Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo

scientific article published on 31 May 2016

Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.9752
P932PMC publication ID5130016
P698PubMed publication ID27259258

P50authorPaul DentQ73523499
P2093author name stringAndrew Poklepovic
Jane L Roberts
Laurence Booth
Thomas Albers
Iryna O Lebedyeva
Mehrad Tavallai
P2860cites workAR-12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Replication.Q38770459
The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14.Q38780596
HSPH1 inhibition downregulates Bcl-6 and c-Myc and hampers the growth of human aggressive B-cell non-Hodgkin lymphoma.Q38921685
OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killingQ39392716
[Pemetrexed + Sorafenib] lethality is increased by inhibition of ERBB1/2/3-PI3K-NFκB compensatory survival signalingQ39888747
Heme oxygenase-1 nuclear translocation regulates bortezomibinduced cytotoxicity and mediates genomic instability in myeloma cellsQ39956732
Blocking the survival of the nastiest by HSP90 inhibitionQ39995934
OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cellsQ40290604
Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.Q40457732
H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.Q40457742
Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cellsQ41504464
Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX.Q42770281
Molecularly targeted therapy for the treatment of head and neck cancer: a review of the ErbB family inhibitorsQ26750719
GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human diseaseQ28254667
Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.Q33946679
Regulation of OSU-03012 toxicity by ER stress proteins and ER stress-inducing drugsQ34289307
Inhibition of the single downstream target BAG1 activates the latent apoptotic potential of MYC.Q35599080
Targeting the glucose-regulated protein-78 abrogates Pten-null driven AKT activation and endometrioid tumorigenesis.Q35958280
ING5 suppresses proliferation, apoptosis, migration and invasion, and induces autophagy and differentiation of gastric cancer cells: a good marker for carcinogenesis and subsequent progressionQ36260589
OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer TherapiesQ36808317
Nexavar/Stivarga and viagra interact to kill tumor cellsQ36808335
GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial DiseasesQ36830763
Celecoxib enhances [sorafenib + sildenafil] lethality in cancer cells and reverts platinum chemotherapy resistanceQ36839023
Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone functionQ37022352
Ruxolitinib synergizes with DMF to kill via BIM+BAD-induced mitochondrial dysfunction and via reduced SOD2/TRX expression and ROSQ37109457
OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cellsQ37172898
The afatinib resistance of in vivo generated H1975 lung cancer cell clones is mediated by SRC/ERBB3/c-KIT/c-MET compensatory survival signalingQ37190128
PTEN-PDZ domain interactions: binding of PTEN to PDZ domains of PTPN13.Q38275375
Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cellsQ38310916
P433issue26
P407language of work or nameEnglishQ1860
P304page(s)40398-40417
P577publication date2016-05-31
P1433published inOncotargetQ1573155
P1476titleMulti-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo
P478volume7

Reverse relations

cites work (P2860)
Q46238888Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species
Q45073629HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo
Q45072959HDAC inhibitors enhance the immunotherapy response of melanoma cells
Q38721255PDE5 inhibitors enhance the lethality of [pemetrexed + sorafenib].
Q42316209PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide
Q57160512Palbociclib augments Neratinib killing of tumor cells that is further enhanced by HDAC inhibition
Q52672956Pazopanib radio-sensitization of human sarcoma tumors.
Q92376425Preclinical Characteristics of the Irreversible Pan-HER Kinase Inhibitor Neratinib Compared with Lapatinib: Implications for the Treatment of HER2-Positive and HER2-Mutated Breast Cancer
Q42341715Repurposing Tecfidera for cancer
Q37725434The HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo