Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders (scientific article published on 16 November 2015)

Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor

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Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission

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Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

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Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome

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Fyn kinase contributes to tyrosine phosphorylation of the GABA(A) receptor gamma2 subunit

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Synaptic targeting and regulation of GABA(A) receptors

Q33985504

Deficient tonic GABAergic conductance and synaptic balance in the fragile X syndrome amygdala

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Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus

Q34048866

GABA-based therapeutic approaches: GABAA receptor subtype functions

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Extrasynaptic GABAA Receptors: Their Function in the CNS and Implications for Disease

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Maternal transmission of a rare GABRB3 signal peptide variant is associated with autism

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GABRB3 gene deficient mice: a potential model of autism spectrum disorder

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Enhanced Tonic Inhibition Influences the Hypnotic and Amnestic Actions of the Intravenous Anesthetics Etomidate and Propofol

Q36937152

GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition

Q37125949

GABA(A) receptor membrane trafficking regulates spine maturity

Q37282369

Impact of inhibitory constraint of interneurons on neuronal excitability

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Deficits in spatial memory correlate with modified {gamma}-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus.

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Postsynaptic GABAB receptor activity regulates excitatory neuronal architecture and spatial memory

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Regulation of GABAARs by phosphorylation

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Tonic GABAA conductance decreases membrane time constant and increases EPSP-spike precision in hippocampal pyramidal neurons

Q41845525

Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders

Q43246437

Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome.

Q46471442

FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A.

Q46832201

Brain-derived neurotrophic factor modulates fast synaptic inhibition by regulating GABA(A) receptor phosphorylation, activity, and cell-surface stability.

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Stabilization of GABA(A) receptors at endocytic zones is mediated by an AP2 binding motif within the GABA(A) receptor β3 subunit.

Q48625801

P4510

describes a project that uses

ImageJ

Q1659584

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

autism

Q38404

autism spectrum disorder

Q1436063

P304

page(s)

14805-14810

P577

publication date

2015-11-16

P1433

published in

Proceedings of the National Academy of Sciences of the United States of America

Q1146531

P1476

title

Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders

P478

volume

112

Reverse relations

cites work (P2860)

Q64120668	Alterations in GABA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders
Q47714716	CNTNAP4 Impacts Epilepsy Through GABAA Receptors Regulation: Evidence From Temporal Lobe Epilepsy Patients and Mouse Models
Q55098524	Common Ribs of Inhibitory Synaptic Dysfunction in the Umbrella of Neurodevelopmental Disorders.
Q45011378	Decreased surface expression of the δ subunit of the GABAA receptor contributes to reduced tonic inhibition in dentate granule cells in a mouse model of fragile X syndrome
Q41664915	Developmental Disruption of GABAAR-Meditated Inhibition in Cntnap2 KO Mice
Q58797852	Developmental seizures and mortality result from reducing GABA receptor α2-subunit interaction with collybistin
Q47369108	Endogenous and synthetic neuroactive steroids evoke sustained increases in the efficacy of GABAergic inhibition via a protein kinase C-dependent mechanism.
Q47810846	GABA type a receptor trafficking and the architecture of synaptic inhibition.
Q36021405	Genetic Deletion of the Clathrin Adaptor GGA3 Reduces Anxiety and Alters GABAergic Transmission
Q64055140	Motor cortex excitability and inhibitory imbalance in autism spectrum disorder assessed with transcranial magnetic stimulation: a systematic review
Q64236596	Neuroactive Steroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model
Q38861076	Regulating the Efficacy of Inhibition Through Trafficking of γ-Aminobutyric Acid Type A Receptors.
Q91781302	Targeting GABAAR-Associated Proteins: New Modulators, Labels and Concepts

P819	ADS bibcode	2015PNAS..11214805V
P356	DOI	10.1073/PNAS.1514657112
P932	PMC publication ID	4672772
P698	PubMed publication ID	26627235
P5875	ResearchGate publication ID	284205293