Controlled delivery of tauroursodeoxycholic acid from biodegradable microspheres slows retinal degeneration and vision loss in P23H rats.

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Controlled delivery of tauroursodeoxycholic acid from biodegradable microspheres slows retinal degeneration and vision loss in P23H rats. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0177998
P932PMC publication ID5444790
P698PubMed publication ID28542454

P50authorNicolas CuencaQ55727127
Laura Fernández-SánchezQ60897303
Sergio Esteban-PérezQ88146709
Alicia Arranz-RomeraQ125202986
Irene Bravo-OsunaQ39518434
Rocio Herrero-VanrellQ39518488
P2093author name stringIsabel Pinilla
Pedro Lax
Victoria Maneu
María Del Mar Puebla-González
P2860cites workImpairment of intrinsically photosensitive retinal ganglion cells associated with late stages of retinal degeneration.Q50908020
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Tauroursodeoxycholic acid preservation of photoreceptor structure and function in the rd10 mouse through postnatal day 30Q24649167
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Calpain and PARP activation during photoreceptor cell death in P23H and S334ter rhodopsin mutant ratsQ33963936
Tauroursodeoxycholic acid (TUDCA) protects photoreceptors from cell death after experimental retinal detachmentQ34035789
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Tauroursodeoxycholic acid prevents retinal degeneration in transgenic P23H rats.Q34179718
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TUDCA slows retinal degeneration in two different mouse models of retinitis pigmentosa and prevents obesity in Bardet-Biedl syndrome type 1 miceQ35797129
Long time remodeling during retinal degeneration evaluated by optical coherence tomography, immunocytochemistry and fundus autofluorescence.Q35828691
Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.Q35861134
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Proinsulin slows retinal degeneration and vision loss in the P23H rat model of retinitis pigmentosaQ36469478
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Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells.Q37384925
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Late histological and functional changes in the P23H rat retina after photoreceptor lossQ39144181
Retinal ganglion cells survival in a glaucoma model by GDNF/Vit E PLGA microspheres prepared according to a novel microencapsulation procedure.Q39518050
Intravitreal injections of GDNF-loaded biodegradable microspheres are neuroprotective in a rat model of glaucomaQ40062586
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Apoptotic cell death in retinal degenerations.Q40839433
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Chemical chaperone TUDCA preserves cone photoreceptors in a mouse model of Leber congenital amaurosisQ41824260
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Retinal ganglion cell numbers and delayed retinal ganglion cell death in the P23H rat retinaQ42855462
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Tauroursodeoxycholic acid improves the survival and function of nigral transplants in a rat model of Parkinson's disease.Q44035977
A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome systemQ44045954
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Regressive and reactive changes in the connectivity patterns of rod and cone pathways of P23H transgenic rat retina.Q44985297
Enhanced cone dysfunction in rats homozygous for the P23H rhodopsin mutationQ46505120
Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucoseQ46518646
Tauroursodeoxycholic Acid Protects Retinal Function and Structure in rd1 MiceQ46661023
Activation of multiple pathways during photoreceptor apoptosis in the rd mouse.Q46722401
Tool from ancient pharmacopoeia prevents vision loss.Q47818770
Macromolecules released from polymers: diffusion into unstirred fluidsQ48872061
P23H rhodopsin transgenic rat: correlation of retinal function with histopathologyQ49055707
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectvision lossQ507787
biodegradationQ696715
microsphereQ1759020
retinal degenerationQ3043268
biodegradable microsphereQ125660129
P304page(s)e0177998
P577publication date2017-05-25
P1433published inPLOS OneQ564954
P1476titleControlled delivery of tauroursodeoxycholic acid from biodegradable microspheres slows retinal degeneration and vision loss in P23H rats
P478volume12

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cites work (P2860)
Q649164223D printed poly(ε-caprolactone) scaffolds function with simvastatin-loaded poly(lactic-co-glycolic acid) microspheres to repair load-bearing segmental bone defects.
Q92841042Control-released Alpha-lipoic acid-loaded PLGA microspheres enhance bone formation in type 2 diabetic rat model
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Q47364210Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration
Q57109454Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in Mice
Q93003986Retinal Cell Protection in Ocular Excitotoxicity Diseases. Possible Alternatives Offered by Microparticulate Drug Delivery Systems and Future Prospects
Q55709318Retinal Vascular Degeneration in the Transgenic P23H Rat Model of Retinitis Pigmentosa.
Q45873271The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy

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