| scholarly article | Q13442814 |
| review article | Q7318358 |
| P8978 | DBLP publication ID | journals/bmcbi/TienCW17 |
| P6179 | Dimensions Publication ID | 1084249897 |
| P356 | DOI | 10.1186/S12859-017-1465-7 |
| P932 | PMC publication ID | 5374707 |
| P698 | PubMed publication ID | 28361715 |
| P2093 | author name string | Kun-Pin Wu | |
| Wei-Sheng Tien | |||
| Jun-Hong Chen | |||
| P2860 | cites work | A soluble form of the giant cadherin Fat1 is released from pancreatic cancer cells by ADAM10 mediated ectodomain shedding | Q21132301 |
| Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | Q21735928 | ||
| Determination of the Molecular Structure of the Human Free Secretory Component | Q21994510 | ||
| CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV | Q24292980 | ||
| Effect of tissue inhibitor of metalloproteinases 3 on DLK1 shedding in cultured human pre-adipocytes and implications for adipose tissue remodelling. | Q50437918 | ||
| Ectodomain shedding of nectin-1 regulates the maintenance of dendritic spine density. | Q50507076 | ||
| Roles of ADAM8 in elimination of injured muscle fibers prior to skeletal muscle regeneration. | Q50615262 | ||
| ADAM10/17-dependent release of soluble c-Met correlates with hepatocellular damage. | Q50927916 | ||
| Ectodomain shedding of CD200 from the B-CLL cell surface is regulated by ADAM28 expression. | Q51020526 | ||
| Shedding of dipeptidyl peptidase 4 is mediated by metalloproteases and up-regulated by hypoxia in human adipocytes and smooth muscle cells. | Q51697808 | ||
| TACE cleaves neogenin to desensitize cortical neurons to the repulsive guidance molecule. | Q51767403 | ||
| Identification of shed proteins from Chinese hamster ovary cells: application of statistical confidence using human and mouse protein databases. | Q51818179 | ||
| Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR). | Q51831758 | ||
| Soluble CD86 is a costimulatory molecule for human T lymphocytes. | Q52024017 | ||
| Soluble human interleukin-4 receptor is produced by activated T cells under the control of metalloproteinases. | Q52033741 | ||
| Maturation of secreted meprin alpha during biosynthesis: role of the furin site and identification of the COOH-terminal amino acids of the mouse kidney metalloprotease subunit. | Q52250662 | ||
| EphA4 receptor shedding regulates spinal motor axon guidance. | Q53015790 | ||
| β-Adrenergic agonists mediate enhancement of β1-adrenergic receptor N-terminal cleavage and stabilization in vivo and in vitro. | Q53139671 | ||
| Shedding of kidney injury molecule-1 by membrane-type 1 matrix metalloproteinase. | Q53154253 | ||
| MMP-14 is expressed in preeclamptic placentas and mediates release of soluble endoglin. | Q53188450 | ||
| Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis. | Q53327257 | ||
| VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage Raw 264.7 cells | Q24294196 | ||
| The Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma | Q24294856 | ||
| Tumor necrosis factor-alpha-converting enzyme controls surface expression of c-Kit and survival of embryonic stem cell-derived mast cells | Q24300017 | ||
| Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases | Q24301116 | ||
| Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23 | Q24303614 | ||
| Processing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleus | Q24304065 | ||
| DJ-1 Cleavage by Matrix Metalloproteinase 3 Mediates Oxidative Stress-Induced Dopaminergic Cell Death | Q24304197 | ||
| Regulation of ApoE receptor proteolysis by ligand binding | Q24305144 | ||
| An RGD motif present in cadherin 17 induces integrin activation and tumor growth | Q24306146 | ||
| Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130 | Q24311654 | ||
| Nuclear signalling by tumour-associated antigen EpCAM | Q24315870 | ||
| ADAM17 (TACE) regulates TGFβ signaling through the cleavage of vasorin | Q24318285 | ||
| Tumor-associated MICA is shed by ADAM proteases | Q24320055 | ||
| Enzymatic processing of beta-dystroglycan recombinant ectodomain by MMP-9: identification of the main cleavage site | Q24323201 | ||
| Junctional adhesion molecule-C is a soluble mediator of angiogenesis | Q24337026 | ||
| Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding. | Q24531403 | ||
| Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2 | Q24550771 | ||
| Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation | Q24556219 | ||
| Signal peptide prediction based on analysis of experimentally verified cleavage sites | Q24645296 | ||
| Proteolytic cleavage of protein tyrosine phosphatase mu regulates glioblastoma cell migration | Q24650562 | ||
| Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations | Q24655327 | ||
| Cellular redistribution of protein tyrosine phosphatases LAR and PTPsigma by inducible proteolytic processing | Q24676734 | ||
| Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing | Q24677883 | ||
| Differential regulation and function of CD73, a glycosyl-phosphatidylinositol-linked 70-kD adhesion molecule, on lymphocytes and endothelial cells | Q24681431 | ||
| Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma | Q24685080 | ||
| SPD--a web-based secreted protein database | Q24796109 | ||
| Cytokines as new treatment targets in chronic heart failure | Q24799394 | ||
| Cardiomyocytes induce macrophage receptor shedding to suppress phagocytosis | Q27302322 | ||
| ADAM10 releases a soluble form of the GPNMB/Osteoactivin extracellular domain with angiogenic properties | Q27321658 | ||
| Estrogen decrease in tight junctional resistance involves matrix-metalloproteinase-7-mediated remodeling of occludin | Q36681213 | ||
| Neuroglycan C, a Novel Membrane-spanning Chondroitin Sulfate Proteoglycan That Is Restricted to the Brain | Q36685387 | ||
| Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry | Q36693984 | ||
| Systematic proteomic analysis identifies β-site amyloid precursor protein cleaving enzyme 2 and 1 (BACE2 and BACE1) substrates in pancreatic β-cells | Q36760343 | ||
| NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17). | Q36814614 | ||
| Shedding of PECAM-1 during HIV infection: a potential role for soluble PECAM-1 in the pathogenesis of NeuroAIDS. | Q36826098 | ||
| Increased soluble CD4 in serum of rheumatoid arthritis patients is generated by matrix metalloproteinase (MMP)-like proteinases | Q36863620 | ||
| Ectodomain Shedding of Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) Is Induced by Vascular Endothelial Growth Factor A (VEGF-A) | Q36898186 | ||
| VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling. | Q36953025 | ||
| The N-terminal ectodomain of Ninjurin1 liberated by MMP9 has chemotactic activity | Q37017491 | ||
| Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase | Q37068079 | ||
| Metalloproteinase- and gamma-secretase-mediated cleavage of protein-tyrosine phosphatase receptor type Z | Q37142719 | ||
| Wound-induced HB-EGF ectodomain shedding and EGFR activation in corneal epithelial cells | Q37152359 | ||
| Matrix metalloproteinase 8 contributes to solubilization of IL-13 receptor alpha2 in vivo | Q37163250 | ||
| Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cells | Q37173281 | ||
| Sys-BodyFluid: a systematical database for human body fluid proteome research | Q37202808 | ||
| mGluR1/5-dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE. | Q37239438 | ||
| Synapse maturation by activity-dependent ectodomain shedding of SIRPα. | Q37289487 | ||
| The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer. | Q37308499 | ||
| The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions | Q37339450 | ||
| TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling | Q37340230 | ||
| Cleavage of transmembrane junction proteins and their role in regulating epithelial homeostasis | Q37428089 | ||
| Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction. | Q37479222 | ||
| Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1. | Q37486259 | ||
| Rapid temporal dynamics of transcription, protein synthesis, and secretion during macrophage activation | Q37623632 | ||
| Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site. | Q37626512 | ||
| Secretion of VEGF-165 has unique characteristics, including shedding from the plasma membrane | Q37669224 | ||
| CD48: A co-stimulatory receptor of immunity | Q37787551 | ||
| Ectdomain shedding and regulated intracellular proteolysis in the central nervous system | Q37792146 | ||
| Membrane targeting, shedding and protein interactions of brain acetylcholinesterase | Q37826782 | ||
| HER2 shedding and serum HER2 extracellular domain: biology and clinical utility in breast cancer. | Q37872909 | ||
| Identification of cleavage sites leading to the shed form of the anti-aging protein klotho | Q38305115 | ||
| Meprin α and meprin β: Procollagen proteinases in health and disease | Q38330769 | ||
| Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors. | Q38400921 | ||
| NKG2D and DNAM-1 Ligands: Molecular Targets for NK Cell-Mediated Immunotherapeutic Intervention in Multiple Myeloma | Q28080823 | ||
| Matrix metalloproteinases cleave tissue factor pathway inhibitor. Effects on coagulation | Q28138670 | ||
| A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE | Q28139998 | ||
| Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival | Q28142897 | ||
| Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain | Q28143103 | ||
| Regulated cleavage of a contact-mediated axon repellent | Q28144522 | ||
| Multiple sites of proteolytic cleavage to release soluble forms of hepatocyte growth factor activator inhibitor type 1 from a transmembrane form | Q28146125 | ||
| Human dendritic cells shed a functional, soluble form of the mannose receptor | Q28146132 | ||
| Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription | Q28201680 | ||
| Phorbol 12-myristate 13-acetate-induced ectodomain shedding and phosphorylation of the human meprinbeta metalloprotease | Q28203824 | ||
| Functional regulation of semaphorin receptors by proprotein convertases | Q28203827 | ||
| The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein | Q28209519 | ||
| Autolytic processing at Glu586-Ser587 within the cysteine-rich domain of human adamalysin 19/disintegrin-metalloproteinase 19 is necessary for its proteolytic activity | Q28209976 | ||
| Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1) | Q28211911 | ||
| The fate of desmosomal proteins in apoptotic cells | Q28212342 | ||
| Ectodysplasin is released by proteolytic shedding and binds to the EDAR protein | Q28213298 | ||
| Growth hormone (GH)-induced dimerization inhibits phorbol ester-stimulated GH receptor proteolysis | Q28213322 | ||
| 2B4 (CD244) and CS1: novel members of the CD2 subset of the immunoglobulin superfamily molecules expressed on natural killer cells and other leukocytes | Q28213670 | ||
| The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qR | Q28214381 | ||
| Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells | Q28235640 | ||
| CD146 and its soluble form regulate monocyte transendothelial migration | Q28235736 | ||
| Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target | Q28243401 | ||
| Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion | Q28244000 | ||
| ADAM28 is activated by MMP-7 (matrilysin-1) and cleaves insulin-like growth factor binding protein-3 | Q28249704 | ||
| Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors | Q28250935 | ||
| Detection of a soluble form of the leukocyte surface antigen CD48 in plasma and its elevation in patients with lymphoid leukemias and arthritis | Q28258148 | ||
| Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid | Q28258980 | ||
| Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans | Q28264269 | ||
| Trafficking and proteolytic processing of APP | Q28265871 | ||
| Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist | Q28273130 | ||
| Increased proteolytic processing of protein tyrosine phosphatase mu in confluent vascular endothelial cells: the role of PC5, a member of the subtilisin family | Q28277426 | ||
| Presenilin/gamma-secretase and alpha-secretase-like peptidases cleave human MHC Class I proteins | Q28277495 | ||
| Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans | Q28278222 | ||
| A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40 kDa vasculostatin from tumor suppressor BAI1. | Q33112696 | ||
| Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration | Q33188043 | ||
| Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates | Q33202468 | ||
| beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase | Q33213947 | ||
| Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells | Q33255013 | ||
| Characterisation of endothelin converting enzyme-1 shedding from endothelial cells | Q33296116 | ||
| Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites | Q33337380 | ||
| Proteomic analysis of ovarian cancer cells reveals dynamic processes of protein secretion and shedding of extra-cellular domains | Q33344488 | ||
| Platelet receptor expression and shedding: glycoprotein Ib-IX-V and glycoprotein VI. | Q33414254 | ||
| Increased levels of soluble CD226 in sera accompanied by decreased membrane CD226 expression on peripheral blood mononuclear cells from cancer patients | Q33458907 | ||
| Identification of beta-secretase (BACE1) substrates using quantitative proteomics | Q33521280 | ||
| Use of a mutant cell line to study the kinetics and function of O-linked glycosylation of low density lipoprotein receptors | Q33581525 | ||
| The FGFRL1 receptor is shed from cell membranes, binds fibroblast growth factors (FGFs), and antagonizes FGF signaling in Xenopus embryos | Q33582073 | ||
| GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase. | Q33643506 | ||
| The secreted form of a melanocyte membrane-bound glycoprotein (Pmel17/gp100) is released by ectodomain shedding | Q33694588 | ||
| Increased ectodomain shedding of cell adhesion molecule 1 from pancreatic islets in type 2 diabetic pancreata: correlation with hemoglobin A1c levels | Q33806981 | ||
| Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity | Q33880454 | ||
| N-glycosylation is required for matriptase-2 autoactivation and ectodomain shedding | Q33888539 | ||
| Glycoprotein nonmetastatic melanoma protein b, a melanocytic cell marker, is a melanosome-specific and proteolytically released protein | Q33891014 | ||
| Metalloproteinase-dependent cleavage of neuregulin and autocrine stimulation of vascular endothelial cells | Q33919411 | ||
| Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia. | Q33937583 | ||
| Prediction of protein cellular attributes using pseudo-amino acid composition | Q33941503 | ||
| Prodomain processing of Asp1 (BACE2) is autocatalytic. | Q33943689 | ||
| Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites | Q33973415 | ||
| Ectodomain shedding of interleukin-2 receptor beta and generation of an intracellular functional fragment | Q33991144 | ||
| Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10). | Q34003851 | ||
| Secretome proteomics for discovery of cancer biomarkers | Q34023121 | ||
| Stimulation of platelet-derived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways | Q34042804 | ||
| Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta. | Q34074338 | ||
| A disintegrin and metalloproteinase 9 is involved in ectodomain shedding of receptor-binding cancer antigen expressed on SiSo cells | Q34079881 | ||
| Ectodomain shedding of TβRIII is required for TβRIII-mediated suppression of TGF-β signaling and breast cancer migration and invasion | Q34081397 | ||
| Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109 | Q34088459 | ||
| Proteolytic cleavage of human acid-sensing ion channel 1 by the serine protease matriptase | Q34094496 | ||
| RETRACTED: Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum | Q34097404 | ||
| Two functionally distinct isoforms of TL1A (TNFSF15) generated by differential ectodomain shedding | Q34195262 | ||
| CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface. | Q34205739 | ||
| Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif | Q34214194 | ||
| Nardilysin-dependent proteolysis of cell-associated VTCN1 (B7-H4) marks type 1 diabetes development | Q34227834 | ||
| Calpain-mediated proteolytic cleavage of the neuronal glycine transporter, GlyT2. | Q34283604 | ||
| The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3. | Q34384684 | ||
| Matriptase-2- and Proprotein Convertase-cleaved Forms of Hemojuvelin Have Different Roles in the Down-regulation of Hepcidin Expression | Q34386073 | ||
| Soluble LRIG2 ectodomain is released from glioblastoma cells and promotes the proliferation and inhibits the apoptosis of glioblastoma cells in vitro and in vivo in a similar manner to the full-length LRIG2 | Q34421021 | ||
| Pericellular proteolysis in cancer | Q34430691 | ||
| Identification of target proteins of N-acetylglucosaminyl transferase V in human colon cancer and implications of protein tyrosine phosphatase kappa in enhanced cancer cell migration. | Q34483274 | ||
| The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment | Q34498087 | ||
| Shed Syndecan-1 is involved in chemotherapy resistance via the EGFR pathway in colorectal cancer | Q34499650 | ||
| A novel mouse Dscam mutation inhibits localization and shedding of DSCAM. | Q34540992 | ||
| Deciphering the human platelet sheddome. | Q34568946 | ||
| gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells | Q34602706 | ||
| Shedding of collagen XXIII is mediated by furin and depends on the plasma membrane microenvironment | Q34649929 | ||
| Ectodomain shedding and autocleavage of the cardiac membrane protease corin | Q34695497 | ||
| Metalloproteinase-dependent TLR2 ectodomain shedding is involved in soluble toll-like receptor 2 (sTLR2) production | Q34756662 | ||
| Cellular roles of ADAM12 in health and disease. | Q34761860 | ||
| Modulation of NKG2D-ligand cell surface expression enhances immune cell therapy of cancer | Q34777479 | ||
| The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity | Q34810293 | ||
| Crimpy enables discrimination of presynaptic and postsynaptic pools of a BMP at the Drosophila neuromuscular junction | Q34820237 | ||
| PMAP: databases for analyzing proteolytic events and pathways | Q34848387 | ||
| Protocadherin-12 cleavage is a regulated process mediated by ADAM10 protein: evidence of shedding up-regulation in pre-eclampsia | Q34869050 | ||
| LRP1 shedding in human brain: roles of ADAM10 and ADAM17. | Q34976135 | ||
| The Coxsackievirus and Adenovirus Receptor (CAR) undergoes ectodomain shedding and regulated intramembrane proteolysis (RIP). | Q34981717 | ||
| Altered expression of glycoproteins on the cell surface of Jurkat cells during etoposide-induced apoptosis: shedding and intracellular translocation of glycoproteins | Q34986591 | ||
| CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling | Q35005223 | ||
| Protein ectodomain shedding | Q35021911 | ||
| Ectodomain shedding of preadipocyte factor 1 (Pref-1) by tumor necrosis factor alpha converting enzyme (TACE) and inhibition of adipocyte differentiation | Q35070932 | ||
| IgLON cell adhesion molecules are shed from the cell surface of cortical neurons to promote neuronal growth | Q35080355 | ||
| Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis | Q35085070 | ||
| Identification of protein tyrosine phosphatase receptor gamma extracellular domain (sPTPRG) as a natural soluble protein in plasma | Q35182285 | ||
| Protein shedding in urothelial bladder cancer: prognostic implications of soluble urinary EGFR and EpCAM. | Q35198309 | ||
| Effects of O-linked glycosylation on the cell surface expression and stability of decay-accelerating factor, a glycophospholipid-anchored membrane protein | Q44256054 | ||
| B cell activation leads to shedding of complement receptor type II (CR2/CD21). | Q44457021 | ||
| Characterization of the ectodomain shedding of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1). | Q44511130 | ||
| Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling | Q44592816 | ||
| ADAMs, a disintegrin and metalloproteinases, mediate shedding of oxytocinase | Q44748005 | ||
| Regulated shedding of PAR1 N-terminal exodomain from endothelial cells | Q44776056 | ||
| Linking receptor-mediated endocytosis and cell signaling: evidence for regulated intramembrane proteolysis of megalin in proximal tubule | Q44924221 | ||
| Zinc metalloproteinase-mediated cleavage of the human Nogo-66 receptor | Q45032587 | ||
| Soluble E-cadherin as a diagnostic and prognostic marker in gastric carcinoma | Q45050142 | ||
| Soluble vascular adhesion protein-1 accumulates in proliferative diabetic retinopathy | Q45053063 | ||
| Estrogen abrogates transcervical tight junctional resistance by acceleration of occludin modulation | Q45096659 | ||
| T-cell immunoglobulin and mucin domain 2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding | Q45799693 | ||
| Neural cell adhesion molecule function is regulated by metalloproteinase-mediated ectodomain release | Q46482116 | ||
| Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55. | Q46527564 | ||
| Counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilrα during the LPS-mediated immune response of murine macrophages. | Q46698589 | ||
| Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation | Q46837449 | ||
| Proteolytic release of soluble UL16-binding protein 2 from tumor cells | Q46970862 | ||
| M-CSF induces the expression of a membrane-bound form of IL-18 in a subset of human monocytes differentiating in vitro toward macrophages | Q47649630 | ||
| Detection of circulating soluble CD28 in patients with systemic lupus erythematosus, primary Sjögren's syndrome and systemic sclerosis | Q47759350 | ||
| Cleavage of CD95 by matrix metalloproteinase-7 induces apoptosis resistance in tumour cells | Q47784861 | ||
| Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation. | Q47846803 | ||
| Soluble form of the (pro)renin receptor generated by intracellular cleavage by furin is secreted in plasma | Q47977163 | ||
| The murine P84 neural adhesion molecule is SHPS-1, a member of the phosphatase-binding protein family | Q48043389 | ||
| Regulated proteolytic processing of LRP6 results in release of its intracellular domain | Q48259334 | ||
| Activity-dependent proteolytic cleavage of neuroligin-1. | Q48328770 | ||
| Proteolytic processing of the receptor-type protein tyrosine phosphatase PTPBR7. | Q48347371 | ||
| Transmembrane semaphorin5B is proteolytically processed into a repulsive neural guidance cue. | Q48433776 | ||
| Activity-dependent cleavage of brain glutamic acid decarboxylase 65 by calpain | Q48458418 | ||
| Two separate metalloproteinase activities are responsible for the shedding and processing of the NG2 proteoglycan in vitro | Q48905531 | ||
| Soluble N-cadherin in human biological fluids | Q49073077 | ||
| Brain ischaemia induces shedding of a BDNF-scavenger ectodomain from TrkB receptors by excitotoxicity activation of metalloproteinases and γ-secretases | Q49087368 | ||
| Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes | Q50068951 | ||
| Different ADAMs have distinct influences on Kit ligand processing: phorbol-ester-stimulated ectodomain shedding of Kitl1 by ADAM17 is reduced by ADAM19. | Q50336712 | ||
| Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17. | Q40443582 | ||
| Proteolytic shedding of the extracellular domain of photoreceptor cadherin. Implications for outer segment assembly | Q40492540 | ||
| Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival | Q40520865 | ||
| Complement inhibitor membrane cofactor protein (MCP; CD46) is constitutively shed from cancer cell membranes in vesicles and converted by a metalloproteinase to a functionally active soluble form | Q40526230 | ||
| Establishment of an ELISA system for determining soluble LAIR-1 levels in sera of patients with HFRS and kidney transplant | Q40526576 | ||
| Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor | Q40529866 | ||
| MT1-MMP mediates MUC1 shedding independent of TACE/ADAM17. | Q40558602 | ||
| Epithelial sodium channels are activated by furin-dependent proteolysis | Q40581030 | ||
| The shed ectodomain of type XIII collagen affects cell behaviour in a matrix-dependent manner | Q40581317 | ||
| Tumor-stroma interaction: positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN. | Q40585451 | ||
| The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. | Q40631641 | ||
| Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases. | Q40669694 | ||
| A residue in the S2 subsite controls substrate selectivity of matrix metalloproteinase-2 and matrix metalloproteinase-9. | Q40669960 | ||
| Multiple metalloproteinases process protransforming growth factor-alpha (proTGF-alpha). | Q40670166 | ||
| Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding | Q40688718 | ||
| The extracellular N terminus of the endothelin B (ETB) receptor is cleaved by a metalloprotease in an agonist-dependent process | Q40704613 | ||
| Shedding of CD9 antigen in acute lymphoblastic leukemia | Q40751330 | ||
| Soluble CD137 (4-1BB) ligand is released following leukocyte activation and is found in sera of patients with hematological malignancies. | Q40779387 | ||
| Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors | Q40779491 | ||
| Helicobacter pylori-induced gastric mucosal TGF-α ectodomain shedding and EGFR transactivation involves Rac1/p38 MAPK-dependent TACE activation | Q40874337 | ||
| The glycosylphosphatidylinositol-anchored form and the transmembrane form of CD58 are released from the cell surface upon antibody binding | Q41010053 | ||
| ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling | Q41107179 | ||
| The dyslexia-associated KIAA0319 protein undergoes proteolytic processing with {gamma}-secretase-independent intramembrane cleavage | Q41130845 | ||
| Collagen type I selectively activates ectodomain shedding of the discoidin domain receptor 1: involvement of Src tyrosine kinase. | Q41371069 | ||
| Soluble complement receptor type 1 (CD35) is released from leukocytes by surface cleavage | Q41431072 | ||
| sE-cadherin serves as a diagnostic and predictive parameter in prostate cancer patients | Q41450346 | ||
| Heat shock-induced shedding of cell surface integrins in A549 human lung tumor cells in culture | Q41507568 | ||
| Human and Murine Interleukin 23 Receptors Are Novel Substrates for A Disintegrin and Metalloproteases ADAM10 and ADAM17. | Q41510241 | ||
| Function of an axonal chemoattractant modulated by metalloprotease activity | Q41757710 | ||
| Studies on the effect of lysosomotropic agents on the release of Gal beta 1-4GlcNAc alpha-2,6-sialytransferase from rat liver slices during the acute-phase response | Q41854425 | ||
| Impaired autoproteolytic cleavage of mCLCA6, a murine integral membrane protein expressed in enterocytes, leads to cleavage at the plasma membrane instead of the endoplasmic reticulum | Q41864321 | ||
| Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements | Q41871371 | ||
| Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation | Q41889980 | ||
| Mannose 6-phosphate/insulin-like growth factor II-binding proteins in human serum and urine. Their relation to the mannose 6-phosphate/insulin-like growth factor II receptor | Q41988519 | ||
| Transforming growth factor-alpha and beta-amyloid precursor protein share a secretory mechanism. | Q42016464 | ||
| MMP9 cleavage of the β4 integrin ectodomain leads to recurrent epithelial erosions in mice | Q42059446 | ||
| Klotho is a substrate for alpha-, beta- and gamma-secretase | Q42078322 | ||
| The conversion of the human membrane-associated folate binding protein (folate receptor) to the soluble folate binding protein by a membrane-associated metalloprotease | Q42126086 | ||
| Nitric oxide inhibits the shedding of the glycosylphosphatidylinositol-anchored dipeptidase from porcine renal proximal tubules | Q42157615 | ||
| Roles of the cleaved N-terminal TLR3 fragment and cell surface TLR3 in double-stranded RNA sensing | Q42183893 | ||
| Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2. | Q42188322 | ||
| Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage | Q42244965 | ||
| Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine | Q42252398 | ||
| Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion | Q42264802 | ||
| Soluble Lutheran/basal cell adhesion molecule is detectable in plasma of hepatocellular carcinoma patients and modulates cellular interaction with laminin-511 in vitro | Q42462697 | ||
| Cleavage of the human thyrotropin receptor by ADAM10 is regulated by thyrotropin. | Q42639478 | ||
| A disintegrin and metalloprotease 10 is a novel mediator of vascular endothelial growth factor-induced endothelial cell function in angiogenesis and is associated with atherosclerosis. | Q42674129 | ||
| The limbic system-associated membrane protein is an Ig superfamily member that mediates selective neuronal growth and axon targeting | Q42680980 | ||
| Rosmarinic acid down-regulates endothelial protein C receptor shedding in vitro and in vivo | Q42710649 | ||
| Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by a disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by γ-secretase complex | Q42802078 | ||
| The noncatalytic TrkCNC2 receptor is cleaved by metalloproteases upon neurotrophin-3 stimulation | Q42805592 | ||
| The shed ectodomain of Nr-CAM stimulates cell proliferation and motility, and confers cell transformation. | Q42807040 | ||
| VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling. | Q42824102 | ||
| Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase | Q42860565 | ||
| Tumor necrosis factor α-converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163. | Q42921094 | ||
| Endoproteolytic cleavage in the extracellular domain of the integral plasma membrane protein CE9 precedes its redistribution from the posterior to the anterior tail of the rat spermatozoon during epididymal maturation. | Q43108047 | ||
| Ectodomain shedding of Fcalpha receptor is mediated by ADAM10 and ADAM17. | Q43199220 | ||
| Comparative analysis of gingival crevicular fluid a disintegrin and metalloproteinase 8 levels in health and periodontal disease: A clinic-biochemical study | Q43219137 | ||
| Shear-induced interaction of platelets with von Willebrand factor results in glycoprotein Ibalpha shedding | Q43263728 | ||
| Proteolysis of the urokinase-type plasminogen activator receptor by metalloproteinase-12: implication for angiogenesis in fibrin matrices | Q43600816 | ||
| The CD27 membrane receptor, a lymphocyte-specific member of the nerve growth factor receptor family, gives rise to a soluble form by protein processing that does not involve receptor endocytosis | Q43601658 | ||
| Analysis of the C-terminal structure of urinary Tamm-Horsfall protein reveals that the release of the glycosyl phosphatidylinositol-anchored counterpart from the kidney occurs by phenylalanine-specific proteolysis | Q43821050 | ||
| An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinase | Q43821714 | ||
| Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy | Q43851616 | ||
| Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes | Q43918218 | ||
| Ectodomain shedding of furin: kinetics and role of the cysteine-rich region | Q44131026 | ||
| Decreased expression of membrane IL-5 receptor alpha on human eosinophils: II. IL-5 down-modulates its receptor via a proteinase-mediated process | Q44223903 | ||
| Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids. | Q38615458 | ||
| Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation. | Q38676029 | ||
| Posttranslational proteolytic processing of Leda-1/Pianp involves cleavage by MMPs, ADAM10/17 and gamma-secretase | Q38761494 | ||
| Proteolytic Cleavage Governs Interleukin-11 Trans-signaling | Q38794232 | ||
| The Parkinson's-disease-associated receptor GPR37 undergoes metalloproteinase-mediated N-terminal cleavage and ectodomain shedding | Q38794844 | ||
| Nucleotide-Induced Membrane-Proximal Proteolysis Controls the Substrate Specificity of T Cell Ecto-ADP-Ribosyltransferase ARTC2.2. | Q38849459 | ||
| Expression and immunoaffinity purification of recombinant soluble human GPR56 protein for the analysis of GPR56 receptor shedding by ELISA. | Q38936536 | ||
| Shedding of epithin/PRSS14 is induced by TGF-β and mediated by tumor necrosis factor-α converting enzyme | Q38954204 | ||
| Membrane-type I matrix metalloproteinase-dependent ectodomain shedding of mucin16/ CA-125 on ovarian cancer cells modulates adhesion and invasion of peritoneal mesothelium | Q38957886 | ||
| Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins | Q38993482 | ||
| Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30. | Q39000284 | ||
| Tetraspanin CD9 modulates ADAM17-mediated shedding of LR11 in leukocytes | Q39008327 | ||
| Production of soluble Neprilysin by endothelial cells | Q39027336 | ||
| In rheumatoid arthritis soluble CD30 ligand is present at high levels and induces apoptosis of CD30(+)T cells | Q39032317 | ||
| ADAM12-cleaved ephrin-A1 contributes to lung metastasis | Q39149986 | ||
| Human P2X7 receptor activation induces the rapid shedding of CXCL16. | Q39190982 | ||
| An emerging role of Sonic hedgehog shedding as a modulator of heparan sulfate interactions | Q39250622 | ||
| The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets | Q39268482 | ||
| Copper modulates zinc metalloproteinase-dependent ectodomain shedding of key signaling and adhesion proteins and promotes the invasion of prostate cancer epithelial cells | Q39287877 | ||
| LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation | Q39333383 | ||
| Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2. | Q39342420 | ||
| Shedding of soluble epidermal growth factor receptor (sEGFR) is mediated by a metalloprotease/fibronectin/integrin axis and inhibited by cetuximab. | Q39408529 | ||
| Release of thy-1.2 and thy-1.1 from lymphoblastoid cells: partial characterization and antigenicity of shed material | Q39491792 | ||
| RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain shedding | Q39580605 | ||
| Golgi and secreted galactosyltransferase | Q39591042 | ||
| Agonist-regulated cleavage of the extracellular domain of parathyroid hormone receptor type 1. | Q39615153 | ||
| Soluble epithin/PRSS14 secreted from cancer cells contains active angiogenic potential | Q39676888 | ||
| Reducing agents induce thrombomodulin shedding in human endothelial cells | Q39683950 | ||
| Crosstalk of EDA-A2/XEDAR in the p53 signaling pathway | Q39700555 | ||
| Circulating CD33 and its clinical value in acute leukemia | Q39719394 | ||
| Receptor activator of NF-kappaB (RANK) ligand induces ectodomain shedding of RANK in murine RAW264.7 macrophages. | Q39745807 | ||
| Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells. | Q39776935 | ||
| Matrilysin (MMP-7) cleaves C-type lectin domain family 3 member A (CLEC3A) on tumor cell surface and modulates its cell adhesion activity | Q39890288 | ||
| RECK forms cowbell-shaped dimers and inhibits matrix metalloproteinase-catalyzed cleavage of fibronectin. | Q39913893 | ||
| Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases | Q39924958 | ||
| Circulating soluble LR11, a novel marker of smooth muscle cell proliferation, is enhanced after coronary stenting in response to vascular injury. | Q53379708 | ||
| The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells. | Q53546934 | ||
| Soluble Collectin-12 (CL-12) Is a Pattern Recognition Molecule Initiating Complement Activation via the Alternative Pathway. | Q53572681 | ||
| Proteolytic cleavage of annexin 1 by human leukocyte elastase. | Q53595231 | ||
| Proteolytic cleavage and nuclear translocation of fibrocystin is regulated by intracellular Ca2+ and activation of protein kinase C. | Q53600876 | ||
| Caspase-specific and nonspecific in vivo protein processing during Fas-induced apoptosis. | Q53656279 | ||
| Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes. | Q53773593 | ||
| Matrix metalloproteinase-7-mediated cleavage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity. | Q54019102 | ||
| Characterization of a hydrophilic form of Thy-1 purified from human cerebrospinal fluid. | Q54376791 | ||
| Human epidermal Langerhans cells secrete a soluble receptor for IgG (Fc gamma RII/CD32) that inhibits the binding of immune complexes to Fc gamma R+ cells. | Q54643703 | ||
| Paracrine regulation of growth factor signaling by shed leucine-rich repeats and immunoglobulin-like domains 1 | Q55463661 | ||
| Calpain-mediated proteolytic cleavage of the neuronal glycine transporter, GlyT2 | Q56602481 | ||
| Biological function of the soluble CEACAM1 protein and implications in TAP2-deficient patients | Q56956239 | ||
| Membrane-anchored CD40 Is Processed by the Tumor Necrosis Factor-α-converting Enzyme | Q57372095 | ||
| Soluble neuropilin-2, a nerve repellent receptor, is increased in rheumatoid arthritis synovium and aggravates sympathetic fiber repulsion and arthritis | Q58042903 | ||
| Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets | Q61866177 | ||
| TACE-induced cleavage of NgR and p75NTRin dorsal root ganglion cultures disinhibits outgrowth and promotes branching of neurites in the presence of inhibitory CNS myelin | Q63286349 | ||
| Shedding of CD9 antigen by bone marrow cells from patients with acute lymphoblastic leukaemia | Q67549565 | ||
| A novel metalloproteinase associated with brain myelin membranes. Isolation and characterization | Q69407705 | ||
| Release of soluble transferrin receptor from the surface of human leukemic HL60 cells | Q69663633 | ||
| Interferon-gamma enhances expression of secretory component, the epithelial receptor for polymeric immunoglobulins | Q70341791 | ||
| Shedding of the 67-kD laminin receptor by human cancer cells | Q71131527 | ||
| Metalloprotease and serine protease are involved in cleavage of CD43, CD44, and CD16 from stimulated human granulocytes. Induction of cleavage of L-selectin via CD16 | Q71608564 | ||
| Identification and characterization of a soluble c-kit receptor produced by human hematopoietic cell lines | Q71688307 | ||
| In vivo modulation of CD26 (dipeptidyl peptidase IV) in the mouse: effects of polyreactive and monoreactive antibodies | Q71700457 | ||
| Shedding and enrichment of the glycolipid-anchored complement lysis inhibitor protectin (CD59) into milk fat globules | Q71739892 | ||
| Released Form of CNTF Receptor α Component as a Soluble Mediator of CNTF Responses | Q72074174 | ||
| Cleavage of lymphocyte surface antigens CD2, CD4, and CD8 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis | Q72169166 | ||
| Purification and characterization of hepatocyte growth factor (HGF)-converting enzyme: activation of pro-HGF | Q72265481 | ||
| Existence of a soluble form of CD50 (intercellular adhesion molecule-3) produced upon human lymphocyte activation. Present in normal human serum and levels are increased in the serum of systemic lupus erythematosus patients | Q72592689 | ||
| Ligand-induced cleavage of the V2 vasopressin receptor by a plasma membrane metalloproteinase | Q72645552 | ||
| Identification of a natural soluble form of human CD5 | Q72995648 | ||
| CD30 shedding from Karpas 299 lymphoma cells is mediated by TNF-alpha-converting enzyme | Q73306726 | ||
| A soluble form of the murine common gamma chain is present at high concentrations in vivo and suppresses cytokine signaling | Q73335969 | ||
| Defective cleavage of membrane bound TGFalpha leads to enhanced activation of the EGF receptor in malignant cells | Q73694697 | ||
| Matrix metalloproteinase-dependent shedding of syndecan-3, a transmembrane heparan sulfate proteoglycan, in Schwann cells | Q73829253 | ||
| TNF-alpha and IL-1 upregulate membrane-bound and soluble E-selectin through a common pathway | Q74087983 | ||
| Soluble HLA-G generated by proteolytic shedding inhibits NK-mediated cell lysis | Q75210985 | ||
| Unaltered cleavage and secretion of angiotensin-converting enzyme in tumor necrosis factor-alpha-converting enzyme-deficient mice | Q77206485 | ||
| Elevated circulating levels of soluble interleukin-1 receptor type II during interleukin-2 immunotherapy | Q77348074 | ||
| An essential role for ectodomain shedding in mammalian development | Q77544828 | ||
| Soluble aminopeptidase N/CD13 in malignant and nonmalignant effusions and intratumoral fluid | Q78632802 | ||
| Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappaB ligand | Q79181865 | ||
| Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17 | Q79433646 | ||
| Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17 | Q79775761 | ||
| Megakaryocyte potentiation factor cleaved from mesothelin precursor is a useful tumor marker in the serum of patients with mesothelioma | Q79954607 | ||
| Free circulating soluble CD52 as a tumor marker in chronic lymphocytic leukemia and its implication in therapy with anti-CD52 antibodies | Q80493152 | ||
| Matrilysin (matrix metalloprotease-7) cleaves membrane-bound annexin II and enhances binding of tissue-type plasminogen activator to cancer cell surfaces | Q39948157 | ||
| Sprouting angiogenesis is regulated by shedding of the C-type lectin family 14, member A (CLEC14A) ectodomain, catalyzed by rhomboid-like 2 protein (RHBDL2). | Q39950351 | ||
| Human Protein Reference Database and Human Proteinpedia as discovery tools for systems biology. | Q39950844 | ||
| Predictions of Cleavability of Calpain Proteolysis by Quantitative Structure-Activity Relationship Analysis Using Newly Determined Cleavage Sites and Catalytic Efficiencies of an Oligopeptide Array | Q39967858 | ||
| Preeclamptic sera induce nephrin shedding from podocytes through endothelin-1 release by endothelial glomerular cells | Q40011026 | ||
| Soluble CD276 (B7-H3) is released from monocytes, dendritic cells and activated T cells and is detectable in normal human serum | Q40025345 | ||
| The ALCAM shedding by the metalloprotease ADAM17/TACE is involved in motility of ovarian carcinoma cells | Q40028830 | ||
| Phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17. | Q40066641 | ||
| Photic injury promotes cleavage of p75NTR by TACE and nuclear trafficking of the p75 intracellular domain | Q40074342 | ||
| Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling. | Q40079532 | ||
| Endogenous metalloprotease solubilizes IL-13 receptor alpha2 in airway epithelial cells | Q40113244 | ||
| Characterization of cis-autoproteolysis of polycystin-1, the product of human polycystic kidney disease 1 gene. | Q40128114 | ||
| The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis. | Q40128252 | ||
| Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases. | Q40143775 | ||
| TCR activation eliminates glutamate receptor GluR3 from the cell surface of normal human T cells, via an autocrine/paracrine granzyme B-mediated proteolytic cleavage. | Q40187335 | ||
| Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells | Q40218329 | ||
| Expression and release of HLA-E by melanoma cells and melanocytes: potential impact on the response of cytotoxic effector cells | Q40241649 | ||
| Toll-like receptor (TLR4) shedding and depletion: acute proximal tubular cell responses to hypoxic and toxic injury | Q40248648 | ||
| ADAM10-mediated release of complement membrane cofactor protein during apoptosis of epithelial cells | Q40273652 | ||
| Characterization of the protease activity that cleaves the extracellular domain of beta-dystroglycan | Q40279812 | ||
| Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients | Q40280283 | ||
| EGFR signaling leads to downregulation of PTP-LAR via TACE-mediated proteolytic processing | Q40316428 | ||
| Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members | Q40333980 | ||
| The function of neurofascin155 in oligodendrocytes is regulated by metalloprotease-mediated cleavage and ectodomain shedding | Q40339194 | ||
| Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM-17) mediates the ectodomain cleavage of intercellular adhesion molecule-1 (ICAM-1). | Q40342802 | ||
| Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases | Q40352720 | ||
| Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition | Q40360721 | ||
| CD74 is a member of the regulated intramembrane proteolysis-processed protein family | Q40384003 | ||
| CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma. | Q40400377 | ||
| Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). | Q40404194 | ||
| Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3. | Q40411230 | ||
| A functional soluble form of the murine mannose receptor is produced by macrophages in vitro and is present in mouse serum | Q28281103 | ||
| A soluble form of the MHC class I-specific CD160 receptor is released from human activated NK lymphocytes and inhibits cell-mediated cytotoxicity | Q28284183 | ||
| Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage | Q28288759 | ||
| CD97, an adhesion receptor on inflammatory cells, stimulates angiogenesis through binding integrin counterreceptors on endothelial cells | Q28296279 | ||
| Extracellular phosphorylation of collagen XVII by ecto-casein kinase 2 inhibits ectodomain shedding | Q28304833 | ||
| The transforming receptor tyrosine kinase, Axl, is post-translationally regulated by proteolytic cleavage | Q28305472 | ||
| 'Shed' furin: mapping of the cleavage determinants and identification of its C-terminus | Q28359665 | ||
| Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases | Q28504779 | ||
| Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death | Q28506221 | ||
| Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis | Q28506743 | ||
| The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion | Q28511911 | ||
| DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites | Q28513585 | ||
| Activity-dependent shedding of the NMDA receptor glycine binding site by matrix metalloproteinase 3: a PUTATIVE mechanism of postsynaptic plasticity | Q28564738 | ||
| Type XXIII collagen, a new transmembrane collagen identified in metastatic tumor cells | Q28568589 | ||
| FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons | Q28571301 | ||
| Ectodomain shedding of neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, by TIMP-2- and TIMP-3-sensitive proteolysis | Q28576716 | ||
| Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family | Q28581126 | ||
| HCSD: the human cancer secretome database | Q28647947 | ||
| The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. | Q29347247 | ||
| UniProt: a hub for protein information | Q29547457 | ||
| Integrin alpha6 cleavage: a novel modification to modulate cell migration. | Q30158058 | ||
| Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands | Q30443463 | ||
| Transition of galactosyltransferase 1 from trans-Golgi cisterna to the trans-Golgi network is signal mediated | Q30478406 | ||
| Polyductin undergoes notch-like processing and regulated release from primary cilia | Q30479973 | ||
| A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling | Q30652639 | ||
| Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability | Q30805022 | ||
| TNF-alpha-converting enzyme cleaves the macrophage colony-stimulating factor receptor in macrophages undergoing activation. | Q31838070 | ||
| Regulation of the activity of matriptase on epithelial cell surfaces by a blood-derived factor | Q32081582 | ||
| Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 levels are elevated in acute coronary syndrome: a novel marker for early diagnosis | Q80976759 | ||
| Critical function for ADAM9 in mouse prostate cancer | Q81362568 | ||
| Local secretion/shedding of tumor-derived CD83 molecules as a novel tumor escape mechanism | Q81363495 | ||
| IL-7 decreases IL-7 receptor alpha (CD127) expression and induces the shedding of CD127 by human CD8+ T cells | Q81488104 | ||
| Cell surface colony-stimulating factor 1 can be cleaved by TNF-alpha converting enzyme or endocytosed in a clathrin-dependent manner | Q81550334 | ||
| Effect of glypican-1 covalently attached chains on turkey myogenic satellite cell proliferation, differentiation, and fibroblast growth factor 2 responsiveness | Q82237226 | ||
| Enhanced circulating soluble LR11 in patients with coronary organic stenosis | Q82389662 | ||
| Enhanced circulating soluble LR11 in patients with diabetic retinopathy | Q84027258 | ||
| Soluble CD200 is critical to engraft chronic lymphocytic leukemia cells in immunocompromised mice | Q84754930 | ||
| SecretePipe: a screening pipeline for secreted proteins with competence to identify potential membrane-bound shed markers | Q85930197 | ||
| Preclinical characterization of AMG 330, a CD3/CD33-bispecific T-cell-engaging antibody with potential for treatment of acute myelogenous leukemia | Q87536236 | ||
| Glypican-3 as a serum marker for hepatocellular carcinoma | Q95818699 | ||
| Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form. | Q35236046 | ||
| Neurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway | Q35262436 | ||
| Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates | Q35264713 | ||
| Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3 | Q35340703 | ||
| Soluble T cell immunoglobulin mucin domain 3 is shed from CD8+ T cells by the sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progression | Q35487768 | ||
| Metalloproteases regulate T-cell proliferation and effector function via LAG-3 | Q35612460 | ||
| Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury | Q35616359 | ||
| Processing, shedding, and endocytosis of membrane type 1-matrix metalloproteinase (MT1-MMP). | Q35770288 | ||
| ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function | Q35917387 | ||
| Syndecan-4 shedding is involved in the oxidative stress and inflammatory responses in left atrial tissue with valvular atrial fibrillation | Q35918992 | ||
| Increased ectodomain shedding of cell adhesion molecule 1 as a cause of type II alveolar epithelial cell apoptosis in patients with idiopathic interstitial pneumonia | Q35937923 | ||
| Negative regulation of signaling by a soluble form of toll-like receptor 9. | Q36048535 | ||
| Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier | Q36058429 | ||
| The ADAM15 ectodomain is shed from secretory exosomes | Q36082432 | ||
| Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons | Q36103683 | ||
| Secreted gliomedin is a perinodal matrix component of peripheral nerves | Q36119690 | ||
| Molecular and cellular mechanisms of ectodomain shedding | Q36210626 | ||
| Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytes | Q36244872 | ||
| CD43, the major sialoglycoprotein of human leukocytes, is proteolytically cleaved from the surface of stimulated lymphocytes and granulocytes | Q36264320 | ||
| Kin of IRRE-like Protein 2 Is a Phosphorylated Glycoprotein That Regulates Basal Insulin Secretion. | Q36283499 | ||
| Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation | Q36322524 | ||
| A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation. | Q36332111 | ||
| Matrix metalloproteinase-2 cleavage of the β1 integrin ectodomain facilitates colon cancer cell motility. | Q36332965 | ||
| Spontaneous release of the Leu-2 (T8) molecule from human T cells | Q36348062 | ||
| Immunochemical analysis of the released Leu-2 (T8) molecule | Q36349271 | ||
| Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins | Q36380055 | ||
| Emerging roles for ectodomain shedding in the regulation of inflammatory responses | Q36432148 | ||
| Insights into ectodomain shedding and processing of protein-tyrosine pseudokinase 7 (PTK7) | Q36451958 | ||
| LOCATE: a mammalian protein subcellular localization database | Q36454350 | ||
| ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors | Q36504484 | ||
| Cleavage of myelin associated glycoprotein by matrix metalloproteinases | Q36513220 | ||
| ADAM17 cleaves CD16b (FcγRIIIb) in human neutrophils | Q36565321 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | Suppl 3 | |
| P921 | main subject | database | Q8513 |
| membrane protein | Q423042 | ||
| genetic marker | Q767511 | ||
| software | Q7397 | ||
| P304 | page(s) | 42 | |
| P577 | publication date | 2017-03-14 | |
| P1433 | published in | BMC Bioinformatics | Q4835939 |
| P1476 | title | SheddomeDB: the ectodomain shedding database for membrane-bound shed markers | |
| P478 | volume | 18 |
| Q64928480 | A toolkit for studying cell surface shedding of diverse transmembrane receptors. |
| Q89433901 | Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments |
| Q51760779 | The tyrosine-kinase inhibitor sunitinib targets vascular endothelial (VE)-cadherin: a marker of response to antitumoural treatment in metastatic renal cell carcinoma. |
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