Insulin-secreting cells derived from stem cells: clinical perspectives, hypes and hopes

scientific article

Insulin-secreting cells derived from stem cells: clinical perspectives, hypes and hopes is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/J.TRIM.2005.09.008
P698PubMed publication ID16412956
P5875ResearchGate publication ID7359275

P50authorEnrique RocheQ57337490
P2093author name stringBernat Soria
Roy Y Calne
John R Isaac
Adolfo Campos
Susan Lim
Beatriz Paredes
Juan Antonio Reig
P2860cites workInsulin signalling and the regulation of glucose and lipid metabolismQ24292020
Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domainsQ24297459
Nuclear reprogramming and stem cell creationQ24620354
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimenQ28141785
New perspectives into the molecular pathogenesis and treatment of type 2 diabetesQ28203726
Regulation of insulin gene transcriptionQ28210255
Genetics of type 1 diabetes mellitusQ28215982
Obesity wars: molecular progress confronts an expanding epidemicQ28240764
Multiple immuno-regulatory defects in type-1 diabetesQ28344695
Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretionQ28368982
Sirolimus (rapamycin)-based therapy in human renal transplantation: similar efficacy and different toxicity compared with cyclosporine. Sirolimus European Renal Transplant Study GroupQ28374428
Transcription factors direct the development and function of pancreatic beta cellsQ28609099
Global and societal implications of the diabetes epidemicQ29614551
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiationQ29614736
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activationQ29617813
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4Q29619280
Different routes of donor-derived hematopoietic stem cell transplantation for donor-specific chimerism induction across MHC barrier.Q33213652
Five-year follow-up after clinical islet transplantationQ33218078
Tacrolimus: the drug for the turn of the millennium?Q33635664
Spontaneous human adult stem cell transformation.Q53358878
In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells.Q53888618
Immune reactivity to glutamic acid decarboxylase 65 in stiffman syndrome and type 1 diabetes mellitus.Q55034045
Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndromeQ55670225
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes RegistryQ55670898
Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cellsQ56903879
Fate of teratocarcinoma cells injected into early mouse embryosQ59085799
Sirolimus-tacrolimus combination immunosuppressionQ60998185
Inhibition of the immune response by rapamycin, a new antifungal antibioticQ67555498
FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitroQ69010285
Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin TreatmentQ70311233
The effects of feeding and various hormones on the glucose tolerance of the sand rat (psammomys obesus)Q72003023
High-level expression of interleukin-4 following electroporation-mediated gene transfer accelerates Type 1 diabetes in NOD miceQ73174050
Interleukin 12 and autoimmune diabetesQ73435269
Evaluation of fine mapping strategies for a multifactorial disease locus: systematic linkage and association analysis of IDDM1 in the HLA region on chromosome 6p21Q73800704
Human feeders support prolonged undifferentiated growth of human inner cell masses and embryonic stem cellsQ74573056
Peritoneal antigen-presenting cells pulsed in vivo with myelin basic protein induce the suppression of experimental autoimmune encephalomyelitis (EAE) in Wistar ratsQ77397628
Epitope dominance: evidence for reciprocal determinant spreading to glutamic acid decarboxylase in non-obese diabetic miceQ77488356
Microchimerism and the pathogenesis of systemic sclerosisQ77542609
Control of autoimmune diabetes in NOD mice by GAD expression or suppression in beta cellsQ77744347
Purified allogeneic hematopoietic stem cell transplantation blocks diabetes pathogenesis in NOD miceQ78719270
Th1 and Th2 pancreatic inflammation differentially affects homing of islet-reactive CD4 cells in nonobese diabetic miceQ78946090
Cyclosporine and tacrolimus (FK506): a comparison of efficacy and safety profilesQ33670571
Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channelsQ33873543
Autonomic regulation of islet hormone secretion--implications for health and diseaseQ33923510
Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphismsQ33942274
Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets.Q33944464
In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cellsQ34031221
Isolation of human embryonal carcinoma stem cells by immunomagnetic sortingQ34102284
Considerations for successful transplantation of encapsulated pancreatic isletsQ34122328
Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approachQ34163786
Mammalian cloning: advances and limitations.Q34185440
From stem cells to beta cells: new strategies in cell therapy of diabetes mellitus.Q34253731
Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cellsQ34328388
Prime role for an insulin epitope in the development of type 1 diabetes in NOD miceQ34345367
Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac graftsQ34387398
Macrolactam immunomodulators for topical treatment of inflammatory skin diseasesQ34405192
Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cellsQ34415516
RETRACTED: Patient-specific embryonic stem cells derived from human SCNT blastocysts.Q34420078
Embryo-derived stem cells: of mice and men.Q34425188
Diabetes mellitus and genetically programmed defects in beta-cell functionQ34462316
beta-Cell death during progression to diabetesQ34462324
Beta-cell protein kinases and the dynamics of the insulin response to glucoseQ34508739
Nonhuman primate parthenogenetic stem cellsQ34582548
Is IL12B a potential genetic target for the prevention of type 1 diabetes through dietary intervention?Q34700825
Immunologic and genetic factors in type 1 diabetesQ34882557
Approaches to type 1 diabetes prevention by intervention in cytokine immunoregulatory circuitsQ34945872
Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetesQ35022159
Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?Q35034481
Lipoapoptosis: its mechanism and its diseasesQ35047180
The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cureQ35103993
A pancreatic beta-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetesQ35170270
In vitro cultivation of human islets from expanded ductal tissueQ35174217
Nuclear transplantation, embryonic stem cells, and the potential for cell therapyQ35179632
Bio-engineering inslulin-secreting cells from embryonic stem cells: a review of progressQ35189283
Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selectionQ35208665
Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetesQ35641719
Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolismQ35641736
Chronic effects of fatty acids on pancreatic beta-cell function: new insights from functional genomics.Q35641748
Plasticity of adult stem cellsQ35684656
Death effectors of beta-cell apoptosis in type 1 diabetesQ35908961
Animal models have little to teach us about type 1 diabetes: 1. In support of this proposalQ35920996
Animal models have little to teach us about type 1 diabetes: 2. In opposition to this proposalQ35926919
An immune origin of type 2 diabetes?Q36112058
Models of T cell anergy: is there a common molecular mechanism?Q36366967
Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells.Q37599148
Nuclei of embryonic stem cells reprogram somatic cellsQ38334452
Upstream AUGs in embryonic proinsulin mRNA control its low translation level.Q38349516
Organized development from human embryonic stem cells after injection into immunodeficient mice.Q40519575
Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cellsQ40521874
Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cellsQ40544422
Association between macrophage activation and function of micro-encapsulated rat isletsQ40587998
Insulin expressing cells from differentiated embryonic stem cells are not beta cellsQ40589116
Supplementation-dependent differences in the rates of embryonic stem cell self-renewal, differentiation, and apoptosisQ40623756
Rapid loss of Oct-4 and pluripotency in cultured rodent blastocysts and derivative cell linesQ40682221
Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1.Q40682801
Correction of a genetic defect by nuclear transplantation and combined cell and gene therapyQ40738121
Target cell defense prevents the development of diabetes after viral infection.Q40741831
Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: addition of IL-4 increases safetyQ40761236
Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells.Q40876310
Genetic analysis of autoimmune diseaseQ40980040
Upstream-downstream: CD28 cosignaling pathways and T cell functionQ41010604
Mechanisms of action of nonglucose insulin secretagoguesQ41053123
Cell death mediators in autoimmune diabetes--no shortage of suspectsQ41420580
Rapamycin inhibits p34cdc2 expression and arrests T lymphocyte proliferation at the G1/S transition.Q41513494
Six-year clinical effect of donor bone marrow infusions in renal transplant patientsQ43605131
Th2 dominance of T helper cell response to preproinsulin in individuals with preclinical type 1 diabetes.Q44000561
Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.Q44172552
Increased nonobese diabetic Th1:Th2 (IFN-gamma:IL-4) ratio is CD4+ T cell intrinsic and independent of APC genetic backgroundQ44223925
Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cellsQ44418714
A double-blind randomized trial of 0.1% tacrolimus vs 0.05% clobetasol for the treatment of childhood vitiligoQ44447045
IL-1beta, IFN-gamma and TNF-alpha increase vulnerability of pancreatic beta cells to autoimmune destructionQ44468596
Bone marrow-derived stem cells initiate pancreatic regeneration.Q44486484
Differentiation of human embryonic stem cells into insulin-producing clustersQ44903372
Lowered glucose suppressed the proliferation and increased the differentiation of murine neural stem cells in vitroQ44997441
In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cellsQ45199702
Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic miceQ45868872
TGF-beta1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotypeQ46431455
Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cellsQ46531971
Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependencyQ47992795
P433issue2
P304page(s)113-129
P577publication date2005-10-17
P1433published inTransplant ImmunologyQ15758510
P1476titleInsulin-secreting cells derived from stem cells: clinical perspectives, hypes and hopes
P478volume15