Inflammatory targets of therapy in sickle cell disease.

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Inflammatory targets of therapy in sickle cell disease. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/J.TRSL.2015.07.001
P932PMC publication ID4684475
P698PubMed publication ID26226206

P50authorAisha WalkerQ81292230
Solomon F Ofori-AcquahQ43124117
Amma Twumwa Owusu-AnsahQ57862405
P2093author name stringChibueze A Ihunnah
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Transgenic sickle mice have vascular inflammationQ78835117
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Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacityQ84806018
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Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signalingQ24655020
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NF-kappaB: a key role in inflammatory diseasesQ29617726
Selective A2A adenosine receptor activation reduces ischemia-reperfusion injury in rat kidneyQ30304269
Adenosine A2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell diseaseQ30429393
NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokinesQ30435470
Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-kappaB in A(2A) adenosine receptor inductionQ30437433
Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytesQ30441945
Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activationQ30442067
NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injuryQ30443445
Therapeutic anti-inflammatory effects of myeloid cell adenosine receptor A2a stimulation in lipopolysaccharide-induced lung injuryQ30444009
Hemopexin down-regulates LPS-induced proinflammatory cytokines from macrophagesQ37304848
Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapiesQ37370659
Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell diseaseQ37489028
FLAP inhibitors for the treatment of inflammatory diseasesQ37624502
Asthma and sickle cell disease: two distinct diseases or part of the same process?Q37653137
Not simply misshapen red cells: multimolecular and cellular events in sickle vaso-occlusionQ37680003
Factors associated with survival in a contemporary adult sickle cell disease cohortQ37705175
Canakinumab for treatment of cryopyrin-associated periodic syndromeQ37800938
A single NFκB system for both canonical and non-canonical signalingQ37811890
CXCR3 ligands: redundant, collaborative and antagonistic functionsQ37827339
Current status of inflammasome blockers as anti-inflammatory drugsQ38011774
Therapeutic approaches to limit hemolysis-driven endothelial dysfunction: scavenging free heme to preserve vasculature homeostasisQ38115527
Systemic corticosteroids in acute chest syndrome: friend or foe?Q38165525
Hemoglobin s polymerization and red cell membrane changesQ38192784
Inflammatory mediators of endothelial injury in sickle cell diseaseQ38192790
Mast cell progenitors: origin, development and migration to tissuesQ38193606
Regulation of NF-κB by TNF family cytokinesQ38222709
Cytokine expression and signaling in drug-induced cellular senescence.Q39791621
Hemolysis in sickle cell diseaseQ39939182
Protease activity of plasma hemopexinQ40398270
Nitric oxide inhibits IgE-dependent cytokine production and Fos and Jun activation in mast cellsQ40489329
The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP).Q40630693
Erythroid DAMPs drive inflammation in SCD.Q40650786
Selective A(2A) adenosine receptor activation reduces skin pressure ulcer formation and inflammationQ40798733
Airway hyperreactivity in children with sickle cell diseaseQ40885154
Acute hemolytic vascular inflammatory processes are prevented by nitric oxide replacement or a single dose of hydroxyurea.Q40895215
Leukotrienes in the pathogenesis of asthmaQ41355232
Serum IL-6, IL-10, and TNFα levels in pediatric sickle cell disease patients during vasoocclusive crisis and steady state conditionQ41609000
Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathologyQ41614701
5-Aminosalicylic acid abrogates T-cell proliferation by blocking interleukin-2 production in peripheral blood mononuclear cells.Q42280189
Role for cAMP-protein kinase A signalling in augmented neutrophil adhesion and chemotaxis in sickle cell diseaseQ42517151
Eicosanoids in sickle cell disease: potential relevance of neutrophil leukotriene B4 to disease pathophysiology.Q42519406
Vascular cell adhesion molecule-1 is involved in mediating hypoxia-induced sickle red blood cell adherence to endothelium: potential role in sickle cell disease.Q42523837
Selective inhibition of l kappaB alpha phosphorylation and HIV-1 LTR-directed gene expression by novel antioxidant compoundsQ42548057
Sickle cell disease (SCD), iNKT cells, and regadenoson infusion.Q42587651
Mast cell activation contributes to sickle cell pathobiology and pain in miceQ42612548
The rat c-kit ligand, stem cell factor, induces c-kit receptor-dependent mouse mast cell activation in vivo. Evidence that signaling through the c-kit receptor can induce expression of cellular functionQ42768479
Cysteinyl leukotrienes regulate endothelial cell inflammatory and proliferative signals through CysLT₂ and CysLT₁ receptorsQ42876825
A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsisQ43012266
Redox reactions of hemoglobin: mechanisms of toxicity and controlQ43182719
Targeting leukotriene B4 in inflammationQ43464822
Modulation of endothelial cell activation in sickle cell disease: a pilot studyQ43550991
Activated polymorphonuclear cells increase sickle red blood cell retention in lung: role of phospholipidsQ43826638
NF-κB is activated in CD4+ iNKT cells by sickle cell disease and mediates rapid induction of adenosine A2A receptorsQ37215741
Extracellular hemin crisis triggers acute chest syndrome in sickle miceQ37259191
Acute chest syndrome in adults with sickle cell diseaseQ73783522
Circulating activated endothelial cells in sickle cell anemiaQ73884398
Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study GroupQ73911088
Cross-talk between nuclear factor-kappa B and the steroid hormone receptors: mechanisms of mutual antagonismQ74083183
Comparative oxidation of hemoglobins A and SQ74477846
Nuclear factor kappa B: important transcription factor and therapeutic targetQ77587561
Elevated IL-8 levels during sickle cell crisisQ77689840
Additive protection against lung ischemia-reperfusion injury by adenosine A2A receptor activation before procurement and during reperfusionQ30445346
Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel membersQ30459060
Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigmQ30476171
Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectinQ30506249
Neutrophil swarms require LTB4 and integrins at sites of cell death in vivoQ30561804
Headache and migraine in children with sickle cell disease are associated with lower hemoglobin and higher pain event rates but not silent cerebral infarction.Q30757538
Angiogenic and inflammatory markers of cardiopulmonary changes in children and adolescents with sickle cell diseaseQ30945205
In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technologyQ33398661
Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signalingQ33694628
Oxygen regulates the band 3-ankyrin bridge in the human erythrocyte membraneQ33726914
Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell diseaseQ33749670
Nuclear factor-kappa B (NFkappaB) component p50 in blood mononuclear cells regulates endothelial tissue factor expression in sickle transgenic mice: implications for the coagulopathy of sickle cell diseaseQ33761124
Pattern of serum cytokine expression and T-cell subsets in sickle cell disease patients in vaso-occlusive crisisQ33768693
NKT-cell subsets: promoters and protectors in inflammatory liver diseaseQ33862229
The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-upQ33890227
The noncanonical NF-κB pathwayQ34031207
LTB4 is a signal-relay molecule during neutrophil chemotaxisQ34077159
Synergistic inflammation is induced by blood degradation products with microbial Toll-like receptor agonists and is blocked by hemopexin.Q34101137
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell diseaseQ34158521
Protease-activated receptors in inflammation, neuronal signaling and painQ34175474
Central nervous system mast cells in peripheral inflammatory nociceptionQ34189684
Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and InflammationQ34254403
Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell AnemiaQ34308407
Hemolysis-induced lethality involves inflammasome activation by hemeQ34314447
Effect of extended-release niacin on serum lipids and on endothelial function in adults with sickle cell anemia and low high-density lipoprotein cholesterol levelsQ34337258
Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle miceQ34350304
FcεR1-mediated mast cell reactivity is amplified through prolonged Toll-like receptor-ligand treatmentQ34391700
The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human diseaseQ34409133
Transcellular biosynthesis of eicosanoid lipid mediatorsQ34438393
Serum levels of substance P are elevated in patients with sickle cell disease and increase further during vaso-occlusive crisis.Q34476932
Mast cell activation syndrome as a significant comorbidity in sickle cell diseaseQ34564293
Neuronal control of skin function: the skin as a neuroimmunoendocrine organ.Q34570825
Participation of Mac-1, LFA-1 and VLA-4 integrins in the in vitro adhesion of sickle cell disease neutrophils to endothelial layers, and reversal of adhesion by simvastatinQ34750520
Differential modulation of adhesion molecule expression by hydroxycarbamide in human endothelial cells from the micro- and macrocirculation: potential implications in sickle cell disease vasoocclusive eventsQ34750534
Sickle erythrocytes and platelets augment lung leukotriene synthesis with downregulation of anti-inflammatory proteins: relevance in the pathology of the acute chest syndromeQ34782494
Blood viscosity and the expression of inflammatory and adhesion markers in homozygous sickle cell disease subjects with chronic leg ulcersQ34901902
InflammasomesQ34931052
A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseasesQ35044923
The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repressionQ35200339
Computation of plasma hemoglobin nitric oxide scavenging in hemolytic anemiasQ35222193
Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell diseaseQ35230235
NF-κB in immunobiology.Q35348282
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.Q35350543
Asthma in children with sickle cell disease and its association with acute chest syndrome.Q35537558
Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cellQ35666145
The Association of Cytokine Levels With Cognitive Function in Children With Sickle Cell Disease and Normal MRI Studies of the BrainQ35739099
FcepsilonR1 and toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cellsQ35849299
Tapered oral dexamethasone for the acute chest syndrome of sickle cell diseaseQ36012888
Mast cells in the development of adaptive immune responsesQ36015885
Mast cell degranulation activates a pain pathway underlying migraine headacheQ36098310
"Minor" hemoglobinopathies: a risk factor for asthmaQ36177317
Leukocyte adhesion and the pathophysiology of sickle cell diseaseQ36327712
Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell diseaseQ36370871
Hydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cellsQ36407169
Potential effector and immunoregulatory functions of mast cells in mucosal immunityQ36539857
Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenosonQ36797240
Detrimental effects of adenosine signaling in sickle cell diseaseQ36818005
Neurobiological mechanisms of pain in sickle cell diseaseQ36831700
Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapiesQ36870257
Headache in children with sickle cell disease: prevalence and associated factorsQ36882504
CD1d-restricted iNKT cells, the 'Swiss-Army knife' of the immune systemQ36898124
Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patientsQ37026772
Elevated urinary leukotriene E4 levels are associated with hospitalization for pain in children with sickle cell diseaseQ37059538
Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell diseaseQ37082000
Association between plasma free haem and incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell diseaseQ37100903
Antagonistic regulation by the transcription factors C/EBPα and MITF specifies basophil and mast cell fatesQ37127767
5-Lipoxygenase: mechanisms of regulationQ37173201
Iron nitrosyl hemoglobin formation from the reactions of hemoglobin and hydroxyureaQ43883526
Nitric oxide donor properties of hydroxyurea in patients with sickle cell diseaseQ43883731
Hydroxyurea downregulates endothelin-1 gene expression and upregulates ICAM-1 gene expression in cultured human endothelial cells.Q43977840
Plasma concentrations of hemopexin, haptoglobin and heme in patients with various hemolytic diseasesQ44496573
Zileuton induces hemoglobin F synthesis in erythroid progenitors: role of the L-arginine-nitric oxide signaling pathwayQ44756903
Hydroxycarbamide reduces eosinophil adhesion and degranulation in sickle cell anaemia patientsQ44765672
Anti-inflammatory therapy ameliorates leukocyte adhesion and microvascular flow abnormalities in transgenic sickle miceQ44786816
Altered levels of pro-inflammatory cytokines in sickle cell disease patients during vaso-occlusive crises and the steady state condition.Q44805631
Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapyQ44929555
Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseasesQ45816370
Urinary cysteinyl leukotriene E4 significantly increases during pain in children and adults with sickle cell diseaseQ46085894
CXCR3+CD4+ T cells mediate innate immune function in the pathophysiology of liver ischemia/reperfusion injuryQ46141630
Urinary cysteinyl leukotriene E(4) is associated with increased risk for pain and acute chest syndrome in adults with sickle cell diseaseQ46172921
The interaction between oxidative stress and mast cell activation plays a role in acute lung injuries induced by intestinal ischemia-reperfusionQ46255702
Elevated immunoreactive tumor necrosis factor and interleukin-1 in sickle cell diseaseQ46343143
Differential effects of hydroxyurea and zileuton on interleukin-13 secretion by activated murine spleen cells: implication on the expression of vascular cell adhesion molecule-1 and vasoocclusion in sickle cell anemiaQ46520590
Adenosine-dependent activation of hypoxia-inducible factor-1 induces late preconditioning in liver cellsQ46572514
Effect of adenosine A2A receptor agonist (CGS) on ischemia/reperfusion injury in isolated rat liverQ46693986
Hydroxyurea attenuates activated neutrophil-mediated sickle erythrocyte membrane phosphatidylserine exposure and adhesion to pulmonary vascular endotheliumQ46907147
Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B.Q47810582
Propofol prevents lung injury after intestinal ischemia-reperfusion by inhibiting the interaction between mast cell activation and oxidative stressQ47864252
Clinical response of patients with sickle cell anemia to cromolyn sodium nasal spray.Q50723169
Activated neutrophil-mediated sickle red blood cell adhesion to lung vascular endothelium: role of phosphatidylserine-exposed sickle red blood cells.Q50734042
Critical role of endothelial cell activation in hypoxia-induced vasoocclusion in transgenic sickle mice.Q50776572
The contribution of endothelial cell P-selectin to the microvascular flow of mouse sickle erythrocytes in vivo.Q50790934
Beneficial effect of intravenous dexamethasone in children with mild to moderately severe acute chest syndrome complicating sickle cell disease.Q50860898
Adherent leukocytes capture sickle erythrocytes in an in vitro flow model of vaso-occlusion.Q51106899
CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells.Q53565669
Periapical cytokine expression in sickle cell disease.Q53641131
Polynitroxyl albumin inhibits inflammation and vasoocclusion in transgenic sickle mice.Q53670384
Niacin inhibits vascular inflammation via the induction of heme oxygenase-1.Q54549073
Asthma in sickle cell disease.Q55043575
Mortality in sickle cell disease. Life expectancy and risk factors for early death.Q55065788
Anti-inflammatory and immunosuppressive effects of the A2A adenosine receptor.Q55230640
Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenaseQ57779720
Mass Spectral Analysis of Asymmetric Hemoglobin Hybrids: Demonstration of Hb FS (α2γβS) in Sickle Cell DiseaseQ58463707
Quaternary Structure Regulates Hemin Dissociation from Human HemoglobinQ59599936
Inhibition of caspase-dependent spontaneous apoptosis via a cAMP-protein kinase A dependent pathway in neutrophils from sickle cell disease patientsQ61713371
Hemopexin-dependent heme uptake via endocytosis regulates the Bach1 transcription repressor and heme oxygenase gene activationQ62746880
Role of hybrid tetramer formation in gelation of haemoglobin SQ66961118
The stability of the heme-globin linkage in some normal, mutant, and chemically modified hemoglobinsQ67669448
Autoxidation of hemoglobin enhanced by dissociation into dimersQ67803009
Hemopexin metabolism in patients with altered serum levelsQ71073072
Serum interleukin-6 levels in the steady state of sickle cell diseaseQ71364127
The acute chest syndrome in sickle cell disease: incidence and risk factors. The Cooperative Study of Sickle Cell DiseaseQ71632332
High-dose intravenous methylprednisolone therapy for pain in children and adolescents with sickle cell diseaseQ72241034
Antisickling activity of sodium cromoglicate in sickle-cell diseaseQ73171663
Morphological and functional demonstration of rat dura mater mast cell-neuron interactions in vitro and in vivoQ73258433
P433issue1
P921main subjectsickle-cell diseaseQ185034
P304page(s)281-297
P577publication date2015-07-11
P1433published inTranslational ResearchQ15761127
P1476titleInflammatory targets of therapy in sickle cell disease
P478volume167

Reverse relations

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