Profound desensitization by ambient GABA limits activation of δ-containing GABAA receptors during spillover

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Profound desensitization by ambient GABA limits activation of δ-containing GABAA receptors during spillover is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.2996-10.2011
P932PMC publication ID3059572
P698PubMed publication ID21228184

P50authorStephen G BrickleyQ50747708
Mark FarrantQ56993626
Damian P BrightQ59563120
P2093author name stringAlastair M Hosie
Massimiliano Renzi
Thomas P McGee
Julian Bartram
Georgina MacKenzie
P2860cites workDevelopment of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptorsQ24530653
GABA A receptors: subtypes provide diversity of function and pharmacologyQ24599057
Enhanced macroscopic desensitization shapes the response of alpha4 subtype-containing GABAA receptors to synaptic and extrasynaptic GABAQ24684762
Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cellsQ28261770
Which GABA(A) receptor subunits are necessary for tonic inhibition in the hippocampus?Q46760540
Pharmacological characterization of agonists at delta-containing GABAA receptors: Functional selectivity for extrasynaptic receptors is dependent on the absence of gamma2.Q46792357
Extrasynaptic GABAA receptors of thalamocortical neurons: a molecular target for hypnotics.Q46851461
GABAA receptor-mediated tonic inhibition in thalamic neurons.Q46851471
Ligand-gated ion channel subunit partnerships: GABAA receptor alpha6 subunit gene inactivation inhibits delta subunit expression.Q48053875
Synaptic release generates a tonic GABA(A) receptor-mediated conductance that modulates burst precision in thalamic relay neuronsQ48250819
Shunting inhibition modulates neuronal gain during synaptic excitation.Q48313474
Neurotransmitters and neuromodulators controlling the hypoxic respiratory response in anaesthetized catsQ48329769
Exposure to novelty and forced swimming evoke stressor-dependent changes in extracellular GABA in the rat hippocampusQ48389023
Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurones of rat hippocampal slicesQ48402561
The transmembrane sodium gradient influences ambient GABA concentration by altering the equilibrium of GABA transportersQ48461910
Spillover-mediated transmission at inhibitory synapses promoted by high affinity alpha6 subunit GABA(A) receptors and glomerular geometryQ48472769
GABA(A) receptor changes in delta subunit-deficient mice: altered expression of alpha4 and gamma2 subunits in the forebrainQ48639428
Slow wave sleep is accompanied by release of certain amino acids in the thalamus of catsQ48761209
Studying properties of neurotransmitter receptors by non-stationary noise analysis of spontaneous synaptic currents.Q53004445
Shunting Inhibition Improves Robustness of Gamma Oscillations in Hippocampal Interneuron Networks by Homogenizing Firing RatesQ56991986
Slow desensitization regulates the availability of synaptic GABA(A) receptorsQ73119652
Development of action potential-dependent and independent spontaneous GABAA receptor-mediated currents in granule cells of postnatal rat cerebellumQ28307635
Two novel GABAA receptor subunits exist in distinct neuronal subpopulationsQ28565909
Contributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 geneQ28580771
Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptorsQ29616809
Dynamics of fast and slow inhibition from cerebellar golgi cells allow flexible control of synaptic integrationQ30457456
Enhanced tonic GABAA inhibition in typical absence epilepsy.Q30493216
In vivo monitoring of amino acids by direct sampling of brain extracellular fluid at ultralow flow rates and capillary electrophoresisQ31038945
Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptorsQ33717685
Control of hippocampal gamma oscillation frequency by tonic inhibition and excitation of interneuronsQ33745042
GABA(A)R plasticity during pregnancy: relevance to postpartum depressionQ33872187
Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus.Q34277867
Ovarian cycle-linked changes in GABA(A) receptors mediating tonic inhibition alter seizure susceptibility and anxietyQ34419058
Dynamic equilibrium of neurotransmitter transporters: not just for reuptake anymoreQ35215960
Gaboxadol--a new awakening in sleepQ36348054
Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice.Q36562979
Mechanisms of sleep induction by GABA(A) receptor agonists.Q36835775
Extrasynaptic GABAA receptors are critical targets for sedative-hypnotic drugs.Q36844290
Activation of GABAA receptors: views from outside the synaptic cleft.Q37022454
Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptorsQ37074693
Context-dependent modulation of alphabetagamma and alphabetadelta GABA A receptors by penicillin: implications for phasic and tonic inhibitionQ37141170
Axonal GABAA receptors.Q37240087
Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptorsQ37457565
Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors.Q39736511
Conserved site for neurosteroid modulation of GABA A receptorsQ39944832
Nonvesicular release of neurotransmitter.Q40713047
Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit.Q40746562
Assembly of GABAA receptor subunits: role of the delta subunitQ41434355
Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1.Q41761189
Presynaptic GABAA receptors enhance transmission and LTP induction at hippocampal mossy fiber synapsesQ41809032
Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit.Q42438034
Investigation on acetylcholine, aspartate, glutamate and GABA extracellular levels from ventral hippocampus during repeated exploratory activity in the rat.Q42439214
GABA Transmission in the Nucleus Accumbens Is Altered after Withdrawal from Repeated CocaineQ42440407
GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain.Q42497057
Channel-mediated tonic GABA release from glia.Q42867099
Adaptive regulation of neuronal excitability by a voltage-independent potassium conductanceQ43601149
CNQX increases GABA-mediated synaptic transmission in the cerebellum by an AMPA/kainate receptor-independent mechanismQ43770973
Furosemide reveals heterogeneous GABA(A) receptor expression at adult rat Golgi cell to granule cell synapses.Q44170021
Maintenance of high-frequency transmission at purkinje to cerebellar nuclear synapses by spillover from boutons with multiple release sitesQ44722213
Hippocampal network hyperactivity after selective reduction of tonic inhibition in GABA A receptor alpha5 subunit-deficient mice.Q44986641
Altered expression of the delta subunit of the GABAA receptor in a mouse model of temporal lobe epilepsy.Q45084946
Acting locally but sensing globally: impact of GABAergic synaptic plasticity on phasic and tonic inhibition in the thalamus.Q45417258
Tonic and spillover inhibition of granule cells control information flow through cerebellar cortexQ45713983
Reconstruct: a free editor for serial section microscopyQ46427266
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectdesensitizationQ2700499
P304page(s)753-763
P577publication date2011-01-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleProfound desensitization by ambient GABA limits activation of δ-containing GABAA receptors during spillover
P478volume31

Reverse relations

cites work (P2860)
Q549814843β-Methyl-Neurosteroid Analogs Are Preferential Positive Allosteric Modulators and Direct Activators of Extrasynaptic δ-Subunit γ-Aminobutyric Acid Type A Receptors in the Hippocampus Dentate Gyrus Subfield.
Q38050417A TRP among the astrocytes
Q34974161A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibition
Q36675803A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABA(A) receptors
Q30606986Anesthetic action on extra-synaptic receptors: effects in neural population models of EEG activity
Q36207476Are extrasynaptic GABAA receptors important targets for sedative/hypnotic drugs?
Q34017529Augmentation of Tonic GABA(A) Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABA(A) Receptors
Q35671450Bestrophin1 Channels are Insensitive to Ethanol and Do not Mediate Tonic GABAergic Currents in Cerebellar Granule Cells
Q48058656Biphasic modulation of parallel fibre synaptic transmission by co-activation of presynaptic GABAA and GABAB receptors in mice
Q35133407Cell-type-specific tonic GABA signaling in the rat central amygdala is selectively altered by acute and chronic ethanol
Q34054093Characterization of neurosteroid effects on hyperpolarizing current at α4β2δ GABAA receptors
Q57987415Chemogenetic Isolation Reveals Synaptic Contribution of δ GABA Receptors in Mouse Dentate Granule Neurons
Q36207379Control of cerebellar granule cell output by sensory-evoked Golgi cell inhibition
Q37093891Copper block of extrasynaptic GABAA receptors in the mature cerebellum and striatum
Q47246914Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites.
Q92502483Direction of action of presynaptic GABAA receptors is highly dependent on the level of receptor activation
Q47138490Distinct kinetics of inhibitory currents in thalamocortical neurons that arise from dendritic or axonal origin
Q36697376Ethanol promotes clathrin adaptor-mediated endocytosis via the intracellular domain of δ-containing GABAA receptors
Q36474834Excitation of rat cerebellar Golgi cells by ethanol: further characterization of the mechanism.
Q48155809Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus.
Q36101696Extrasynaptic GABA(A) receptors: their function in the CNS and implications for disease
Q36608004Extrasynaptic GABAA receptors in rat pontine reticular formation increase wakefulness
Q37736018Fast and Slow Inhibition in the Visual Thalamus Is Influenced by Allocating GABAA Receptors with Different γ Subunits
Q38991640Fast detection of extrasynaptic GABA with a whole-cell sniffer
Q57165010GABA beyond the synapse: defining the subtype-specific pharmacodynamics of non-synaptic GABA receptors
Q48153790GABA transporters regulate tonic and synaptic GABAA receptor-mediated currents in the suprachiasmatic nucleus neurons.
Q41457577GABA-independent GABAA receptor openings maintain tonic currents.
Q34315862GABAA receptor modulation by neurosteroids in models of temporal lobe epilepsies
Q36042974GABAA receptors increase excitability and conduction velocity of cerebellar parallel fiber axons
Q48232406Identification of the transmitter and receptor mechanisms responsible for REM sleep paralysis.
Q37601683Integration and regulation of glomerular inhibition in the cerebellar granular layer circuit
Q38688873Mechanisms for the Specific Properties of γ-Hydroxybutyrate in Brain
Q91272235Mechanisms of GABAB receptor enhancement of extrasynaptic GABAA receptor currents in cerebellar granule cells
Q34399901Menthol enhances phasic and tonic GABAA receptor-mediated currents in midbrain periaqueductal grey neurons
Q26859850Methods for recording and measuring tonic GABAA receptor-mediated inhibition
Q38313203Mini-Review: Effects of Ethanol on GABAA Receptor-Mediated Neurotransmission in the Cerebellar Cortex--Recent Advances.
Q33742750Mutations in the main cytoplasmic loop of the GABA(A) receptor α4 and δ subunits have opposite effects on surface expression
Q34576877Na+/K+-ATPase inhibition partially mimics the ethanol-induced increase of the Golgi cell-dependent component of the tonic GABAergic current in rat cerebellar granule cells
Q37320505Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability
Q37014212Novel subunit-specific tonic GABA currents and differential effects of ethanol in the central amygdala of CRF receptor-1 reporter mice
Q21129461Pathophysiological power of improper tonic GABA(A) conductances in mature and immature models
Q34383389Perimenstrual-like hormonal regulation of extrasynaptic δ-containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity.
Q41831739Perisynaptic GABA Receptors The Overzealous Protector.
Q33639456Phasic, nonsynaptic GABA-A receptor-mediated inhibition entrains thalamocortical oscillations.
Q49971672Probing GABAA receptors with inhibitory neurosteroids
Q34193221Protein kinase C regulates tonic GABA(A) receptor-mediated inhibition in the hippocampus and thalamus
Q36595521Rapid regulation of tonic GABA currents in cultured rat hippocampal neurons
Q33781379Selective modulation of GABAergic tonic current by dopamine in the nucleus accumbens of alcohol-dependent rats
Q36428248Sensitivity of GABAergic Tonic Currents to Acute Ethanol in Cerebellar Granule Neurons is Not Age- or δ Subunit-Dependent in Developing Rats
Q35947466Setting the time course of inhibitory synaptic currents by mixing multiple GABA(A) receptor α subunit isoforms.
Q37408496The contribution of δ subunit-containing GABAA receptors to phasic and tonic conductance changes in cerebellum, thalamus and neocortex
Q100958563The desensitization pathway of GABAA receptors, one subunit at a time
Q47966272The effects of volatile anesthetics on the extracellular accumulation of [(3)H]GABA in rat brain cortical slices
Q47835541The flavonoid, 2'-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia
Q30430187The influence of stress at puberty on mood and learning: role of the α4βδ GABAA receptor
Q42184644The population firing rate in the presence of GABAergic tonic inhibition in single neurons and application to general anaesthesia.
Q38534666The ubiquitous nature of multivesicular release.
Q35787576Tonic GABAA receptor conductance in medial subnucleus of the tractus solitarius neurons is inhibited by activation of μ-opioid receptors
Q42510918Tonic inhibition enhances fidelity of sensory information transmission in the cerebellar cortex.
Q37045414Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down's syndrome.
Q37138725α4βδ GABAA receptors and tonic inhibitory current during adolescence: effects on mood and synaptic plasticity
Q38849244δ Subunit-containing GABAA receptors are preferred targets for the centrally acting analgesic flupirtine.

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