Optimal Management of Autoimmune Lymphoproliferative Syndrome in Children

scientific article published on 30 April 2016

Optimal Management of Autoimmune Lymphoproliferative Syndrome in Children is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1036062472
P356DOI10.1007/S40272-016-0175-3
P698PubMed publication ID27139496

P50authorDavid T TeacheyQ82889836
P2093author name stringLindsey A George
P2860cites workFas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutationsQ22254363
Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damageQ24603171
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How I treat autoimmune lymphoproliferative syndromeQ24633207
Treatment with sirolimus results in complete responses in patients with autoimmune lymphoproliferative syndromeQ24650472
Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)Q24685850
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The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunityQ28139188
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Reversion of autoimmune lymphoproliferative syndrome with an antimalarial drug: preliminary results of a clinical cohort study and molecular observationsQ28210645
A composite picture of TcR alpha/beta(+) CD4(-)CD8(-) T Cells (alpha/beta-DNTCs) in humans with autoimmune lymphoproliferative syndromeQ28215936
FAS haploinsufficiency is a common disease mechanism in the human autoimmune lymphoproliferative syndromeQ28235519
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Mycophenolate mofetil and Sirolimus as second or further line treatment in children with chronic refractory Primitive or Secondary Autoimmune Cytopenias: a single centre experience.Q41172796
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Induction of apoptosis and modulation of activation and effector function in T cells by immunosuppressive drugsQ43977140
Clincal, immunologic, and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosisQ44455328
IL-17 protects T cells from apoptosis and contributes to development of ALPS-like phenotypes.Q45115236
Fluorodeoxyglucose positron emission tomography (FDG-PET) for monitoring lymphadenopathy in the autoimmune lymphoproliferative syndrome (ALPS).Q46908424
Friends not foes: CTLA-4 blockade and mTOR inhibition cooperate during CD8+ T cell priming to promote memory formation and metabolic readiness.Q50755650
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Pyrimethamine treatment does not ameliorate lymphoproliferation or autoimmune disease in MRL/lpr-/- mice or in patients with autoimmune lymphoproliferative syndromeQ28239313
A survey of 90 patients with autoimmune lymphoproliferative syndrome related to TNFRSF6 mutationQ28246980
Use of mycophenolate mofetil for chronic, refractory immune cytopenias in children with autoimmune lymphoproliferative syndromeQ28248908
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Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutationsQ28250725
Development of lymphoma in Autoimmune Lymphoproliferative Syndrome (ALPS) and its relationship to Fas gene mutationsQ28263161
Identifying autoimmune lymphoproliferative syndrome in children with Evans syndrome: a multi-institutional studyQ28270195
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Autoimmune lymphoproliferative syndrome with somatic Fas mutationsQ28285625
Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS)Q28293136
FAS-L, IL-10, and double-negative CD4- CD8- TCR alpha/beta+ T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of functionQ28307801
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosisQ30080034
Safety, efficacy, and immune reconstitution after rituximab therapy in pediatric patients with chronic or refractory hematologic autoimmune cytopenias.Q33375562
Increased lymphocyte Fas expression and high incidence of common variable immunodeficiency disorder in childhood Evans' syndromeQ33377012
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Clinical, immunological, and pathological consequences of Fas-deficient conditionsQ33496872
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Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation.Q34148939
Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasisQ34149957
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Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiencyQ34380652
Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signalingQ34391120
Onset of autoimmune lymphoproliferative syndrome (ALPS) in humans as a consequence of genetic defect accumulationQ34428954
Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3KQ34452767
New insights into childhood autoimmune hemolytic anemia: a French national observational study of 265 childrenQ34890377
Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia.Q35132088
A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld diseaseQ35604700
Caspase-8 Deficiency Presenting as Late-Onset Multi-Organ Lymphocytic Infiltration with Granulomas in two Adult SiblingsQ35629669
NRAS mutation causes a human autoimmune lymphoproliferative syndrome.Q35829141
Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trialQ36443121
Helper T cells down-regulate CD4 expression upon chronic stimulation giving rise to double-negative T cellsQ37209943
Natural history of autoimmune lymphoproliferative syndrome associated with FAS gene mutationsQ37670054
Histologic features of sinus histiocytosis with massive lymphadenopathy in patients with autoimmune lymphoproliferative syndromeQ38442307
Spectrum of Phenotypes Associated with Mutations in LRBA.Q38680451
P433issue4
P921main subjectautoimmune lymphoproliferative syndromeQ1151300
P1104number of pages12
P304page(s)261-272
P577publication date2016-04-30
P1433published inPediatric DrugsQ15767256
P1476titleOptimal Management of Autoimmune Lymphoproliferative Syndrome in Children
P478volume18

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cites work (P2860)
Q90383784An updated review on phenocopies of primary immunodeficiency diseases
Q47151016Autoimmune lymphoproliferative syndrome: more than a FAScinating disease.

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