PARN deadenylase is involved in miRNA-dependent degradation of TP53 mRNA in mammalian cells

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PARN deadenylase is involved in miRNA-dependent degradation of TP53 mRNA in mammalian cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKV959
P932PMC publication ID4678859
P698PubMed publication ID26400160
P5875ResearchGate publication ID282153124

P2093author name stringFrida E Kleiman
Xiaokan Zhang
Michael R Murphy
Mirjana Persaud
Emral Devany
Galina Glazman
P2860cites workSystematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundanceQ21090092
BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.Q24302667
Nuclear deadenylation/polyadenylation factors regulate 3' processing in response to DNA damageQ24306262
Ubiquitin-mediated proteolysis of HuR by heat shockQ24309514
The deadenylating nuclease (DAN) is involved in poly(A) tail removal during the meiotic maturation of Xenopus oocytes.Q24312841
AU-rich elements and associated factors: are there unifying principles?Q24535929
The mechanism and regulation of deadenylation: identification and characterization of Xenopus PARNQ24540032
CUG-BP binds to RNA substrates and recruits PARN deadenylaseQ24544335
Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sitesQ24653978
A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53Q24657532
HuR recruits let-7/RISC to repress c-Myc expressionQ24657731
Tristetraprolin and Its Family Members Can Promote the Cell-Free Deadenylation of AU-Rich Element-Containing mRNAs by Poly(A) RibonucleaseQ24673281
Determinants and implications of mRNA poly(A) tail size--does this protein make my tail look big?Q26865066
The structure and function of the eukaryotic ribosomeQ27022315
Involvement of microRNA in AU-rich element-mediated mRNA instabilityQ28118466
A 54-kDa fragment of the Poly(A)-specific ribonuclease is an oligomeric, processive, and cap-interacting Poly(A)-specific 3' exonucleaseQ28143855
The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppressionQ28205420
Identification of the active site of poly(A)-specific ribonuclease by site-directed mutagenesis and Fe(2+)-mediated cleavageQ28210768
Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnoverQ28281490
Localization of AU-rich element-containing mRNA in cytoplasmic granules containing exosome subunitsQ28300045
miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodelingQ28304542
Poly(A) tail shortening by a mammalian poly(A)-specific 3'-exoribonucleaseQ28307408
Cytoplasmic 5'-3' exonuclease Xrn1p is also a genome-wide transcription factor in yeast.Q29346872
Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cellsQ29615863
Polyamine Depletion Increases Cytoplasmic Levels of RNA-binding Protein HuR Leading to Stabilization of Nucleophosmin and p53 mRNAsQ30051907
HNS, a nuclear-cytoplasmic shuttling sequence in HuRQ33579107
A PASport to cellular proliferation.Q53463555
Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways.Q54328681
Studying RNA–Protein Interactions In Vivo By RNA ImmunoprecipitationQ57230552
Expression and purification of recombinant poly(A)-specific ribonuclease (PARN)Q83168208
Distinct passenger strand and mRNA cleavage activities of human Argonaute proteinsQ84962168
Deadenylation of mRNA by the CCR4-NOT complex in Drosophila: molecular and developmental aspectsQ33660244
Negative regulation of tumor suppressor p53 by microRNA miR-504Q33979178
AU-rich element-mediated mRNA decay can occur independently of the miRNA machinery in mouse embryonic fibroblasts and Drosophila S2-cellsQ34130321
Negative regulation of the tumor suppressor p53 gene by microRNAs.Q34142778
To polyadenylate or to deadenylate: that is the questionQ34150385
The complex transcriptional landscape of the anucleate human plateletQ34549628
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiationQ35168095
Genomic analyses of the RNA-binding protein Hu antigen R (HuR) identify a complex network of target genes and novel characteristics of its binding sitesQ35423239
Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stabilityQ35562869
Connections between 3'-end processing and DNA damage responseQ35588235
Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cellsQ35780150
Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimmingQ35907950
NF-κB-dependent microRNA-125b up-regulation promotes cell survival by targeting p38α upon ultraviolet radiationQ36294827
A molecular link between miRISCs and deadenylases provides new insight into the mechanism of gene silencing by microRNAsQ36418018
Role of RNA binding protein HuR in ductal carcinoma in situ of the breastQ36418983
Positive and negative feedback loops in the p53 and mRNA 3' processing pathwaysQ36653865
MicroRNA miR-30 family regulates non-attachment growth of breast cancer cellsQ36697933
Nucleolin mediates microRNA-directed CSF-1 mRNA deadenylation but increases translation of CSF-1 mRNA.Q36910809
MicroRNA-directed transcriptional gene silencing in mammalian cellsQ36945167
Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development.Q37160188
siRNA modifications and sub-cellular localization: a question of intracellular transport?Q37347459
3' UTR-isoform choice has limited influence on the stability and translational efficiency of most mRNAs in mouse fibroblastsQ37358020
The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich elementQ37412430
Expanded RNA-binding activities of mammalian Argonaute 2.Q37477536
Global changes in processing of mRNA 3' untranslated regions characterize clinically distinct cancer subtypesQ37480345
Distinct roles of the R3H and RRM domains in poly(A)-specific ribonuclease structural integrity and catalysis.Q38317893
p53 inhibits mRNA 3' processing through its interaction with the CstF/BARD1 complexQ39579705
MicroRNA-125b is a novel negative regulator of p53.Q39871732
MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage responseQ41911349
Poly(A)-specific ribonuclease mediates 3'-end trimming of Argonaute2-cleaved precursor microRNAsQ42136359
Alterations of deadenylase expression in acute leukemias: evidence for poly(a)-specific ribonuclease as a potential biomarker.Q46970131
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue22
P407language of work or nameEnglishQ1860
P304page(s)10925-10938
P577publication date2015-09-22
P1433published inNucleic Acids ResearchQ135122
P1476titlePARN deadenylase is involved in miRNA-dependent degradation of TP53 mRNA in mammalian cells
P478volume43

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cites work (P2860)
Q37644513A feedback mechanism between PLD and deadenylase PARN for the shortening of eukaryotic poly(A) mRNA tails that is deregulated in cancer cells
Q49682959A poly(A) ribonuclease controls the cellotriose-based interaction between Piriformospora indica and its host Arabidopsis
Q38924996Expanding the repertoire of deadenylases.
Q47862483FXR1a-associated microRNP: A driver of specialized non-canonical translation in quiescent conditions
Q47721202How miRs and mRNA deadenylases could post-transcriptionally regulate expression of tumor-promoting protein PLD.
Q91627344Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models
Q41827348Interplay between RNA-binding protein HuR and microRNA-125b regulates p53 mRNA translation in response to genotoxic stress
Q37001441Intronic cleavage and polyadenylation regulates gene expression during DNA damage response through U1 snRNA
Q28854360Mammalian PNLDC1 is a novel poly(A) specific exonuclease with discrete expression during early development
Q64105081MicroRNAs as Molecular Switches in Macrophage Activation
Q47371346Nucleolin phosphorylation regulates PARN deadenylase activity during cellular stress response.
Q60949698Shrimp miR-1000 Functions in Antiviral Immunity by Simultaneously Triggering the Degradation of Two Viral mRNAs
Q90399991Surveillance of Tumour Development: The Relationship Between Tumour-Associated RNAs and Ribonucleases
Q55180659The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure.
Q92455061The Intrinsically Disordered C-Terminal Domain Triggers Nucleolar Localization and Function Switch of PARN in Response to DNA Damage
Q91631598The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation
Q61809258The microRNA and the perspectives of miR-302
Q64069116The p53 mRNA: an integral part of the cellular stress response
Q60264991The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells
Q92635734Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN)