Correlation between charge movement and ionic current during slow inactivation in Shaker K+ channels

scientific article

Correlation between charge movement and ionic current during slow inactivation in Shaker K+ channels is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1085/JGP.110.5.579
P932PMC publication ID2229383
P698PubMed publication ID9348329
P5875ResearchGate publication ID277515574

P2093author name stringR Latorre
F Bezanilla
L Toro
E Stefani
R Olcese
P2860cites workA quantitative description of membrane current and its application to conduction and excitation in nerveQ22337072
Biophysical and molecular mechanisms of Shaker potassium channel inactivationQ29617879
C-type inactivation of a voltage-gated K+ channel occurs by a cooperative mechanismQ34047165
Cooperative subunit interactions in C-type inactivation of K channelsQ34047793
Gating of Shaker K+ channels: I. Ionic and gating currentsQ34115107
Gating of Shaker K+ channels: II. The components of gating currents and a model of channel activationQ34115111
An engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal bindingQ34115140
Gating of single Shaker potassium channels in Drosophila muscle and in Xenopus oocytes injected with Shaker mRNA.Q34305026
Slow changes of potassium permeability in the squid giant axonQ34356798
Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channelQ34396702
Distribution and kinetics of membrane dielectric polarization. 1. Long-term inactivation of gating currentsQ36408617
Effective gating charges per channel in voltage-dependent K+ and Ca2+ channelsQ36435717
Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channelsQ37530408
Slow gating charge immobilization in the human potassium channel Kv1.5 and its prevention by 4-aminopyridineQ41184284
Dynamic rearrangement of the outer mouth of a K+ channel during gatingQ41212365
Inactivation of the sodium channel. II. Gating current experimentsQ41933393
Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB.Q42630418
Two types of inactivation in Shaker K+ channels: effects of alterations in the carboxy-terminal region.Q45930888
Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channelsQ46048873
Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channelsQ46066064
Inactivation determined by a single site in K+ poresQ49157028
Molecular basis of gating charge immobilization in Shaker potassium channels.Q50796639
P433issue5
P304page(s)579-589
P577publication date1997-11-01
P1433published inThe Journal of General PhysiologyQ1092259
P1476titleCorrelation between charge movement and ionic current during slow inactivation in Shaker K+ channels
P478volume110

Reverse relations

cites work (P2860)
Q35723314"Slow" Voltage-Dependent Inactivation of CaV2.2 Calcium Channels Is Modulated by the PKC Activator Phorbol 12-Myristate 13-Acetate (PMA).
Q36412275A conducting state with properties of a slow inactivated state in a shaker K(+) channel mutant
Q50722032A conserved glutamate is important for slow inactivation in K+ channels.
Q50646634A conserved ring of charge in mammalian Na+ channels: a molecular regulator of the outer pore conformation during slow inactivation.
Q41828199A direct demonstration of closed-state inactivation of K+ channels at low pH.
Q37121989A gating charge interaction required for late slow inactivation of the bacterial sodium channel NavAb
Q44757373A proton pore in a potassium channel voltage sensor reveals a focused electric field
Q37267654A single charged voltage sensor is capable of gating the Shaker K+ channel
Q34172155Acceleration of P/C-type inactivation in voltage-gated K(+) channels by methionine oxidation
Q40783466Altered state dependence of c-type inactivation in the long and short forms of human Kv1.5.
Q24297846Amino-terminal determinants of U-type inactivation of voltage-gated K+ channels
Q36667879Atomic constraints between the voltage sensor and the pore domain in a voltage-gated K+ channel of known structure
Q39258375Basis for allosteric open-state stabilization of voltage-gated potassium channels by intracellular cations
Q80094809Block by internal Mg2+ causes voltage-dependent inactivation of Kv1.5.
Q42598538C-type inactivation involves a significant decrease in the intracellular aqueous pore volume of Kv1.4 K+ channels expressed in Xenopus oocytes.
Q36568471C-type inactivation of voltage-gated K+ channels: pore constriction or dilation?
Q36445145Cations affect the rate of gating charge recovery in wild-type and W434F Shaker channels through a variety of mechanisms
Q42586187Charge movement of a voltage-sensitive fluorescent protein
Q37040647Closed state-coupled C-type inactivation in BK channels
Q48682233Conformational changes in the M2 muscarinic receptor induced by membrane voltage and agonist binding
Q42070841Contributions of intracellular ions to kv channel voltage sensor dynamics
Q36295859Cross talk between activation and slow inactivation gates of Shaker potassium channels
Q36412133Deletion of the S3-S4 linker in the Shaker potassium channel reveals two quenching groups near the outside of S4
Q44114996Depolarization induces intersubunit cross-linking in a S4 cysteine mutant of the Shaker potassium channel
Q40184341Dilated and defunct K channels in the absence of K+.
Q34180133Effect of S6 tail mutations on charge movement in Shaker potassium channels
Q40021651Effects of changes in extracellular pH and potassium concentration on Kv1.3 inactivation
Q36442029Electrostatics and the gating pore of Shaker potassium channels
Q44527174Evidence for intersubunit interactions between S4 and S5 transmembrane segments of the Shaker potassium channel
Q36412177Extracellular Mg(2+) modulates slow gating transitions and the opening of Drosophila ether-à-Go-Go potassium channels
Q41576828Fast and slow voltage sensor rearrangements during activation gating in Kv1.2 channels detected using tetramethylrhodamine fluorescence
Q36412045Fast inactivation in Shaker K+ channels. Properties of ionic and gating currents
Q36967583Filter gate closure inhibits ion but not water transport through potassium channels
Q40195554Gating charge immobilization caused by the transition between inactivated states in the Kv1.5 channel
Q36471344Gating charge immobilization in Kv4.2 channels: the basis of closed-state inactivation
Q40970162Gating current studies reveal both intra- and extracellular cation modulation of K+ channel deactivation
Q46795750Gating currents
Q89239672Gating currents
Q35918682Gating currents associated with intramembrane charge displacement in HERG potassium channels
Q28571572Gating currents from a Kv3 subfamily potassium channel: charge movement and modification by BDS-II toxin
Q40164179Gating of the HypoPP-1 mutations: I. Mutant-specific effects and cooperativity
Q36445425Gating of the bacterial sodium channel, NaChBac: voltage-dependent charge movement and gating currents
Q41277802Gating pore currents, a new pathological mechanism underlying cardiac arrhythmias associated with dilated cardiomyopathy.
Q35787126Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor
Q34310266Hv1 proton channel opening is preceded by a voltage-independent transition
Q36445714Hysteresis in the voltage dependence of HCN channels: conversion between two modes affects pacemaker properties
Q38968792Hysteresis in voltage-gated channels
Q35503208Hysteresis of gating underlines sensitization of TRPV3 channels
Q36420427Inactivation gating of Kv4 potassium channels: molecular interactions involving the inner vestibule of the pore
Q36412096Inactivation of gating currents of L-type calcium channels. Specific role of the alpha 2 delta subunit
Q40939691Interaction between permeant ions and voltage sensor during inactivation of N-type Ca2+ channels
Q36436105Intermediate conductances during deactivation of heteromultimeric Shaker potassium channels
Q49527743Inverse Modulation of Neuronal Kv12.1 and Kv11.1 Channels by 4-Aminopyridine and NS1643.
Q41980375It's spring-time for slow inactivation
Q38110757K(+) channels: function-structural overview.
Q89943460KV1.2 channels inactivate through a mechanism similar to C-type inactivation
Q36436387KcsA: it's a potassium channel
Q39687841Kinetic analysis of the effects of H+ or Ni2+ on Kv1.5 current shows that both ions enhance slow inactivation and induce resting inactivation.
Q34176096Kv4 channels exhibit modulation of closed-state inactivation in inside-out patches
Q34169066Loss of shaker K channel conductance in 0 K+ solutions: role of the voltage sensor
Q36436044Macroscopic Na+ currents in the "Nonconducting" Shaker potassium channel mutant W434F.
Q48660231Mechanism of accelerated current decay caused by an episodic ataxia type-1-associated mutant in a potassium channel pore.
Q38044382Mechanism of electromechanical coupling in voltage-gated potassium channels
Q30481111Mechanism of the modulation of Kv4:KChIP-1 channels by external K+
Q48886804Mechanisms for the time-dependent decay of inward currents through cloned Kir2.1 channels expressed in Xenopus oocytes
Q37811650Mechanisms of closed-state inactivation in voltage-gated ion channels
Q41939192Mechanisms underlying modulation of neuronal KCNQ2/KCNQ3 potassium channels by extracellular protons
Q36412511Membrane tension accelerates rate-limiting voltage-dependent activation and slow inactivation steps in a Shaker channel
Q42722538Mode shift of the voltage sensors in Shaker K+ channels is caused by energetic coupling to the pore domain
Q24681855Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels
Q36353455Modeling-independent elucidation of inactivation pathways in recombinant and native A-type Kv channels
Q34028236Modification of hERG1 channel gating by Cd2+.
Q90410795Modulation of hERG K+ Channel Deactivation by Voltage Sensor Relaxation
Q28258802Modulation of the voltage sensor of L-type Ca2+ channels by intracellular Ca2+
Q38266367Molecular biology and biophysical properties of ion channel gating pores.
Q36436295Molecular coupling of S4 to a K(+) channel's slow inactivation gate
Q39407044Molecular determinants of the inhibition of human Kv1.5 potassium currents by external protons and Zn(2+).
Q34170431N-type calcium channel inactivation probed by gating-current analysis
Q40268694Na+ permeation and block of hERG potassium channels
Q33385659Non-native R1 substitution in the s4 domain uniquely alters Kv4.3 channel gating
Q47851925Pore accessibility during C-type inactivation in Shaker K+ channels
Q34368444Position and motions of the S4 helix during opening of the Shaker potassium channel
Q36427215Potassium-dependent changes in the conformation of the Kv2.1 potassium channel pore
Q34594650Properties of deactivation gating currents in Shaker channels
Q36436101Protein rearrangements underlying slow inactivation of the Shaker K+ channel
Q83971686RETRACTED ARTICLE: Deprotonation of arginines in S4 is involved in NaChBac gating
Q24644527Rapid induction of P/C-type inactivation is the mechanism for acid-induced K+ current inhibition
Q36985914Reciprocal voltage sensor-to-pore coupling leads to potassium channel C-type inactivation
Q73133104Reconstructing voltage sensor-pore interaction from a fluorescence scan of a voltage-gated K+ channel
Q36493507Resting potential-dependent regulation of the voltage sensitivity of sodium channel gating in rat skeletal muscle in vivo
Q36634324Retigabine holds KV7 channels open and stabilizes the resting potential
Q40432092Role of extracellular Ca2+ in gating of CaV1.2 channels
Q37338024S3-S4 linker length modulates the relaxed state of a voltage-gated potassium channel
Q36976792S4-based voltage sensors have three major conformations
Q40234789SCAM analysis reveals a discrete region of the pore turret that modulates slow inactivation in Kv1.5.
Q40397556Separation of P/C- and U-type inactivation pathways in Kv1.5 potassium channels
Q41820997Sequence of gating charge movement and pore gating in HERG activation and deactivation pathways
Q40917738Sequential gating in the human heart K(+) channel Kv1.5 incorporates Q(1) and Q(2) charge components
Q41218381Shab K (+) channel slow inactivation: a test for U-type inactivation and a hypothesis regarding K (+) -facilitated inactivation mechanisms
Q87215445Shaker IR T449 mutants separate C- from U-type inactivation
Q44454996ShakerIR and Kv1.5 mutant channels with enhanced slow inactivation also exhibit K⁺ o-dependent resting inactivation
Q30442687Shedding light on voltage-dependent gating
Q40343935Single channel analysis reveals different modes of Kv1.5 gating behavior regulated by changes of external pH.
Q42608566Slow conformational changes of the voltage sensor during the mode shift in hyperpolarization-activated cyclic-nucleotide-gated channels.
Q36980031Slow inactivation in Shaker K channels is delayed by intracellular tetraethylammonium.
Q34350663Slow inactivation in voltage gated potassium channels is insensitive to the binding of pore occluding peptide toxins.
Q40604322Slow inactivation of the Ca(V)3.1 isotype of T-type calcium channels.
Q36412550Specificity of charge-carrying residues in the voltage sensor of potassium channels
Q50192004Stabilization of the Activated hERG Channel Voltage Sensor by Depolarization Involves the S4-S5 Linker
Q37244466Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer
Q24630547Structural mechanism of C-type inactivation in K(+) channels
Q34072325Taking apart the gating of voltage-gated K+ channels
Q41558471The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure
Q40267541The binding of kappa-Conotoxin PVIIA and fast C-type inactivation of Shaker K+ channels are mutually exclusive
Q34243021The contribution of individual subunits to the coupling of the voltage sensor to pore opening in Shaker K channels: effect of ILT mutations in heterotetramers
Q34482244The cooperative voltage sensor motion that gates a potassium channel
Q40277956The external K+ concentration and mutations in the outer pore mouth affect the inhibition of kv1.5 current by Ni2+.
Q37388692The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel
Q34180381The link between ion permeation and inactivation gating of Kv4 potassium channels
Q30483659The membrane-based mechanism of cell motility in cochlear outer hair cells
Q46288808The voltage sensor of excitation-contraction coupling in mammals: Inactivation and interaction with Ca2.
Q35808791Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel
Q34181414Two components of voltage-dependent inactivation in Ca(v)1.2 channels revealed by its gating currents.
Q28344502U-type inactivation of Kv3.1 and Shaker potassium channels
Q33467370Use of voltage clamp fluorimetry in understanding potassium channel gating: a review of Shaker fluorescence data
Q36412147Voltage dependence of slow inactivation in Shaker potassium channels results from changes in relative K(+) and Na(+) permeabilities
Q42054305Voltage sensor inactivation in potassium channels
Q39310214Voltage sensor of ion channels and enzymes
Q36856367Voltage-dependent C-type inactivation in a constitutively open K+ channel
Q30494869Voltage-dependent membrane displacements measured by atomic force microscopy
Q36412161Voltage-dependent structural interactions in the Shaker K(+) channel
Q36209603Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels
Q41949792What's in gating currents? Going beyond the voltage sensor movement
Q44939604pH-dependent modulation of Kv1.3 inactivation: role of His399.

Search more.