Mapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies

scientific article published on 26 September 2019

Mapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41379-019-0372-Z
P698PubMed publication ID31558782

P50authorNicola L LawsonQ90317682
P2093author name stringGareth H Williams
Eileen J McCall
James Hunt
Marianne Schimpl
Jill Walker
Craig Barker
Christopher J Stubbs
Carly I Dix
Edmond Wong
Emma DeVries
Liam Hutchinson
Paul W Scorer
P2860cites workB7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretionQ22010866
Impact of pre-analytical factors on the proteomic analysis of formalin-fixed paraffin-embedded tissueQ26851269
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Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applicationsQ33844511
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A Quantitative Comparison of Antibodies to Programmed Cell Death 1 Ligand 1.Q36107885
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Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non-Small-Cell Lung CancerQ37087884
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity.Q37237202
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Tissue fixation and the effect of molecular fixatives on downstream staining proceduresQ38190394
PD-L1 Expression as a Predictive Biomarker in Cancer ImmunotherapyQ38361400
A Prospective, Multi-institutional, Pathologist-Based Assessment of 4 Immunohistochemistry Assays for PD-L1 Expression in Non-Small Cell Lung CancerQ38375652
Agreement between Programmed Cell Death Ligand-1 Diagnostic Assays across Multiple Protein Expression Cutoffs in Non-Small Cell Lung CancerQ38376439
Comparison of Different Antibody Clones for Immunohistochemistry Detection of Programmed Cell Death Ligand 1 (PD-L1) on Non-Small Cell Lung CarcinomaQ38673895
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Programmed Death Ligand-1 Immunohistochemistry--A New Challenge for Pathologists: A Perspective From Members of the Pulmonary Pathology SocietyQ38919358
A high-yielding CHO transient system: coexpression of genes encoding EBNA-1 and GS enhances transient protein expressionQ39084230
Programmed death 1 (PD-1) and its ligand (PD-L1) as a new frontier in cancer Immunotherapy and challenges for the Pathologist: state of the art.Q39134751
PD-L1 Immunohistochemistry Assays for Lung Cancer: Results from Phase 1 of the Blueprint PD-L1 IHC Assay Comparison ProjectQ39135152
PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome.Q41526004
Functional reconstruction and synthetic mimicry of a conformational epitope using CLIPS technologyQ46854849
Assessment of Concordance between 22C3 and SP142 Immunohistochemistry Assays regarding PD-L1 Expression in Non-Small Cell Lung CancerQ47102822
Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2.Q47999524
Comparison of Four PD-L1 Immunohistochemical Assays in Lung CancerQ49635725
Multicenter French harmonization study for PD-L1 IHC testing in non-small cell lung cancerQ49916859
Determinants of variability of five programmed death ligand-1 immunohistochemistry assays in non-small cell lung cancer samplesQ50347895
Immune checkpoint pathways in non-small cell lung cancer.Q52581741
PD-L1 expression testing in non-small cell lung cancer.Q52584388
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P433issue4
P921main subjectimmunohistochemistryQ899285
immuno-oncologyQ16979420
P304page(s)518-530
P577publication date2019-09-26
P1433published inModern PathologyQ15724578
P1476titleMapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies
P478volume33

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cites work (P2860)
Q101240470Formalin fixation for optimal concordance of programmed death-ligand 1 immunostaining between cytologic and histologic specimens from patients with non-small cell lung cancer
Q102152343TFEB rearranged renal cell carcinoma. A clinicopathologic and molecular study of 13 cases. Tumors harboring MALAT1-TFEB, ACTB-TFEB, and the novel NEAT1-TFEB translocations constantly express PDL1

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