T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity

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T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1038/SJ.EMBOR.7400682
P932PMC publication ID1479560
P698PubMed publication ID16670682
P5875ResearchGate publication ID7109308

P50authorWolfgang SchamelQ1503533
Mahima SwamyQ42410771
Balbino AlarcónQ43376020
P2093author name stringHisse M van Santen
P2860cites workDirect observation of ligand recognition by T cells.Q46020608
T cell killing does not require the formation of a stable mature immunological synapse.Q46039675
Ligand recognition by alpha beta T cell receptorsQ46222293
Altered TCR signaling from geometrically repatterned immunological synapsesQ46591680
Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivityQ46681223
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.Q46793124
Differences in pairing and cluster formation of T cell receptor alpha- and beta-chains in T cell clones and fusion hybridomasQ46832192
Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]Q46842083
Antigen receptor tail clue.Q55060334
Erratum: Costimulation and endogenous MHC ligands contribute to T cell recognitionQ57962311
The semiotics of chargeQ59018971
Membrane protein association by potential intrarnembrane charge pairsQ59054338
Receptor clustering as a cellular mechanism to control sensitivityQ59065873
A conformation- and avidity-based proofreading mechanism for the TCR-CD3 complexQ62001653
Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonismQ77530678
Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer modelQ24314448
Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active formQ29619372
Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexesQ30778649
Structure of the T-cell antigen receptor: evidence for two CD3 epsilon subunits in the T-cell receptor-CD3 complexQ33800570
The organizing principle in the formation of the T cell receptor-CD3 complex.Q34167740
Lipid traffic: floppy drives and a superhighway.Q34555516
Multivalent structure of an alphabetaT cell receptorQ35000179
An evolutionary and structural perspective on T cell antigen receptor functionQ35076666
Initiation of TCR signaling: regulation within CD3 dimersQ35076671
Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chainsQ36363495
Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of responseQ36402779
Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signalingQ37695679
Biochemical differences in the alphabeta T cell receptor.CD3 surface complex between CD8+ and CD4+ human mature T lymphocytesQ40570794
Concentration of MHC class II molecules in lipid rafts facilitates antigen presentationQ40820913
The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomersQ40831490
Monomeric and oligomeric complexes of the B cell antigen receptorQ40863334
Stoichiometry of the T-cell receptor-CD3 complex and key intermediates assembled in the endoplasmic reticulumQ40917234
TCRzeta is transported to and retained in the Golgi apparatus independently of other TCR chains: implications for TCR assemblyQ40950177
Evidence for multivalent structure of T-cell antigen receptor complexQ41315792
Serial triggering of many T-cell receptors by a few peptide-MHC complexesQ41346263
Structure of the T cell receptor in a Ti alpha V beta 2, alpha V beta 8-positive T cell lineQ41469343
Tetrameric cell-surface MHC class I molecules.Q41624545
Assembly and function of the T cell antigen receptor. Requirement of either the lysine or arginine residues in the transmembrane region of the alpha chainQ41725004
Structure of the T cell antigen receptor (TCR): two CD3 epsilon subunits in a functional TCR/CD3 complexQ42767821
Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapseQ43186964
A symmetrical view of the T-cell receptor-CD3 complex.Q44044405
Pharmacological disintegration of lipid rafts decreases specific tetramer binding and disrupts the CD3 complex and CD8 heterodimer in human cytotoxic T lymphocytesQ44316830
P433issue5
P921main subjectstoichiometryQ213185
P304page(s)490-495
P577publication date2006-05-01
P1433published inEMBO ReportsQ5323356
P1476titleT-cell antigen-receptor stoichiometry: pre-clustering for sensitivity
P478volume7

Reverse relations

cites work (P2860)
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Q30660872Application limits and data correction in number of molecules and brightness analysis
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Q50477309Blue native polyacrylamide gel electrophoresis (BN-PAGE) for the identification and analysis of multiprotein complexes.
Q42410761Cholesterol and sphingomyelin drive ligand-independent T-cell antigen receptor nanoclustering
Q35209066DNAM-1-based chimeric antigen receptors enhance T cell effector function and exhibit in vivo efficacy against melanoma
Q41957570Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficiencies
Q34113293Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of alpha beta T cell receptors
Q37026523Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol
Q27002652Linking form to function: Biophysical aspects of artificial antigen presenting cell design
Q37605803Localization and socialization: experimental insights into the functional architecture of IP3 receptors
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Q34708948Molecular architecture of the αβ T cell receptor-CD3 complex
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Q34320305Organization of the resting TCR in nanoscale oligomers
Q37661366Pairing computation with experimentation: a powerful coupling for understanding T cell signalling
Q35091238Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells.
Q42128282Pre-clustering of the B cell antigen receptor demonstrated by mathematically extended electron microscopy
Q33988097Quantitative analysis of protein phosphorylations and interactions by multi-colour IP-FCM as an input for kinetic modelling of signalling networks
Q38211020Receptor Pre-Clustering and T cell Responses: Insights into Molecular Mechanisms
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Q33542874Stoichiometry and intracellular fate of TRIM-containing TCR complexes
Q27319571Structural Model of the Extracellular Assembly of the TCR-CD3 Complex
Q27333772Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity
Q88874297Synaptic activity induces input-specific rearrangements in a targeted synaptic protein interaction network
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Q24658051T cell activation
Q35022108T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters
Q39043852The Allostery Model of TCR Regulation
Q33351190The SCHOOL of nature: I. Transmembrane signaling

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