Why do defects in the Fas-Fas ligand system cause autoimmunity?

scientific article published on December 1997

Why do defects in the Fas-Fas ligand system cause autoimmunity? is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/S0091-6749(97)70013-7
P698PubMed publication ID9440553

P2093author name stringSuda T
Nagata S
P2860cites workMolecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor familyQ28285445
Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligandQ28513283
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosisQ29618601
The Fas death factorQ29620461
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosisQ30080034
Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunityQ33488225
Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative diseaseQ34602392
Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr miceQ36129002
Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicideQ36297378
Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr miceQ36362973
Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I.Q36364361
Enhanced and accelerated lymphoproliferation in Fas-null miceQ37711034
The APO-1/Fas (CD95) receptor is expressed in homozygous MRL/lpr miceQ38302171
The role of B cell abnormalities in the systemic autoimmune syndromes of lpr and gld miceQ40745058
Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)Q41371079
Reduced development of CD4-8-B220+ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I moleculesQ41664431
Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate Fas and Fas ligandQ41860508
The contribution of L3T4+ T cells to lymphoproliferation and autoantibody production in MRL-lpr/lpr miceQ42019842
Cytotoxicity of fresh NK1.1+ T cell receptor alpha/beta+ thymocytes against a CD4+8+ thymocyte population associated with intact Fas antigen expression on the targetQ42942508
Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibodyQ42942821
Fas-mediated cytotoxicity by freshly isolated natural killer cellsQ42942845
CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cellsQ45971909
Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells.Q52206363
Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells.Q54177718
Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndromeQ55670225
A role for CD95 ligand in preventing graft rejectionQ59066471
Fas Ligand-Induced Apoptosis as a Mechanism of Immune PrivilegeQ63408406
Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant miceQ68059685
Self-nonself discrimination by T cellsQ68090702
Activated B cells express functional Fas ligandQ71012013
Expression of Fas in B cells of the mouse germinal center and Fas-dependent killing of activated B cellsQ71363470
The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic miceQ71678868
P433issue6 Pt 2
P407language of work or nameEnglishQ1860
P304page(s)S97-101
P577publication date1997-12-01
P1433published inThe Journal of Allergy and Clinical ImmunologyQ7743550
P1476titleWhy do defects in the Fas-Fas ligand system cause autoimmunity?
P478volume100

Reverse relations

cites work (P2860)
Q88500089Administration of activated lymphocyte-derived DNA accelerates and aggravates lupus nephritis in B6/lpr mice: a new approach to modify a lupus murine model
Q35097949Aerosol therapy for the treatment of osteosarcoma lung metastases: targeting the Fas/FasL pathway and rationale for the use of gemcitabine
Q36659043CD8+CD122+CD49dlow regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicity
Q62735931Caspase 1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand
Q74582446Combination of molecular mimicry and aberrant autoantigen expression is important for development of anti-Fas ligand autoantibodies in patients with systemic lupus erythematosus
Q73862693Detection of alternatively spliced variant messages of Fas gene and mutational screening of Fas and Fas ligand coding regions in peripheral blood mononuclear cells derived from silicosis patients
Q39251222Dual Role of Fas/FasL-Mediated Signal in Peripheral Immune Tolerance.
Q34564667Enhanced auto-antibody production and Mott cell formation in FcμR-deficient autoimmune mice.
Q28371293Estradiol prevents and testosterone promotes Fas-dependent apoptosis in CD4+ Th2 cells by altering Bcl 2 expression
Q74610140Expression of Fas antigen (CD95) in peripheral blood lymphocytes and in liver-infiltrating, cytotoxic lymphocytes in patients with hepatocellular carcinoma
Q27484988Fas Ligand Interactions Contribute to CD8+ T-Cell-Mediated Control of West Nile Virus Infection in the Central Nervous System
Q28574439Fas antigen/CD-95 upregulation and activation during castration-induced regression of the rat ventral prostate gland
Q40520855Fas ligand induces cell-autonomous NF-kappaB activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha.
Q36572935High distribution of CD40 and TRAF2 in Th40 T cell rafts leads to preferential survival of this auto-aggressive population in autoimmunity
Q44087976Immunoglobulin and autoantibody responses in MRL/lpr mice treated with 'toxic oils'.
Q37754703Inflammation and arthritis: perspectives of the glycobiologist
Q35199945Killer B lymphocytes and their fas ligand positive exosomes as inducers of immune tolerance
Q38838638Liver receptor homolog-1 (NR5a2) regulates CD95/Fas ligand transcription and associated T-cell effector functions.
Q99552352Longitudinal immune profiling of mild and severe COVID-19 reveals innate and adaptive immune dysfunction and provides an early prediction tool for clinical progression
Q73348111Over-expression of the decoy receptor 3 (DcR3) gene in peripheral blood mononuclear cells (PBMC) derived from silicosis patients
Q37350948Reduced Fas ligand-expressing splenic CD5+ B lymphocytes in severe collagen-induced arthritis.
Q23924040Selective induction of apoptosis through the FADD/caspase-8 pathway by a p53 c-terminal peptide in human pre-malignant and malignant cells
Q91993969Thalidomide with blockade of co-stimulatory molecules prolongs the survival of alloantigen-primed mice with cardiac allografts
Q37393827The role of apoptosis in immune hyporesponsiveness following AAV8 liver gene transfer

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