Doxorubicin-Hyaluronan Conjugated Super-Paramagnetic Iron Oxide Nanoparticles (DOX-HA-SPION) Enhanced Cytoplasmic Uptake of Doxorubicin and Modulated Apoptosis, IL-6 Release and NF-kappaB Activity in Human MDA-MB-231 Breast Cancer Cells

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Doxorubicin-Hyaluronan Conjugated Super-Paramagnetic Iron Oxide Nanoparticles (DOX-HA-SPION) Enhanced Cytoplasmic Uptake of Doxorubicin and Modulated Apoptosis, IL-6 Release and NF-kappaB Activity in Human MDA-MB-231 Breast Cancer Cells is …
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scholarly articleQ13442814

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P356DOI10.1166/JNN.2015.10834
P932PMC publication ID4681409
P698PubMed publication ID26690867

P50authorXuefei HuangQ39185199
P2093author name stringDinesh Vyas
Marc D Basson
Mary F Walsh
Arpita K Vyas
Lakshmi S Chaturvedi
M El-Dakdouki
Nicolas Lopez-Hisijos
Sulakshana Gandhi
P2860cites workChemotherapy-enhanced inflammation may lead to the failure of therapy and metastasisQ26858839
Towards a targeted multi-drug delivery approach to improve therapeutic efficacy in breast cancerQ28291499
Molecular definition of breast tumor heterogeneityQ28292256
Time for more optimism in metastatic breast cancer?Q30354522
Assessing the in vivo efficacy of doxorubicin loaded hyaluronan nanoparticlesQ30570691
Development of drug loaded nanoparticles for tumor targeting. Part 1: Synthesis, characterization, and biological evaluation in 2D cell culturesQ30607164
Tumor ablation with radio-frequency energyQ30620718
Propofol's effects on phagocytosis, proliferation, nitrate production, and cytokine secretion in pressure-stimulated microglial cellsQ33450850
Synthesis and Characterization of Thermo-Sensitive Nanoparticles for Drug Delivery ApplicationsQ33595897
Multifunctional Stable and pH-Responsive Polymer Vesicles Formed by Heterofunctional Triblock Copolymer for Targeted Anticancer Drug Delivery and Ultrasensitive MR ImagingQ33722416
Evolution of breast cancer therapeutics: Breast tumour kinase's role in breast cancer and hope for breast tumour kinase targeted therapyQ34023653
Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die on basis of high IL-6 levels.Q34049911
Hormonal therapy of breast cancerQ34054302
Development of Receptor Targeted Magnetic Iron Oxide Nanoparticles for Efficient Drug Delivery and Tumor ImagingQ34069767
Effect of adriamycin on DNA, RNA, and protein synthesis in cell-free systems and intact cellsQ34200724
National Institutes of Health Consensus Development Conference Statement: adjuvant therapy for breast cancer, November 1-3, 2000.Q34299708
Autocrine IL-6 signaling: a key event in tumorigenesis?Q34732166
The role of nitric oxide in cancerQ35045661
Polyacrylic acid modified upconversion nanoparticles for simultaneous pH-triggered drug delivery and release imagingQ35050793
Enhanced 4T1 breast carcinoma anticancer activity by co-delivery of doxorubicin and curcumin with core-shell drug-carrier based on heparin modified poly(L-lactide) grafted polyethylenimine cationic nanoparticlesQ35149949
Doxorubicin loaded pH-responsive micelles capable of rapid intracellular drug release for potential tumor therapyQ35205959
Overview of bevacizumab: a new cancer therapeutic strategy targeting vascular endothelial growth factorQ35955367
Modulation of eIF5A expression using SNS01 nanoparticles inhibits NF-κB activity and tumor growth in murine models of multiple myelomaQ36085366
NF-kappaB activation and interleukin 6 production in fibroblasts by estrogen receptor-negative breast cancer cell-derived interleukin 1alpha.Q36501960
Cardiotoxic consequences of anthracycline-containing therapy in patients with breast cancerQ36509680
Multidrug resistance: retrospect and prospects in anti-cancer drug treatment.Q36536479
Inflammation and cancer: how hot is the link?Q36556766
Prognostic value of serum levels of interleukin 6 and of serum and plasma levels of vascular endothelial growth factor in hormone-refractory metastatic breast cancer patientsQ36649036
Neoadjuvant systemic therapy and the surgical management of breast cancerQ36820261
Complications in breast surgeryQ36820270
Overview of adjuvant systemic therapy in early stage breast cancerQ36820287
Enhanced permeability and retention of macromolecular drugs in solid tumors: a royal gate for targeted anticancer nanomedicines.Q36900208
Population and target considerations for triple-negative breast cancer clinical trialsQ36914317
Neoadjuvant chemotherapy for "triple negative" breast cancer: a review of current practice and future outlookQ37513837
Management of primary and advanced breast cancer in older unfit patients (medical treatment).Q37599110
Triple negative breast cancers: clinical and prognostic implications.Q37602289
Reporter genes: application to the study of mammalian gene transcriptionQ37826420
Current strategy for triple-negative breast cancer: appropriate combination of surgery, radiation, and chemotherapyQ37835104
Surface engineering of iron oxide nanoparticles for targeted cancer therapy.Q37870178
Current treatment options in triple negative breast cancerQ37903580
Radiation therapy. Recent advances and nursing implicationsQ37921716
Understanding the dual nature of CD44 in breast cancer progressionQ37942289
Prognostic value of serum level of interleukin-6 and interleukin-8 in metastatic breast cancer patients.Q53461351
Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphomaQ56903494
Novel pH-Sensitive Micelles Generated by Star-Shape Copolymers Containing Zwitterionic Sulfobetaine for Efficient Cellular InternalizationQ61687047
Doxorubicin-Loaded Cyclic Peptide Nanotube Bundles Overcome Chemoresistance in Breast Cancer CellsQ62677205
Adjuvant therapy in breast cancerQ67244697
Daunorubicin cardiotoxicity: evidence for the importance of the quinone moiety in a free-radical-independent mechanismQ73045056
Effects of combined conventional and modified ultrafiltration in adult patientsQ73580566
A practical guide to prescribing hormone replacement therapyQ74777872
The origin of vimentin expression in invasive breast cancer: epithelial-mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential?Q81768433
Enhanced permeability and retention (EPR) effect for anticancer nanomedicine drug targetingQ83165400
The prognostic value of triple negative in stage II/III breast cancerQ83662713
Nanoparticles containing nitric oxide donor with antileishmanial agent for synergistic effect against visceral leishmaniasisQ83839704
Conjugation of doxorubicin to cell penetrating peptides sensitizes human breast MDA-MB 231 cancer cells to endogenous TRAIL-induced apoptosisQ84514602
A novel protein-based anticancer drug encapsulating nanosphere: apoferritin-doxorubicin complexQ84525324
Current and proposed biomarkers of anthracycline cardiotoxicity in cancer: emerging opportunities in oxidative damage and autophagyQ37980166
Dissecting the heterogeneity of triple-negative breast cancerQ37997760
Neoadjuvant treatments for triple-negative breast cancer (TNBC).Q38046580
Targeted approaches to triple-negative breast cancer: current practice and future directionsQ38070725
Relapsed triple-negative breast cancer: challenges and treatment strategiesQ38120666
Risk assessment, genetic counseling, and genetic testing for BRCA-related cancer in women: a systematic review to update the U.S. Preventive Services Task Force recommendationQ38173683
Applications of nanomedicine in breast cancer detection, imaging, and therapyQ38204453
Features of breast cancer in developing countries, examples from North-AfricaQ38207239
Surgical treatment of primary breast cancer in the neoadjuvant settingQ38212607
Adjuvant chemotherapy in older women with breast cancer: who and what?Q38215489
Chemotherapy response assay test and prognosis for breast cancer patients who have undergone anthracycline- and taxane-based chemotherapyQ38465537
Effect of iontophoresis on topical delivery of doxorubicin-loaded solid lipid nanoparticlesQ38997576
Enhanced anticancer activity and circumvention of resistance mechanisms by novel polymeric/ phospholipidic nanocarriers of doxorubicinQ38997579
Tea nanoparticles for immunostimulation and chemo-drug delivery in cancer treatment.Q39002570
Antitumor efficacy of DMSA modified Fe3O4 magnetic nanoparticles combined with arsenic trioxide and adriamycin in Raji cellsQ39003541
Development of drug loaded nanoparticles for tumor targeting. Part 2: Enhancement of tumor penetration through receptor mediated transcytosis in 3D tumor models.Q39172417
Temperature-sensitive polymer-coated magnetic nanoparticles as a potential drug delivery system for targeted therapy of thyroid cancerQ39266980
The effects of silver nanoparticles and doxorubicin combination on DNA structure and its antiproliferative effect against T47D and MCF7 cell lines.Q39266988
Folic acid protected silver nanocarriers for targeted drug deliveryQ39298452
Genistein inhibits MDA-MB-231 triple-negative breast cancer cell growth by inhibiting NF-κB activity via the Notch-1 pathwayQ39349283
Development of cationic solid lipid nanoparticles with factorial design-based studies for topical administration of doxorubicin.Q39362380
Development of multifunctional hyaluronan-coated nanoparticles for imaging and drug delivery to cancer cellsQ39388913
Doxorubicin encapsulated nanocarriers for targeted delivery to estrogen responsive breast cancerQ39560019
Chondroitin sulphate decorated nanoparticulate carriers of 5-fluorouracil: development and in vitro characterization.Q39591847
Development of idarubicin and doxorubicin solid lipid nanoparticles to overcome Pgp-mediated multiple drug resistance in leukemiaQ39754914
Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells.Q39828317
Oxalate stimulates IL-6 production in HK-2 cells, a line of human renal proximal tubular epithelial cellsQ40398277
Nuclear factor kappa B (NF-kappa B), nuclear factor interleukin-6 (NFIL-6 or C/EBP beta) and nuclear factor interleukin-6 beta (NFIL6-beta or C/EBP delta) are not sufficient to activate the endogenous interleukin-6 gene in the human breast carcinomaQ41180081
Hyaluronan binding by cell surface CD44.Q41743967
Management of stage III breast cancer.Q41749436
Effects of extracellular pressure and alcohol on the microglial response to inflammatory stimulationQ42515745
Toxicity issues in cancer drug development.Q43055933
Novel nanoparticles generated by polymeric amphiphiles with pi-pi conjugated small molecules for anti-tumor drug deliveryQ43804665
Surface functionalized gold nanoparticles for drug delivery.Q43987066
Reduced T-cell and dendritic cell function is related to cyclooxygenase-2 overexpression and prostaglandin E2 secretion in patients with breast cancerQ44781880
Serum levels of tumor necrosis factor alpha correlate with response to neoadjuvant chemotherapy in locally advanced breast cancer.Q44979729
Polyaspartic acid functionalized gold nanoparticles for tumor targeted doxorubicin deliveryQ45388867
Poly(ethylene glycol) versus dendrimer prodrug conjugates: influence of prodrug architecture in cellular uptake and transferrin mediated targetingQ45719161
p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells.Q53428375
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectdoxorubicinQ18936
NF-κBQ411114
P304page(s)6413-6422
P577publication date2015-09-01
P1433published inJournal of Nanoscience and NanotechnologyQ2364336
P1476titleDoxorubicin-Hyaluronan Conjugated Super-Paramagnetic Iron Oxide Nanoparticles (DOX-HA-SPION) Enhanced Cytoplasmic Uptake of Doxorubicin and Modulated Apoptosis, IL-6 Release and NF-kappaB Activity in Human MDA-MB-231 Breast Cancer Cells
P478volume15