Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier

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Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E15-03-0147
P932PMC publication ID4569309
P698PubMed publication ID26224314

P50authorAsma NusratQ77916415
P2093author name stringCharles A Parkos
Porfirio Nava
Hikaru Nishio
Mingli Feng
Ryuta Kamekura
Miguel Quiros
Dominique A Weber
P2860cites workThe disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesionQ24300435
Molecular interactions between desmosomal cadherinsQ24533764
Direct Ca2+-dependent Heterophilic Interaction between Desmosomal Cadherins, Desmoglein and Desmocollin, Contributes to Cell–Cell AdhesionQ24678410
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Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactionsQ28609149
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EGFR and ADAMs cooperate to regulate shedding and endocytic trafficking of the desmosomal cadherin desmoglein 2.Q30485264
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A unique role for nonmuscle myosin heavy chain IIA in regulation of epithelial apical junctionsQ33292672
A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cellsQ33581409
Loss of the desmosomal cadherin desmoglein-2 suppresses colon cancer cell proliferation through EGFR signalingQ33769890
Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathwaysQ33808592
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.Q33878896
Epithelial barriers in homeostasis and diseaseQ34093056
The ins and outs of E-cadherin traffickingQ34340762
The Role of cis Dimerization of Signal Regulatory Protein α (SIRPα) in Binding to CD47Q34351985
Clinicopathologic study of dextran sulfate sodium experimental murine colitis.Q42506472
Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytesQ42507955
Cleavage of E-Cadherin by Matrix Metalloproteinase-7 Promotes Cellular Proliferation in Nontransformed Cell Lines via Activation of RhoA.Q42734789
Desmoglein 2-mediated adhesion is required for intestinal epithelial barrier integrity.Q43659297
Soluble serum E-cadherin as a marker of tumour progression in colorectal cancer patientsQ47815750
Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cellsQ50335755
Imaging and force spectroscopy on desmoglein 1 using atomic force microscopy reveal multivalent Ca(2+)-dependent, low-affinity trans-interaction.Q51795763
Enterococcus faecalis metalloprotease compromises epithelial barrier and contributes to intestinal inflammation.Q53238530
Soluble adhesion molecules E-cadherin, intercellular adhesion molecule-1, and E-selectin as lung cancer biomarkers.Q53293812
Matrix metalloproteinase levels are elevated in inflammatory bowel diseaseQ61758671
Staphylococcal exfoliative toxin B specifically cleaves desmoglein 1Q64378888
Soluble 80-kd fragment of cell-CAM 120/80 disrupts cell-cell adhesionQ69140550
The role of an 80 kDa fragment of E-cadherin in the metastatic progression of prostate cancerQ75207599
ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitisQ80503595
Plakoglobin rescues adhesive defects induced by ectodomain truncation of the desmosomal cadherin desmoglein 1: implications for exfoliative toxin-mediated skin blisteringQ34358279
IFNγ-induced suppression of β-catenin signaling: evidence for roles of Akt and 14.3.3ζ.Q34504019
Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury.Q34695953
Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresisQ34718289
Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signalingQ34803102
ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signalingQ34979291
Characterization of full-length and proteolytic cleavage fragments of desmoglein-2 in native human colon and colonic epithelial cell linesQ35534067
Cadherins as Modulators of Cellular PhenotypeQ35564806
Soluble-E-cadherin activates HER and IAP family members in HER2+ and TNBC human breast cancersQ35770840
Desmoglein-2: a novel regulator of apoptosis in the intestinal epitheliumQ36095710
Desmosomal adhesion inhibits invasive behaviorQ36166865
Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation, and epidermal differentiationQ36237073
Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cellsQ36255048
Role of matrix metalloproteinases in intestinal inflammationQ36462632
Intestinal crypts reproducibly expand in cultureQ36846558
Emerging roles of ADAM and ADAMTS metalloproteinases in cancer.Q36963327
Desmosomes: new perspectives on a classicQ36970223
Structure and function of desmosomesQ36983434
Soluble E-cadherin: an early marker of severity in acute pancreatitis.Q37172829
Desmosomes: new perpetrators in tumour suppressionQ37237903
Desmoglein 1-dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesisQ37267606
Tight junction-based epithelial microenvironment and cell proliferationQ37333599
Cleavage of transmembrane junction proteins and their role in regulating epithelial homeostasisQ37428089
Novel anticancer targets: revisiting ERBB2 and discovering ERBB3.Q37523202
The life and death of epithelia during inflammation: lessons learned from the gut.Q37916584
Dishonorable discharge: the oncogenic roles of cleaved E-cadherin fragmentsQ38015669
The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activationQ38291507
Soluble E-cadherin: a critical oncogene modulating receptor tyrosine kinases, MAPK and PI3K/Akt/mTOR signaling.Q39210902
The EGF receptor and HER2 participate in TNF-α-dependent MAPK activation and IL-8 secretion in intestinal epithelial cellsQ39276410
Membrane-impermeable cross-linking provides evidence for homophilic, isoform-specific binding of desmosomal cadherins in epithelial cellsQ39628824
Attenuation of dextran sodium sulphate induced colitis in matrix metalloproteinase-9 deficient mice.Q40214318
The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytesQ40351730
Coordinated expression of desmoglein 1 and desmocollin 1 regulates intercellular adhesion.Q40479627
Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cellsQ40543731
Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanismsQ40614064
Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1.Q40838158
Removal of calcium ions triggers a novel type of intercadherin interaction.Q40917664
Inhibition of adhesion and induction of epithelial cell invasion by HAV-containing E-cadherin-specific peptides.Q40990214
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signallingQ41107179
Cytokines in inflammatory bowel diseaseQ41730146
P4510describes a project that usesImageJQ1659584
P433issue18
P304page(s)3165-3177
P577publication date2015-07-29
P1433published inMolecular Biology of the CellQ2338259
P1476titleInflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier
P478volume26

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cites work (P2860)
Q48213706Adherens junctions and desmosomes are damaged by Entamoeba histolytica: Participation of EhCPADH complex and EhCP112 protease.
Q47552491Associations of the Top 20 Alzheimer Disease Risk Variants With Brain Amyloidosis
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Q38936511Pathobiology of neutrophil-epithelial interactions
Q36329547SheddomeDB: the ectodomain shedding database for membrane-bound shed markers
Q37437211c-Src/Cav1-dependent activation of the EGFR by Dsg2

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