Decreased endothelial nitric oxide synthase expression and function contribute to impaired mitochondrial biogenesis and oxidative stress in fetal lambs with persistent pulmonary hypertension

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Decreased endothelial nitric oxide synthase expression and function contribute to impaired mitochondrial biogenesis and oxidative stress in fetal lambs with persistent pulmonary hypertension is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPLUNG.00392.2014
P932PMC publication ID4698434
P698PubMed publication ID26519208

P2093author name stringSatyan Lakshminrusimha
Ru-Jeng Teng
Annie Eis
Adeleye J Afolayan
Girija G Konduri
Teresa Michalkiewicz
Maxwell Alexander
P2860cites workSynergistic activation of endothelial nitric-oxide synthase (eNOS) by HSP90 and Akt: calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-bound eNOS complexQ44473651
A randomized trial of early versus standard inhaled nitric oxide therapy in term and near-term newborn infants with hypoxic respiratory failureQ48012531
UK collaborative randomised trial of neonatal extracorporeal membrane oxygenation. UK Collaborative ECMO Trail GroupQ71177552
Early compared with delayed inhaled nitric oxide in moderately hypoxaemic neonates with respiratory failure: a randomised controlled trial. The Franco-Belgium Collaborative NO Trial GroupQ73048667
Adenosine and ATP cause nitric oxide-dependent pulmonary vasodilation in fetal lambsQ73109675
Oxidant stress from uncoupled nitric oxide synthase impairs vasodilation in fetal lambs with persistent pulmonary hypertensionQ79400720
Randomized controlled trial of early compared with delayed use of inhaled nitric oxide in newborns with a moderate respiratory failure and pulmonary hypertensionQ84849549
The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesisQ24564869
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}Q28235481
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolismQ28266830
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and uglyQ29547442
Prenatal programming of pulmonary hypertension induced by chronic hypoxia or ductal ligation in sheepQ33806234
Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesisQ34101012
Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cellsQ34122975
The genetics and pathology of oxidative phosphorylationQ34237999
Nuclear activators and coactivators in mammalian mitochondrial biogenesisQ34657768
Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthaseQ35217368
Transcriptional regulatory circuits controlling mitochondrial biogenesis and functionQ35683727
Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-alphaQ36042273
Developmental expression of vasoactive and growth factors in human lung. Role in pulmonary vascular resistance adaptation at birth.Q36092149
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Pulmonary arterial contractility in neonatal lambs increases with 100% oxygen resuscitationQ36169607
Decreases in manganese superoxide dismutase expression and activity contribute to oxidative stress in persistent pulmonary hypertension of the newbornQ36454374
The role of AMP-activated protein kinase in mitochondrial biogenesisQ36482349
AMP kinase activation improves angiogenesis in pulmonary artery endothelial cells with in utero pulmonary hypertensionQ36527961
Key regulators of mitochondrial biogenesis are increased in kidneys of growth hormone receptor knockout (GHRKO) miceQ36928810
Meconium aspiration syndrome: historical aspectsQ37341662
Impact of early surfactant and inhaled nitric oxide therapies on outcomes in term/late preterm neonates with moderate hypoxic respiratory failure.Q37346298
PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditureQ37412140
Oxygen concentration and pulmonary hemodynamics in newborn lambs with pulmonary hypertension.Q37436986
Mitochondria in vascular health and diseaseQ38060230
PGC1α and mitochondrial metabolism--emerging concepts and relevance in ageing and neurodegenerative disordersQ38070667
Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide.Q38357891
Reactive oxygen nitrogen species decrease cystic fibrosis transmembrane conductance regulator expression and cAMP-mediated Cl- secretion in airway epitheliaQ40708706
Pulmonary hypertension in the perinatal aspiration syndromesQ41807994
Inducible HSP70 regulates superoxide dismutase-2 and mitochondrial oxidative stress in the endothelial cells from developing lungs.Q41943801
Decreased association of HSP90 impairs endothelial nitric oxide synthase in fetal lambs with persistent pulmonary hypertensionQ42438968
DNA damage-induced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiaeQ43180435
Role of oxidative phosphorylation and ATP release in mediating birth-related pulmonary vasodilation in fetal lambsQ44138447
Developmental changes in nitric oxide synthase isoform expression and nitric oxide production in fetal baboon lung.Q44185723
P4510describes a project that usesImageJQ1659584
P433issue1
P921main subjectarterial hypertensionQ41861
endotheliumQ111140
P304page(s)L40-9
P577publication date2015-10-30
P1433published inAmerican Journal of Physiology - Lung Cellular and Molecular PhysiologyQ4352992
P1476titleDecreased endothelial nitric oxide synthase expression and function contribute to impaired mitochondrial biogenesis and oxidative stress in fetal lambs with persistent pulmonary hypertension
P478volume310