Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice

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Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.190.5.691
P8608Fatcat IDrelease_nse5e5ipgfahfanuiwabaqhv3m
P932PMC publication ID2195620
P698PubMed publication ID10477553
P5875ResearchGate publication ID12821678

P2093author name stringS Litwin
M Weigert
E L Prak
F Brard
M Shannon
P2860cites workSomatic hypermutation introduces insertions and deletions into immunoglobulin V genesQ24652779
The Fas death factorQ29620461
Clonal deletion of autoreactive B lymphocytes in bone marrow chimerasQ34313426
Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambdaQ35331370
V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signallingQ35911221
Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 miceQ36231704
Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutationQ36350233
Receptor editing: an approach by autoreactive B cells to escape toleranceQ36361497
Receptor editing in self-reactive bone marrow B cellsQ36361578
B lymphocytes may escape tolerance by revising their antigen receptorsQ36361618
Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytesQ36363024
Light chain editing in kappa-deficient animals: a potential mechanism of B cell toleranceQ36364008
Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosusQ36364520
Immunoglobulin chain loss in hybridoma linesQ36364766
Light chain replacement: a new model for antibody gene rearrangementQ36365220
Regulation of anti-DNA B cells in recombination-activating gene-deficient miceQ36401575
Efficient peripheral clonal elimination of B lymphocytes in MRL/lpr mice bearing autoantibody transgenesQ36404207
Antinuclear antibodies: diagnostic markers and clues to the basis of systemic autoimmunityQ38190657
A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavageQ38349361
Genetic and structural evidence for antigen selection of anti-DNA antibodies.Q40661152
Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigensQ41170875
The lupus autoantigens and the pathogenesis of systemic lupus erythematosusQ41355812
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.Q41423746
Ig H and L chain contributions to autoimmune specificitiesQ42623521
Residues that mediate DNA binding of autoimmune antibodiesQ42799912
Variable region genes of anti-histone autoantibodies from a MRL/Mp-lpr/lpr mouseQ42800186
Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesisQ43586184
Linked sets of antinuclear antibodies: what do they mean?Q44218886
CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cellsQ45971909
DNA-binding antibodies from viable motheaten mutant mice: implications for B cell toleranceQ48045089
Light chain contribution to specificity in anti-DNA antibodiesQ48070592
B cell selection and allelic exclusion of an anti-DNA Ig transgene in MRL-lpr/lpr mice.Q48074053
The mechanism of autoantibody production in an autoimmune MRL/lpr mouse.Q48077827
V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr miceQ48132884
A new role for B cells in systemic autoimmunity: B cells promote spontaneous T cell activation in MRL-lpr/lpr mice.Q52039800
Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells.Q54177718
Expression of anti-DNA immunoglobulin transgenes in non-autoimmune miceQ59065295
The role of clonal selection and somatic mutation in autoimmunityQ59082893
Oligoclonality of rheumatoid factors arising spontaneously in lpr/lpr miceQ68256179
Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcriptionQ69230362
Analysis of central B cell tolerance in autoimmune-prone MRL/lpr mice bearing autoantibody transgenesQ71197127
Immunoglobulin heavy chain gene replacement: a mechanism of receptor editingQ71457193
Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cellsQ71854871
Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cellsQ71854877
Effects of the lpr mutation on elimination and inactivation of self-reactive B cellsQ72166872
Editing disease-associated autoantibodiesQ73115270
Characterization of B cells expressing recombination activating genes in germinal centers of immunized mouse lymph nodesQ73128594
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)691-704
P577publication date1999-09-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleSomatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice
P478volume190

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cites work (P2860)
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