BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis

scientific article published on November 2006

BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M609138200
P698PubMed publication ID17082179

P2093author name stringJagruti H Patel
Steven B McMahon
P2860cites workMolecular characterization of mitochondrial apoptosis-inducing factorQ22001452
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell deathQ24291746
Targeting of Miz-1 is essential for Myc-mediated apoptosisQ24298658
The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteinsQ24328753
An alternative pathway for gene regulation by MycQ24532791
miR-15 and miR-16 induce apoptosis by targeting BCL2Q24536069
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helixQ24537504
Myc represses transcription through recruitment of DNA methyltransferase corepressorQ24557458
c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-XLQ24653312
Genomic targets of the human c-Myc proteinQ24672480
c-Myc-regulated microRNAs modulate E2F1 expressionQ27861046
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpDQ28115105
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibitionQ28115131
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosisQ28189945
Myc pathways provoking cell suicide and cancerQ28190322
Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoterQ28204860
c-MYC: more than just a matter of life and deathQ28205057
Definition of a consensus binding site for p53Q28207794
Negative regulation of the mammalian UV response by Myc through association with Miz-1Q28212421
Puma is an essential mediator of p53-dependent and -independent apoptotic pathwaysQ28213279
Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesisQ28593886
An inhibitor of Bcl-2 family proteins induces regression of solid tumoursQ29547595
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalizationQ29614701
The Bcl2 family: regulators of the cellular life-or-death switchQ29614982
Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damageQ33209569
MYC oncogenes and human neoplastic diseaseQ33667340
Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosisQ33965061
Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoproteinQ34047970
BH3-Only proteins-essential initiators of apoptotic cell deathQ34117362
Cooperative interaction between c-myc and bcl-2 proto-oncogenesQ34255596
Amplification of IGH/MYC fusion in clinically aggressive IGH/BCL2-positive germinal center B-cell lymphomas.Q34413839
Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesionQ35107957
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cellsQ35153635
p53 and E2F-1 cooperate to mediate apoptosisQ35185411
Promoter-binding and repression of PDGFRB by c-Myc are separable activitiesQ35618448
Myc-interacting protein 1 target gene profile: a link to microtubules, extracellular signal-regulated kinase, and cell growthQ35733509
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progressionQ35804203
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosisQ35885582
Evasion of the p53 tumour surveillance network by tumour-derived MYC mutantsQ36142180
Promoting apoptosis as a strategy for cancer drug discoveryQ36292878
Transient excess of MYC activity can elicit genomic instability and tumorigenesisQ36455522
The Myc negative autoregulation mechanism requires Myc-Max association and involves the c-myc P2 minimal promoterQ36564631
Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2Q36678903
Enforced expression of the c-myc oncogene inhibits cell differentiation by precluding entry into a distinct predifferentiation state in G0/G1.Q36786710
myc and src oncogenes have complementary effects on cell proliferation and expression of specific extracellular matrix components in definitive chondroblastsQ36886471
The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteinsQ37162513
Bim is a suppressor of Myc-induced mouse B cell leukemiaQ37647369
Polycomb mediates Myc autorepression and its transcriptional control of many loci in DrosophilaQ38317655
Max: functional domains and interaction with c-MycQ38331173
c-Myc-induced sensitization to apoptosis is mediated through cytochrome c releaseQ40443976
Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathwayQ40495521
Skp2 regulates Myc protein stability and activityQ40644685
Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1.Q40769247
Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP.Q40772219
Control of cell growth by c-Myc in the absence of cell divisionQ40919064
Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosisQ41563751
Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.Q41714456
Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlappingQ41722866
Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironmentQ42440856
c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanismQ42458575
E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS eliminationQ42814364
Autorepression of c-myc requires both initiator and E2F-binding site elements and cooperation with the p107 gene productQ42832476
Identification of chelerythrine as an inhibitor of BclXL functionQ44408527
Analysis of genomic targets reveals complex functions of MYC.Q47259237
Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment.Q51211851
Expression of c-myc changes during differentiation of mouse erythroleukaemia cells.Q51230900
Pontin and Reptin regulate cell proliferation in early Xenopus embryos in collaboration with c-Myc and Miz-1.Q52053549
Analysis of the Myc and Max interaction specificity with lambda repressor-HLH domain fusions.Q52208388
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic miceQ57338722
Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)Q59085244
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)5-13
P577publication date2006-11-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleBCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis
P478volume282

Reverse relations

cites work (P2860)
Q34609728A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins
Q35012114ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation
Q40092568An N-Myc truncation analogous to c-Myc-S induces cell proliferation independently of transactivation but dependent on Myc homology box II.
Q37310199Apoptotic signaling by c-MYC.
Q37256816BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma
Q39851009Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl-CoA/acetate metabolism
Q52902019Decreased MIZ1 Expression in Severe Experimental Acute Pancreatitis: A Rat Study.
Q39126093Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma
Q42722662Emerging Concepts in the Analysis of Transcriptional Targets of the MYC Oncoprotein: Are the Targets Targetable?
Q26770001Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function
Q37367194Genome-wide identification of post-translational modulators of transcription factor activity in human B cells.
Q35599080Inhibition of the single downstream target BAG1 activates the latent apoptotic potential of MYC.
Q33790662MYC association with cancer risk and a new model of MYC-mediated repression
Q34083178MYC cofactors: molecular switches controlling diverse biological outcomes
Q92377180MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer
Q24323957Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1
Q27304900Miz1 is a critical repressor of cdkn1a during skin tumorigenesis
Q35104755Molecular mechanisms of cigarette smoke-induced proliferation of lung cells and prevention by vitamin C.
Q38811147Myc Induces miRNA-Mediated Apoptosis in Response to HDAC Inhibition in Hematologic Malignancies
Q29616653Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
Q33713849Nac1 interacts with the POZ-domain transcription factor, Miz1.
Q41633837Nuclear factor-kappa B1 inhibits early apoptosis of glioma cells by promoting the expression of Bcl-2
Q36771814Prognostic impact of concurrent MYC and BCL6 rearrangements and expression in de novo diffuse large B-cell lymphoma.
Q37699714Regulation of CDKN2B expression by interaction of Arnt with Miz-1--a basis for functional integration between the HIF and Myc gene regulatory pathways
Q34721114Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1
Q35761146Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells
Q39785267The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis
Q24620437The Bcl-2 apoptotic switch in cancer development and therapy
Q27010254The role of MIZ-1 in MYC-dependent tumorigenesis
Q39583166Transcriptional regulation of Wnt inhibitory factor-1 by Miz-1/c-Myc.
Q90797260c-Myc promotes tubular cell apoptosis in ischemia-reperfusion-induced renal injury by negatively regulating c-FLIP and enhancing FasL/Fas-mediated apoptosis pathway

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