Sensitivity of GABAergic Tonic Currents to Acute Ethanol in Cerebellar Granule Neurons is Not Age- or δ Subunit-Dependent in Developing Rats

scientific article

Sensitivity of GABAergic Tonic Currents to Acute Ethanol in Cerebellar Granule Neurons is Not Age- or δ Subunit-Dependent in Developing Rats is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/ACER.12940
P932PMC publication ID4700547
P698PubMed publication ID26727526
P5875ResearchGate publication ID289355190

P50authorMarvin DiazQ80305709
P2093author name stringC Fernando Valenzuela
P2860cites workDevelopment of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptorsQ24530653
Enhanced macroscopic desensitization shapes the response of alpha4 subtype-containing GABAA receptors to synaptic and extrasynaptic GABAQ24684762
The GABA excitatory/inhibitory developmental sequence: a personal journeyQ26995461
A 21-year longitudinal analysis of the effects of prenatal alcohol exposure on young adult drinkingQ28191023
Targeted disruption of the GABA(A) receptor delta subunit gene leads to an up-regulation of gamma 2 subunit-containing receptors in cerebellar granule cellsQ28507614
Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinitiesQ28574478
Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptorsQ29616809
Dynamics of fast and slow inhibition from cerebellar golgi cells allow flexible control of synaptic integrationQ30457456
Opposite actions of alcohol on tonic GABA(A) receptor currents mediated by nNOS and PKC activityQ33616871
Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptorsQ33717685
Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activityQ33787183
Alcohol excites cerebellar Golgi cells by inhibiting the Na+/K+ ATPaseQ33998538
Behavioral Effects of Ethanol in Cerebellum Are Age Dependent: Potential System and Molecular MechanismsQ34336312
Low level of response to alcohol as a predictor of future alcoholismQ34348860
Na+/K+-ATPase inhibition partially mimics the ethanol-induced increase of the Golgi cell-dependent component of the tonic GABAergic current in rat cerebellar granule cellsQ34576877
Profound desensitization by ambient GABA limits activation of δ-containing GABAA receptors during spilloverQ34688851
A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibitionQ34974161
Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptorsQ35326774
Bestrophin1 Channels are Insensitive to Ethanol and Do not Mediate Tonic GABAergic Currents in Cerebellar Granule CellsQ35671450
Tonically active GABA A receptors: modulating gain and maintaining the tone.Q35757312
Adolescent alcohol exposure: Are there separable vulnerable periods within adolescence?Q35793227
Effects of Ethanol on the Cerebellum: Advances and ProspectsQ35822508
Perinatal cerebellar injury in human and animal modelsQ35864287
Does moderate drinking harm the fetal brain? Insights from animal models.Q35946906
Mechanisms of Ethanol-Induced Death of Cerebellar Granule CellsQ35969388
Extrasynaptic GABA(A) receptors: their function in the CNS and implications for diseaseQ36101696
Ethanol modulation of GABAergic transmission: the view from the sliceQ36373898
Excitation of rat cerebellar Golgi cells by ethanol: further characterization of the mechanism.Q36474834
Acute ethanol exposure increases firing and induces oscillations in cerebellar Golgi cells of freely moving ratsQ36821428
Novel subunit-specific tonic GABA currents and differential effects of ethanol in the central amygdala of CRF receptor-1 reporter miceQ37014212
Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptorsQ37074693
A developmental perspective on underage alcohol use.Q37386650
Repeated intermittent alcohol exposure during the third trimester-equivalent increases expression of the GABA(A) receptor δ subunit in cerebellar granule neurons and delays motor development in ratsQ37619550
Mini-Review: Effects of Ethanol on GABAA Receptor-Mediated Neurotransmission in the Cerebellar Cortex--Recent Advances.Q38313203
The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalonQ38330309
GABAA receptor α and γ subunits shape synaptic currents via different mechanismsQ41984180
Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons.Q42691157
Channel-mediated tonic GABA release from glia.Q42867099
Outwardly rectifying tonically active GABAA receptors in pyramidal cells modulate neuronal offset, not gain.Q43231756
Regional differences in cell loss associated with binge-like alcohol exposure during the first two trimesters equivalent in the rat.Q43562440
Acute, rapid, and chronic tolerance during ontogeny: observations when equating ethanol perturbation across age.Q43754872
Multiple modes of GABAergic inhibition of rat cerebellar granule cellsQ44317053
The distribution of thirteen GABAA receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal developmentQ44767968
Alcohol enhances GABAergic transmission to cerebellar granule cells via an increase in Golgi cell excitability.Q44844941
Hippocampal network hyperactivity after selective reduction of tonic inhibition in GABA A receptor alpha5 subunit-deficient mice.Q44986641
Low ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABAA receptors in hippocampal neurons.Q45072876
The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus.Q46039131
Effects of prenatal and postnatal maternal ethanol on offspring response to alcohol and psychostimulants in long evans rats.Q46059858
Expression of distinct alpha subunits of GABAA receptor regulates inhibitory synaptic strengthQ47717822
Extrasynaptic alphabeta subunit GABAA receptors on rat hippocampal pyramidal neurons.Q48403423
Molecular basis for the GABAA receptor-mediated tonic inhibition in rat somatosensory cortexQ48414314
Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibitionQ48529489
Ethanol untangles the amygdala-anxiety circuit through tonic GABA inhibition.Q48874839
Spontaneously opening GABA(A) channels in CA1 pyramidal neurones of rat hippocampus.Q51409397
Age at first alcohol use: a risk factor for the development of alcohol disorders.Q52278305
Prenatal alcohol exposure and family history of alcoholism in the etiology of adolescent alcohol problemsQ77152302
Postnatal development and kinetics of [3H]gaboxadol binding in rat brain: in vitro homogenate binding and quantitative autoradiographyQ80783705
P433issue1
P304page(s)83-92
P577publication date2016-01-01
P1433published inAlcoholism: Clinical and Experimental ResearchQ4713331
P1476titleSensitivity of GABAergic Tonic Currents to Acute Ethanol in Cerebellar Granule Neurons is Not Age- or δ Subunit-Dependent in Developing Rats
P478volume40

Reverse relations

cites work (P2860)
Q47901530Alcohol and the Brain: Neuronal Molecular Targets, Synapses, and Circuits.
Q92502483Direction of action of presynaptic GABAA receptors is highly dependent on the level of receptor activation
Q39289210Effects of acute alcohol on excitability in the CNS.
Q91272235Mechanisms of GABAB receptor enhancement of extrasynaptic GABAA receptor currents in cerebellar granule cells
Q48169442Protective roles of hepatic gamma-aminobutyric acid signaling in acute ethanol exposure-induced liver injury
Q88599123The Cerebellar GABAAR System as a Potential Target for Treating Alcohol Use Disorder

Search more.