Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon

scientific article published on 25 June 2009

Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2009-03-211540
P932PMC publication ID2738572
P698PubMed publication ID19556424
P5875ResearchGate publication ID245990286

P2093author name stringPeter J Munson
Sharon M Wahl
Teresa Greenwell-Wild
Wenwen Jin
Zoila Rangel
Nancy Vázquez
P2860cites workThe interferon response inhibits HIV particle production by induction of TRIM22Q21131598
CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tractQ22242965
Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tractQ22242981
WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27Q24307411
Antiviral actions of interferonsQ24550676
TRIM family proteins and their emerging roles in innate immunityQ24607229
Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activityQ24677778
Secretory Leukocyte Protease Inhibitor Binds to Annexin II, a Cofactor for Macrophage HIV-1 InfectionQ27485184
IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cellsQ28214882
Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus 1 activity in vitroQ28293679
Tetherin inhibits retrovirus release and is antagonized by HIV-1 VpuQ29547836
The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu proteinQ29619540
HIV-induced type I interferon and tryptophan catabolism drive T cell dysfunction despite phenotypic activationQ33359564
Human immunodeficiency virus type 1-induced macrophage gene expression includes the p21 gene, a target for viral regulationQ33707301
Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15.Q34335062
HIV entry inhibitors.Q34654433
Viral and host cofactors facilitate HIV-1 replication in macrophagesQ35213767
Noninfectious papilloma virus-like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27.Q35642774
Understanding the pro- and anti-inflammatory properties of IL-27.Q35829406
Adenosine A2a receptors induce heterologous desensitization of chemokine receptorsQ35849780
Myeloid differentiation and susceptibility to HIV-1 are linked to APOBEC3 expressionQ35850696
HIV accomplices and adversaries in macrophage infectionQ36565458
Advances in macrophage and dendritic cell biology in HIV-1 infection stress key understudied areas in infection, pathogenesis, and analysis of viral reservoirs.Q36578963
HIV-1 immunopathogenesis: how good interferon turns bad.Q36656715
The biology and therapeutic potential of interleukin 27.Q36733744
Induction of alpha interferon by human immunodeficiency virus type 1 in human monocyte-macrophage culturesQ36822798
An update in the development of HIV entry inhibitorsQ36879432
Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral responseQ36913335
Non-conventional signal transduction by type 1 interferons: the NF-kappaB pathwayQ36957641
Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulationQ37006843
The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelementsQ37096085
Rapid myeloid cell transcriptional and proteomic responses to periodontopathogenic Porphyromonas gingivalisQ37164554
Cellular reservoirs of HIV-1 and their role in viral persistenceQ37196089
Hemin activation ameliorates HIV-1 infection via heme oxygenase-1 inductionQ38971294
Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism.Q40224822
Interferon-induced exonuclease ISG20 exhibits an antiviral activity against human immunodeficiency virus type 1.Q40395336
An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cellsQ40517735
APOBEC-mediated editing of viral RNA.Q40529937
Lecithinized superoxide dismutase: an inhibitor of human immunodeficiency virus replicationQ41124430
Alpha interferon potently enhances the anti-human immunodeficiency virus type 1 activity of APOBEC3G in resting primary CD4 T cellsQ42799017
Differential antiviral effect of PEG-interferon-alpha-2b on HIV and HCV in the treatment of HIV/HCV co-infected patientsQ43040277
IFN-alpha regulates Toll-like receptor-mediated IL-27 gene expression in human macrophagesQ43941711
IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophagesQ48019121
IL-27 and IFN-αSignal via Stat1 and Stat3 and Induce T-Bet and IL-12Rβ2 in Naive T CellsQ50335939
IFN-beta modulates the response to TLR stimulation in human DC: involvement of IFN regulatory factor-1 (IRF-1) in IL-27 gene expressionQ54431573
Macrophages as a source of HIV during opportunistic infectionsQ73427586
The macrophage origin of the HIV-expressing multinucleated giant cells in hyperplastic tonsils and adenoidsQ77882766
Stimulation of cell surface CCR5 and CD40 molecules by their ligands or by HSP70 up-regulates APOBEC3G expression in CD4(+) T cells and dendritic cellsQ79609733
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous systemQ80102518
IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor 3Q80427885
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectinterleukinsQ194908
HIVQ15787
P304page(s)1864-1874
P577publication date2009-06-25
P1433published inBloodQ885070
P1476titleInterleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon
P478volume114

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cites work (P2860)
Q34009882A novel role for Slit2/Robo1 axis in modulating HIV-1 replication in T cells
Q21131084AID and APOBECs span the gap between innate and adaptive immunity
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Q64279721Association of interleukin-27 gene polymorphisms with susceptibility to HIV infection and disease progression
Q40279352BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity
Q33730835CD56+ T cells inhibit HIV-1 infection of macrophages
Q35242525Chitinases in the salivary glands and circulation of patients with Sjögren's syndrome: Macrophage harbingers of disease severity
Q99605551Clearing of Foreign Episomal DNA from Human Cells by CRISPRa-Mediated Activation of Cytidine Deaminases
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Q35041156Endogenous CCL2 neutralization restricts HIV-1 replication in primary human macrophages by inhibiting viral DNA accumulation
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Q36463634IL-27 increases BST-2 expression in human monocytes and T cells independently of type I IFN.
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