Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice

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Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2002PNAS...99..878Z
P356DOI10.1073/PNAS.022326699
P3181OpenCitations bibliographic resource ID1340657
P932PMC publication ID117399
P698PubMed publication ID11782530
P5875ResearchGate publication ID11574841

P2093author name stringY Zhang
R A Edwards
S F Schlossman
Mei X Wu
Ching-Nan Ou
J Gu
P2860cites workIdentification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholineQ24312195
Inhibition of death receptor signals by cellular FLIPQ24316446
IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survivalQ24323200
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κBQ28508403
A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair familiesQ28776415
TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaBQ29614706
An essential role for NF-kappaB in preventing TNF-alpha-induced cell deathQ29614707
The Bcl-2 protein family: arbiters of cell survivalQ29618158
Suppression of TNF-alpha-induced apoptosis by NF-kappaBQ29618717
Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin BQ33243937
T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.Q33560835
Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environmentQ33652471
NF-kappaB and the innate immune responseQ33840493
Autoimmunity as a consequence of retrovirus-mediated expression of C-FLIP in lymphocytesQ33885931
Genetics of systemic autoimmunity in mouse models of lupusQ34051987
Identification and characterization of a radiation-inducible glycosylated human early-response gene.Q34375596
Genomic organization, promoter cloning, and chromosomal localization of the Dif-2 gene.Q34468161
The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB.Q34476192
Regulation of a novel immediate early response gene, IEX-1, in keratinocytes by 1alpha,25-dihydroxyvitamin D3.Q34477486
A novel immediate early response gene, IEX-1, is induced by ultraviolet radiation in human keratinocytesQ34486211
Monocytes are required to prime peripheral blood T cells to undergo apoptosisQ34628777
Tumor necrosis factor sustains the generalized lymphoproliferative disorder (gld) phenotypeQ36375875
Viral and bacterial infections interfere with peripheral tolerance induction and activate CD8+ T cells to cause immunopathologyQ36400410
Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice.Q37353515
Infection breaks T-cell tolerance.Q39228571
Fas and Fas ligand: lpr and gld mutationsQ40398275
Functional disruption of IEX-1 expression by concatemeric hammerhead ribozymes alters growth properties of 293 cellsQ40811748
Activation-induced cell death (apoptosis) of mature peripheral T lymphocytesQ40841803
Hierarchical control of lymphocyte survivalQ41145162
Autoimmune disease results from multiple interactive defects in apoptosis induction molecules and signaling pathways.Q41251249
Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cellsQ41553512
Systemic autoimmune disease as a consequence of defective lymphocyte deathQ41716668
Genomic structure, cDNA sequence, and expression of gly96, a growth factor-inducible immediate-early gene encoding a short-lived glycosylated proteinQ42811388
Expression of the NF-kappa B target gene IEX-1 (p22/PRG1) does not prevent cell death but instead triggers apoptosis in Hela cellsQ43539821
Respiratory syncytial virus infection induces expression of the anti-apoptosis gene IEX-1L in human respiratory epithelial cells.Q44750390
Bystander virus infection prolongs activated T cell survivalQ45750055
Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunityQ46094710
Human autoimmune lymphoproliferative syndrome, a defect in the apoptosis-inducing Fas receptor: a lesson from the mouse modelQ48019243
Immunological adjuvants promote activated T cell survival via induction of Bcl-3.Q48367905
Lipopolysaccharide interferes with the induction of peripheral T cell death.Q54179786
Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndromeQ55670225
CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivoQ56908416
bcl-2 transgene inhibits T cell death and perturbs thymic self-censorshipQ57338704
ALPS: an autoimmune human lymphoproliferative syndrome associated with abnormal lymphocyte apoptosisQ73231104
Mullerian inhibiting substance inhibits breast cancer cell growth through an NFkappa B-mediated pathwayQ73939153
Human PACAP response gene 1 (p22/PRG1): proliferation-associated expression in pancreatic carcinoma cellsQ77412155
The genetics of human systemic lupus erythematosusQ77892094
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectautoimmune diseaseQ8084905
apoptotic processQ14599311
P304page(s)878-883
P577publication date2002-01-08
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleImpaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
P478volume99

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cites work (P2860)
Q35192106A novel vitamin D-regulated immediate-early gene, IEX-1, alters cellular growth and apoptosis
Q24312475ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response
Q30443591Death pathways in T cell homeostasis and their role in autoimmune diabetes
Q79133933Development of T-cell lymphomas in Emu-IEX-1 mice
Q40299284Distinct domains for anti- and pro-apoptotic activities of IEX-1.
Q28589777Elevated blood pressure and cardiac hypertrophy after ablation of the gly96/IEX-1 gene
Q58077011Emerging Potential of Immediate Early Response Gene X-1 in Cardiovascular and Metabolic Diseases
Q36229628Enhanced Th17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling
Q47139668Exome and transcriptome sequencing identifies loss of PDLIM2 in metastatic colorectal cancers.
Q45952956Gene expression profiles during human CD4+ T cell differentiation.
Q36593309Genetics of SLE in mice
Q34987317Genetics of autoimmune diseases in humans and in animal models
Q36054813Genetics of lupus nephritis
Q42676828Geno-transcriptomic dissection of proteinuria in the uninephrectomized rat uncovers a molecular complexity with sexual dimorphism.
Q53562830IER3 Promotes Expansion of Adipose Progenitor Cells in Response to Changes in Distinct Microenvironmental Effectors.
Q36785325IEX-1 deficiency induces browning of white adipose tissue and resists diet-induced obesity
Q39605276IEX-1 suppresses apoptotic damage in human intestinal epithelial Caco-2 cells induced by co-culturing with macrophage-like THP-1 cells
Q28507057IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation
Q24534869IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation
Q37120304IF-combined smRNA FISH reveals interaction of MCPIP1 protein with IER3 mRNA.
Q46862617Ikaros increases normal apoptosis in adult erythroid cells
Q46690768Immediate Early Response Gene X-1 (IEX-1) Mediates Ischemic Preconditioning-Induced Cardioprotection in Rats
Q40234132Immediate early gene IEX-1 induces astrocytic differentiation of U87-MG human glioma cells
Q24305468Immediate early gene X-1 interacts with proteins that modulate apoptosis
Q31163900Immediate early gene X1 (IEX-1) is organized in subnuclear structures and partially co-localizes with promyelocytic leukemia protein in HeLa cells.
Q35240656Immediate early response gene X-1, a potential prognostic biomarker in cancers
Q36631057Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling
Q35675523Links between type I interferons and the genetic basis of disease in mouse lupus.
Q34480237Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells
Q24321570Microcephaly with simplified gyration, epilepsy, and infantile diabetes linked to inappropriate apoptosis of neural progenitors
Q33599208Modification of T cell responses by stem cell mobilization requires direct signaling of the T cell by G-CSF and IL-10
Q51637669Molecular understanding of oxygen-tension and patient-variability effects on ex vivo expanded T cells.
Q35900991NF-kappaB2 mutation targets TRAF1 to induce lymphomagenesis
Q30466128Noise-induced changes in gene expression in the cochleae of mice differing in their susceptibility to noise damage
Q36061611Notch controls the magnitude of T helper cell responses by promoting cellular longevity.
Q35221409Novel mRNA targets for tristetraprolin (TTP) identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts
Q36005381Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis
Q39970794Overexpression of immediate early gene X-1 (IEX-1) enhances gamma-radiation-induced apoptosis of human glioma cell line, U87-MG.
Q35168115Rearrangements and amplification of IER3 (IEX-1) represent a novel and recurrent molecular abnormality in myelodysplastic syndromes.
Q35835628Resistance of Sézary cells to TNF-α-induced apoptosis is mediated in part by a loss of TNFR1 and a high level of the IER3 expression
Q30396765Role of the immediate early response 3 (IER3) gene in cellular stress response, inflammation and tumorigenesis
Q24297546Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis
Q38162595Stemness of T cells and the hematopoietic stem cells: fate, memory, niche, cytokines
Q33410496Stress-induced hematopoietic failure in the absence of immediate early response gene X-1 (IEX-1, IER3)
Q78315319Synergistic and opposing regulation of the stress-responsive gene IEX-1 by p53, c-Myc, and multiple NF-kappaB/rel complexes
Q35128527The Mechanisms of Apoptosis in Biology and Medicine: A New Focus for Ophthalmology
Q34996258The Stress-Inducible Immediate-Early Responsive Gene IEX-1 Is Activated in Cells Infected with Herpes Simplex Virus 1, but Several Viral Mechanisms, Including 3′ Degradation of Its RNA, Preclude Expression of the Gene
Q40645798The early response gene IEX-1 attenuates NF-kappaB activation in 293 cells, a possible counter-regulatory process leading to enhanced cell death
Q61813132The expression of immediate early gene X-1 (IEX-1) is differentially induced by retinoic acids in NB4 and KG1 cells: possible implication in the distinct phenotype of retinoic acid-responsive and -resistant leukemic cells
Q39742421Transient up-regulation of immunity- and apoptosis-related genes in Caco-2 cells cocultured with THP-1 cells evaluated by DNA microarray analysis

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