The space where aging acts: focus on the GABAergic synapse

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The space where aging acts: focus on the GABAergic synapse is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/ACEL.12605
P932PMC publication ID5506442
P698PubMed publication ID28497576

P50authorMonika Liguz-LecznarQ79748991
Aleksandra RóżyckaQ95970491
P2860cites workGABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeletonQ22008682
Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortexQ24620160
Somatostatin and Somatostatin-Containing Neurons in Shaping Neuronal Activity and PlasticityQ26738420
Altered cortical GABA neurotransmission in schizophrenia: insights into novel therapeutic strategiesQ26827100
Molecular aspects of age-related cognitive decline: the role of GABA signalingQ27021454
Interneuron Progenitor Transplantation to Treat CNS DysfunctionQ28077603
Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibitionQ43703062
The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance.Q43787738
Activity- and age-dependent GABAergic synaptic plasticity in the developing rat hippocampusQ43892617
Signaling cascade regulating long-term potentiation of GABA(A) receptor responsiveness in cerebellar Purkinje neurons.Q43999159
Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar corticesQ44174105
Differential balance of prefrontal synaptic activity in successful versus unsuccessful cognitive agingQ44195349
Rat hippocampal GABAergic molecular markers are differentially affected by ageingQ44390564
GABA and Its Agonists Improved Visual Cortical Function in Senescent MonkeysQ44429563
A disinhibitory microcircuit for associative fear learning in the auditory cortex.Q44450801
GABAB receptor- and metabotropic glutamate receptor-dependent cooperative long-term potentiation of rat hippocampal GABAA synaptic transmissionQ44578379
Normal aging results in decreased synaptic excitation and increased synaptic inhibition of layer 2/3 pyramidal cells in the monkey prefrontal cortexQ44819762
Different forms of homeostatic plasticity are engaged with distinct temporal profilesQ44984996
Stereological quantification of GAD-67-immunoreactive neurons and boutons in the hippocampus of middle-aged and old Fischer 344 x Brown Norway ratsQ45059701
Differential GABAA receptor clustering determines GABA synapse plasticity in rat oxytocin neurons around parturition and the onset of lactation.Q45193527
Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brainsQ45251046
Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice.Q45304186
Aging-related decline in somatosensory inhibition of the human cerebral cortex.Q45341219
Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.Q46022290
Variations in excitatory and inhibitory postsynaptic protein content in rat cerebral cortex with respect to aging and cognitive statusQ46184800
Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors.Q46287550
Age-related changes in GAD levels in the central auditory system of the rat.Q46310702
GABAB receptor antagonist SGS742 improves spatial memory and reduces protein binding to the cAMP response element (CRE) in the hippocampusQ46460575
Age-related decline of functional inhibition in rat cortexQ46590119
Modification upon aging of the density of presynaptic modulation systems in the hippocampus.Q46730188
Changes in parvalbumin immunoreactivity with aging in the central auditory system of the rat.Q50451776
Altered glutamate/GABA equilibrium in aged mice cortex influences cortical plasticity.Q50675562
Sex-differences in age-related cognitive decline in C57BL/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivity.Q51829444
Metaplasticity: tuning synapses and networks for plasticity.Q51959982
Age-related decrease in GABAB receptor binding in the Fischer 344 rat inferior colliculusQ72634127
GABAB binding sites in early adult and aging rat brainQ72634131
GABAA and alpha-amino-3-hydroxy-5-methylsoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampusQ73634577
Therapeutic potential of GABA(B) receptor ligands in drug addiction, anxiety, depression and other CNS disorders.Q38122963
Environment and brain plasticity: towards an endogenous pharmacotherapyQ38175136
Structure, function, and plasticity of GABA transportersQ38225534
GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer's diseaseQ38225536
Neuroligins, synapse balance and neuropsychiatric disordersQ38242474
GABAA receptor subunit expression changes in the rat cerebellum and cerebral cortex during agingQ38347345
Neuronal epigenetics and the aging synapseQ38527773
Age-related gene expression change of GABAergic system in visual cortex of rhesus macaqueQ39178540
The GABAergic septohippocampal connection is impaired in a mouse model of tauopathy.Q39288881
Rapid, learning-induced inhibitory synaptogenesis in murine barrel fieldQ39731444
Sensory learning differentially affects GABAergic tonic currents in excitatory neurons and fast spiking interneurons in layer 4 of mouse barrel cortex.Q39938998
Effects of aging on paired-pulse behavior of rat somatosensory cortical neuronsQ39973316
Central auditory aging: GABA changes in the inferior colliculusQ40412618
Subunit-selective modulation of GABA type A receptor neurotransmission and cognition in schizophreniaQ40748688
Developmental changes in GABAergic mechanisms in human visual cortex across the lifespanQ41529865
Age-related changes in calbindin-D28k, calretinin, and parvalbumin-immunoreactive neurons in the human cerebral cortexQ42443528
Environmental enrichment promotes neurogenesis and changes the extracellular concentrations of glutamate and GABA in the hippocampus of aged ratsQ42496371
GABAB receptor-dependent modulation of network activity in the rat prefrontal cortex in vitroQ43044085
Neurophysiological correlates of age-related changes in working memory capacityQ46742322
A synaptic memory trace for cortical receptive field plasticityQ46773093
Decreased proportion of GABA neurons accompanies age-related degradation of neuronal function in cat striate cortexQ46834093
Cognitive impairment and transmitter-specific pre- and postsynaptic changes in the rat cerebral cortex during ageingQ46844395
Accelerated aging of the GABAergic septohippocampal pathway and decreased hippocampal rhythms in a mouse model of Alzheimer's disease.Q47336718
Aging in the rat hippocampus is associated with widespread reductions in the number of glutamate decarboxylase-67 positive interneurons but not interneuron degenerationQ47927647
Selective degeneration of septal and hippocampal GABAergic neurons in a mouse model of amyloidosis and tauopathyQ48009565
Sensory learning-induced enhancement of inhibitory synaptic transmission in the barrel cortex of the mouseQ48133886
Synaptopathy: dysfunction of synaptic function?Q48268727
Two dynamically distinct inhibitory networks in layer 4 of the neocortexQ48276407
Neocortical, hippocampal and septal parvalbumin- and somatostatin-containing neurons in young and aged rats: correlation with passive avoidance and water maze performanceQ48327931
The vesicular GABA transporter, VGAT, localizes to synaptic vesicles in sets of glycinergic as well as GABAergic neurons.Q48346693
Impairment of experience-dependent cortical plasticity in aged miceQ48381003
Functional degradation of visual cortical cells in aged ratsQ48409223
Multiple forms of synaptic plasticity triggered by selective suppression of activity in individual neurons.Q48435334
Potentiation of cortical inhibition by visual deprivation.Q48438986
Age-related alterations of GABAergic input to CA1 pyramidal neurons and its control by nicotinic acetylcholine receptors in rat hippocampus.Q48454269
GAD67-positive puncta: contributors to learning-dependent plasticity in the barrel cortex of adult mice.Q48476283
Age-correlated decline in [3H]tiagabine binding to GAT-1 in human frontal cortex.Q48486110
Changes in neocortical and hippocampal GABAA receptor subunit distribution during brain maturation and aging.Q48494406
Age-related changes in calbindin and calretinin immunoreactivity in the central auditory system of the rat.Q48537846
Differences in synaptic GABA(A) receptor number underlie variation in GABA mini amplitude.Q48618394
Age-related changes in calbindin D-28k and calretinin immunoreactivity in the inferior colliculus of CBA/CaJ and C57Bl/6 mice.Q48625723
Vision and visual plasticity in ageing mice.Q48652297
Increased excitability of somatosensory cortex in aged humans is associated with impaired tactile acuity.Q48677329
Age-related changes of VIP, NPY and somatostatin-immunoreactive neurons in the cerebral cortex of aged rats.Q48729408
Somatostatin and brain-derived neurotrophic factor mRNA expression in the primate brain: decreased levels of mRNAs during aging.Q48795076
Age-related loss of the GABA synthetic enzyme glutamic acid decarboxylase in rat primary auditory cortex.Q48909353
Aging-related subunit expression changes of the GABAA receptor in the rat hippocampus.Q48932806
Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.Q48960635
Interneurons containing somatostatin are affected by learning-induced cortical plasticity.Q48986707
Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistinQ28258590
Activity-dependent scaling of quantal amplitude in neocortical neuronsQ28264163
Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP.Q28574897
Interneurons of the neocortical inhibitory systemQ29547509
Parvalbumin neurons and gamma rhythms enhance cortical circuit performanceQ29619163
Potential of GABA-ergic cell therapy for schizophrenia, neuropathic pain, and Alzheimer's and Parkinson's diseases.Q30357529
Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain studyQ30366283
Learning-Dependent Plasticity of the Barrel Cortex Is Impaired by Restricting GABA-Ergic TransmissionQ30396492
Trajectory of the main GABAergic interneuron populations from early development to old age in the rat primary auditory cortexQ30436933
Insult-induced adaptive plasticity of the auditory systemQ30437180
Age-related GABAA receptor changes in rat auditory cortexQ30439233
Shaping the aging brain: role of auditory input patterns in the emergence of auditory cortical impairmentsQ30449063
Reduced GABA(A) receptor-mediated tonic inhibition in aged rat auditory thalamus.Q30452018
Pathways from the ventral hippocampus and caudal amygdala to forebrain regions that regulate sensorimotor gating in the rat.Q30477520
Recovery of functional and structural age-related changes in the rat primary auditory cortex with operant trainingQ30479874
Differential effects of excitatory and inhibitory plasticity on synaptically driven neuronal input-output functionsQ30487357
Inhibitory neurotransmission, plasticity and aging in the mammalian central auditory systemQ30491938
Learning-related long-term potentiation of inhibitory synapses in the cerebellar cortexQ30497177
Inhibitory sharpening of receptive fields contributes to whisker map plasticity in rat somatosensory cortexQ30499311
Cortical plasticity induced by transplantation of embryonic somatostatin or parvalbumin interneuronsQ30612200
Evolution of the aging brain transcriptome and synaptic regulationQ33373343
Blockade of GABA(B) receptors completely reverses age-related learning impairment.Q33870626
Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortexQ33886504
A critical role for alpha4betadelta GABAA receptors in shaping learning deficits at puberty in miceQ33919819
Molecular determinants of presynaptic active zonesQ33941567
Neural plasticity in the ageing brainQ33992481
Two genes encode distinct glutamate decarboxylasesQ34023413
International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and functionQ34130831
Subunit composition, distribution and function of GABA(A) receptor subtypesQ34143787
The brain's microenvironment, early functional loss, and the conversion to Alzheimer's diseaseQ34148896
Interneuron dysfunction in psychiatric disordersQ34247716
Therapeutic potential of vasoactive intestinal peptide and its receptors in neurological disorders.Q34259060
Molecular heterogeneity of central synapses: afferent and target regulationQ34259134
Neuropeptides as targets for the development of anticonvulsant drugs.Q34413859
GABAA receptor trafficking-mediated plasticity of inhibitory synapsesQ34979365
Interneuron loss reduces dendritic inhibition and GABA release in hippocampus of aged ratsQ35032466
Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's diseaseQ35079696
Age-related expression of Neurexin1 and Neuroligin3 is correlated with presynaptic density in the cerebral cortex and hippocampus of male miceQ35096358
Genetics and function of neocortical GABAergic interneurons in neurodevelopmental disordersQ35173644
Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging.Q35222558
Age-related changes in the central auditory systemQ35550895
Properties of glutamate receptors of Alzheimer's disease brain transplanted to frog oocytes.Q35669831
GABA(B) receptor GTP-binding is decreased in the prefrontal cortex but not the hippocampus of aged ratsQ35848364
GABA Targets for the Treatment of Cognitive Dysfunction in SchizophreniaQ35916950
Loss of functional GABA(A) receptors in the Alzheimer diseased brainQ36056348
Loss of calbindin-D28K is associated with the full range of tangle pathology within basal forebrain cholinergic neurons in Alzheimer's diseaseQ36271705
Selective degeneration and synaptic reorganization of hippocampal interneurons in a chronic model of temporal lobe epilepsyQ36355831
Synaptic remodeling during aging and in Alzheimer's disease.Q36568081
Brain plasticity and functional losses in the aged: scientific bases for a novel interventionQ36626123
The ageing cortical synapse: hallmarks and implications for cognitive declineQ36668062
Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers.Q36682401
Changes in the structural complexity of the aged brainQ36739538
Synapses are lost during aging in the primate prefrontal cortexQ36739543
Molecular aging of the brain, neuroplasticity, and vulnerability to depression and other brain-related disordersQ36755164
GABA(B) receptors: structure and functionQ36820569
Loss of GABAergic neurons in the hippocampus and cerebral cortex of Engrailed-2 null mutant mice: implications for autism spectrum disordersQ36853199
GABA(A) receptors in aging and Alzheimer's diseaseQ36917138
Control of timing, rate and bursts of hippocampal place cells by dendritic and somatic inhibitionQ37035543
Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?Q37155476
GABAergic Interneurons in the Neocortex: From Cellular Properties to CircuitsQ37167275
Inhibitory plasticity dictates the sign of plasticity at excitatory synapsesQ37502437
Learning-induced enhancement of feedback inhibitory synaptic transmissionQ37527444
Prefrontal cortical GABAergic dysfunction contributes to age-related working memory impairmentQ37617345
Alzheimer's disease: synaptic dysfunction and AbetaQ37636545
Long-term plasticity at inhibitory synapsesQ37844877
The many forms and functions of long term plasticity at GABAergic synapses.Q37905611
Molecular and functional heterogeneity of GABAergic synapses.Q37982256
Plasticity of inhibitionQ38045480
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue4
P921main subjectcarboxylic acidQ134856
membrane proteinQ423042
cellQ7868
amino acidQ8066
butyrateQ1018145
cell surface receptorQ2476074
nervous systemQ9404
cognitive dysfunctionQ57859955
P304page(s)634-643
P577publication date2017-05-12
2017-08-01
P1433published inAging CellQ2221073
P1476titleThe space where aging acts: focus on the GABAergic synapse
P478volume16

Reverse relations

cites work (P2860)
Q57039792A Brain without Brakes: Reduced Inhibition Is Associated with Enhanced but Dysregulated Plasticity in the Aged Rat Auditory Cortex
Q92471986A new method of recording from the giant fiber of Drosophila melanogaster shows that the strength of its auditory inputs remains constant with age
Q60016768Age-related differences in GABA levels are driven by bulk tissue changes
Q92201706Aging alters signaling properties in the mouse spinal dorsal horn
Q57498420Arousal increases neural gain via the locus coeruleus-norepinephrine system in younger adults but not in older adults
Q59808032Cisplatin treatment induces attention deficits and impairs synaptic integrity in the prefrontal cortex in mice
Q98466592DNA Methyltransferase 1 (DNMT1) Function Is Implicated in the Age-Related Loss of Cortical Interneurons
Q92152447GABAA Receptors Are Well Preserved in the Hippocampus of Aged Mice
Q49791234Influences of 12-Week Physical Activity Interventions on TMS Measures of Cortical Network Inhibition and Upper Extremity Motor Performance in Older Adults-A Feasibility Study.
Q92605610L-655,708 Does not Prevent Isoflurane-induced Memory Deficits in Old Mice
Q92510283Neurobiology and Therapeutic Potential of α5-GABA Type A Receptors
Q102379197Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms
Q55516314Reduced Balance Restoration Capacities Following Unilateral Vestibular Insult in Elderly Mice.
Q47162103Regulation of neuronal survival by DNA methyltransferases
Q61448589Sex- and age-related changes in GABA signaling components in the human cortex
Q57486415Somatostatin and Neuropeptide Y in Cerebrospinal Fluid: Correlations With Amyloid Peptides Aβ and Tau Proteins in Elderly Patients With Mild Cognitive Impairment
Q64881155Stroke Induces a BDNF-Dependent Improvement in Cognitive Flexibility in Aged Mice.
Q92633582Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses

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