Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection

scientific article

Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20051128
P932PMC publication ID2213170
P698PubMed publication ID16186188
P5875ResearchGate publication ID7578604

P2093author name stringGary A Koretzky
Jonathan S Maltzman
James L Clements
Lisa Kovoor
P2860cites workMolecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cellsQ24312990
Essential role for ZAP-70 in both positive and negative selection of thymocytesQ24321424
The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signalingQ28586244
An architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptorsQ34180840
New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decisionQ34547220
Adaptors as central mediators of signal transduction in immune cellsQ35055629
Mice lacking major histocompatibility complex class I and class II moleculesQ36271130
Constitutive endocytosis and degradation of the pre-T cell receptor.Q36369757
Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cellsQ36370932
Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor proteinQ36375439
CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidityQ36401360
Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function.Q40599629
Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stagesQ44151375
Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.Q47720762
Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell developmentQ47837774
Thymocyte stimulation by anti-TCR-β, but not by anti-TCR-α, leads to induction of developmental transcription programQ49922658
Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo.Q52093756
Cutting edge: identification of the targets of clonal deletion in an unmanipulated thymus.Q52110901
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.Q52126962
PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytesQ58617364
Normal sequence of phenotypic transitions in one cohort of 5-bromo-2'-deoxyuridine-pulse-labeled thymocytes. Correlation with T cell receptor expressionQ70504035
Competitive displacement of pT alpha by TCR-alpha during TCR assembly prevents surface coexpression of pre-TCR and alpha beta TCRQ73163114
Restoration of thymocyte development and function in zap-70-/- mice by the Syk protein tyrosine kinaseQ73767622
LAT links the pre-BCR to calcium signalingQ73836551
SLP-76 expression is restricted to hemopoietic cells of monocyte, granulocyte, and T lymphocyte lineage and is regulated during T cell maturation and activationQ77436813
Thymocyte stimulation by anti-TCR-beta, but not by anti-TCR-alpha, leads to induction of developmental transcription programQ95817971
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectthymocyteQ7799635
P304page(s)893-900
P577publication date2005-09-26
P1433published inJournal of Experimental MedicineQ3186912
P1476titleConditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection
P478volume202

Reverse relations

cites work (P2860)
Q36062659A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice
Q33640077Ablation of SLP-76 signaling after T cell priming generates memory CD4 T cells impaired in steady-state and cytokine-driven homeostasis.
Q92556937Bridging the Gap: Modulatory Roles of the Grb2-Family Adaptor, Gads, in Cellular and Allergic Immune Responses
Q36877284Compartmentalization of ITAM and integrin signaling by adapter molecules
Q35072158Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses
Q37746483Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76
Q36055077Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo
Q42238133Cutting edge: rescue of pre-TCR but not mature TCR signaling in mice expressing membrane-targeted SLP-76.
Q36155051Deconstructing Ras signaling in the thymus
Q42737245Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice
Q36229486Distinct roles for Syk and ZAP-70 during early thymocyte development
Q37618290ERK and cell death: ERK location and T cell selection
Q36179534FADD regulates thymocyte development at the β-selection checkpoint by modulating Notch signaling
Q88137939Fit αβ T-cell receptor suppresses leukemogenesis of Pten-deficient thymocytes
Q51970307Impaired thymic selection in mice expressing altered levels of the SLP-76 adaptor protein.
Q34119792Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation
Q34541698Loss of tonic T-cell receptor signals alters the generation but not the persistence of CD8+ memory T cells
Q34060500Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production
Q36779409Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.
Q36604409Novel Molecular Insights into Classical and Alternative Activation States of Microglia as Revealed by Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-based Proteomics
Q37971728Physiological and pathophysiological functions of SOCE in the immune system
Q35883118Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling
Q37376338Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
Q37270535Regulation of T cell integrin function by adapter proteins
Q41892341SLP-76 is required for optimal CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow
Q28298645SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
Q34648944T-cell receptor signaling to integrins
Q34541692T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool
Q37682609The Role of SH2 Domain-containing Leukocyte Phosphoprotein of 76 kDa in the Regulation of Immune Cell Development and Function
Q38829466The SLP-76 Src homology 2 domain is required for T cell development and activation.
Q28506969The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency
Q30490766The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells
Q37166773The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage
Q37262507The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation
Q37802005Understanding signal integration through targeted mutations of an adapter protein
Q33796333c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway
Q39021436iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo .

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