The protease cathepsin L regulates Th17 cell differentiation

scientific article

The protease cathepsin L regulates Th17 cell differentiation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JAUT.2015.08.006
P932PMC publication ID4679515
P698PubMed publication ID26343333
P5875ResearchGate publication ID281455101

P50authorRobert N. PikeQ47502140
Matthew BogyoQ87128638
P2093author name stringEileen Remold-O'Donnell
Jessica Cooley
Lifei Hou
Richard Swanson
Steven T Olson
Poh Chee Ong
P2860cites workTGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat functionQ24314628
L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and LQ24531160
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivoQ24600773
Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infectionQ24629018
The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infectionQ24676095
Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophagesQ24676370
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsQ27860620
The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sitesQ28211676
Serpin structure, mechanism, and functionQ28217095
Transforming growth factor-beta induces development of the T(H)17 lineageQ28237370
Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient miceQ28513876
A validated regulatory network for Th17 cell specificationQ28586624
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17Q29547855
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesQ29547871
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathwaysQ29614839
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclatureQ29618777
Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery toolsQ30950444
The role of lysosomal proteinases in MHC class II-mediated antigen processing and presentationQ33815394
Gene targeting of the cysteine peptidase cathepsin H impairs lung surfactant in miceQ34056201
Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumainQ34127426
Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.Q35141261
Dynamic regulatory network controlling TH17 cell differentiationQ36799525
Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclastsQ36800896
Intracellular complement activation sustains T cell homeostasis and mediates effector differentiationQ37397572
SerpinB1 regulates homeostatic expansion of IL-17+ γδ and CD4+ Th17 cells.Q37581430
Specialized roles for cysteine cathepsins in health and disease.Q37797839
Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice.Q46499913
Identification of early gene expression changes during human Th17 cell differentiation.Q54440476
Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivoQ73077056
Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorptionQ77449793
P921main subjectcell differentiationQ210861
P304page(s)56-63
P577publication date2015-09-03
P1433published inJournal of AutoimmunityQ15716783
P1476titleThe protease cathepsin L regulates Th17 cell differentiation
P478volume65

Reverse relations

cites work (P2860)
Q37239169An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells
Q58566649Asparaginyl Endopeptidase (Legumain) Supports Human Th1 Induction via Cathepsin L-Mediated Intracellular C3 Activation
Q47196269Complement as a regulator of adaptive immunity
Q90290679Cysteine Cathepsins in Tumor-Associated Immune Cells
Q33863687Ethyl Caffeate Ameliorates Collagen-Induced Arthritis by Suppressing Th1 Immune Response
Q94559865Harnessing proteases for T regulatory cell immunotherapy
Q92965325Latent-period stool proteomic assay of multiple sclerosis model indicates protective capacity of host-expressed protease inhibitors
Q39181451Mold and Human Health: a Reality Check
Q58699937Multiple Sclerosis-Associated Changes in the Composition and Immune Functions of Spore-Forming Bacteria
Q90240437SerpinB1 controls encephalitogenic T helper cells in neuroinflammation
Q52401205Tsc1-dependent transcriptional programming of dendritic cell homeostasis and function.

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