A pivotal role of cell-bound but not soluble CD4 molecules in full development of lupus-like manifestations in MRL-Fas(lprcg)/Fas(lprcg) mice

scientific article published on 01 October 2000

A pivotal role of cell-bound but not soluble CD4 molecules in full development of lupus-like manifestations in MRL-Fas(lprcg)/Fas(lprcg) mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1046/J.1365-2249.2000.01347.X
P932PMC publication ID1905752
P698PubMed publication ID11012628

P2093author name stringY Zhang
M Kimura
H Nagase
T Yasuda
A Matsuzawa
C R Wang
T Yoshimoto
M Takamoto
A Tsubura
P2860cites workLymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosisQ30080034
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Cryoglobulinemia induced by a murine IgG3 rheumatoid factor: skin vasculitis and glomerulonephritis arise from distinct pathogenic mechanismsQ33928012
Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative diseaseQ34602392
Host modifier genes affect mouse autoimmunity induced by the lpr geneQ35764934
Crescentic glomerulonephritis in CD4- and CD8-deficient mice. Requirement for CD4 but not CD8 cellsQ35765175
Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying lociQ36232118
A new allele of the lpr locus, lprcg, that complements the gld gene in induction of lymphadenopathy in the mouseQ36350481
Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr miceQ36362973
Molecular genetics of murine lupus modelsQ38692994
Fas and Fas ligand: lpr and gld mutationsQ40398275
Autoimmunity in mice bearing lprcg: a novel mutant geneQ40635194
Anti-CD4 monoclonal antibody therapy suppresses autoimmune disease in MRL/Mp-lpr/lpr miceQ41117425
Reduced development of CD4-8-B220+ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I moleculesQ41664431
The contribution of L3T4+ T cells to lymphoproliferation and autoantibody production in MRL-lpr/lpr miceQ42019842
Constitutive expression of high levels of soluble mouse CD4 in transgenic mice does not interfere with their immune functionQ44271114
Class II major histocompatibility complex-restricted T cell function in CD4-deficient miceQ45011727
Genetic determinants of autoimmune disease and coronary vasculitis in the MRL-lpr/lpr mouse model of systemic lupus erythematosus.Q45943164
Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells.Q52206363
Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndromeQ55670225
IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr miceQ60998067
Immunological characterization of C3H mice congenic for Fas(lprcg), C3h/HeJ-Fas(lprcg)/Fas(lprcg)Q64388610
Long-term anti-CD4 treatment of MRL/lpr mice ameliorates immunopathology and lymphoproliferation but fails to suppress rheumatoid factor productionQ68033777
Nephritogenicity of the lprcg gene on the MRL backgroundQ68046895
Binding of anti-DNA antibodies and inhibition of glomerulonephritis in MRL-lpr/lpr mice by heparinQ68575559
Treatment of murine lupus with monoclonal anti-T cell antibodyQ69863949
Murine models of systemic lupus erythematosusQ69894910
Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr/lpr miceQ71243470
In vivo CD4+ lymph node T cells from lpr mice generate CD4-CD8-B220+TCR-beta low cellsQ71651086
Reduction of mortality and lymphadenopathy in MRL-lpr/lpr mice treated with nonmitogenic anti-CD3 monoclonal antibodyQ72340231
Polyclonal B cell activation arises from different mechanisms in lupus-prone (NZB x NZW)F1 and MRL/MpJ-lpr/lpr miceQ72658815
Effects of early and late treatment with anti-CD4 monoclonal antibody on autoimmune disease in MRL/MP-lpr/lpr miceQ72670029
Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal diseaseQ72692778
Novel mutant mice secreting soluble CD4 without expression of membrane-bound CD4Q74375570
P433issue1
P304page(s)124-132
P577publication date2000-10-01
P1433published inClinical and Experimental ImmunologyQ15716708
P1476titleA pivotal role of cell-bound but not soluble CD4 molecules in full development of lupus-like manifestations in MRL-Fas(lprcg)/Fas(lprcg) mice
P478volume122

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