking in human disease
Q37892324Cell biology of retroviral RNA packaging.
Q37182721Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
Q35543719Cell-type-dependent targeting of human immunodeficiency virus type 1 assembly to the plasma membrane and the multivesicular body
Q36690080Cellular phosphoinositides and the maturation of bluetongue virus, a non-enveloped capsid virus.
Q36228143Cellular virology
Q33905233Central neuroinvasion and demyelination by inflammatory macrophages after peripheral virus infection is controlled by SHP-1.
Q36412305Characterization and role of lentivirus-associated host proteins
Q37340427Characterization of a third generation lentiviral vector pseudotyped with Nipah virus envelope proteins for endothelial cell transduction
Q35570996Citron kinase, a RhoA effector, enhances HIV-1 virion production by modulating exocytosis
Q33619173Class II transactivator (CIITA) enhances cytoplasmic processing of HIV-1 Pr55Gag
Q33374009Clathrin- and caveolin-independent entry of human papillomavirus type 16--involvement of tetraspanin-enriched microdomains (TEMs)
Q64902278Co- but not Sequential Infection of DCs Boosts Their HIV-Specific CTL-Stimulatory Capacity.
Q92340185Contribution of the Cytoplasmic Determinants of Vpu to the Expansion of Virus-Containing Compartments in HIV-1-Infected Macrophages
Q30527789Critical role for the kinesin KIF3A in the HIV life cycle in primary human macrophages
Q55286937Cytotoxicity assessment, inflammatory properties, and cellular uptake of Neutraplex lipid-based nanoparticles in THP-1 monocyte-derived macrophages.
Q40331521Deletion of a Cys-His motif from the Alpharetrovirus nucleocapsid domain reveals late domain mutant-like budding defects
Q34632997Dendritic Cells and HIV-1 Trans-Infection
Q36352268Dendritic cell maturation, but not type I interferon exposure, restricts infection by HTLV-1, and viral transmission to T-cells.
Q34572043Dendritic-cell interactions with HIV: infection and viral dissemination
Q30443327Depletion of cellular cholesterol inhibits membrane binding and higher-order multimerization of human immunodeficiency virus type 1 Gag.
Q40096523Distinct intracellular trafficking of equine infectious anemia virus and human immunodeficiency virus type 1 Gag during viral assembly and budding revealed by bimolecular fluorescence complementation assays.
Q36341770Do Alix and ALG-2 really control endosomes for better or for worse?
Q42688106Dominant negative inhibition of human immunodeficiency virus particle production by the nonmyristoylated form of gag.
Q21245209Dual effect of the SR proteins ASF/SF2, SC35 and 9G8 on HIV-1 RNA splicing and virion production
Q36102200Dynamic Association between HIV-1 Gag and Membrane Domains.
Q33707507Dynamic fluorescent imaging of human immunodeficiency virus type 1 gag in live cells by biarsenical labeling
Q27311049Dynamics of HIV-containing compartments in macrophages reveal sequestration of virions and transient surface connections
Q24792862Early steps of retrovirus replicative cycle
Q41928771Effects of Amprenavir on HIV-1 Maturation, Production and Infectivity Following Drug Withdrawal in Chronically-Infected Monocytes/Macrophages
Q36746951Electron microscopy analysis of viral morphogenesis
Q27331060Electron tomography of HIV-1 infection in gut-associated lymphoid tissue
Q35857301Electrostatic interactions drive membrane association of the human immunodeficiency virus type 1 Gag MA domain
Q53139509Endocytosis and signaling: a relationship under development.
Q35911166Endosomal membrane traffic: convergence point targeted by Mycobacterium tuberculosis and HIV.
Q30490064Endosomal trafficking of HIV-1 gag and genomic RNAs regulates viral egress.
Q34059457Endosomal trafficking of nanoformulated antiretroviral therapy facilitates drug particle carriage and HIV clearance.
Q35989046Endosome-to-cytosol transport of viral nucleocapsids
Q36524040Equine Infectious Anemia Virus Gag Assembly and Export Are Directed by Matrix Protein through trans-Golgi Networks and Cellular Vesicles
Q37946431Essential and supporting host cell factors for HIV-1 budding
Q44619422Evidence That HIV Budding in Primary Macrophages Occurs through the Exosome Release Pathway
Q35313971Evidence of a role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) machinery in HIV-1 assembly and release
Q34684340Evidence that Vpu modulates HIV-1 Gag-envelope interaction towards envelope incorporation and infectivity in a cell type dependent manner
Q37191818Evidence that productive human immunodeficiency virus type 1 assembly can occur in an intracellular compartment
Q24303407Exosomal-like vesicles are present in human blood plasma
Q28301729Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane
Q33943140Filamin A protein interacts with human immunodeficiency virus type 1 Gag protein and contributes to productive particle assembly
Q40272140Foamy virus capsid assembly occurs at a pericentriolar region through a cytoplasmic targeting/retention signal in Gag.
Q35382894Gag induces the coalescence of clustered lipid rafts and tetraspanin-enriched microdomains at HIV-1 assembly sites on the plasma membrane.
Q45414100Gamma-adaptin, a novel ubiquitin-interacting adaptor, and Nedd4 ubiquitin ligase control hepatitis B virus maturation
Q36323002HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein.
Q51760002HIV and the Macrophage: From Cell Reservoirs to Drug Delivery to Viral Eradication.
Q64118463HIV infection and latency induce a unique metabolic signature in human macrophages
Q37229398HIV interactions with monocytes and dendritic cells: viral latency and reservoirs
Q34420382HIV life cycle, innate immunity and autophagy in the central nervous system
Q57065390HIV's great escape
Q37178360HIV-1 Assembly at the Plasma Membrane: Gag Trafficking and Localization
Q57371251HIV-1 Egress is Gated Through Late Endosomal Membranes
Q34983799HIV-1 Gag: flipped out for PI(4,5)P(2).
Q39118089HIV-1 Nef promotes the localization of Gag to the cell membrane and facilitates viral cell-to-cell transfer
Q57065358HIV-1 Trafficking to the Dendritic Cell-T-Cell Infectious Synapse Uses a Pathway of Tetraspanin Sorting to the Immunological Synapse
Q37945213HIV-1 Virological Synapse: Live Imaging of Transmission
Q33614489HIV-1 Vpr oligomerization but not that of Gag directs the interaction between Vpr and Gag.
Q40036254HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes
Q30815492HIV-1 Vpu promotes release and prevents endocytosis of nascent retrovirus particles from the plasma membrane
Q33888565HIV-1 assembly at the plasma membrane
Q37726306HIV-1 assembly in macrophages
Q38023864HIV-1 assembly, budding, and maturation
Q33279812HIV-1 buds predominantly at the plasma membrane of primary human macrophages
Q57030223HIV-1 cell-to-cell transmission and broadly neutralizing antibodies
Q53521281HIV-1 harboring renal tubular epithelial cell interaction with T cells results in T cell trans-infection.
Q34156875HIV-1 is budded from CD4+ T lymphocytes independently of exosomes
Q27345288HIV-1 matrix dependent membrane targeting is regulated by Gag mRNA trafficking
Q36702218HIV-1 matrix protein: a mysterious regulator of the viral life cycle
Q37396586HIV-1 persists in breast milk cells despite antiretroviral treatment to prevent mother-to-child transmission
Q37607912HIV-1 regulation of latency in the monocyte-macrophage lineage and in CD4+ T lymphocytes
Q41921236HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim.
Q24676087Hepatitis B virus maturation is sensitive to functional inhibition of ESCRT-III, Vps4, and gamma 2-adaptin
Q34190539Hepatitis C virus egress and release depend on endosomal trafficking of core protein
Q33884090Heterologous late-domain sequences have various abilities to promote budding of human immunodeficiency virus type 1.
Q33286754Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes
Q34174790Hormonally active vitamin D3 (1alpha,25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection
Q36746350Host factors exploited by retroviruses
Q37890247Host factors involved in retroviral budding and release.
Q37922877Host factors mediating HIV-1 replication
Q35745418Human Cytomegalovirus UL135 and UL136 Genes Are Required for Postentry Tropism in Endothelial Cells
Q37035170Human Discs Large is a new negative regulator of human immunodeficiency virus-1 infectivity
Q36071753Human Immunodeficiency Virus Type 2 (HIV-2) Gag Is Trafficked in an AP-3 and AP-5 Dependent Manner.
Q30436618Human Ubc9 contributes to production of fully infectious human immunodeficiency virus type 1 virions
Q37035419Human herpesvirus-6 induces MVB formation, and virus egress occurs by an exosomal release pathway
Q36512300Human immunodeficiency virus (HIV) infects human arterial smooth muscle cells in vivo and in vitro: implications for the pathogenesis of HIV-mediated vascular disease
Q40883661Human immunodeficiency virus type 1 Gag contains a dileucine-like motif that regulates association with multivesicular bodies
Q30480954Human immunodeficiency virus type 1 and influenza virus exit via different membrane microdomains.
Q42056475Human immunodeficiency virus type 1 assembly, budding, and cell-cell spread in T cells take place in tetraspanin-enriched plasma membrane domains
Q36857103Human immunodeficiency virus type 1 assembly, release, and maturation.
Q35597822Human immunodeficiency virus type 1 endocytic trafficking through macrophage bridging conduits facilitates spread of infection
Q35914355Human immunodeficiency virus type 1 protease cleaves procaspase 8 in vivo
Q33763110Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinase
Q36694200IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation
Q36708826Identification of HIV inhibitors guided by free energy perturbation calculations
Q40046367Identification of host proteins associated with retroviral vector particles by proteomic analysis of highly purified vector preparations.
Q35894459Identification of mumps virus protein and lipid composition by mass spectrometry.
Q34781463Imaging the biogenesis of individual HIV-1 virions in live cells
Q34270884Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection
Q35634348Impact of natural polymorphism within the gp41 cytoplasmic tail of human immunodeficiency virus type 1 on the intracellular distribution of envelope glycoproteins and viral assembly.
Q36118172In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53.
Q27005938Inhibition of human immunodeficiency virus type-1 through autophagy
Q39023294Insertion of host-derived costimulatory molecules CD80 (B7.1) and CD86 (B7.2) into human immunodeficiency virus type 1 affects the virus life cycle
Q36483820Interaction between the human immunodeficiency virus type 1 Gag matrix domain and phosphatidylinositol-(4,5)-bisphosphate is essential for efficient gag membrane binding
Q34448034Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2.
Q40269589Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1.
Q42115515Intracellular assembly and budding of the Murine Leukemia Virus in infected cells
Q40096537Intracellular trafficking and maturation of herpes simplex virus type 1 gB and virus egress require functional biogenesis of multivesicular bodies
Q34439347Intracellular trafficking of Gag and Env proteins and their interactions modulate pseudotyping of retroviruses
Q37194255Intracellular transport of human immunodeficiency virus type 1 genomic RNA and viral production are dependent on dynein motor function and late endosome positioning
Q40367288Intracellular versus cell surface assembly of retroviral pseudotypes is determined by the cellular localization of the viral glycoprotein, its capacity to interact with Gag, and the expression of the Nef protein.
Q35840550Involvement of host cellular multivesicular body functions in hepatitis B virus budding
Q27316251Ion-abrasion scanning electron microscopy reveals surface-connected tubular conduits in HIV-infected macrophages
Q25255905Latency: the hidden HIV-1 challenge
Q34979935Lateral organization of membrane proteins: tetraspanins spin their web.
Q41865429Lentiviral vectors containing mouse Csf1r control elements direct macrophage-restricted expression in multiple species of birds and mammals
Q33695334Lineage specificity of gene expression patterns
Q21245090Loss of Niemann Pick type C proteins 1 and 2 greatly enhances HIV infectivity and is associated with accumulation of HIV Gag and cholesterol in late endosomes/lysosomes
Q47218999Low-level HIV replication in mixed glial cultures is associated with alterations in the processing of p55(Gag).
Q35083192Macrophage bridging conduit trafficking of HIV-1 through the endoplasmic reticulum and Golgi network
Q30510067Macrophage internal HIV-1 is protected from neutralizing antibodies
Q34931267Macrophages and Cell-Cell Spread of HIV-1.
Q33215934Macrophages archive HIV-1 virions for dissemination in trans
Q38761136Major histocompatibility complex class II molecules promote human immunodeficiency virus type 1 assembly and budding to late endosomal/multivesicular body compartments.
Q38282025Major histocompatibility complex class-II molecules promote targeting of human immunodeficiency virus type 1 virions in late endosomes by enhancing internalization of nascent particles from the plasma membrane
Q30480407Mapping of tetraspanin-enriched microdomains that can function as gateways for HIV-1.
Q37359745Maturation of the Gag core decreases the stability of retroviral lipid membranes
Q54260276Mechanisms for Cell-to-Cell Transmission of HIV-1.
Q45502425Meeting report: EMBO workshop 'Cell Biology of Virus Infection', September 25-29, 2004, EMBL, Heidelberg, Germany
Q38210206Membrane interaction of retroviral Gag proteins
Q34730602Mice transgenic for CD4-specific human CD4, CCR5 and cyclin T1 expression: a new model for investigating HIV-1 transmission and treatment efficacy
Q43119311Microbial strategies to exploit host cells. Meeting on spatial and temporal dynamics of the endomembrane system
Q36424527Modulation of human immunodeficiency virus type 1 infectivity through incorporation of tetraspanin proteins
Q39578041Molecular Determinants Directing HIV-1 Gag Assembly to Virus-Containing Compartments in Primary Macrophages
Q33864438Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage
Q36790007Monocyte-derived macrophages exhibit distinct and more restricted HIV-1 integration site repertoire than CD4(+) T cells
Q36791778More than one door - Budding of enveloped viruses through cellular membranes
Q40277987Multivesicular bodies as a platform for formation of the Marburg virus envelope
Q34262061Murine leukemia virus Gag localizes to the uropod of migrating primary lymphocytes
Q33352053Murine leukemia virus spreading in mice impaired in the biogenesis of secretory lysosomes and Ca2+-regulated exocytosis
Q36735631Mutation of Glycosylation Sites in BST-2 Leads to Its Accumulation at Intracellular CD63-Positive Vesicles without Affecting Its Antiviral Activity against Multivesicular Body-Targeted HIV-1 and Hepatitis B Virus
Q35023995Mutation of dileucine-like motifs in the human immunodeficiency virus type 1 capsid disrupts virus assembly, gag-gag interactions, gag-membrane binding, and virion maturation
Q47141408Myeloid Cell Interaction with HIV: A Complex Relationship.
Q34544143Myristate exposure in the human immunodeficiency virus type 1 matrix protein is modulated by pH.
Q37043004Nature, nurture and HIV: The effect of producer cell on viral physiology
Q35116068Nedd4-mediated increase in HIV-1 Gag and Env proteins and immunity following DNA-vaccination of BALB/c mice
Q49587948Nef Secretion into Extracellular Vesicles or Exosomes Is Conserved across Human and Simian Immunodeficiency Viruses.
Q40486921Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivity
Q57373224New Insights into Human Immunodeficiency Virus—Type 1 Replication
Q36307738New insights into HIV assembly and trafficking
Q38227869New insights into retroviral Gag-Gag and Gag-membrane interactions.
Q24699386Novel factors interfering with human immunodeficiency virus-type 1 replication in vivo and in vitro
Q37160836Oligomerization of the macrophage mannose receptor enhances gp120-mediated binding of HIV-1.
Q30543436Organization and regulation of intracellular plasma membrane-connected HIV-1 assembly compartments in macrophages
Q36343823Pathways of cell-cell transmission of HTLV-1
Q24563708Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma membrane
Q35020445Placental Hofbauer cells assemble and sequester HIV-1 in tetraspanin-positive compartments that are accessible to broadly neutralizing antibodies.
Q27334953Plasma membrane is the site of productive HIV-1 particle assembly
Q30481367Probing the structural states of human immunodeficiency virus type 1 pr55gag by using monoclonal antibodies
Q40132008Productive human immunodeficiency virus type 1 assembly takes place at the plasma membrane.
Q36857096Properties, functions, and drug targeting of the multifunctional nucleocapsid protein of the human immunodeficiency virus.
Q33255758Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages
Q26853681Proteomics, biomarkers, and HIV-1: A current perspective
Q24533383Rab9 GTPase is required for replication of human immunodeficiency virus type 1, filoviruses, and measles virus
Q39826186Reactivation from latency displays HIV particle budding at plasma membrane, accompanying CD44 upregulation and recruitment
Q27318996Real-time visualization of HIV-1 GAG trafficking in infected macrophages
Q39069264Recombinant extracellular domains of tetraspanin proteins are potent inhibitors of the infection of macrophages by human immunodeficiency virus type 1.
Q40172752Regulation of cargo transfer between ESCRT-0 and ESCRT-I complexes by flotillin-1 during endosomal sorting of ubiquitinated cargo.
Q34666503Relationships between plasma membrane microdomains and HIV-1 assembly
Q36871864Replication of HIV-1 in vivo and in vitro
Q36546903Replication of human immunodeficiency virus type 1 from entry to exit
Q41819754Requirement for an intact T-cell actin and tubulin cytoskeleton for efficient assembly and spread of human immunodeficiency virus type 1.
Q45422412Rescue of internal scaffold-deleted Mason-Pfizer monkey virus particle production by plasma membrane targeting
Q80146470Resolution of de novo HIV production and trafficking in immature dendritic cells
Q38218411Retrospective on the all-in-one retroviral nucleocapsid protein
Q35836276Retroviral mRNA nuclear export elements regulate protein function and virion assembly.
Q35856741Retroviral spread by induction of virological synapses
Q35965257Retrovirus budding.
Q41445328Retrovirus infection strongly enhances scrapie infectivity release in cell culture
Q35634169Rev-dependent lentiviral expression vector
Q56333817Role of Exosomes in Human Retroviral Mediated Disorders
Q38227871Role of Gag and lipids during HIV-1 assembly in CD4(+) T cells and macrophages.
Q37755250Role of macrophages in HIV infection and persistence
Q35761675Role of the HIV-1 Matrix Protein in Gag Intracellular Trafficking and Targeting to the Plasma Membrane for Virus Assembly
Q42831702Role of the human T-cell leukemia virus type 1 PTAP motif in Gag targeting and particle release.
Q38228643Role of the nucleocapsid region in HIV-1 Gag assembly as investigated by quantitative fluorescence-based microscopy
Q34615838Roles played by acidic lipids in HIV-1 Gag membrane binding
Q41972090SNAREs in HIV-1 assembly
Q27485184Secretory Leukocyte Protease Inhibitor Binds to Annexin II, a Cofactor for Macrophage HIV-1 Infection
Q30480956Sequence of human immunodeficiency virus type 1 (HIV-1) Gag localization and oligomerization monitored with live confocal imaging of a replication-competent, fluorescently tagged HIV-1.
Q34085094Short communication: Activating stimuli enhance immunotoxin-mediated killing of HIV-infected macrophages
Q36262599Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1.
Q30382341Strategies for targeting tetraspanin proteins: potential therapeutic applications in microbial infections.
Q24522711Subversion of cellular autophagosomal machinery by RNA viruses
Q41924135T cell-macrophage fusion triggers multinucleated giant cell formation for HIV-1 spreading.
Q36578830TLR-4 engagement of dendritic cells confers a BST-2/tetherin-mediated restriction of HIV-1 infection to CD4+ T cells across the virological synapse.
Q24315160TLR2-dependent pathway of heterologous down-modulation for the CC chemokine receptors 1, 2, and 5 in human blood monocytes
Q34713979TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion.
Q36533706Targeting of tetraspanin proteins--potential benefits and strategies
Q31172123Tetherin can restrict cell-free and cell-cell transmission of HIV from primary macrophages to T cells
Q41990109Tetherin/BST-2 is essential for the formation of the intracellular virus-containing compartment in HIV-infected macrophages.
Q55084010Tetraspanin Assemblies in Virus Infection.
Q38875152Tetraspanin CD63 is a regulator of HIV-1 replication
Q27470936Tetraspanins in viral infections: a fundamental role in viral biology?
Q42567174Tetraspanins regulate cell-to-cell transmission of HIV-1
Q27002500The Complex Interaction Between Methamphetamine Abuse and HIV-1 Pathogenesis
Q42429503The HIV-1 matrix protein does not interact directly with the protein interactive domain of AP-3δ.
Q61812881The Incorporation of Host Proteins into the External HIV-1 Envelope
Q24294993The Protein Network of HIV Budding
Q32183747The Role of Caveolin 1 in HIV Infection and Pathogenesis
Q41653444The Src kinase Lck facilitates assembly of HIV-1 at the plasma membrane
Q40083997The Vpu-regulated endocytosis of HIV-1 Gag is clathrin-independent
Q29620561The biogenesis of multivesicular endosomes
Q37520101The cell biology of HIV-1 virion genesis
Q34591671The cellular protein La functions in enhancement of virus release through lipid rafts facilitated by murine leukemia virus glycosylated Gag.
Q39235790The chitinases expression is related to Simian Immunodeficiency Virus Encephalitis (SIVE) and in HIV encephalitis (HIVE).
Q35942353The clathrin adaptor complex AP-1 binds HIV-1 and MLV Gag and facilitates their budding.
Q37621290The dual role of tetraspanin CD63 in HIV-1 replication
Q38964223The effect of the membrane-proximal tyrosine-based sorting signal of HIV-1 gp41 on viral infectivity depends on sequences within gp120.
Q37218425The functionally exchangeable L domains in RSV and HIV-1 Gag direct particle release through pathways linked by Tsg101
Q24315925The host protein Staufen1 interacts with the Pr55Gag zinc fingers and regulates HIV-1 assembly via its N-terminus
Q34261545The intracellular virus-containing compartments in primary human macrophages are largely inaccessible to antibodies and small molecules
Q26823236The macrophage: a therapeutic target in HIV-1 infection
Q40589969The matrix protein of Marburg virus is transported to the plasma membrane along cellular membranes: exploiting the retrograde late endosomal pathway
Q36505647The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy
Q38269331The role of human dendritic cells in HIV-1 infection
Q33796306The roles of tetraspanins in HIV-1 replication
Q34390403The tetraspanin web modulates immune-signalling complexes
Q24557498The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production
Q37754779The yeast protein sorting pathway as an experimental model for lysosomal trafficking
Q30588474Three-dimensional imaging of HIV-1 virological synapses reveals membrane architectures involved in virus transmission.
Q28485225Toll-like receptor 8 ligands activate a vitamin D mediated autophagic response that inhibits human immunodeficiency virus type 1
Q24304953Trafficking of HIV-1 RNA is mediated by heterogeneous nuclear ribonucleoprotein A2 expression and impacts on viral assembly
Q40418986Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding
Q39428496Viral Interactions with Host Cell Rab GTPases
Q36204700Virus-producing cells determine the host protein profiles of HIV-1 virion cores
Q40616484Visualization of retroviral replication in living cells reveals budding into multivesicular bodies.
Q30476308Visualization of retrovirus budding with correlated light and electron microscopy.
Q37901609Visualizing HIV-1 assembly
Q42028162Vpu and Tsg101 regulate intracellular targeting of the human immunodeficiency virus type 1 core protein precursor Pr55gag
Q27934077Vta1p and Vps46p regulate the membrane association and ATPase activity of Vps4p at the yeast multivesicular body
Q42976627ZAP-70 kinase regulates HIV cell-to-cell spread and virological synapse formation.
Q57065265β2 Integrin Adhesion Complexes Maintain the Integrity of HIV-1 Assembly Compartments in Primary Macrophages

Search more.