IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation

scientific article published on 4 March 2013

IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20120572
P932PMC publication ID3600911
P698PubMed publication ID23460728
P5875ResearchGate publication ID235787938

P50authorRichard A. LempickiQ37391952
Joseph W AdelsbergerQ115624462
P2093author name stringJun Yang
Xin Zheng
Tomozumi Imamichi
Qian Chen
H Clifford Lane
Stephen J Lockett
Robin L Dewar
Ronald L Hornung
Yanmei Wang
DaWei Huang
Kelsey A Canizales
Kristy B Lidie
Lue Dai
Tauseef Rehman
P2860cites workSTAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylationQ24297971
Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 CommitmentQ24301442
Identification of host proteins required for HIV infection through a functional genomic screenQ24306298
WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27Q24307411
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by VpxQ24605940
SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cellsQ24615124
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphatesQ24624362
BST-2/tetherin: a new component of the innate immune response to enveloped virusesQ24630382
Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 proteinQ24635842
Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeletonQ24647043
HIV-1 Vif, APOBEC, and intrinsic immunityQ24647833
Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activityQ24685633
Localization and Structure of the Ankyrin-binding Site on  2-SpectrinQ27653198
Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif proteinQ27860488
Human macrophages accumulate HIV-1 particles in MHC II compartmentsQ28201737
Cloning of a portion of the chromosomal gene and cDNA for human beta-fodrin, the nonerythroid form of beta-spectrinQ28264542
Tetherin inhibits retrovirus release and is antagonized by HIV-1 VpuQ29547836
Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytesQ29619514
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.Q30421200
Role of cholesterol in human immunodeficiency virus type 1 envelope protein-mediated fusion with host cellsQ30865013
Macrophages archive HIV-1 virions for dissemination in transQ33215934
Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restrictionQ33331396
Host cell factors in HIV replication: meta-analysis of genome-wide studiesQ33455551
CCR5 Expression Correlates with Susceptibility of Maturing Monocytes to Human Immunodeficiency Virus Type 1 InfectionQ33782193
Relative replication fitness of a high-level 3'-azido-3'-deoxythymidine-resistant variant of human immunodeficiency virus type 1 possessing an amino acid deletion at codon 67 and a novel substitution (Thr-->Gly) at codon 69.Q33826453
Identification of shared populations of human immunodeficiency virus type 1 infecting microglia and tissue macrophages outside the central nervous system.Q33850041
Localization of human immunodeficiency virus type 1 Gag and Env at the plasma membrane by confocal imagingQ33874415
Myristoylation as a target for inhibiting HIV assembly: unsaturated fatty acids block viral buddingQ34191382
Interleukin-27, an anti-HIV-1 cytokine, inhibits replication of hepatitis C virusQ34242185
Revisiting HIV-1 uncoatingQ34387732
Functional correlation between a novel amino acid insertion at codon 19 in the protease of human immunodeficiency virus type 1 and polymorphism in the p1/p6 Gag cleavage site in drug resistance and replication fitnessQ34651403
Cytokines and HIV-1: interactions and clinical implicationsQ35213295
Macrophage HIV-1 infection and the gastrointestinal tract reservoirQ35213769
Increased susceptibility of differentiated mononuclear phagocytes to productive infection with human immunodeficiency virus-1 (HIV-1)Q35596389
Noninfectious papilloma virus-like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27.Q35642774
HIV-1 coreceptor usage, transmission, and disease progressionQ35713425
Labeling HIV-1 virions with two fluorescent proteins allows identification of virions that have productively entered the target cellQ35828541
Understanding the pro- and anti-inflammatory properties of IL-27.Q35829406
Human immunodeficiency virus type 1 replication is blocked prior to reverse transcription and integration in freshly isolated peripheral blood monocytesQ35861719
Infectious HIV-1 assembles in late endosomes in primary macrophagesQ36323044
Visualization of the intracellular behavior of HIV in living cellsQ36323740
Mutational inactivation of an inhibitory sequence in human immunodeficiency virus type 1 results in Rev-independent gag expressionQ36687102
Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammationQ36732543
Host factors exploited by retrovirusesQ36746350
A mutation in the human immunodeficiency virus type 1 transmembrane glycoprotein gp41 dominantly interferes with fusion and infectivityQ36756570
Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infectionQ37066263
Vpu enhances HIV-1 virus release in the absence of Bst-2 cell surface down-modulation and intracellular depletionQ37115275
Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferonQ37334618
Characterization of restrictions to human immunodeficiency virus type 1 infection of monocytesQ37730431
Novel single-cell-level phenotypic assay for residual drug susceptibility and reduced replication capacity of drug-resistant human immunodeficiency virus type 1.Q38449098
In vitro uncoating of HIV-1 coresQ39439240
Actin-Dependent Receptor Colocalization Required for Human Immunodeficiency Virus Entry into Host CellsQ39581009
Postentry restriction to human immunodeficiency virus-based vector transduction in human monocytesQ39602905
Evidence for Human Immunodeficiency Virus Type 1 Replication In Vivo in CD14 + Monocytes and Its Potential Role as a Source of Virus in Patients on Highly Active Antiretroviral TherapyQ39685944
Interleukin-27 induces a STAT1/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes.Q39697211
Interleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytesQ39828171
Kinetics of human immunodeficiency virus type 1 reverse transcription in blood mononuclear phagocytes are slowed by limitations of nucleotide precursorsQ40039220
KSHV/HHV-8 infection of human hematopoietic progenitor (CD34+) cells: persistence of infection during hematopoiesis in vitro and in vivoQ40303480
An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cellsQ40517735
Actin-binding proteins 1: spectrin superfamilyQ40983843
Interleukin-10 suppresses human immunodeficiency virus-1 replication in vitro in cells of the monocyte/macrophage lineageQ41461305
Investigations into the mechanism by which sulfated polysaccharides inhibit HIV infection in vitroQ41650013
A mechanical bottleneck explains the variation in cup growth during FcgammaR phagocytosisQ41819597
A novel motif in HIV-1 Nef that regulates MIP-1beta chemokine release in macrophagesQ41871764
Mutation of Cys672 allows recombinant expression of activatible macrophage-stimulating proteinQ42799761
Efficient HIV-1 transmission from macrophages to T cells across transient virological synapsesQ44307172
Identification of an intracellular trafficking and assembly pathway for HIV-1 gag.Q45345415
Analysis of cellular factors influencing the replication of human immunodeficiency virus type I in human macrophages derived from blood of different healthy donorsQ45736539
Interleukin 10 blocks HIV replication in macrophages by inhibiting the autocrine loop of tumor necrosis factor alpha and interleukin 6 induction of virusQ45784159
Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathyQ45836320
Human T lymphotropic virus type III infection of human alveolar macrophages.Q45836633
The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infectionQ47388000
IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophagesQ48019121
Quantitative four-dimensional tracking of cytoplasmic and nuclear HIV-1 complexesQ48925951
Detection of infectious HIV in circulating monocytes from patients on prolonged highly active antiretroviral therapyQ54057499
Monitoring drug resistance for herpesvirusesQ54067239
A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migrationQ72133316
Chemokine Receptor Regulation and HIV Type 1 Tropism in Monocyte-MacrophagesQ74173208
IL-27 induces Th1 differentiation via p38 MAPK/T-bet- and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathwaysQ79370177
Genome-scale RNAi screen for host factors required for HIV replicationQ79769455
IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38Q81119978
Impact of HIV infection, highly active antiretroviral therapy, and hepatitis C coinfection on serum interleukin-27Q84020360
P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectmacrophageQ184204
P304page(s)517-534
P577publication date2013-03-04
P1433published inJournal of Experimental MedicineQ3186912
P1476titleIL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation
P478volume210