GABA type a receptor trafficking and the architecture of synaptic inhibition.

scientific article published on 13 September 2017

GABA type a receptor trafficking and the architecture of synaptic inhibition. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/DNEU.22536
P932PMC publication ID6589839
P698PubMed publication ID28901728

P50authorJoshua M Lorenz-GuertinQ56983075
Tija C JacobQ88971372
P2093author name stringTija C Jacob
P2860cites workGephyrin, the enigmatic organizer at GABAergic synapsesQ21129486
GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeletonQ22008682
The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clusteringQ24297620
Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1Q24298403
Specific functions of BIG1 and BIG2 in endomembrane organizationQ24305411
Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroliginsQ24336796
GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesinQ24337834
Calsyntenins function as synaptogenic adhesion molecules in concert with neurexinsQ24338932
Maf1p, a negative effector of RNA polymerase III in Saccharomyces cerevisiaeQ24550904
GABA A receptors: subtypes provide diversity of function and pharmacologyQ24599057
KCC2 expression in immature rat cortical neurons is sufficient to switch the polarity of GABA responsesQ24600970
NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currentsQ24630525
GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factorQ24632996
Regulation of cortical microcircuits by unitary GABA-mediated volume transmissionQ24646245
Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptorsQ24673026
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2Q26269865
Neurexins physically and functionally interact with GABA(A) receptorsQ26269882
Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2Q26269913
Advances in the Understanding of the Gabaergic Neurobiology of FMR1 Expanded Alleles Leading to Targeted Treatments for Fragile X Spectrum DisorderQ26781265
Altered Neuronal and Circuit Excitability in Fragile X Syndrome.Q26796317
Advancing epilepsy genetics in the genomic eraQ26798035
Anxiety disorders and GABA neurotransmission: a disturbance of modulationQ27003916
Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromesQ27023257
Diffusion dynamics of synaptic molecules during inhibitory postsynaptic plasticityQ27024084
Differential vesicular sorting of AMPA and GABAA receptorsQ27316505
Crystal structure of a human GABAA receptorQ27644591
Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor  2 subunitQ27649952
An unexpected role of neuroligin-2 in regulating KCC2 and GABA functional switchQ36866887
Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofolQ36937152
Activation of GABAA receptors: views from outside the synaptic cleft.Q37022454
γ-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains.Q37065672
Proteomic Characterization of Inhibitory Synapses Using a Novel pHluorin-tagged γ-Aminobutyric Acid Receptor, Type A (GABAA), α2 Subunit Knock-in MouseQ37066077
GABA(A) receptors in normal development and seizures: friends or foes?Q37104140
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibitionQ37125949
GABAA receptor alpha5 subunits contribute to GABAA,slow synaptic inhibition in mouse hippocampus.Q37152399
Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndromeQ37175224
GABAergic signalling to adult-generated neuronsQ37176906
The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABA(A)-receptor γ2 subunitQ37196318
Agonist-dependent endocytosis of γ-aminobutyric acid type A (GABAA) receptors revealed by a γ2(R43Q) epilepsy mutation.Q37201295
Filamin A regulates neuronal migration through brefeldin A-inhibited guanine exchange factor 2-dependent Arf1 activation.Q37208478
Disrupting the clustering of GABAA receptor α2 subunits in the frontal cortex leads to reduced γ-power and cognitive deficitsQ37236602
Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cellsQ37275701
GABA(A) receptor membrane trafficking regulates spine maturityQ37282369
Neuroligin-2 accelerates GABAergic synapse maturation in cerebellar granule cellsQ37340270
Ubiquitin-dependent lysosomal targeting of GABA(A) receptors regulates neuronal inhibitionQ37389012
Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcoholQ37401303
Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmissionQ37405321
SAHA enhances Proteostasis of epilepsy-associated α1(A322D)β2γ2 GABA(A) receptors.Q37412871
Blocking L-type voltage-gated Ca2+ channels with dihydropyridines reduces gamma-aminobutyric acid type A receptor expression and synaptic inhibitionQ37432042
Deficits in spatial memory correlate with modified {gamma}-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus.Q37446532
Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane traffickingQ37494369
The impact of tonic GABAA receptor-mediated inhibition on neuronal excitability varies across brain region and cell type.Q37541565
Gephyrin plays a key role in BDNF-dependent regulation of amygdala surface GABAARsQ37543141
Synaptic localization of α5 GABA (A) receptors via gephyrin interaction regulates dendritic outgrowth and spine maturationQ37589513
Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognitionQ37686937
DISC1 and SLC12A2 interaction affects human hippocampal function and connectivityQ37722074
Long-term plasticity at inhibitory synapsesQ37844877
The GABA system in anxiety and depression and its therapeutic potentialQ37926048
Defined criteria for auxiliary subunits of glutamate receptorsQ37938644
Brain excitability in stroke: the yin and yang of stroke progressionQ37944185
Ubiquitin-like proteinsQ37992156
Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptorsQ33717685
Stress-induced plasticity of GABAergic inhibition.Q33720496
Fyn kinase contributes to tyrosine phosphorylation of the GABA(A) receptor gamma2 subunitQ33823681
Ethanol reduces GABAA alpha1 subunit receptor surface expression by a protein kinase Cgamma-dependent mechanism in cultured cerebral cortical neurons.Q33862025
GABA(A)R plasticity during pregnancy: relevance to postpartum depressionQ33872187
A critical role for alpha4betadelta GABAA receptors in shaping learning deficits at puberty in miceQ33919819
Egr3 stimulation of GABRA4 promoter activity as a mechanism for seizure-induced up-regulation of GABA(A) receptor alpha4 subunit expression.Q33920058
Assessment of GABA concentration in human brain using two-dimensional proton magnetic resonance spectroscopyQ33928395
Synaptic GABAA receptor clustering without the γ2 subunitQ33969791
Brain-derived neurotrophic factor promotes gephyrin protein expression and GABAA receptor clustering in immature cultured hippocampal cellsQ33997720
Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: the membrane activation modelQ34001982
Neurosteroid effects on GABAergic synaptic plasticity in hippocampusQ34016634
Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticusQ34048866
Phosphorylation of GABAA receptors influences receptor trafficking and neurosteroid actionsQ34053899
Alterations of cortical GABA neurons and network oscillations in schizophrenia.Q34058473
Role of the PLC-related, catalytically inactive protein p130 in GABA(A) receptor functionQ34085948
GABA acts as a ligand chaperone in the early secretory pathway to promote cell surface expression of GABAA receptorsQ34140020
Maf1 is an essential mediator of diverse signals that repress RNA polymerase III transcriptionQ34167339
GABAergic synaptic scaling in embryonic motoneurons is mediated by a shift in the chloride reversal potential.Q34175358
Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatmentsQ34282066
Ubiquitination and selective autophagyQ34283289
Gephyrin is critical for glycine receptor clustering but not for the formation of functional GABAergic synapses in hippocampal neurons.Q34289045
A combined transgenic proteomic analysis and regulated trafficking of neuroligin-2.Q34355827
Assembly and cell surface expression of heteromeric and homomeric gamma-aminobutyric acid type A receptors.Q34370307
Perimenstrual-like hormonal regulation of extrasynaptic δ-containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity.Q34383389
Ovarian cycle-linked changes in GABA(A) receptors mediating tonic inhibition alter seizure susceptibility and anxietyQ34419058
Engineering a light-regulated GABAA receptor for optical control of neural inhibition.Q34434222
Protein kinase C phosphorylation regulates membrane insertion of GABAA receptor subtypes that mediate tonic inhibition.Q34438954
Regulation of GABAergic synapse formation and plasticity by GSK3beta-dependent phosphorylation of gephyrin.Q34472152
Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor systemQ34482509
Mutations of protocadherin 19 in female epilepsy (PCDH19-FE) lead to allopregnanolone deficiency.Q34482877
Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABAA receptorsQ34550994
Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrusQ34664222
A conformational switch in collybistin determines the differentiation of inhibitory postsynapsesQ27684897
Glutamate and GABA imbalance following traumatic brain injuryQ28081232
In vivo assessment of neurotransmitters and modulators with magnetic resonance spectroscopy: application to schizophreniaQ28083121
Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibitQ28119157
Adjacent phosphorylation sites on GABAA receptor beta subunits determine regulation by cAMP-dependent protein kinaseQ28140825
Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament systemQ28206200
Interaction of calcineurin and type-A GABA receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapsesQ28208051
A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunitsQ28210677
GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1Q28214808
Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsyQ28216597
GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillationsQ28252805
Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistinQ28258590
The state of the actin cytoskeleton determines its association with gephyrin: role of ena/VASP family membersQ28288690
GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptorsQ28305869
Short-term exposure to a neuroactive steroid increases alpha4 GABA(A) receptor subunit levels in association with increased anxiety in the female ratQ28345578
Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptorsQ28367959
Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunitsQ28504846
Neuroligins determine synapse maturation and functionQ28505855
Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient miceQ28509344
The specific α-neurexin interactor calsyntenin-3 promotes excitatory and inhibitory synapse developmentQ28511444
Palmitoylation of gephyrin controls receptor clustering and plasticity of GABAergic synapsesQ28540745
Cyclin-dependent kinase 5 is involved in the phosphorylation of gephyrin and clustering of GABAA receptors at inhibitory synapses of hippocampal neuronsQ28541617
The cell adhesion molecule neuroplastin-65 is a novel interaction partner of γ-aminobutyric acid type A receptorsQ28564302
Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.Q28565331
Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+Q28566203
Activated radixin is essential for GABAA receptor alpha5 subunit anchoring at the actin cytoskeletonQ28568588
NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptorsQ28569362
Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neuronsQ28572963
Molecular basis of the γ-aminobutyric acid A receptor α3 subunit interaction with the clustering protein gephyrinQ28574183
Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP.Q28574897
Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmissionQ28575080
GABAA receptor-associated phosphoinositide 3-kinase is required for insulin-induced recruitment of postsynaptic GABAA receptorsQ28576036
The brefeldin A-inhibited GDP/GTP exchange factor 2, a protein involved in vesicular trafficking, interacts with the beta subunits of the GABA receptorsQ28577263
Ring finger protein 34 (RNF34) interacts with and promotes γ-aminobutyric acid type-A receptor degradation via ubiquitination of the γ2 subunitQ28578977
Insulin exerts neuroprotection by counteracting the decrease in cell-surface GABA receptors following oxygen-glucose deprivation in cultured cortical neuronsQ45192492
Regulation of gephyrin and GABAA receptor binding within the amygdala after fear acquisition and extinction.Q45221827
Block of gamma-aminobutyric acid-A receptor insertion in the amygdala impairs extinction of conditioned fear.Q45989556
The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus.Q46039131
Changes in expression and function of extrasynaptic GABAA receptors in the rat hippocampus during pregnancy and after deliveryQ46124586
Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus.Q46667850
Neurosteroid synthesis-mediated regulation of GABA(A) receptors: relevance to the ovarian cycle and stress.Q46762900
The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin.Q46767741
Gephyrin regulates the cell surface dynamics of synaptic GABAA receptors.Q46798855
GABARAP is not essential for GABA receptor targeting to the synapseQ46819867
Presynaptic terminals independently regulate synaptic clustering and autophagy of GABAA receptors in Caenorhabditis elegans.Q46935379
A GABA(A) receptor of defined subunit composition and positioning: concatenation of five subunits.Q46957801
Sequential postsynaptic maturation governs the temporal order of GABAergic and glutamatergic synaptogenesis in rat embryonic cultures.Q46968753
Endogenous and synthetic neuroactive steroids evoke sustained increases in the efficacy of GABAergic inhibition via a protein kinase C-dependent mechanism.Q47369108
Is plasma GABA level a biomarker of Post-Traumatic Stress Disorder (PTSD) severity? A preliminary studyQ47428286
Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairmentsQ47723867
Benzodiazepine-dependent stabilization of GABA(A) receptors at synapses.Q47779632
Women with PTSD have a changed sensitivity to GABA-A receptor active substancesQ47795585
Pro-brain-derived neurotrophic factor inhibits GABAergic neurotransmission by activating endocytosis and repression of GABAA receptorsQ47805851
Neuropeptide Y neuronal network dysfunction in the frontal lobe of a genetic mouse model of schizophreniaQ47832225
Benzodiazepine ligands rapidly influence GABAA receptor diffusion and clustering at hippocampal inhibitory synapsesQ47857610
Immunohistochemical evaluation of the GABAergic neuronal system in the prefrontal cortex of a DISC1 knockout mouse model of schizophreniaQ47912489
Quantitative nanoscopy of inhibitory synapses: counting gephyrin molecules and receptor binding sitesQ47927535
Effects of whisker trimming on GABA(A) receptor binding in the barrel cortex of developing and adult ratsQ48036138
Brain-derived neurotrophic factor modulates fast synaptic inhibition by regulating GABA(A) receptor phosphorylation, activity, and cell-surface stability.Q48094170
A local reduction in cortical GABAergic synapses after a loss of endogenous brain-derived neurotrophic factor, as revealed by single-cell gene knock-out method.Q48115791
Sustained structural change of GABA(A) receptor-associated protein underlies long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron.Q48130763
The gamma 2 subunit of GABA(A) receptors is required for maintenance of receptors at mature synapses.Q48165507
Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.Q48194302
Differential role of GABAA receptors and neuroligin 2 for perisomatic GABAergic synapse formation in the hippocampus.Q48227767
Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrinQ48240102
Molecular reconstitution of functional GABAergic synapses with expression of neuroligin-2 and GABAA receptorsQ48254259
Molecular motor KIF5A is essential for GABA(A) receptor transport, and KIF5A deletion causes epilepsyQ48264353
GARLH Family Proteins Stabilize GABAA Receptors at SynapsesQ48270838
Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface.Q48272441
New neurons in the vestibular nuclei complex after unilateral vestibular neurectomy in the adult cat.Q48301920
Kindling alters neurosteroid-induced modulation of phasic and tonic GABAA receptor-mediated currents: role of phosphorylationQ48303119
Neuronal Dystroglycan Is Necessary for Formation and Maintenance of Functional CCK-Positive Basket Cell Terminals on Pyramidal Cells.Q48318901
A comprehensive small interfering RNA screen identifies signaling pathways required for gephyrin clustering.Q48331210
Increased number of synaptic GABA(A) receptors underlies potentiation at hippocampal inhibitory synapses.Q48392164
Pro-Brain-Derived Neurotrophic Factor (proBDNF)-Mediated p75NTR Activation Promotes Depolarizing Actions of GABA and Increases Susceptibility to Epileptic SeizuresQ48408039
Dissociation of Golgi-associated DHHC-type Zinc Finger Protein (GODZ)- and Sertoli Cell Gene with a Zinc Finger Domain-β (SERZ-β)-mediated Palmitoylation by Loss of Function Analyses in Knock-out MiceQ48420512
Potentiation of cortical inhibition by visual deprivation.Q48438986
Brefeldin A-inhibited guanine nucleotide exchange protein 3 is localized in lysosomes and regulates GABA signaling in hippocampal neurons.Q48454249
delta-Subunit containing GABAA receptor knockout mice are less sensitive to the actions of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-ol.Q48495840
Activity-dependent ubiquitination of GABA(A) receptors regulates their accumulation at synaptic sites.Q48542489
The kinesin KIF21B participates in the cell surface delivery of γ2 subunit-containing GABAA receptors.Q48574706
Stabilization of GABA(A) receptors at endocytic zones is mediated by an AP2 binding motif within the GABA(A) receptor β3 subunit.Q48625801
Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder.Q48667447
Homomeric beta 1 gamma-aminobutyric acid A receptor-ion channels: evaluation of pharmacological and physiological properties.Q49018817
Distinct regulation of beta2 and beta3 subunit-containing cerebellar synaptic GABAA receptors by calcium/calmodulin-dependent protein kinase II.Q49046219
Calsyntenin-3 molecular architecture and interaction with neurexin 1α.Q34683137
Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in miceQ34713732
Effects of antidepressant treatment on neuroactive steroids in major depressionQ34749115
Multiple roles of protein kinases in the modulation of gamma-aminobutyric acid(A) receptor function and cell surface expression.Q34792806
Rapid brain-derived neurotrophic factor-dependent sequestration of amygdala and hippocampal GABA(A) receptors via different tyrosine receptor kinase B-mediated phosphorylation pathwaysQ34797692
Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylationQ34926002
Cation-chloride cotransporters in neuronal development, plasticity and diseaseQ34959293
GABAA receptor trafficking-mediated plasticity of inhibitory synapsesQ34979365
Activity-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics.Q34986638
Revisiting the TRAK family of proteins as mediators of GABAA receptor traffickingQ35016493
Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors.Q35037894
The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunitsQ35058291
The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segmentQ35085163
Early depolarizing GABA controls critical-period plasticity in the rat visual cortexQ35114245
Activity blockade and GABAA receptor blockade produce synaptic scaling through chloride accumulation in embryonic spinal motoneurons and interneuronsQ35147839
Inhibitory synapse formation in a co-culture model incorporating GABAergic medium spiny neurons and HEK293 cells stably expressing GABAA receptors.Q35160645
Is plasticity of GABAergic mechanisms relevant to epileptogenesis?Q35207594
Memory deficits induced by inflammation are regulated by α5-subunit-containing GABAA receptors.Q35343518
Tyrosine phosphorylation of GABAA receptor γ2-subunit regulates tonic and phasic inhibition in the thalamus.Q35450484
Protein kinase C-dependent growth-associated protein 43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapsesQ35516501
Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory.Q35543244
Neuronal gamma-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA.Q35617513
Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic DiseasesQ35745930
Presynaptic LTP and LTD of excitatory and inhibitory synapsesQ35762827
Reversal of neurosteroid effects at alpha4beta2delta GABAA receptors triggers anxiety at pubertyQ35765765
GABA system dysfunction in autism and related disorders: from synapse to symptomsQ35770888
Dihydromyricetin as a novel anti-alcohol intoxication medication.Q35797477
Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophreniaQ35804056
Interneuron- and GABA(A) receptor-specific inhibitory synaptic plasticity in cerebellar Purkinje cellsQ35898450
Whisker Deprivation Drives Two Phases of Inhibitory Synapse Weakening in Layer 4 of Rat Somatosensory CortexQ35913504
Sex differences in GABAergic gene expression occur in the anterior cingulate cortex in schizophrenia.Q35915861
Clustered dynamics of inhibitory synapses and dendritic spines in the adult neocortex.Q35923505
The GABAA receptor alpha1 subunit epilepsy mutation A322D inhibits transmembrane helix formation and causes proteasomal degradationQ35928809
Activity-dependent mismatch between axo-axonic synapses and the axon initial segment controls neuronal outputQ35946134
Downregulation of GABAA Receptor Recycling Mediated by HAP1 Contributes to Neuronal Death in In Vitro Brain Ischemia.Q49048584
Changes in GABA(A) receptor subunit expression in the midbrain during the oestrous cycle in Wistar rats.Q49053852
Reduced GABAergic Action in the Autistic Brain.Q49089611
Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms.Q49100043
The developmental switch in GABA polarity is delayed in fragile X mice.Q50344880
Neurofascin regulates the formation of gephyrin clusters and their subsequent translocation to the axon hillock of hippocampal neurons.Q50670682
Sensitization of gamma-aminobutyric acidA receptors to neuroactive steroids in rats during ethanol withdrawal.Q51565987
Mechanisms underlying LTP of inhibitory synaptic transmission in the deep cerebellar nuclei.Q52165393
Calcineurin-mediated LTD of GABAergic inhibition underlies the increased excitability of CA1 neurons associated with LTP.Q52168558
C. elegans Punctin Clusters GABA(A) Receptors via Neuroligin Binding and UNC-40/DCC Recruitment.Q52660530
DISC1 is a coordinator of intracellular trafficking to shape neuronal development and connectivity.Q52671081
Amyloid-β Impairs Synaptic Inhibition via GABA(A) Receptor Endocytosis.Q53477415
GABAA receptor subunit composition and competition at synapses are tuned by GABAB receptor activity.Q54358799
Association of GRIP1 with a GABAA receptor associated protein suggests a role for GRIP1 at inhibitory synapsesQ57359606
GABAA receptor dephosphorylation followed by internalization is coupled to neuronal death in in vitro ischemiaQ57652534
Neonatal sensory deprivation induces selective changes in the quantitative distribution of GABA-immunoreactive neurons in the rat barrel field cortexQ59457890
Postsynaptic mechanisms underlying long-term depression of GABAergic transmission in neurons of the deep cerebellar nucleiQ71604324
Alpha-subunit of calcium/calmodulin-dependent protein kinase II enhances gamma-aminobutyric acid and inhibitory synaptic responses of rat neurons in vitroQ71923823
Assembly of GABAA receptor subunits: alpha 1 beta 1 and alpha 1 beta 1 gamma 2S subunits produce unique ion channels with dissimilar single-channel propertiesQ72075616
Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neuronsQ73119677
Persistent activation of GABA(A) receptor/Cl(-) channels by astrocyte-derived GABA in cultured embryonic rat hippocampal neuronsQ74296363
GABAA receptor subunit gamma2 and delta subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblastsQ77610176
Spectrin- and ankyrin-based membrane domains and the evolution of vertebratesQ86692165
The role of neurexins and neuroligins in the formation, maturation, and function of vertebrate synapsesQ37994376
The GABA excitatory/inhibitory shift in brain maturation and neurological disordersQ38006669
Functional role of ambient GABA in refining neuronal circuits early in postnatal developmentQ38130493
GABA receptors in brain development, function, and injuryQ38211328
Shaping inhibition: activity dependent structural plasticity of GABAergic synapses.Q38266876
Regulation of GABAARs by phosphorylationQ38323692
Molecules interacting with PRIP-2, a novel Ins(1,4,5)P3 binding protein type 2: Comparison with PRIP-1.Q38360108
De novo synaptogenesis induced by GABA in the developing mouse cortexQ38436532
Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomesQ38630111
L-type Calcium Channel Blockers Enhance Trafficking and Function of Epilepsy-associated α1(D219N) Subunits of GABA(A) Receptors.Q38853747
Neuronal nitric oxide synthase-dependent S-nitrosylation of gephyrin regulates gephyrin clustering at GABAergic synapses.Q38988084
Nanoscale Molecular Reorganization of the Inhibitory Postsynaptic Density Is a Determinant of GABAergic Synaptic PotentiationQ39028297
GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses.Q39116467
Proteomic Analysis of Unbounded Cellular Compartments: Synaptic CleftsQ39348340
BDNF Signaling Promotes Vestibular Compensation by Increasing Neurogenesis and Remodeling the Expression of Potassium-Chloride Cotransporter KCC2 and GABAA Receptor in the Vestibular NucleiQ39699187
Rapid, learning-induced inhibitory synaptogenesis in murine barrel fieldQ39731444
Conserved site for neurosteroid modulation of GABA A receptorsQ39944832
Mechanisms involved in the reduction of GABAA receptor alpha1-subunit expression caused by the epilepsy mutation A322D in the trafficking-competent receptorQ39974702
Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors.Q39990495
The Timing of the Excitatory-to-Inhibitory GABA Switch Is Regulated by the Oxytocin Receptor via KCC2Q40002215
Molecular basis of gephyrin clustering at inhibitory synapses: role of G- and E-domain interactions.Q40191650
Direct interaction of N-ethylmaleimide-sensitive factor with GABA(A) receptor beta subunitsQ40386213
PKC modulation of GABAA receptor endocytosis and function is inhibited by mutation of a dileucine motif within the receptor beta 2 subunit.Q40461441
Neurosteroids shift partial agonist activation of GABA(A) receptor channels from low- to high-efficacy gating patterns.Q40611808
Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit.Q40746562
Clathrin-independent endocytosis of GABA(A) receptors in HEK 293 cellsQ40769159
Neuroligin 2 deletion alters inhibitory synapse function and anxiety-associated neuronal activation in the amygdalaQ40769352
Constitutive tyrosine phosphorylation of the GABA(A) receptor gamma 2 subunit in rat brain.Q40773804
State-dependent bidirectional modification of somatic inhibition in neocortical pyramidal cellsQ40871862
Assembly, trafficking and function of α1β2γ2 GABAA receptors are regulated by N-terminal regions, in a subunit-specific manner.Q40897947
Pharmacological and physiological characterization of murine homomeric beta3 GABA(A) receptorsQ41065249
Recruitment of functional GABA(A) receptors to postsynaptic domains by insulinQ41094368
GABA-independent GABAA receptor openings maintain tonic currents.Q41457577
Oxytocin modulates GABAAR subunits to confer neuroprotection in stroke in vitroQ41524085
Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neuronesQ41628434
Corrigendum: Genetic Variants Identified from Epilepsy of Unknown Etiology in Chinese Children by Targeted Exome SequencingQ41788596
Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activityQ41809864
Splice-specific glycine receptor binding, folding, and phosphorylation of the scaffolding protein gephyrinQ41831840
TrkB receptor signaling is required for establishment of GABAergic synapses in the cerebellumQ41874895
Intracellular chloride concentration influences the GABAA receptor subunit compositionQ41983696
Bidirectional Control of Synaptic GABAAR Clustering by Glutamate and CalciumQ42028417
Identification of an elaborate complex mediating postsynaptic inhibitionQ42046503
Ubiquitin-proteasome dependent degradation of GABAAα1 in autism spectrum disorderQ42281034
GABAergic Synapses at the Axon Initial Segment of Basolateral Amygdala Projection Neurons Modulate Fear ExtinctionQ42290890
Phosphorylation of gephyrin in hippocampal neurons by cyclin-dependent kinase CDK5 at Ser-270 is dependent on collybistinQ42324526
Neuroligin 2 controls the maturation of GABAergic synapses and information processing in the retinaQ42455989
Brain-derived neurotrophic factor (BDNF)-induced synthesis of early growth response factor 3 (Egr3) controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neuronsQ42499572
GIT1 and βPIX are essential for GABA(A) receptor synaptic stability and inhibitory neurotransmission.Q42531323
Novel α1 and γ2 GABAA receptor subunit mutations in families with idiopathic generalized epilepsy.Q42607120
MADD-4/Punctin and Neurexin Organize C. elegans GABAergic Postsynapses through NeuroliginQ42644634
Activity deprivation reduces miniature IPSC amplitude by decreasing the number of postsynaptic GABA(A) receptors clustered at neocortical synapses.Q42670226
Direct binding of GABAA receptor β2 and β3 subunits to gephyrin.Q42679282
Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons.Q42691157
GABAA receptor-associated protein traffics GABAA receptors to the plasma membrane in neuronsQ28581327
Structure of excitatory synapses and GABAA receptor localization at inhibitory synapses are regulated by neuroplastin-65Q28585420
The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradationQ28591685
The residence time of GABA(A)Rs at inhibitory synapses is determined by direct binding of the receptor α1 subunit to gephyrinQ28593470
Trace fear conditioning involves hippocampal alpha5 GABA(A) receptorsQ28594296
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypesQ29616326
Kinesin transports RNA: isolation and characterization of an RNA-transporting granuleQ29618417
Complex role of collybistin and gephyrin in GABAA receptor clusteringQ30156108
Neurosteroid-sensitive δ-GABAA receptors: A role in epileptogenesis?Q30252495
Phosphatase inhibition prevents the activity-dependent trafficking of GABAA receptors during status epilepticus in the young animal.Q30278891
Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1.Q30374041
Biological studies of post-traumatic stress disorder.Q30378702
Subunit-specific trafficking of GABA(A) receptors during status epilepticusQ30435939
Diminished neurosteroid sensitivity of synaptic inhibition and altered location of the alpha4 subunit of GABA(A) receptors in an animal model of epilepsyQ30436043
Status epilepticus increases the intracellular accumulation of GABAA receptorsQ30436046
The GABAergic deficit hypothesis of major depressive disorder.Q30464954
Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism.Q30474084
Target cell-specific modulation of neuronal activity by astrocytes.Q30477598
Short-term steroid treatment increases delta GABAA receptor subunit expression in rat CA1 hippocampus: pharmacological and behavioral effectsQ30481043
GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapsesQ30481850
NMDA receptors regulate GABAA receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the γ2 subunitQ30496715
Selective translocation of Ca2+/calmodulin protein kinase IIalpha (CaMKIIalpha) to inhibitory synapses.Q30497563
Recombinant probes for visualizing endogenous synaptic proteins in living neuronsQ30545902
Plasticity of GABAA receptor diffusion dynamics at the axon initial segmentQ30580414
Pin1-dependent signalling negatively affects GABAergic transmission by modulating neuroligin2/gephyrin interactionQ30592691
Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain inductionQ30596884
Synaptic and nonsynaptic localization of GABAA receptors containing the alpha5 subunit in the rat brainQ30826932
Endosomal Phosphatidylinositol 3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory PostsynapsesQ30836646
An E3-ligase-based method for ablating inhibitory synapsesQ30838882
Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defectsQ30845425
Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic antidepressantsQ30887852
A four PDZ domain-containing splice variant form of GRIP1 is localized in GABAergic and glutamatergic synapses in the brainQ31085577
Structural determinants of fast desensitization and desensitization-deactivation coupling in GABAa receptors.Q31839971
Dystroglycan mediates homeostatic synaptic plasticity at GABAergic synapsesQ33606977
Techniques: Use of concatenated subunits for the study of ligand-gated ion channels.Q35960346
Postsynaptic scaffold proteins at non-synaptic sites. The role of postsynaptic scaffold proteins in motor-protein-receptor complexesQ36005852
Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient miceQ36013388
Surface trafficking of receptors between synaptic and extrasynaptic membranes: and yet they do move!Q36062613
Regulation of AMPA receptor trafficking and synaptic plasticity.Q36083970
Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic currentQ36090268
Steroid hormone fluctuations and GABA(A)R plasticity.Q36101683
γ-Aminobutyric acid type A (GABAA) receptor α subunits play a direct role in synaptic versus extrasynaptic targetingQ36201800
DISC1 Protein Regulates γ-Aminobutyric Acid, Type A (GABAA) Receptor Trafficking and Inhibitory Synaptic Transmission in Cortical Neurons.Q36282891
Brefeldin A-inhibited guanine exchange factor 2 regulates filamin A phosphorylation and neuronal migration.Q36340949
Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disordersQ36354827
Benzodiazepine treatment induces subtype-specific changes in GABA(A) receptor trafficking and decreases synaptic inhibitionQ36389492
Adult neurogenesis and functional plasticity in neuronal circuitsQ36404122
Flumazenil decreases surface expression of α4β2δ GABAA receptors by increasing the rate of receptor internalizationQ36418506
Regulation of Extrasynaptic GABAA α4 Receptors by Ethanol-Induced Protein Kinase A, but Not Protein Kinase C Activation in Cultured Rat Cerebral Cortical NeuronsQ36432290
alpha1beta2delta, a silent GABAA receptor: recruitment by tracazolate and neurosteroidsQ36495131
Glutamatergic axon-derived BDNF controls GABAergic synaptic differentiation in the cerebellumQ36527261
Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice.Q36562979
RNA binding proteins accumulate at the postsynaptic density with synaptic activityQ36580790
The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZQ36631283
Enrichment of GABAA Receptor α-Subunits on the Axonal Initial Segment Shows Regional DifferencesQ36632594
Postnatal growth and morphological development of the brain: a species comparisonQ36635203
A Comprehensive Optogenetic Pharmacology Toolkit for In Vivo Control of GABA(A) Receptors and Synaptic InhibitionQ36642249
Structure, pharmacology, and function of GABAA receptor subtypes.Q36686927
Altered chloride homeostasis in neurological disorders: a new targetQ36689467
Ca(2+)-induced rebound potentiation of gamma-aminobutyric acid-mediated currents requires activation of Ca2+/calmodulin-dependent kinase II.Q36694575
Ethanol promotes clathrin adaptor-mediated endocytosis via the intracellular domain of δ-containing GABAA receptorsQ36697376
Ethanol Regulation of Synaptic GABAA α4 Receptors Is Prevented by Protein Kinase A ActivationQ36733514
The ubiquitin-like protein Plic-1 enhances the membrane insertion of GABAA receptors by increasing their stability within the endoplasmic reticulumQ36739604
Insulin-Independent GABAA Receptor-Mediated Response in the Barrel Cortex of Mice with Impaired Met ActivityQ36740958
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanismQ36742170
The cellular, molecular and ionic basis of GABA(A) receptor signallingQ36820573
Grp94 Protein Delivers γ-Aminobutyric Acid Type A (GABAA) Receptors to Hrd1 Protein-mediated Endoplasmic Reticulum-associated Degradation.Q36850007
Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABAA receptorsQ33627122
GABA levels are decreased after stroke and GABA changes during rehabilitation correlate with motor improvementQ33698708
Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptorsQ33717631
Positive feedback regulation between gamma-aminobutyric acid type A (GABA(A)) receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neuronsQ42772124
Distinct FGFs promote differentiation of excitatory and inhibitory synapsesQ42805622
Three epilepsy-associated GABRG2 missense mutations at the γ+/β- interface disrupt GABAA receptor assembly and trafficking by similar mechanisms but to different extents.Q42906676
BDNF selectively regulates GABAA receptor transcription by activation of the JAK/STAT pathwayQ43169237
Regulation of inhibitory synaptic transmission by a conserved atypical interaction of GABA(A) receptor beta- and gamma-subunits with the clathrin AP2 adaptorQ43185150
BDNF reduces miniature inhibitory postsynaptic currents by rapid downregulation of GABA(A) receptor surface expressionQ43572473
Gephyrin-independent clustering of postsynaptic GABA(A) receptor subtypesQ43646274
Intact sorting, targeting, and clustering of gamma-aminobutyric acid A receptor subtypes in hippocampal neurons in vitroQ43856121
Direct in vivo measurement of human cerebral GABA concentration using MEGA-editing at 7 TeslaQ43973300
Dystroglycan is selectively associated with inhibitory GABAergic synapses but is dispensable for their differentiation.Q44012202
Control of synaptic strength, a novel function of Akt.Q44485250
TNF-α downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptorsQ44734604
GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein.Q45015208
P433issue3
P1104number of pages33
P304page(s)238-270
P577publication date2017-09-19
P1433published inDevelopmental NeurobiologyQ15716734
P1476titleGABA type a receptor trafficking and the architecture of synaptic inhibition
P478volume78

Reverse relations

cites work (P2860)
Q91957909Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice
Q49907280Introduction to the special issue on membrane trafficking in neurons.
Q91811743LMAN1 (ERGIC-53) promotes trafficking of neuroreceptors
Q88727192Rapid non-classical effects of steroids on the membrane receptor dynamics and downstream signaling in neurons
Q91781302Targeting GABAAR-Associated Proteins: New Modulators, Labels and Concepts
Q88599123The Cerebellar GABAAR System as a Potential Target for Treating Alcohol Use Disorder
Q94510071Visualizing GABA A Receptor Trafficking Dynamics with Fluorogenic Protein Labeling
Q58712240γ2 GABAR Trafficking and the Consequences of Human Genetic Variation

Search more.