Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP.

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Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP. is …
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scholarly articleQ13442814

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P819ADS bibcode2014NatCo...5.3921P
P6179Dimensions Publication ID1052156392
P356DOI10.1038/NCOMMS4921
P932PMC publication ID4059940
P698PubMed publication ID24894704
P5875ResearchGate publication ID262845293

P50authorMatthias KneusselQ15430041
Umberto OlceseQ29997882
P2093author name stringJean-Baptiste Sibarita
Stephen J Moss
Victor Racine
Fabio Benfenati
Paolo Medini
Tija C Jacob
Torben J Hausrat
Andrea Barberis
Giuliano Iurilli
Enrica Maria Petrini
Tiziana Ravasenga
P2860cites workCalcineurin-mediated LTD of GABAergic inhibition underlies the increased excitability of CA1 neurons associated with LTP.Q52168558
Differential phosphorylation of intracellular domains of gamma-aminobutyric acid type A receptor subunits by calcium/calmodulin type 2-dependent protein kinase and cGMP-dependent protein kinase.Q54630466
Non-NMDA glutamate receptor occupancy and open probability at a rat cerebellar synapse with single and multiple release sitesQ57985782
Three Ca2+ levels affect plasticity differently: the LTP zone, the LTD zone and no man's landQ73764935
Conserved phosphorylation of the intracellular domains of GABA(A) receptor beta2 and beta3 subunits by cAMP-dependent protein kinase, cGMP-dependent protein kinase protein kinase C and Ca2+/calmodulin type II-dependent protein kinaseQ74019649
Multiple association states between glycine receptors and gephyrin identified by SPT analysisQ24682417
Neuronal cotransport of glycine receptor and the scaffold protein gephyrinQ24683956
Diversity and dynamics of dendritic signalingQ28142303
GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillationsQ28252805
Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistinQ28258590
Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient miceQ28509344
NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptorsQ28569362
CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazinQ28583959
The residence time of GABA(A)Rs at inhibitory synapses is determined by direct binding of the receptor α1 subunit to gephyrinQ28593470
Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operationsQ29620030
Complex role of collybistin and gephyrin in GABAA receptor clusteringQ30156108
Delayed plasticity of inhibitory neurons in developing visual cortexQ30484359
Synaptic activation modifies microtubules underlying transport of postsynaptic cargoQ30487600
NMDA receptors regulate GABAA receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the γ2 subunitQ30496715
Selective translocation of Ca2+/calmodulin protein kinase IIalpha (CaMKIIalpha) to inhibitory synapses.Q30497563
Endocytic trafficking and recycling maintain a pool of mobile surface AMPA receptors required for synaptic potentiationQ33761839
Critical period for inhibitory plasticity in rodent binocular V1Q33765420
Detection of spontaneous synaptic events with an optimally scaled templateQ33907017
Gephyrin is critical for glycine receptor clustering but not for the formation of functional GABAergic synapses in hippocampal neurons.Q34289045
Diffusion barriers constrain receptors at synapsesQ34389190
Regulation of GABAergic synapse formation and plasticity by GSK3beta-dependent phosphorylation of gephyrin.Q34472152
Pyramidal neurons: dendritic structure and synaptic integrationQ34588296
Activity-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics.Q34986638
Modulation of GABAA receptor activity by phosphorylation and receptor trafficking: implications for the efficacy of synaptic inhibitionQ35172815
The dynamic modulation of GABA(A) receptor trafficking and its role in regulating the plasticity of inhibitory synapsesQ35244210
Dynamic impact of temporal context of Ca²⁺ signals on inhibitory synaptic plasticityQ35551636
Gephyrin-independent GABA(A)R mobility and clustering during plasticity.Q35918121
Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient miceQ36013388
Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic currentQ36090268
Ca(2+)-induced rebound potentiation of gamma-aminobutyric acid-mediated currents requires activation of Ca2+/calmodulin-dependent kinase II.Q36694575
Role of activity-dependent regulation of neuronal chloride homeostasis in developmentQ36711847
Regulatory mechanisms of AMPA receptors in synaptic plasticityQ36712947
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanismQ36742170
GABA regulates excitatory synapse formation in the neocortex via NMDA receptor activationQ37198498
GABA(A) receptor membrane trafficking regulates spine maturityQ37282369
CaMKII phosphorylation of the GABA(A) receptor: receptor subtype- and synapse-specific modulationQ37427074
Long-term plasticity at inhibitory synapsesQ37844877
Impact of synaptic neurotransmitter concentration time course on the kinetics and pharmacological modulation of inhibitory synaptic currents.Q37898524
The dynamic synapse.Q38158719
Direct imaging of lateral movements of AMPA receptors inside synapsesQ39958761
State-dependent bidirectional modification of somatic inhibition in neocortical pyramidal cellsQ40871862
Splice-specific glycine receptor binding, folding, and phosphorylation of the scaffolding protein gephyrinQ41831840
Phosphorylation of gephyrin in hippocampal neurons by cyclin-dependent kinase CDK5 at Ser-270 is dependent on collybistinQ42324526
Surface mobility of postsynaptic AMPARs tunes synaptic transmissionQ42581248
Shared calcium signaling pathways in the induction of long-term potentiation and synaptic disinhibition in CA1 pyramidal cell dendritesQ42635074
Direct binding of GABAA receptor β2 and β3 subunits to gephyrin.Q42679282
Gephyrin-independent clustering of postsynaptic GABA(A) receptor subtypesQ43646274
Retrograde activation of presynaptic NMDA receptors enhances GABA release at cerebellar interneuron-Purkinje cell synapsesQ44851674
Regulation of gephyrin and GABAA receptor binding within the amygdala after fear acquisition and extinction.Q45221827
Wavelet analysis for single molecule localization microscopyQ45814205
Regulation of F-actin stability in dendritic spines by glutamate receptors and calcineurin.Q46290655
Homeostatic regulation of synaptic GlyR numbers driven by lateral diffusion.Q46455075
Early expression of KCC2 in rat hippocampal cultures augments expression of functional GABA synapsesQ46551398
The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin.Q46767741
Gephyrin regulates the cell surface dynamics of synaptic GABAA receptors.Q46798855
Identification of the sites for CaMK-II-dependent phosphorylation of GABA(A) receptors.Q48198075
Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrinQ48240102
NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampusQ48327089
A comprehensive small interfering RNA screen identifies signaling pathways required for gephyrin clustering.Q48331210
Increased number of synaptic GABA(A) receptors underlies potentiation at hippocampal inhibitory synapses.Q48392164
Potentiation of cortical inhibition by visual deprivation.Q48438986
Kinase-dead knock-in mouse reveals an essential role of kinase activity of Ca2+/calmodulin-dependent protein kinase IIalpha in dendritic spine enlargement, long-term potentiation, and learning.Q48577304
Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells.Q48958606
P275copyright licenseCreative Commons Attribution-NonCommercial-ShareAlike 3.0 UnportedQ15643954
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectGephyrinQ21496399
P304page(s)3921
P577publication date2014-06-04
P1433published inNature CommunicationsQ573880
P1476titleSynaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP.
P478volume5

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