C. elegans DAF-16/FOXO interacts with TGF-ß/BMP signaling to induce germline tumor formation via mTORC1 activation

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C. elegans DAF-16/FOXO interacts with TGF-ß/BMP signaling to induce germline tumor formation via mTORC1 activation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PGEN.1006801
P932PMC publication ID5467913
P698PubMed publication ID28549065

P50authorWenjing QiQ88164019
P2093author name stringDietmar Pfeifer
Ralf Baumeister
Wolfgang Maier
Yimin Wang
Erika Donner V Gromoff
Yijian Yan
P2860cites workRaptor, a binding partner of target of rapamycin (TOR), mediates TOR actionQ24302566
MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1Q24304413
C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life spanQ24324828
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegansQ24603590
Lessons from C. elegans: signaling pathways for longevityQ24609529
SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegansQ24658178
C. elegans rrf-1 mutations maintain RNAi efficiency in the soma in addition to the germlineQ27304475
Autophagy and modular restructuring of metabolism control germline tumor differentiation and proliferation in C. elegansQ27311265
Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegansQ27332314
Systematic functional analysis of the Caenorhabditis elegans genome using RNAiQ27860839
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferationQ28117650
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegansQ28131830
TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translationQ44133461
Mutations that increase the life span of C. elegans inhibit tumor growth.Q45963028
Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespanQ46366442
FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegansQ46550848
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life spanQ47068907
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegansQ47069190
The Caenorhabditis elegans schnurri homolog sma-9 mediates stage- and cell type-specific responses to DBL-1 BMP-related signalingQ47069398
Hypodermal expression of Caenorhabditis elegans TGF-beta type I receptor SMA-6 is essential for the growth and maintenance of body length.Q47069537
A Caenorhabditis elegans type I TGF beta receptor can function in the absence of type II kinase to promote larval development.Q47069602
Body size, insulin/IGF signaling and aging in the nematode Caenorhabditis elegansQ47173498
Germ-line tumor formation caused by activation of glp-1, a Caenorhabditis elegans member of the Notch family of receptors.Q50972299
Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networksQ28255399
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life spanQ28272121
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE projectQ28301622
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factorQ28611335
Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi libraryQ28770084
Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway componentsQ29036482
Ras, PI(3)K and mTOR signalling controls tumour cell growthQ29614734
On the role of RNA amplification in dsRNA-triggered gene silencingQ29617698
limma powers differential expression analyses for RNA-sequencing and microarray studiesQ29617988
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signalingQ29619762
FOXO1/3 depletion in granulosa cells alters follicle growth, death and regulation of pituitary FSH.Q30415092
Regulation of genes affecting body size and innate immunity by the DBL-1/BMP-like pathway in Caenorhabditis elegansQ33596760
Insulin signaling promotes germline proliferation in C. elegansQ33684279
Antagonistic Smad transcription factors control the dauer/non-dauer switch in C. elegansQ33807573
gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegansQ33964440
A Caenorhabditis elegans TGF-beta, DBL-1, controls the expression of LON-1, a PR-related protein, that regulates polyploidization and body lengthQ34085955
DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxOQ34175789
glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegansQ34187240
TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenanceQ34204996
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemiasQ34212654
Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegansQ34393505
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutantsQ34985669
A FoxO-Smad synexpression group in human keratinocytesQ35036428
The forkhead transcription factor UNC-130 is required for the graded spatial expression of the UNC-129 TGF-beta guidance factor in C. elegansQ35204643
mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevityQ35209468
S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cellsQ35741892
The novel tumour suppressor Madm regulates stem cell competition in the Drosophila testisQ36529610
Endocrine signaling in Caenorhabditis elegans controls stress response and longevityQ36561397
Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPaseQ36623662
Sensory regulation of the C. elegans germline through TGF-β-dependent signaling in the nicheQ36787837
FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic systemQ37121014
The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signalingQ38515423
TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemiaQ39744014
A BMP homolog acts as a dose-dependent regulator of body size and male tail patterning in Caenorhabditis elegans.Q39758628
PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevityQ42585902
The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators.Q43095956
Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-beta signaling pathway in Caenorhabditis elegans epidermisQ43415018
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
limmaQ112236343
P433issue5
P921main subjectCaenorhabditis elegansQ91703
Dwarfin sma-3 CELE_R13F6.9Q29795045
P304page(s)e1006801
P577publication date2017-05-26
P1433published inPLOS GeneticsQ1893441
P1476titleC. elegans DAF-16/FOXO interacts with TGF-ß/BMP signaling to induce germline tumor formation via mTORC1 activation
P478volume13

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cites work (P2860)
Q47377482Caenorhabditis elegans DBL-1/BMP Regulates Lipid Accumulation via Interaction with Insulin Signaling
Q68471390DAF‐16 stabilizes the aging transcriptome and is activated in mid‐aged Caenorhabditis elegans to cope with internal stress
Q47441918Keeping Neurons Young and Foxy: FoxOs Promote Neuronal Plasticity
Q99611342MicroRNA-223 decreases cell proliferation, migration, invasion and enhances cell apoptosis in childhood acute lymphoblastic leukemia via targeting Forkhead box O1
Q90597750TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging
Q90264252Vitellogenins - Yolk Gene Function and Regulation in Caenorhabditis elegans

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