Quantitative mass spectrometry analysis of PD-L1 protein expression, N-glycosylation and expression stoichiometry with PD-1 and PD-L2 in human melanoma

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Quantitative mass spectrometry analysis of PD-L1 protein expression, N-glycosylation and expression stoichiometry with PD-1 and PD-L2 in human melanoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/MCP.RA117.000037
P932PMC publication ID5629259
P698PubMed publication ID28546465

P50authorJustin M. BalkoQ90244216
P2093author name stringDouglas B Johnson
Daniel C Liebler
Lisa J Zimmerman
Carlos A Morales-Betanzos
Hyoungjoo Lee
Paula I Gonzalez Ericsson
P2860cites workMelanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy.Q27853331
The blockade of immune checkpoints in cancer immunotherapyQ27860852
PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinationsQ28075712
PD-1 and its ligands in tolerance and immunityQ28131650
Differential binding properties of B7-H1 and B7-DC to programmed death-1Q28191344
PD-L2 is a second ligand for PD-1 and inhibits T cell activationQ28202471
T cell exclusion, immune privilege, and the tumor microenvironmentQ28259872
Design, implementation and multisite evaluation of a system suitability protocol for the quantitative assessment of instrument performance in liquid chromatography-multiple reaction monitoring-MS (LC-MRM-MS)Q28681060
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated MelanomaQ29615443
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancerQ29615679
Pembrolizumab versus Ipilimumab in Advanced MelanomaQ29618134
PD-1 blockade induces responses by inhibiting adaptive immune resistanceQ29620856
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung CancerQ29620902
Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung CancerQ29620913
Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapyQ29964482
Skyline: an open source document editor for creating and analyzing targeted proteomics experimentsQ30080030
Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung CancerQ38975751
Programmed Death-Ligand 1 Expression and Response to the Anti-Programmed Death 1 Antibody Pembrolizumab in MelanomaQ39013253
VISTA is a novel broad-spectrum negative checkpoint regulator for cancer immunotherapyQ39181190
A novel regulation of PD-1 ligands on mesenchymal stromal cells through MMP-mediated proteolytic cleavage.Q40437353
Nivolumab versus Everolimus in Advanced Renal-Cell CarcinomaQ41316099
Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint BlockadeQ41596176
Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and NeckQ43164702
Abundance-ratio-based semiquantitative analysis of site-specific N-linked glycopeptides present in the plasma of hepatocellular carcinoma patients.Q43879974
Separation of glycopeptides by high performance liquid chromatographyQ72926747
Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trialQ30277192
Nivolumab monotherapy in recurrent metastatic urothelial carcinoma (CheckMate 032): a multicentre, open-label, two-stage, multi-arm, phase 1/2 trialQ33435967
Quantification of beta-catenin signaling components in colon cancer cell lines, tissue sections, and microdissected tumor cells using reaction monitoring mass spectrometryQ33621574
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasmaQ33794491
VISTA Regulates the Development of Protective Antitumor ImmunityQ33978040
Parallel reaction monitoring for high resolution and high mass accuracy quantitative, targeted proteomicsQ34292436
Tim-3: an emerging target in the cancer immunotherapy landscapeQ34418718
Neoantigens in cancer immunotherapy.Q34470074
Statistical characterization of multiple-reaction monitoring mass spectrometry (MRM-MS) assays for quantitative proteomicsQ34487045
Combination cancer immunotherapy and new immunomodulatory targetsQ34487698
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapyQ34522172
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistryQ34603412
Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trialQ34670965
Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream EffectorsQ34913785
Methods for peptide and protein quantitation by liquid chromatography-multiple reaction monitoring mass spectrometryQ35026899
Quantitative Profiling of Protein Tyrosine Kinases in Human Cancer Cell Lines by Multiplexed Parallel Reaction Monitoring AssaysQ35859573
PD-1/PD-L1 inhibitors.Q35893753
Assembly Dynamics and Stoichiometry of the Apoptosis Signal-regulating Kinase (ASK) Signalosome in Response to Electrophile StressQ35967130
Precision of multiple reaction monitoring mass spectrometry analysis of formalin-fixed, paraffin-embedded tissueQ36011667
Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma.Q36040373
Quantitative analysis of energy metabolic pathways in MCF-7 breast cancer cells by selected reaction monitoring assayQ36144177
Antibody-free, targeted mass-spectrometric approach for quantification of proteins at low picogram per milliliter levels in human plasma/serumQ36280125
Targeted proteomic quantification on quadrupole-orbitrap mass spectrometer.Q36455720
Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1.Q36577841
Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective FcγR EngagementQ37155745
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity.Q37237202
Multiparametric profiling of non-small-cell lung cancers reveals distinct immunophenotypesQ37277198
Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumorsQ37474092
An unexpected N-terminal loop in PD-1 dominates binding by nivolumabQ37637845
Clinical blockade of PD1 and LAG3--potential mechanisms of actionQ38298241
Targeted Next Generation Sequencing Identifies Markers of Response to PD-1 BlockadeQ38377528
Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potentialQ38414485
Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer.Q38762520
Programmed Death Ligand-1 Immunohistochemistry--A New Challenge for Pathologists: A Perspective From Members of the Pulmonary Pathology SocietyQ38919358
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectstoichiometryQ213185
glycosylationQ898365
P304page(s)1705-1717
P577publication date2017-05-25
P1433published inMolecular & Cellular ProteomicsQ6895932
P1476titleQuantitative mass spectrometry analysis of PD-L1 protein expression, N-glycosylation and expression stoichiometry with PD-1 and PD-L2 in human melanoma
P478volume16

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cites work (P2860)
Q92381156Accelerated instability testing reveals quantitative mass spectrometry overcomes specimen storage limitations associated with PD-L1 immunohistochemistry
Q96577423Analysis of Immune Checkpoint Drug Targets and Tumor Proteotypes in Non-Small Cell Lung Cancer
Q92066104External quality assessment demonstrates that PD-L1 22C3 and SP263 assays are systematically different
Q64966271Intracranial antitumor responses of nivolumab and ipilimumab: a pharmacodynamic and pharmacokinetic perspective, a scoping systematic review.
Q95925488Loss of core fucosylation enhances the anticancer activity of cytotoxic T lymphocytes by increasing PD-1 degradation
Q90317686Mapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies
Q52630284Modulating PD-L1 expression in multiple myeloma: an alternative strategy to target the PD-1/PD-L1 pathway.
Q89450162Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy
Q97067351The impact of PD-L1 N-linked glycosylation on cancer therapy and clinical diagnosis
Q90481320The role of proteomics in the age of immunotherapies

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