Proinsulin slows retinal degeneration and vision loss in the P23H rat model of retinitis pigmentosa

scientific article

Proinsulin slows retinal degeneration and vision loss in the P23H rat model of retinitis pigmentosa is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1089/HUM.2012.067
P932PMC publication ID3523255
P698PubMed publication ID23017108
P5875ResearchGate publication ID231223426

P50authorNicolas CuencaQ55727127
Eduard AyusoQ56260306
Fatima BoschQ57321512
Laura Fernández-SánchezQ60897303
P2093author name stringCarolina Isiegas
Enrique J de la Rosa
Pedro de la Villa
Pedro Lax
José M Ruiz
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Proinsulin/insulin is synthesized locally and prevents caspase- and cathepsin-mediated cell death in the embryonic mouse retinaQ61805633
Hypoglycemic Activity and Immunological Half-life of Porcine Insulin and Proinsulin in Baboons and SwineQ71751893
Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerationsQ73277924
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A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosaQ34366637
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Antioxidants reduce cone cell death in a model of retinitis pigmentosaQ34983972
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Upstream AUGs in embryonic proinsulin mRNA control its low translation level.Q38349516
Late histological and functional changes in the P23H rat retina after photoreceptor lossQ39144181
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Preservation of outer retina and its synaptic connectivity following subretinal injections of human RPE cells in the Royal College of Surgeons rat.Q40100777
The developing CNS: a scenario for the action of proinsulin, insulin and insulin-like growth factorsQ40527824
Glial cell line derived neurotrophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosaQ40764969
Two animal models of retinal degeneration are rescued by recombinant adeno-associated virus-mediated production of FGF-5 and FGF-18.Q40810201
Apoptotic cell death in retinal degenerations.Q40839433
Structure and function in rhodopsin. 7. Point mutations associated with autosomal dominant retinitis pigmentosaQ41467175
Current concepts in the treatment of retinitis pigmentosaQ42105112
Focus on molecules: proinsulin in the eye: precursor or pioneer?Q42701274
Retinal ganglion cell numbers and delayed retinal ganglion cell death in the P23H rat retinaQ42855462
Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene.Q43262568
Melatonin delays photoreceptor degeneration in the rds/rds mouseQ43575894
Biological properties of chemically modified insulins. I. Biological activity of proinsulin and insulin modified at A1-glycine and B29-lysineQ43926783
A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome systemQ44045954
Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage.Q44451978
Retinal remodeling triggered by photoreceptor degenerations.Q44515244
Regressive and reactive changes in the connectivity patterns of rod and cone pathways of P23H transgenic rat retina.Q44985297
Decreased glutathione transferase levels in rd1/rd1 mouse retina: replenishment protects photoreceptors in retinal explantsQ45303839
High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiencyQ45855465
Long-term expression and repeated administration of AAV type 1, 2 and 5 vectors in skeletal muscle of immunocompetent adult miceQ45858191
Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle.Q45858699
Intraretinal processing following photoreceptor rescue by non-retinal cells.Q45982448
Enhanced cone dysfunction in rats homozygous for the P23H rhodopsin mutationQ46505120
Attenuation of vision loss and delay in apoptosis of photoreceptors induced by proinsulin in a mouse model of retinitis pigmentosa.Q46564965
Tool from ancient pharmacopoeia prevents vision loss.Q47818770
A comparative study on the metabolism of human insulin and porcine proinsulin in man.Q47908587
Repeated injections of a ciliary neurotrophic factor analogue leading to long-term photoreceptor survival in hereditary retinal degeneration.Q48217416
P23H rhodopsin transgenic rat: correlation of retinal function with histopathology.Q49055707
Differential, age-dependent MEK-ERK and PI3K-Akt activation by insulin acting as a survival factor during embryonic retinal development.Q51979870
P433issue12
P921main subjectvision lossQ507787
retinitis pigmentosaQ847057
retinal degenerationQ3043268
P304page(s)1290-1300
P577publication date2012-11-05
P1433published inHuman Gene TherapyQ15757580
P1476titleProinsulin slows retinal degeneration and vision loss in the P23H rat model of retinitis pigmentosa
P478volume23

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cites work (P2860)
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Q59808710The Prohormone Proinsulin as a Neuroprotective Factor: Past History and Future Prospects
Q45873271The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy

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