Inhibition of the single downstream target BAG1 activates the latent apoptotic potential of MYC.

scientific article published on 10 October 2011

Inhibition of the single downstream target BAG1 activates the latent apoptotic potential of MYC. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.06297-11
P932PMC publication ID3233020
P698PubMed publication ID21986497

P50authorIsidore RigoutsosQ39754828
Andrei Thomas-TikhonenkoQ42324213
P2093author name stringLewis A Chodosh
Duonan Yu
Renato Baserga
Hestia S Mellert
Alpana Kumari
Timothy J Stanek
Xiao-Yong Zhang
Graham Packham
Robyn T Sussman
Steven B McMahon
Hans E Seidel
Harla K Pfeiffer
P2860cites workTargeting of Miz-1 is essential for Myc-mediated apoptosisQ24298658
The ubiquitin-specific protease USP28 is required for MYC stabilityQ24308568
The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteinsQ24328753
The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-MycQ24554343
BAG-1 haplo-insufficiency impairs lung tumorigenesisQ24809688
Integration of external signaling pathways with the core transcriptional network in embryonic stem cellsQ29547179
Induction of apoptosis in fibroblasts by c-myc proteinQ29614346
Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profilesQ29617464
Reverse engineering of regulatory networks in human B cellsQ30004211
c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutationsQ31929763
Thioflavin S (NSC71948) interferes with Bcl-2-associated athanogene (BAG-1)-mediated protein-protein interactions.Q33494790
Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoproteinQ34047970
A novel doxycycline-inducible system for the transgenic analysis of mammary gland biologyQ34116752
Evolutionarily conserved regions of the human c-myc protein can be uncoupled from transforming activityQ34585486
Modelling Myc inhibition as a cancer therapyQ34811008
Distinct thresholds govern Myc's biological output in vivoQ34897529
Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter.Q35080744
c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targetsQ35212190
Intrinsic tumour suppressionQ35953133
The c-Myc target gene networkQ36564217
c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis.Q36671497
Definition of regions in human c-myc that are involved in transformation and nuclear localizationQ36839982
Multiple, but concerted cellular activities of the human protein Hap46/BAG-1M and isoformsQ37462230
BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-kappaB activityQ38294434
Myc-binding-site recognition in the human genome is determined by chromatin contextQ38312447
Overexpression and gene amplification of BAG-1L in hormone-refractory prostate cancer.Q40132834
BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosisQ40212744
Identification of novel targets of MYC whose transcription requires the essential MbII domainQ40325423
Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation.Q40424280
Antisense BAG-1 sensitizes HeLa cells to apoptosis by multiple pathwaysQ40606537
Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell linesQ40739242
p53-dependent apoptosis or growth arrest induced by different forms of radiation in U2OS cells: p21WAF1/CIP1 repression in UV induced apoptosisQ40926717
Inhibition of proliferation and induction of apoptosis by doxycycline in cultured human osteosarcoma cellsQ41077817
Ratcheting Myc.Q42279416
Acetylation of the p53 DNA-binding domain regulates apoptosis inductionQ43019120
Expression of BAG-1 protein correlates with aggressive behavior of prostate cancers.Q43520641
Molecular profiling of pediatric mature B-cell lymphoma treated in population-based prospective clinical trialsQ45326535
Efficient production of human FVIII in hemophilic mice using lentiviral vectorsQ45861949
Analysis of genomic targets reveals complex functions of MYC.Q47259237
Estrogen receptor beta (ERbeta) protein expression correlates with BAG-1 and prognosis in brain glial tumoursQ48693039
A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling.Q51940347
Regulation of heat shock protein 70 gene expression by c-myc.Q52520921
Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cellsQ59054505
BAG-1: a multi-functional pro-survival moleculeQ80842987
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
P304page(s)5037-5045
P577publication date2011-10-10
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleInhibition of the single downstream target BAG1 activates the latent apoptotic potential of MYC.
P478volume31

Reverse relations

cites work (P2860)
Q37434035BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor β (TGF-β1) in colorectal tumour cells
Q38852621Bag-1 promotes cell survival through c-Myc-mediated ODC upregulation that is not preferred under apoptotic stimuli in MCF-7 cells
Q64059696Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC
Q33790668MYC and the control of apoptosis
Q36350155MYC, Cell Competition, and Cell Death in Cancer: The Inseparable Triad
Q26785379MYC-driven aggressive B-cell lymphomas: biology, entity, differential diagnosis and clinical management
Q38034482Mass spectrometry-based metabolomics towards understanding of gene functions with a diversity of biological contexts
Q33730792MicroRNA 28 controls cell proliferation and is down-regulated in B-cell lymphomas.
Q37684426Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer
Q37457895Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo
Q90018540Targeting epigenetics using synthetic lethality in precision medicine
Q39260973The retinoblastoma protein (Rb) as an anti-apoptotic factor: expression of Rb is required for the anti-apoptotic function of BAG-1 protein in colorectal tumour cells.

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