Macrophage paraoxonase 2 regulates calcium homeostasis and cell survival under endoplasmic reticulum stress conditions and is sufficient to prevent the development of aggravated atherosclerosis in paraoxonase 2 deficiency/apoE-/- mice on a Western d

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Macrophage paraoxonase 2 regulates calcium homeostasis and cell survival under endoplasmic reticulum stress conditions and is sufficient to prevent the development of aggravated atherosclerosis in paraoxonase 2 deficiency/apoE-/- mice on a Western d is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YMGME.2012.06.020
P932PMC publication ID3483415
P698PubMed publication ID22864055

P2093author name stringSrinivasa T Reddy
Satoshi Imaizumi
David Meriwether
Asokan Devarajan
Bo-Chul Shin
Sherin U Devaskar
Victor R Grijalva
Noam Bourquard
P2860cites workMitochondrial dysfunction in atherosclerosis.Q36749083
Antioxidants reduce endoplasmic reticulum stress and improve protein secretionQ36985084
Impaired hepatic insulin signalling in PON2-deficient mice: a novel role for the PON2/apoE axis on the macrophage inflammatory responseQ37095596
Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in miceQ37143384
Is it just paraoxonase 1 or are other members of the paraoxonase gene family implicated in atherosclerosis?Q37209388
Macrophage apoptosis in atherosclerosis: consequences on plaque progression and the role of endoplasmic reticulum stressQ37401270
Role of cardiolipin peroxidation and Ca2+ in mitochondrial dysfunction and diseaseQ37445214
Oxidative stress caused by mitochondrial calcium overloadQ37774693
Oxidative protein folding in the secretory pathway and redox signaling across compartments and cellsQ37780570
Endoplasmic-reticulum calcium depletion and diseaseQ37858336
Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2.Q39347729
Thapsigargin activates a calcium influx pathway in the unfertilized mouse egg and suppresses repetitive calcium transients in the fertilized eggQ41094869
Mitochondrial function is involved in LDL oxidation mediated by human cultured endothelial cells.Q41095877
Mitochondrial decay and impairment of antioxidant defenses in aging RPE cellsQ43125561
Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice.Q46030815
Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis.Q46129152
Mitochondrial reactive oxygen species in mice lacking superoxide dismutase 2: attenuation via antioxidant treatmentQ46798323
Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicityQ46942358
Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondriaQ70080329
Tunicamycin increases intracellular calcium levels in bovine aortic endothelial cellsQ73847632
Paraoxonase-2 reduces oxidative stress in vascular cells and decreases endoplasmic reticulum stress-induced caspase activationQ80087721
Isolation of mitochondria from tissues and cells by differential centrifugationQ80568321
AtherosclerosisQ24644573
Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoproteinQ28189491
The paraoxonase gene family and atherosclerosisQ28298957
Protectors or Traitors: The Roles of PON2 and PON3 in Atherosclerosis and CancerQ28384857
PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell deathQ28387637
One enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activityQ28397498
Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosisQ28586997
The mammalian unfolded protein responseQ29547400
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stressQ29615495
Mediators of endoplasmic reticulum stress-induced apoptosisQ29615496
ER stress triggers apoptosis by activating BH3-only protein BimQ29617730
Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP.Q30488194
Measuring intracellular calcium signaling in murine NK cells by flow cytometryQ33520717
Type 1 inositol 1,4,5-trisphosphate receptor knock-out mice: their phenotypes and their meaning in neuroscience and clinical practiceQ33699274
Absence of myeloid COX-2 attenuates acute inflammation but does not influence development of atherosclerosis in apolipoprotein E null miceQ33808556
The Role of Endoplasmic Reticulum Stress in the Progression of AtherosclerosisQ34141006
Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosisQ34447321
Paraoxonase 2 (PON2) in the mouse central nervous system: a neuroprotective role?Q35163293
The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL.Q35732501
Hormonal and chemical regulation of paraoxonases in miceQ36174199
Mitochondria and endoplasmic reticulum: the lethal interorganelle cross-talkQ36259144
Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptorQ36320445
Paraoxonase 1 gene transfer lowers vascular oxidative stress and improves vasomotor function in apolipoprotein E-deficient mice with pre-existing atherosclerosis.Q36456886
P433issue3
P921main subjectatherosclerosisQ12252367
endoplasmic reticulumQ79927
macrophageQ184204
P304page(s)416-427
P577publication date2012-07-14
P1433published inMolecular Genetics and MetabolismQ6895949
P1476titleMacrophage paraoxonase 2 regulates calcium homeostasis and cell survival under endoplasmic reticulum stress conditions and is sufficient to prevent the development of aggravated atherosclerosis in paraoxonase 2 deficiency/apoE-/- mice on a Western d
P478volume107

Reverse relations

cites work (P2860)
Q36589917An involvement of oxidative stress in endoplasmic reticulum stress and its associated diseases
Q26767386Endoplasmic Reticulum Stress and Associated ROS
Q45300046Hyperglycemia magnifies bupivacaine-induced cell apoptosis triggered by mitochondria dysfunction and endoplasmic reticulum stress
Q26849832Inflammation, infection, cancer and all that…the role of paraoxonases
Q37283840Neuroprotective effect of ginkgolide B on bupivacaine-induced apoptosis in SH-SY5Y cells
Q43120971Paraoxonase 2 Induces a Phenotypic Switch in Macrophage Polarization Favoring an M2 Anti-Inflammatory State
Q52659536Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer.
Q91891589Paraoxonase 2 protects against acute myocardial ischemia-reperfusion injury by modulating mitochondrial function and oxidative stress via the PI3K/Akt/GSK-3β RISK pathway
Q33825970Paraoxonase enzyme protects retinal pigment epithelium from chlorpyrifos insult
Q37238748Role of PON2 in innate immune response in an acute infection model

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