Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production

scientific article

Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/OBY.21243
P932PMC publication ID4688084
P698PubMed publication ID26576827
P5875ResearchGate publication ID284172309

P50authorCaroline M. ApovianQ54032792
Douglas A. LauffenburgerQ59755238
Anna BelkinaQ43159937
P2093author name stringMin Zhu
Thomas B Kepler
Qiang Xiao
Marie E McDonnell
Barbara S Nikolajczyk
Nicholas A Cilfone
Jason DeFuria
Madhumita Jagannathan-Bogdan
Blanche Ip
Ramya Kuchibhatla
P2860cites workCD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiationQ43406136
The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications.Q45998987
Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetesQ46323162
PLS-regression: a basic tool of chemometricsQ56454404
Immunotherapy of insulin-dependent diabetes mellitusQ74620017
Expression of CD80/86 on B cells is essential for autoreactive T cell activation and the development of arthritisQ81386261
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodiesQ24598772
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistanceQ24617743
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin ResistanceQ28131660
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteinsQ29547534
Development, cytokine profile and function of human interleukin 17-producing helper T cellsQ29617131
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesityQ29617380
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parametersQ29617381
Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412Q29622893
Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunctionQ33642021
Toll-like receptors regulate B cell cytokine production in patients with diabetesQ33954398
IL-17 regulates adipogenesis, glucose homeostasis, and obesityQ34401701
Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular diseaseQ34444895
HIV-1 infection induces strong production of IP-10 through TLR7/9-dependent pathwaysQ34889163
Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes.Q34950622
Normalization of obesity-associated insulin resistance through immunotherapyQ34994222
T-cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humansQ35654752
Induction and molecular signature of pathogenic TH17 cellsQ36283752
B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profileQ36729660
Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammationQ36747890
Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistanceQ36793320
Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals.Q37130138
In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKsQ37657176
T cells in multiple sclerosis and experimental autoimmune encephalomyelitis.Q37777431
Induction treatment with monoclonal antibodies for heart transplantationQ37815275
Anti-CD3 clinical trials in type 1 diabetes mellitusQ38111027
T cell-derived IL-22 amplifies IL-1β-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes.Q39024643
Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesityQ41834087
Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodiesQ41854046
IL-21 is a major negative regulator of IRF4-dependent lipolysis affecting Tregs in adipose tissue and systemic insulin sensitivity.Q42808014
The effects of weight loss and gastric banding on the innate and adaptive immune system in type 2 diabetes and prediabetes.Q43106768
P433issue1
P921main subjectobesityQ12174
type 2 diabetesQ3025883
P304page(s)102-112
P577publication date2015-11-18
P1433published inObesityQ15763232
P1476titleTh17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production
P478volume24

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