Statins in the critically ill

scientific article

Statins in the critically ill is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1015978304
P356DOI10.1186/2110-5820-2-19
P932PMC publication ID3488539
P698PubMed publication ID22709377
P5875ResearchGate publication ID227341106

P2093author name stringJean-Charles Preiser
Isabelle De Loecker
P2860cites workContinuation of Statin Therapy in Patients with Presumed InfectionQ59523754
Adherence to Lipid-lowering Therapy and the Use of Preventive Health Services: An Investigation of the Healthy User EffectQ59531972
Impact of statins and angiotensin-converting enzyme inhibitors on mortality of subjects hospitalised with pneumoniaQ60484520
Impact of Previous Statin and Angiotensin II Receptor Blocker Use on Mortality in Patients Hospitalized with SepsisQ60484529
Statins and sepsis: do we really need to further decrease monocyte HLA-DR expression to treat septic patients?Q60547640
Statin therapy prior to ICU admission: protection against infection or a severity marker?Q64135581
Decreased antioxidant status and increased lipid peroxidation in patients with septic shock and secondary organ dysfunctionQ72146881
Anti-inflammatory therapies to treat sepsis and septic shock: a reassessmentQ73536075
Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsisQ74181851
Long-term mortality and medical care charges in patients with severe sepsisQ79075244
The effect of statin therapy on infection-related mortality in patients with atherosclerotic diseasesQ79495597
Effects of acute pravastatin treatment on intensity of rescue therapy, length of inpatient stay, and 6-month outcome in patients after aneurysmal subarachnoid hemorrhageQ80108389
Influenza and COPD mortality protection as pleiotropic, dose-dependent effects of statinsQ80140729
Statins do not improve short-term survival in an oriental population with sepsisQ80418456
Statin use was not associated with less vasospasm or improved outcome after subarachnoid hemorrhageQ80997584
Septic shockQ81245367
Statin therapy is associated with fewer deaths in patients with bacteraemiaQ81470480
Statins in the management of aneurysmal subarachnoid hemorrhage--not (yet) a standard of careQ83270550
Meta-analysis of statins for aneurysmal subarachnoid hemorrhage falls shortQ83270556
Oxidative stressQ83388224
Comment on "Statin administration did not influence the progression of lung injury or associated organ failures in a cohort of patients with acute lung injury"Q83826745
Calcium antagonists for aneurysmal subarachnoid haemorrhageQ24244167
The effect of prior statin use on 30-day mortality for patients hospitalized with community-acquired pneumonia.Q24811721
Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domainQ27619685
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome NetworkQ27861021
SSRI and statin use increases the risk for vasospasm after subarachnoid hemorrhageQ28211026
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial responseQ28298985
Effect of statin treatment on short term mortality after pneumonia episode: cohort studyQ28741391
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive proteinQ29547752
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)Q29547825
The pathophysiology and treatment of sepsisQ29619103
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study GroupQ29619842
Association of statin therapy and increased survival in patients with multiple organ dysfunction syndromeQ30320030
The antioxidant defense protein heme oxygenase 1 is a novel target for statins in endothelial cellsQ30320333
Rosuvastatin upregulates the antioxidant defense protein heme oxygenase-1.Q30320421
Tidal volume reduction in patients with acute lung injury when plateau pressures are not highQ30489181
Cellular antioxidant effects of atorvastatin in vitro and in vivoQ30809431
Why immunomodulatory therapies have not worked in sepsisQ33693724
Preadmission statin use and one-year mortality among patients in intensive care - a cohort studyQ33919029
Normal responses to injury prevent systemic inflammation and can be immunosuppressiveQ34141225
Prehemorrhage statin use and the risk of vasospasm after aneurysmal subarachnoid hemorrhageQ34271800
The effect of statins on mortality in patients with bacteremiaQ34374856
Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitorsQ34432988
Simvastatin decreases nitric oxide overproduction and reverts the impaired vascular responsiveness induced by endotoxic shock in ratsQ34545086
The safety of statins in clinical practiceQ34636135
Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndromeQ35007498
Effect of statin treatment on vasospasm, delayed cerebral ischemia, and functional outcome in patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis updateQ35010436
Understanding the potential role of statins in pneumonia and sepsisQ35116076
Statins and outcomes in patients admitted to hospital with community acquired pneumonia: population based prospective cohort studyQ35128843
Current overview of statin-induced myopathyQ35684789
Diffuse alveolar damage--the role of oxygen, shock, and related factors. A reviewQ36078168
Recently published papers: Sepsis, glucose control and patient-doctor relationshipsQ36641996
Acute lung injury and the acute respiratory distress syndrome in Ireland: a prospective audit of epidemiology and managementQ36642058
Immunostimulation is a rational therapeutic strategy in sepsisQ36767892
A randomized, double-blind, placebo-controlled pilot study of simvastatin in aneurysmal subarachnoid hemorrhageQ46460439
Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytesQ46463155
Statin treatment after onset of sepsis in a murine model improves survivalQ46584997
Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage: a phase II randomized placebo-controlled trialQ46622603
Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trialQ46624720
Simvastatin suppresses endotoxin-induced upregulation of toll-like receptors 4 and 2 in vivo.Q46916581
Simvastatin in aneurysmal subarachnoid haemorrhage (STASH): a multicentre randomised phase 3 trialQ46977957
Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland.Q47614282
Sustained increased cerebral blood flow with prophylactic hypertensive hypervolemic hemodilution ("triple-H" therapy) after subarachnoid hemorrhageQ48864563
Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units.Q50738804
Predictive value of monocyte histocompatibility leukocyte antigen-DR expression and plasma interleukin-4 and -10 levels in critically ill patients with sepsis.Q51294957
Time course of C-reactive protein reduction with simvastatin therapy in patients with type 2 diabetes mellitus.Q51484046
Plasma antioxidant potential in severe sepsis: a comparison of survivors and nonsurvivors.Q51568511
Statins are associated with improved outcomes of bloodstream infection in solid-organ transplant recipients.Q51864833
Effectiveness of statins in reducing the rate of severe sepsis: a retrospective evaluation.Q53244439
Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury.Q53662097
Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) studyQ57021865
Statins, vitamin D, and severe sepsisQ57200523
Statin use and mortality within 180 days after bacteremia: A population-based cohort study*Q57300690
A Randomized Clinical Trial of Hydroxymethylglutaryl– Coenzyme A Reductase Inhibition for Acute Lung Injury (The HARP Study)Q57913605
Statins and sepsis: multiple modifications at multiple levels.Q36797719
Role of statins in cerebral vasospasmQ37154638
Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsisQ37198654
Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteersQ37225099
Statin use and risk of community acquired pneumonia in older people: population based case-control studyQ37229844
Statin adherence and risk of accidents: a cautionary tale.Q37347962
Simvastatin for the prevention of symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage: a single-institution prospective cohort studyQ37387209
Activation and regulation of systemic inflammation in ARDS: rationale for prolonged glucocorticoid therapyQ37607923
Statins in the management of patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysisQ37634417
The effect of statins on mortality from severe infections and sepsis: a systematic review and meta-analysisQ37736067
Clinical practice. Vitamin D insufficiencyQ37830043
Immunomodulatory agents in the treatment of community-acquired pneumonia: a systematic review.Q37901715
Effects of methylprednisolone infusion on markers of inflammation, coagulation, and angiogenesis in early acute respiratory distress syndromeQ38407730
Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injuryQ38521023
Statin therapy is associated with decreased mortality in patients with infectionQ39877436
Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial.Q40453111
A preliminary study of atorvastatin plasma concentrations in critically ill patients with sepsis.Q42604349
Rosuvastatin and vitamin D: might there be hypovitaminosis D on JUPITER?Q43014569
Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin siteQ43625666
Withdrawal of statins increases event rates in patients with acute coronary syndromesQ43933090
Simvastatin lowers C-reactive protein within 14 days: an effect independent of low-density lipoprotein cholesterol reductionQ44138516
Simvastatin inhibits inflammatory properties of Staphylococcus aureus alpha-toxinQ44179197
Possible role of increased oxidant stress in multiple organ failure after systemic inflammatory response syndromeQ44184903
Do statins improve outcomes and reduce the incidence of vasospasm after aneurysmal subarachnoid hemorrhage: a meta-analysisQ44191718
Statins and sepsis in patients with cardiovascular disease: a population-based cohort analysisQ44277349
Statins and the risk of pneumonia: a population-based, nested case-control studyQ44356684
Statin effects on cholesterol micro-domains in brain plasma membranesQ44356716
Reduction in mortality associated with statin therapy in patients with severe sepsisQ44463455
HMG-CoA reductase inhibitors inhibit inducible nitric oxide synthase gene expression in macrophagesQ44490081
Simvastatin ameliorates injury in an experimental model of lung ischemia-reperfusionQ44556166
Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulationQ44576675
Fluvastatin treatment inhibits leucocyte adhesion and extravasation in models of complement-mediated acute inflammation.Q44738348
HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsisQ44880979
Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection.Q45037051
A role for hydroxy-methylglutaryl coenzyme a reductase in pulmonary inflammation and host defense.Q45183033
Preadmission use of statins and outcomes after hospitalization with pneumonia: population-based cohort study of 29,900 patientsQ45240501
Adenovirus-mediated transfer of heme oxygenase-1 cDNA attenuates severe lung injury induced by the influenza virus in miceQ45735385
The impact of statins, ACE inhibitors and gastric acid suppressants on pneumonia mortality in a UK general practice population cohortQ45894119
Statins and vitamin D : editorial to: "increased levels of 25 hydroxyvitamin D and 1,25-dihydroxyvitamin D after rosuvastatin treatment: a novel pleiotropic effect of statins?" by Bunyamin Yavuz et al.Q45925295
Biologic effects of simvastatin in patients with aneurysmal subarachnoid hemorrhage: a double-blind, placebo-controlled randomized trial.Q46003090
Statins may not protect against vasospasm in subarachnoid haemorrhage.Q46115414
The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: a randomized double-blind placebo controlled clinical trialQ46127227
Prior statin use is associated with improved outcomes in community-acquired pneumoniaQ46292549
Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expressionQ46433219
A case control study of statin and magnesium administration in patients after aneurysmal subarachnoid hemorrhage: incidence of delayed cerebral ischemia and mortalityQ46437410
P433issue1
P304page(s)19
P577publication date2012-06-18
P1433published inAnnals of Intensive CareQ18712109
P1476titleStatins in the critically ill
P478volume2

Reverse relations

cites work (P2860)
Q64882879A possible association between statin use and improved Clostridioides difficile infection mortality in veterans.
Q38285554Acute respiratory distress syndrome on the intensive care unit
Q43568688Combined administration of RG7652, a recombinant human monoclonal antibody against PCSK9, and atorvastatin does not result in reduction of immune function
Q41338177Combined treatment with atorvastatin and imipenem improves survival and vascular functions in mouse model of sepsis
Q38921506Effect of Statins on the Mortality of Bacteremic Patients: A Systematic Review and Meta-analysis of Clinical Trials
Q58584684Improved survival with continuation of statins in bacteremic patients
Q64906632Lipid profile and statin use in critical care setting: implications for kidney outcome.
Q52138888Neurologic Complications in the Intensive Care Unit.
Q34413797New treatments for influenza
Q38245046Pathogenesis and host defence against Mucorales: the role of cytokines and interaction with antifungal drugs
Q41975149Pharmacological interventions in acute respiratory distress syndrome
Q35230483Prescribing Patterns of Drugs in Acute Respiratory Distress Syndrome (ARDS): An Observational Study
Q35603020Sepsis outcomes in patients receiving statins prior to hospitalization for sepsis: comparison of in-hospital mortality rates between patients who received atorvastatin and those who received simvastatin.
Q90732855Simvastatin Enhances the Immune Response Against Mycobacterium tuberculosis
Q93046928Statin use and Vital Organ Failure in Patients With Asthma-Chronic Obstructive Pulmonary Disease Overlap: A Time-Dependent Population-Based Study
Q37265029Systematic review of statins in sepsis: There is no evidence of dose response.

Search more.