The structure and function of the eukaryotic ribosome

scientific article

The structure and function of the eukaryotic ribosome is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1101/CSHPERSPECT.A011536
P3181OpenCitations bibliographic resource ID874808
P932PMC publication ID3331703
P698PubMed publication ID22550233

P50authorDaniel N. WilsonQ41599954
P2093author name stringJamie H Doudna Cate
P2860cites workStructural rearrangements of the ribosome at the tRNA proofreading stepQ57980812
Eukaryotic initiation factor 3 does not prevent association through physical blockage of the ribosomal subunit-subunit interfaceQ68227316
The Elongation Factor 3 Unique in Higher Fungi and Essential for Protein Biosynthesis Is an E Site FactorQ72017042
Replacement of L7/L12.L10 protein complex in Escherichia coli ribosomes with the eukaryotic counterpart changes the specificity of elongation factor bindingQ72993743
A comparison of the yeast and rabbit 80 S ribosome reveals the topology of the nascent chain exit tunnel, inter-subunit bridges and mammalian rRNA expansion segmentsQ74112933
Structural analyses of peptide release factor 1 from Thermotoga maritima reveal domain flexibility required for its interaction with the ribosomeQ80456132
Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndromeQ24301073
The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitroQ24302384
Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivoQ24540322
Structures of the bacterial ribosome in classical and hybrid states of tRNA bindingQ24635922
Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosomeQ24647686
The comparative RNA web (CRW) site: an online database of comparative sequence and structure information for ribosomal, intron, and other RNAsQ24802442
The crystal structure of human eukaryotic release factor eRF1--mechanism of stop codon recognition and peptidyl-tRNA hydrolysisQ27621393
Solution structure of the E. coli 70S ribosome at 11.5 A resolutionQ27621780
The complete atomic structure of the large ribosomal subunit at 2.4 A resolutionQ27626400
The structural basis of ribosome activity in peptide bond synthesisQ27626414
Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolutionQ27627220
Structure of the 30S ribosomal subunitQ27627261
Structural basis for nucleotide exchange and competition with tRNA in the yeast elongation factor complex eEF1A:eEF1BalphaQ27628860
Crystal structure of the ribosome at 5.5 A resolutionQ27630949
High resolution structure of the large ribosomal subunit from a mesophilic eubacteriumQ27636568
Bacterial polypeptide release factor RF2 is structurally distinct from eukaryotic eRF1Q27637184
Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocaseQ27640976
Locking and unlocking of ribosomal motionsQ27641675
Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunitQ27642366
Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocationQ27643165
Structures of modified eEF2 80S ribosome complexes reveal the role of GTP hydrolysis in translocationQ27644523
Eukaryotic initiation factor (eIF) 1 carries two distinct eIF5-binding faces important for multifactor assembly and AUG selectionQ27648930
Structure of the Mammalian 80S Ribosome at 8.7 Å ResolutionQ27650283
Visualization of the eEF2–80S Ribosome Transition-State Complex by Cryo-Electron MicroscopyQ27651281
Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating RibosomeQ27658307
Structural insight into nascent polypeptide chain-mediated translational stalling.Q27658309
Comprehensive Molecular Structure of the Eukaryotic RibosomeQ27658581
eIF1 controls multiple steps in start codon recognition during eukaryotic translation initiationQ37441324
Begin at the beginning: evolution of translational initiationQ37540901
A structural view on the mechanism of the ribosome-catalyzed peptide bond formationQ37549187
The role of mRNA structure in translational control in bacteriaQ37626653
Spatially restricting gene expression by local translation at synapsesQ37715121
The ribosomal tunnel as a functional environment for nascent polypeptide folding and translational stallingQ37840649
The mechanism of peptidyl transfer catalysis by the ribosomeQ37872768
Translational control by 80S formation and 60S availability: the central role of eIF6, a rate limiting factor in cell cycle progression and tumorigenesis.Q37949891
On the specificity of antibiotics targeting the large ribosomal subunit.Q37970717
Comparative analysis of ribosomal proteins in complete genomes: an example of reductive evolution at the domain scaleQ39696564
alpha-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnelQ41619420
Structure of the signal recognition particle interacting with the elongation-arrested ribosome.Q41628639
Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complexQ41633493
A model of protein synthesis based on cryo-electron microscopy of the E. coli ribosomeQ41634310
Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformationQ41871917
The role of ABCE1 in eukaryotic posttermination ribosomal recyclingQ41929275
The fidelity of translation initiation: reciprocal activities of eIF1, IF3 and YciH.Q42043465
A trans-membrane segment inside the ribosome exit tunnel triggers RAMP4 recruitment to the Sec61p translocase.Q43092073
Distinct functions of elongation factor G in ribosome recycling and translocationQ43141504
The crystal structure of eEF1A refines the functional predictions of an evolutionary analysis of rate changes among elongation factorsQ43937252
Signal sequence-independent membrane targeting of ribosomes containing short nascent peptides within the exit tunnelQ44364537
The roles of ribosomal proteins in the structure assembly, and evolution of the large ribosomal subunitQ44926888
Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins.Q47987631
Architecture of the protein-conducting channel associated with the translating 80S ribosomeQ49485686
In vitro reconstitution of eukaryotic translation reveals cooperativity between release factors eRF1 and eRF3Q52162413
Localization and dynamic behavior of ribosomal protein L30e.Q52938850
Cryo-EM visualization of a viral internal ribosome entry site bound to human ribosomes: the IRES functions as an RNA-based translation factor.Q54501268
Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM.Q55038938
Crystal structure of the 30 s ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 s RNAQ56396627
Mapping the electrostatic potential within the ribosomal exit tunnelQ57132363
The Geometry of the Ribosomal Polypeptide Exit TunnelQ57954617
Mechanism of eIF6-mediated Inhibition of Ribosomal Subunit JoiningQ27660379
Structural aspects of messenger RNA reading frame maintenance by the ribosomeQ27660608
Structure of the Dom34-Hbs1 complex and implications for no-go decayQ27664879
Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptideQ27664949
Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolutionQ27665394
The Mechanism for Activation of GTP Hydrolysis on the RibosomeQ27665613
Crystal structure of the eukaryotic ribosomeQ27666069
Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1Q27666453
How mutations in tRNA distant from the anticodon affect the fidelity of decodingQ27667189
Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosomeQ27668080
Structure and Dynamics of the Mammalian Ribosomal Pretranslocation ComplexQ27675157
Crystal structure of the eukaryotic 60S ribosomal subunit in complex with initiation factor 6Q27675379
The structure of the eukaryotic ribosome at 3.0 Å resolutionQ27675638
Structural basis of highly conserved ribosome recycling in eukaryotes and archaeaQ27677430
Structure of the 70S ribosome complexed with mRNA and tRNAQ27860602
Structures of the bacterial ribosome at 3.5 A resolutionQ27860848
rRNA suppressor of a eukaryotic translation initiation factor 5B/initiation factor 2 mutant reveals a binding site for translational GTPases on the small ribosomal subunit.Q27934058
The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosomeQ27934357
The iron-sulphur protein RNase L inhibitor functions in translation terminationQ27936576
The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeastQ27936929
The nucle(ol)ar Tif6p and Efl1p are required for a late cytoplasmic step of ribosome synthesis.Q27938566
Regulation of translation initiation in eukaryotes: mechanisms and biological targetsQ28111696
Following the signal sequence from ribosomal tunnel exit to signal recognition particleQ28272496
Eukaryotic initiation factors eIF-2 and eIF-3: interactions, structure and localization in ribosomal initiation complexesQ28297357
Translation elongation by a hybrid ribosome in which proteins at the GTPase center of the Escherichia coli ribosome are replaced with rat counterpartsQ28583841
The DARC site: a database of aligned ribosomal complexesQ28740963
The mechanism of eukaryotic translation initiation and principles of its regulationQ29547270
Structure of the 80S ribosome from Saccharomyces cerevisiae--tRNA-ribosome and subunit-subunit interactionsQ29614569
Hepatitis C virus IRES RNA-induced changes in the conformation of the 40s ribosomal subunitQ29619046
A posttermination ribosomal complex is the guanine nucleotide exchange factor for peptide release factor RF3.Q31015410
Ribosomal RNAs are tolerant toward genetic insertions: evolutionary origin of the expansion segmentsQ33331698
Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosomeQ33573600
Position of eukaryotic initiation factor eIF1 on the 40S ribosomal subunit determined by directed hydroxyl radical probingQ33589752
SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase centerQ33803719
The structure of the 80S ribosome from Trypanosoma cruzi reveals unique rRNA componentsQ33895767
The Cryo-EM structure of a complete 30S translation initiation complex from Escherichia coliQ33959135
The eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivoQ34116876
The C-terminal region of eukaryotic translation initiation factor 3a (eIF3a) promotes mRNA recruitment, scanning, and, together with eIF3j and the eIF3b RNA recognition motif, selection of AUG start codons.Q34119657
Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosomeQ34166370
When ribosomes go bad: diseases of ribosome biogenesisQ34248659
The mechanism of eukaryotic translation initiation: new insights and challengesQ34289214
Localization of eukaryote-specific ribosomal proteins in a 5.5-Å cryo-EM map of the 80S eukaryotic ribosomeQ34359294
The cryo-EM structure of a translation initiation complex from Escherichia coliQ34423776
Structural insights into translational fidelityQ34426043
The 80S rat liver ribosome at 25 A resolution by electron cryomicroscopy and angular reconstitutionQ34464904
Structural roles for human translation factor eIF3 in initiation of protein synthesisQ34472092
Signal recognition particle receptor exposes the ribosomal translocon binding site.Q34522101
Release of initiation factors from 48S complexes during ribosomal subunit joining and the link between establishment of codon-anticodon base-pairing and hydrolysis of eIF2-bound GTP.Q34553474
Regulatory nascent peptides in the ribosomal tunnelQ34563139
Structure of eEF3 and the mechanism of transfer RNA release from the E-siteQ34570311
Structure of the ribosome-bound cricket paralysis virus IRES RNA.Q34582937
Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivoQ34628703
eIF3j is located in the decoding center of the human 40S ribosomal subunitQ34641203
Linear ubiquitin fusion to Rps31 and its subsequent cleavage are required for the efficient production and functional integrity of 40S ribosomal subunitsQ34942783
Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunitQ35088062
Molecular mechanism of scanning and start codon selection in eukaryotesQ35192105
The Birth of a ChannelQ35558419
N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selectionQ35691356
The eIF3c/NIP1 PCI domain interacts with RNA and RACK1/ASC1 and promotes assembly of translation preinitiation complexesQ35860658
The yeast eIF3 subunits TIF32/a, NIP1/c, and eIF5 make critical connections with the 40S ribosome in vivo.Q35964439
An rRNA variable region has an evolutionarily conserved essential role despite sequence divergenceQ36655518
eIF3a cooperates with sequences 5' of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA.Q36869067
Structural studies of elongation and release factorsQ37063056
A signal-anchor sequence stimulates signal recognition particle binding to ribosomes from inside the exit tunnelQ37068989
Electrostatics in the ribosomal tunnel modulate chain elongation ratesQ37127214
Physiological roles of ribosomal protein S6: one of its kindQ37243586
Position of eukaryotic translation initiation factor eIF1A on the 40S ribosomal subunit mapped by directed hydroxyl radical probing.Q37318477
A structural view of translation initiation in bacteriaQ37326466
P433issue5
P407language of work or nameEnglishQ1860
P577publication date2012-05-01
P1433published inCold Spring Harbor Perspectives in BiologyQ3927509
P1476titleThe structure and function of the eukaryotic ribosome
P478volume4

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