Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

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Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/0092-8674(95)90013-6
P698PubMed publication ID7540117

P2093author name stringM J Lenardo
W Strober
S E Straus
J M Puck
A Y Lin
J K Dale
G H Fisher
F J Rosenberg
L A Middleton
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectautoimmune lymphoproliferative syndromeQ1151300
apoptotic processQ14599311
P304page(s)935-46
P577publication date1995-06-16
P1433published inCellQ655814
P1476titleDominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
P478volume81

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cites work (P2860)
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Q34941147Nitric oxide as an inflammatory mediator in autoimmune MRL-lpr/lpr mice
Q34242689Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammation
Q56908682Non-HLA genes and the susceptibility to insulin dependent diabetes: the role of the CTLA-4 gene
Q35557615Non-apoptotic functions of caspases in cellular proliferation and differentiation
Q34415756Nonlymphoid Fas ligand in peptide-induced peripheral lymphocyte deletion
Q37248354Novel molecular and cellular therapeutic targets in acute lymphoblastic leukemia and lymphoproliferative disease
Q34397101Of mice and men: the relevance of the mouse to the study of human SLE.
Q73590802Oligoclonal expansion of CD45RO+ T lymphocytes in Omenn syndrome
Q33541431On costimulatory signals and T cell tolerance: relevance for transplantation immunity.
Q34428954Onset of autoimmune lymphoproliferative syndrome (ALPS) in humans as a consequence of genetic defect accumulation
Q38823961Optimal Management of Autoimmune Lymphoproliferative Syndrome in Children
Q89977010Oral Microbes and Mucosal Dendritic Cells, "Spark and Flame" of Local and Distant Inflammatory Diseases
Q73348111Over-expression of the decoy receptor 3 (DcR3) gene in peripheral blood mononuclear cells (PBMC) derived from silicosis patients
Q37691426Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice.
Q42252275Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus.
Q37798037PKC-θ is a Drug Target for Prevention of T Cell-Mediated Autoimmunity and Allograft Rejection
Q64892906Paradoxical CD4 Lymphopenia in Autoimmune Lymphoproliferative Syndrome (ALPS).
Q33383468Pathobiology of secondary immune thrombocytopenia
Q35257857Pathogenesis of juvenile chronic arthritis: genetic and environmental factors
Q35754536Pathological findings in human autoimmune lymphoproliferative syndrome
Q38200384Pathophysiology and spectrum of diseases caused by defects in lymphocyte cytotoxicity.
Q36148396Paths to understanding the genetic basis of autoimmune disease
Q41514577Pathways leading to cell death in T cells
Q28204372Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency
Q29620319Points of control in inflammation
Q40666242Porcine Fas-ligand gene: genomic sequence analysis and comparison with human gene.
Q52571131Possible Association of Multicentric Castleman's Disease with Autoimmune Lymphoproliferative Syndrome.
Q31104620Precise mapping of the CD95 pre-ligand assembly domain
Q73315105Prediction of the three-dimensional structure of the human Fas receptor by comparative molecular modeling
Q39232124Primary/Congenital Immunodeficiency: 2015 SH/EAHP Workshop Report-Part 5.
Q41894662Pro- and anti-apoptotic CD95 signaling in T cells
Q33847243Probiotic sonicates selectively induce mucosal immune cells apoptosis through ceramide generation via neutral sphingomyelinase
Q79828647Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinoma
Q46163524Programmed cell death (apoptosis) in cord blood lymphocytes
Q39120700Programmed cell death and the immune system
Q37773421Programmed cell death of dendritic cells in immune regulation
Q45888106Programmed cell death: the influence of CD40, CD95 (Fas or Apo-I) and their ligands
Q36659578Proteasome regulation of activation-induced T cell death
Q38076413Protecting and rescuing the effectors: roles of differentiation and survival in the control of memory T cell development
Q37950926RIP1-mediated regulation of lymphocyte survival and death responses
Q40245571Rapid CD40-mediated rescue from CD95-induced apoptosis requires TNFR-associated factor-6 and PI3K.
Q41728141Recent advances. Immunology
Q41737516Receptors and ligands that mediate activation-induced death of T cells
Q36375186Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis
Q90041758Regulation of B-cell function by NF-kappaB c-Rel in health and disease
Q23910429Regulation of Fas (CD95)-induced apoptosis by nuclear factor-KB and tumor necrosis factor- alpha in macrophages
Q28592335Regulation of Fas ligand expression and cell death by apoptosis-linked gene 4
Q37306636Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon.
Q36368347Regulation of fas ligand expression during activation-induced cell death in T cells by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase.
Q36562855Regulatory T cells in human autoimmune diseases
Q42436232Regulatory role of CD95 ligation on human B cells induced in vivo capable of spontaneous and high-rate Ig secretion
Q57384656Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex
Q40826064Resistance to CD95-mediated apoptosis through constitutive c-FLIP expression in a non-Hodgkin's lymphoma B cell line.
Q35125091Review: Environmental exposure to mercury and its toxicopathologic implications for public health
Q24632569Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop
Q33376403Rituximab responsive immune thrombocytopenic purpura in an adult with underlying autoimmune lymphoproliferative syndrome due to a splice-site mutation (IVS7+2 T>C) affecting the Fas gene
Q41102922Role of Fas-mediated cell death in the regulation of immune responses
Q35084896Role of endogenous retroviruses in autoimmune diseases
Q35107838Role of inherited defects decreasing Fas function in autoimmunity.
Q37365961Roles of interferon-gamma and interleukin-4 in murine lupus
Q36322794SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane
Q41399533Searching for genes involved in the pathogenesis of primary immunodeficiency diseases: lessons from mouse knockouts
Q37377927Sequential decisions on FAS sequencing guided by biomarkers in patients with lymphoproliferation and autoimmune cytopenia
Q33588768Serum markers of apoptosis decrease with age and cancer stage
Q34563012Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas.
Q74556952Significant role of Fas ligand-binding but defective Fas receptor (CD95) in lymph node hyperplasia composed of abnormal double-negative T cells
Q77312788Soluble Fas mRNA is dominantly expressed in cases with silicosis
Q34149957Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis
Q41908763Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction
Q35092629Specific elimination of effector memory CD4+ T cells due to enhanced Fas signaling complex formation and association with lipid raft microdomains
Q36400965Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions
Q43014937Structural insight for the roles of fas death domain binding to FADD and oligomerization degree of the Fas-FADD complex in the death-inducing signaling complex formation: a computational study
Q41276439Suicide by order: some open questions about the cell-killing activities of the TNF ligand and receptor families
Q47611305Survival of autoreactive T lymphocytes by microRNA-mediated regulation of apoptosis through TRAIL and Fas in type 1 diabetes.
Q35183209Survival signals in leukemic large granular lymphocytes
Q77892082Susceptibility to lupus nephritis in the NZB/W model system
Q35148616Systemic lupus erythematosus and apoptosis: a question of balance
Q34082803Systemic lupus erythematosus, complement deficiency, and apoptosis
Q36399210T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis
Q36473831T cell-tumor cell: a fatal interaction?
Q34093608T-cell receptor complex is essential for Fas signal transduction.
Q34716347T-cell signalling and autoimmunity: molecular mechanisms of disease
Q39877053T-lymphocyte downregulation after acute viral infection is not dependent on CD95 (Fas) receptor-ligand interactions.
Q73411964TCR stimulation protects CD8+ T cells from CD95 mediated apoptosis
Q59783966TNF-related ligands and their receptors
Q33971049TNFRSF1A mutations and autoinflammatory syndromes
Q64900451TRAIL and FasL Functions in Cancer and Autoimmune Diseases: Towards an Increasing Complexity.
Q30988219TRAIL death receptor-4, decoy receptor-1 and decoy receptor-2 expression on CD8+ T cells correlate with the disease severity in patients with rheumatoid arthritis
Q64078760TRAIL-R1 and TRAIL-R2 Mediate TRAIL-Dependent Apoptosis in Activated Primary Human B Lymphocytes
Q37111489Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network
Q71794021Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver
Q35577256The "fuzzy logic" of the death-inducing signaling complex in lymphocytes
Q57078448The Autoimmune Lymphoproliferative Syndrome with Defective FAS or FAS-Ligand Functions
Q35031256The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions
Q33533982The CD95(APO-1/Fas)/CD95L system
Q34047933The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types
Q54967366The Effect of a Competitive Futsal Match on T Lymphocyte Surface Receptor Signaling and Functions.
Q36367323The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand
Q41515265The Fas pathway in apoptosis.
Q24302236The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations
Q24621785The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells
Q36114138The Fas/CD95 Receptor Regulates the Death of Autoreactive B Cells and the Selection of Antigen-Specific B Cells
Q34459289The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens
Q44196945The anti-inflammatory sesquiterpene lactone parthenolide suppresses CD95-mediated activation-induced-cell-death in T-cells
Q37294307The apoptotic members CD95, BclxL, and Bcl-2 cooperate to promote cell migration by inducing Ca(2+) flux from the endoplasmic reticulum to mitochondria
Q34195490The autoimmune lymphoproliferative syndrome. A disorder of human lymphocyte apoptosis
Q28264600The autoimmune lymphoproliferative syndrome: an experiment of nature involving lymphocyte apoptosis
Q25256839The cancer stem cell: evidence for its origin as an injured autoreactive T cell
Q34283820The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes
Q77577103The clinical spectrum in a large kindred with autoimmune lymphoproliferative syndrome caused by a Fas mutation that impairs lymphocyte apoptosis
Q40707239The conformational alteration of the mutated extracellular domain of Fas in an adult T cell leukemia cell line
Q42067854The death domain of FADD is essential for embryogenesis, lymphocyte development, and proliferation
Q33996534The death domain superfamily in intracellular signaling of apoptosis and inflammation
Q35116679The death effector domain protein family: regulators of cellular homeostasis
Q37828761The emergence of ADAM10 as a regulator of lymphocyte development and autoimmunity
Q34573771The enemy within: keeping self-reactive T cells at bay in the periphery
Q39805021The expression of Fas Ligand by macrophages and its upregulation by human immunodeficiency virus infection.
Q35855040The genetics of familial lymphomas
Q37989934The immunogenetic architecture of autoimmune disease
Q34205697The many roles of FAS receptor signaling in the immune system
Q33836041The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations
Q41692805The molecular basis of intractable diarrhoea of infancy
Q24685932The molecular pathology of primary immunodeficiencies
Q28139188The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity
Q34584971The origin of CD95-gene mutations in B-cell lymphoma
Q36401438The peripheral deletion of autoreactive CD8+ T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1).
Q34009654The power and the promise of restimulation-induced cell death in human immune diseases
Q34071289The pre-ligand binding assembly domain: a potential target of inhibition of tumour necrosis factor receptor function
Q74012642The regulation of FasL expression--a distinquishing feature between monocytes and T lymphocytes/NK cells with possible implications for SLE
Q33636111The role of Fas and related death receptors in autoimmune and other disease states
Q73205341The role of Fas in autoimmune diabetes
Q33898921The role of fas ligand in vivo as a cause and regulator of pathogenesis
Q41659044The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
Q71066518The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance
Q33500825The spectrum of Evans' syndrome
Q64044425The technological transformation of patient-driven human immunology research
Q37852758The tumour necrosis factor/TNF receptor superfamily: therapeutic targets in autoimmune diseases
Q33955244Thyroid cell apoptosis. A new understanding of thyroid autoimmunity
Q41850711Trifluoperazine regulation of calmodulin binding to Fas: a computational study
Q40975748Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.
Q74497763Up-regulation of Fas ligand (FasL) mRNA expression in peripheral blood mononuclear cells (PBMC) after major surgery
Q35575327Update on primary immunodeficiency: defects of lymphocytes
Q33420245Updated Understanding of Autoimmune Lymphoproliferative Syndrome (ALPS).
Q24643047Use of rituximab for refractory cytopenias associated with autoimmune lymphoproliferative syndrome (ALPS)
Q34809111Variations of the UNC13D gene in patients with autoimmune lymphoproliferative syndrome
Q36880053Vitamin E and apoptosis
Q24309135Whole-exome-sequencing-based discovery of human FADD deficiency
Q41688188Why do defects in the Fas-Fas ligand system cause autoimmunity?
Q73047439[Thymus: old gland, new ideas]
Q36405075cFLIP regulation of lymphocyte activation and development

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