GABA(B) receptors: structure and function

scientific article published on January 2007

GABA(B) receptors: structure and function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0079-6123(06)60004-6
P698PubMed publication ID17499108
P5875ResearchGate publication ID6333208

P2093author name stringPiers C Emson
P2860cites workHeterodimerization is required for the formation of a functional GABA(B) receptorQ22008591
Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1Q22010017
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptorsQ24308093
G-protein-coupled receptor heterodimerization modulates receptor functionQ24603239
Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channelsQ24644316
The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFxQ24673707
Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activityQ28138682
Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9Q28139298
Distribution of the GABA(B) receptor subunit gb2 in rat CNSQ28139311
Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501Q28201055
Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor traffickingQ28245383
Alternative splicing generates a novel isoform of the rat metabotropic GABA(B)R1 receptorQ28566794
Association of GABA(B) receptors and members of the 14-3-3 family of signaling proteinsQ28567775
Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly foldedQ28909851
Cloning and tissue distribution of a novel isoform of the rat GABA(B)R1 receptor subunitQ30661325
Heterodimerization of gamma-aminobutyric acid B receptor subunits as revealed by the yeast two-hybrid system.Q30846602
Cloning and tissue distribution of novel splice variants of the rat GABAB receptorQ31942020
Distribution of GABA(B(1a)), GABA(B(1b)) and GABA(B2) receptor protein in cerebral cortex and thalamus of adult ratsQ32106594
Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor.Q33910806
Signal transduction by GABA(B) receptor heterodimersQ34047419
International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and functionQ34130831
Advances in the molecular understanding of GABA(B) receptors.Q34224641
N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.Q34227806
(-)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor.Q34251383
3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brainQ34252242
Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepinesQ34317012
The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptorQ34318688
GABA(B)-receptor subtypes assemble into functional heteromeric complexes.Q34485514
Role of heteromer formation in GABAB receptor functionQ34485603
Gamma-aminobutyric acid binding to receptor sites in the rat central nervous system.Q35119680
Molecular structure and physiological functions of GABA(B) receptorsQ35842984
Unravelling the unusual signalling properties of the GABA(B) receptor.Q35903162
Activation mechanism of the heterodimeric GABA(B) receptorQ35903180
My close encounter with GABA(B) receptorsQ35903187
Molecular mechanisms of GABA(B) receptor activation: new insights from the mechanism of action of CGP7930, a positive allosteric modulator.Q35922936
Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression.Q35998178
Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturationQ36062581
Allosteric functioning of dimeric class C G-protein-coupled receptors.Q36162457
Phosphinic Acid Analogs of GABA. 2. Selective, Orally Active GABAB AntagonistsQ36691386
GABAB receptor modulation of Ca2+ currents in rat sensory neurones by the G protein G(0): antisense oligonucleotide studiesQ38315479
Assembly-dependent surface targeting of the heterodimeric GABAB Receptor is controlled by COPI but not 14-3-3.Q39847411
Coupling of GABAB receptor GABAB2 subunit to G proteins: evidence from Xenopus oocyte and baby hamster kidney cell expression systemQ40381689
Subtype-selective interaction with the transcription factor CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) regulates cell surface expression of GABA(B) receptors.Q40388680
The RXR-type endoplasmic reticulum-retention/retrieval signal of GABAB1 requires distant spacing from the membrane to functionQ40439915
Mechanisms of allosteric modulation at GABAB receptors by CGP7930 and GS39783: effects on affinities and efficacies of orthosteric ligands with distinct intrinsic properties.Q40456690
Subcellular distribution of GABA(B) receptor homo- and hetero-dimers.Q40477512
Ectopically expressed gamma-aminobutyric acid receptor B is functionally down-regulated in isolated lipid raft-enriched membranesQ40517328
Closed state of both binding domains of homodimeric mGlu receptors is required for full activity.Q40538867
Locking the dimeric GABA(B) G-protein-coupled receptor in its active state.Q40599293
Functional interactions between mu opioid and alpha 2A-adrenergic receptors.Q40612786
Multiple GABAB receptorsQ40713467
GABAB receptor pharmacologyQ40854043
The heteromeric GABA-B receptor recognizes G-protein alpha subunit C-terminiQ40913899
Mutagenesis and modeling of the GABAB receptor extracellular domain support a venus flytrap mechanism for ligand bindingQ40957427
GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.Q40984747
Immunohistochemical localization of GABA(B) receptors in the rat central nervous systemQ41613293
Bicuculline-insensitive gaba receptors on peripheral autonomic nerve terminalsQ42451411
Immunocytochemical distribution of the GABA(B) receptor splice variants GABA(B) R1a and R1b in the rat CNS and dorsal root ganglia.Q42481366
Characteristics of GABAB receptor binding sites on rat whole brain synaptic membranesQ42635308
Characterization of [(3)H]-CGP54626A binding to heterodimeric GABA(B) receptors stably expressed in mammalian cellsQ43264386
Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient miceQ43646279
N-type Ca2+ channels as scaffold proteins in the assembly of signaling molecules for GABAB receptor effectsQ44816874
GABAB receptors couple to G proteins Go, Go* and Gi1 but not to Gi2.Q44867236
Floxed allele for conditional inactivation of the GABAB(1) geneQ45113865
A physiological role for GABAB receptors in the central nervous system.Q46128796
Differing actions of beta-phenyl-GABA and baclofen in the guinea pig isolated ileumQ46958215
Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice.Q47230908
gamma-aminobutyric acid type B receptor splice variant proteins GBR1a and GBR1b are both associated with GBR2 in situ and display differential regional and subcellular distributionQ48116576
Morpholin-2-yl-phosphinic acids are potent GABA(B) receptor antagonists in rat brainQ48321740
Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits.Q48498588
Human GABA(B)R genomic structure: evidence for splice variants in GABA(B)R1 but not GABA(B)R2.Q48712665
Multiple motifs regulate the trafficking of GABA(B) receptors at distinct checkpoints within the secretory pathwayQ48950577
Phaclofen: a peripheral and central baclofen antagonistQ53879796
The GABAB2 subunit is critical for the trafficking and function of native GABAB receptorsQ57931922
GABAB receptors as potential targets for drugs able to prevent excessive excitatory amino acid transmission in the spinal cordQ60895847
Central action of bicucullineQ70052166
Inhibition of GABAB receptor binding by guanyl nucleotidesQ70186044
Neurochemistry of synaptic transmission in the cerebral cortexQ72583047
Altered regulation of potassium and calcium channels by GABA(B) and adenosine receptors in hippocampal neurons from mice lacking Galpha(o)Q73434917
The expression of GABA(B1) and GABA(B2) receptor subunits in the cNS differs from that in peripheral tissuesQ74341548
P407language of work or nameEnglishQ1860
P304page(s)43-57
P577publication date2007-01-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inProgress in Brain ResearchQ15800382
P1476titleGABA(B) receptors: structure and function
P478volume160

Reverse relations

cites work (P2860)
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