Platelet-derived HMGB1 is a critical mediator of thrombosis. (scientific article)

Extracellular cyclophilin A activates platelets via EMMPRIN (CD147) and PI3K/Akt signaling, which promotes platelet adhesion and thrombus formation in vitro and in vivo.

Q30316872

Highly specific, membrane-permeant peptide blockers of cGMP-dependent protein kinase Ialpha inhibit NO-induced cerebral dilation

Q31836174

Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation

Q32000831

Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo

Q33368585

Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway

Q33384817

Activated platelets interfere with recruitment of mesenchymal stem cells to apoptotic cardiac cells via high mobility group box 1/Toll-like receptor 4-mediated down-regulation of hepatocyte growth factor receptor MET

Q33676193

The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function.

Q33890246

Prehospital use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of trauma-induced coagulopathy

Q33896084

Platelet-derived Toll-like receptor 4 (Tlr-4) is sufficient to promote microvascular thrombosis in endotoxemia.

Q34387761

Systemic inflammation and liver injury following hemorrhagic shock and peripheral tissue trauma involve functional TLR9 signaling on bone marrow-derived cells and parenchymal cells.

Q34400381

Disseminated intravascular coagulation in trauma patients

Q34461301

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

Q34660102

Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury in hemorrhagic shock and resuscitation

Q34734986

DNA attenuates enterocyte Toll-like receptor 4-mediated intestinal mucosal injury after remote trauma

Q34979970

Platelets in atherothrombosis

Q34986345

Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation.

Q35183879

Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation

Q35266258

Cyclic GMP-dependent protein kinases and the cardiovascular system: insights from genetically modified mice.

Q35582722

Differential dynamics of platelet contact and spreading

Q35743292

HMGB1 is a therapeutic target for sterile inflammation and infection

Q35953553

Necrotic cell-derived high mobility group box 1 attracts antigen-presenting cells but inhibits hepatocyte growth factor-mediated tropism of mesenchymal stem cells for apoptotic cell death.

Q36067773

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

Q36068299

Platelets in inflammation and atherogenesis.

Q36328825

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

Q36403403

Circulating histones are mediators of trauma-associated lung injury.

Q36605094

Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling

Q36915561

Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection

Q37409524

Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice

Q37662678

Arterial thrombosis--insidious, unpredictable and deadly

Q37953778

HMGB1 and leukocyte migration during trauma and sterile inflammation

Q38064648

Role of multiligand/RAGE axis in platelet activation.

Q38167989

Pseudofracture: an acute peripheral tissue trauma model

Q38353270

Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection

Q38959156

Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein

Q40609759

Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells

Q40686939

Rescue of cGMP kinase I knockout mice by smooth muscle specific expression of either isozyme

Q42519481

Increased adhesion and aggregation of platelets lacking cyclic guanosine 3',5'-monophosphate kinase I.

Q42944020

A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha IIbbeta3.

Q43720106

A stimulatory role for cGMP-dependent protein kinase in platelet activation

Q44277303

A platelet secretion pathway mediated by cGMP-dependent protein kinase

Q44997709

Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps.

Q45868008

Role of high-mobility group box 1 protein in post-infarction healing process and left ventricular remodelling

Q46264543

Benzyl alcohol attenuates acetaminophen-induced acute liver injury in a Toll-like receptor-4-dependent pattern in mice

Q47875295

Elevated high-mobility group box 1 levels in patients with cerebral and myocardial ischemia

Q48524719

Intracellular cyclophilin A is an important Ca(2+) regulator in platelets and critically involved in arterial thrombus formation.

Q51758034

HMGB1 binds to activated platelets via the receptor for advanced glycation end products and is present in platelet rich human coronary artery thrombi.

Q53412748

Macrophage migration inhibitory factor limits activation-induced apoptosis of platelets via CXCR7-dependent Akt signaling.

Q54318761

Systemic inflammation and remote organ injury following trauma require HMGB1

Q60692866

Introduction: HMGB1 in inflammation and innate immunity

Q60746175

Circulating platelets as a source of the damage-associated molecular pattern HMGB1 in patients with systemic sclerosis

Q61780011

High-Mobility Group Box-1 in Ischemia-Reperfusion Injury of the Heart

Q63384080

Occurrence of amphoterin (HMG1) as an endogenous protein of human platelets that is exported to the cell surface upon platelet activation

Q73387665

Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo

Q79220440

High-mobility group box 1 protein promotes development of microvascular thrombosis in rats

Q79613873

Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling

Q80257425

IL-6 and maturation govern TLR2 and TLR4 induced TLR agonist tolerance and cross-tolerance in dendritic cells

Q81464256

Plasma concentrations and importance of High Mobility Group Box protein in the prognosis of organ failure in patients with disseminated intravascular coagulation

Q81641908

The correlation between platelet activation markers and HMGB1 in patients with disseminated intravascular coagulation and hematologic malignancy

Q83717385

Imaging the elastic modulus of human platelets during thrombin-induced activation using scanning ion conductance microscopy

Q85889876

Elevated mitochondrial membrane potential of circulating monocyte-platelet aggregates in patients with coronary heart disease

Q86253017

P4510

describes a project that uses

ImageJ

Q1659584

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

thrombosis

Q261327

P304

page(s)

4638-4654

P577

publication date

2015-11-09

P1433

published in

Journal of Clinical Investigation

Q3186904

P1476

title

Platelet-derived HMGB1 is a critical mediator of thrombosis

P478

volume

125

Reverse relations

cites work (P2860)

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