MYC, Cell Competition, and Cell Death in Cancer: The Inseparable Triad

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MYC, Cell Competition, and Cell Death in Cancer: The Inseparable Triad is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/GENES8040120
P932PMC publication ID5406867
P698PubMed publication ID28420161

P50authorSimone di GiacomoQ57069824
Daniela GrifoniQ57076717
Manuela SollazzoQ57078728
P2093author name stringSimona Paglia
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
Drosophila myc regulates cellular growth during development.Q52573250
Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways.Q52652438
Is cell competition relevant to cancer?Q52687651
Cell competition time line: winners kill losers, which are extruded and engulfed by hemocytes.Q52743805
Cell competition may function either as tumour-suppressing or as tumour-stimulating factor in Drosophila.Q52760951
Cell Competition Drives the Formation of Metastatic Tumors in a Drosophila Model of Epithelial Tumor Formation.Q52842729
Correlation between Apoptosis and Histological Grade of Transitional Cell Carcinoma of Urinary Bladder.Q53227857
Apoptosis index is a predictor of metastatic phenotype in patients with early stage squamous carcinoma of the tongue: a hypothesis to support this paradoxical associationQ73421735
p53-independent apoptosis associated with c-Myc-mediated block in myeloid cell differentiationQ73934753
Antiapoptotic BCL-2 is required for maintenance of a model leukemiaQ80591496
Extent, relationship and prognostic significance of apoptosis and cell proliferation in synovial sarcomaQ83298735
Myc inhibits JNK-mediated cell death in vivoQ50457874
Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development.Q50777362
Persistent competition among stem cells and their daughters in the Drosophila ovary germline niche.Q51826206
Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila.Q52086513
Genetic mosaic techniques for studying Drosophila development.Q52100307
The first 30 years of p53: growing ever more complexQ24645732
Evolutionary determinants of cancerQ26801710
How cell death shapes cancerQ27021441
MYC activation is a hallmark of cancer initiation and maintenanceQ27026026
Putting tumours in contextQ28207789
Concurrent translocation of BCL2 and MYC with a single immunoglobulin locus in high-grade B-cell lymphomasQ28235615
Developmental compartmentalisation of the wing disk of DrosophilaQ28242316
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and CancerQ28269498
Myc-driven endogenous cell competition in the early mammalian embryoQ28294348
Elimination of unfit cells maintains tissue health and prolongs lifespanQ28387112
Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse MinuteQ28587678
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalizationQ29614701
The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancyQ30494710
Tumors as organs: complex tissues that interface with the entire organismQ30495528
Nutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory elementQ33525405
Controlling the Master: Chromatin Dynamics at the MYC Promoter Integrate Developmental SignalingQ33608508
dMyc functions downstream of Yorkie to promote the supercompetitive behavior of hippo pathway mutant cellsQ33707393
MYC and the control of apoptosisQ33790668
c-Myc target genes involved in cell growth, apoptosis, and metabolismQ33956988
Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regenerationQ34001599
Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivoQ34032753
Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signalingQ34034164
A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathwayQ34093277
Human c-Myc isoforms differentially regulate cell growth and apoptosis in Drosophila melanogasterQ34124162
Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanismQ34490491
Hippo signaling: growth control and beyondQ34625638
An intergenic regulatory region mediates Drosophila Myc-induced apoptosis and blocks tissue hyperplasiaQ34714830
Drosophila Myc: A master regulator of cellular performanceQ34873737
Distinct thresholds govern Myc's biological output in vivoQ34897529
Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapyQ35093740
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.Q35204486
Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesisQ35208288
Disease implications of the Hippo/YAP pathwayQ35269102
Crosstalk between MYCN and MDM2-p53 signal pathways regulates tumor cell growth and apoptosis in neuroblastomaQ35556976
Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic roleQ46222720
Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila.Q46821350
Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanismsQ46902175
Engulfment is required for cell competitionQ47070024
Cell mixing induced by myc is required for competitive tissue invasion and destructionQ47070153
Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development.Q47070908
Drosophila myc regulates organ size by inducing cell competitionQ47071644
Max-independent functions of Myc in Drosophila melanogasterQ47071837
dMyc transforms cells into super-competitorsQ47072112
Induction of apoptosis by Drosophila Myc.Q47072146
Active JNK-dependent secretion of Drosophila Tyrosyl-tRNA synthetase by loser cells recruits haemocytes during cell competitionQ47072184
The Drosophila F box protein archipelago regulates dMyc protein levels in vivoQ47072740
c-Myc regulates mammalian body size by controlling cell number but not cell sizeQ47197283
In silico screening of alleged miRNAs associated with cell competition: an emerging cellular event in cancerQ47898879
Cell competition promotes phenotypically silent cardiomyocyte replacement in the mammalian heartQ50449935
Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphomaQ35565000
Inhibition of the single downstream target BAG1 activates the latent apoptotic potential of MYC.Q35599080
Tumor suppression by cell competition through regulation of the Hippo pathwayQ35673635
Tissue Crowding Induces Caspase-Dependent Competition for SpaceQ35929701
Soluble factors mediate competitive and cooperative interactions between cells expressing different levels of Drosophila Myc.Q36276873
C-myc-induced apoptosis in polycystic kidney disease is Bcl-2 and p53 independentQ36380929
Myc/Max/Mad in invertebrates: the evolution of the Max networkQ36451372
The ribosomal protein genes and Minute loci of Drosophila melanogasterQ36465627
Cell Competition Drives the Growth of Intestinal Adenomas in DrosophilaQ36632955
Epithelial neoplasia in Drosophila entails switch to primitive cell statesQ36932325
Competitive interactions eliminate unfit embryonic stem cells at the onset of differentiation.Q37022942
The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growthQ37096606
The microenvironments of multistage carcinogenesisQ37154505
Cell competition and its possible relation to cancerQ37218503
Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinasesQ37233375
Cellular MYCro economics: Balancing MYC function with MYC expressionQ37256438
Myc overexpression enhances of epicardial contribution to the developing heart and promotes extensive expansion of the cardiomyocyte populationQ37371548
Apoptosis in Drosophila: compensatory proliferation and undead cells.Q37402591
An overview of MYC and its interactomeQ37406278
Socializing with MYC: cell competition in development and as a model for premalignant cancerQ37670765
The beneficial role of extracellular reactive oxygen species in apoptosis-induced compensatory proliferationQ37705394
Targeting apoptosis for anticancer therapyQ38214561
dMyc is required for larval growth and endoreplication in DrosophilaQ38341569
Myc and Max homologs in DrosophilaQ38351278
Supercompetitor status of Drosophila Myc cells requires p53 as a fitness sensor to reprogram metabolism and promote viabilityQ38563566
Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanismQ38732164
Cell Competition and Its Role in the Regulation of Cell Fitness from Development to CancerQ38965873
Emergent properties of a computational model of tumour growthQ39603486
Drosophila SPARC is a self-protective signal expressed by loser cells during cell competition.Q39643477
The Drosophila caspase DRONC is regulated by DIAP1Q40387067
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cellsQ40572608
Ras enhances Myc protein stability.Q40967066
Parameters of cell competition in the compartments of the wing disc of DrosophilaQ41624173
Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.Q41714456
Drosophila p53 binds a damage response element at the reaper locusQ41731875
Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of YapQ42023045
Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in DrosophilaQ42474244
The steroid hormone ecdysone controls systemic growth by repressing dMyc function in Drosophila fat cellsQ42971715
Regenerative growth in Drosophila imaginal discs is regulated by Wingless and Myc.Q43102038
Minutes: Mutants of Drosophila autonomously affecting cell division rateQ44889355
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcell deathQ2383867
P577publication date2017-04-17
P1433published inGenesQ5532699
P1476titleMYC, Cell Competition, and Cell Death in Cancer: The Inseparable Triad
P478volume8

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cites work (P2860)
Q64118821A Computational Model of Tumor Growth and Anakoinosis
Q90103107Drosophila Models of Cell Polarity and Cell Competition in Tumourigenesis
Q59132736Evaluating the Remote Control of Programmed Cell Death, with or without a Compensatory Cell Proliferation
Q42282618Human Cancer Cells Signal Their Competitive Fitness Through MYC Activity
Q55343224Learning on the Fly: The Interplay between Caspases and Cancer.
Q52310247Modelling Cooperative Tumorigenesis in Drosophila.
Q93163721Myc plays an important role in Drosophila P-M hybrid dysgenesis to eliminate germline cells with genetic damage
Q90356863Single-cell branching morphogenesis in the Drosophila trachea
Q52715807The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues.
Q91736360circKIF4A promotes tumorogenesis of glioma by targeting miR-139-3p to activate Wnt5a signaling

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